Pimozide_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimozide_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.268367
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.123222
AKAP12 A kinase (PRKA) anchor protein 12 0.118742
PDE4D phosphodiesterase 4D, cAMP-specific 0.106656
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.103836
GPC6 glypican 6 0.0931667
PRRC2C proline-rich coiled-coil 2C 0.0924988
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0868676
IGF2 insulin-like growth factor 2 0.0857282
EEF2 eukaryotic translation elongation factor 2 0.082859
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0714748
PDLIM5 PDZ and LIM domain 5 0.0711161
MYH9 myosin, heavy chain 9, non-muscle 0.0637484
LOX lysyl oxidase 0.0635504
DGKD diacylglycerol kinase, delta 130kDa 0.0610468
CUX1 cut-like homeobox 1 0.0592484
CALD1 caldesmon 1 0.0582402
COL6A3 collagen, type VI, alpha 3 0.054805
HLA-B major histocompatibility complex, class I, B 0.0544737
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0542197
SETD5 SET domain containing 5 0.0540067
RASA2 RAS p21 protein activator 2 0.053917
WAC WW domain containing adaptor with coiled-coil 0.0532899
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0529336
TGFBI transforming growth factor, beta-induced, 68kDa 0.0516245
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0512767
EHBP1 EH domain binding protein 1 0.0512068
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.051028
FNBP1 formin binding protein 1 0.0483649
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0471227
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0471133
FAM193A family with sequence similarity 193, member A 0.046561
GLS2 glutaminase 2 (liver, mitochondrial) 0.0454799
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0452012
SEC31A SEC31 homolog A (S. cerevisiae) 0.044451
SMAD3 SMAD family member 3 0.0434336
DOCK4 dedicator of cytokinesis 4 0.0432284
SYT1 synaptotagmin I 0.0429951
PHF3 PHD finger protein 3 0.0428508
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0428139
VCL vinculin 0.0428044
KIZ kizuna centrosomal protein 0.0427463
MT2A metallothionein 2A 0.0427214
STRN3 striatin, calmodulin binding protein 3 0.0418765
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0417348
NDRG1 N-myc downstream regulated 1 0.0415779
PRKCA protein kinase C, alpha 0.0415083
CCND1 cyclin D1 0.0411526
TNRC6B trinucleotide repeat containing 6B 0.0410929
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0409215
TPD52 tumor protein D52 0.0405654
NPAS2 neuronal PAS domain protein 2 0.0404335
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0399031
XRN1 5'-3' exoribonuclease 1 0.0395963
BRD2 bromodomain containing 2 0.0394986
MBD5 methyl-CpG binding domain protein 5 0.0385668
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0381657
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0381344
ATXN1 ataxin 1 0.0378386
STC1 stanniocalcin 1 0.0378272
PHF21A PHD finger protein 21A 0.0377881
LIMS1 LIM and senescent cell antigen-like domains 1 0.0376264
PSD3 pleckstrin and Sec7 domain containing 3 0.0372833
LEPROT leptin receptor overlapping transcript 0.0369642
RPL34 ribosomal protein L34 0.0365773
SLMAP sarcolemma associated protein 0.036565
CCDC91 coiled-coil domain containing 91 0.0364426
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0357776
CALR calreticulin 0.0356558
FNDC3B fibronectin type III domain containing 3B 0.0356329
SPATA13 spermatogenesis associated 13 0.0352206
KIAA1217 KIAA1217 0.0352171
EFNA5 ephrin-A5 0.034904
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0346963
CLASP1 cytoplasmic linker associated protein 1 0.0338736
HOOK2 hook microtubule-tethering protein 2 0.0337425
KDM4B lysine (K)-specific demethylase 4B 0.0335833
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0335549
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0333007
ZNF106 zinc finger protein 106 0.0329768
ERRFI1 ERBB receptor feedback inhibitor 1 0.0328177
CCNL1 cyclin L1 0.0327102
NACA nascent polypeptide-associated complex alpha subunit 0.0326167
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0325988
TM4SF1 transmembrane 4 L six family member 1 0.032583
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0324464
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.032292
CA12 carbonic anhydrase XII 0.0319772
ACTN4 actinin, alpha 4 0.0319382
FLNA filamin A, alpha 0.0317342
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0317077
MT1X metallothionein 1X 0.0314447
ITGAV integrin, alpha V 0.0314047
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0313055
TAOK1 TAO kinase 1 0.0312777
PGK1 phosphoglycerate kinase 1 0.0310696
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0309724
BIRC6 baculoviral IAP repeat containing 6 0.0305887
KDM4C lysine (K)-specific demethylase 4C 0.0304135
MAML2 mastermind-like 2 (Drosophila) 0.0302527

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.178562
FTL ferritin, light polypeptide -0.12907
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.110192
LMO7 LIM domain 7 -0.102361
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0988096
KRT17 keratin 17, type I -0.0968339
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0919968
TPT1 tumor protein, translationally-controlled 1 -0.0904062
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.089755
TXNRD1 thioredoxin reductase 1 -0.0890584
LAMB3 laminin, beta 3 -0.0887684
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0868019
TMSB10 thymosin beta 10 -0.0842259
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0789329
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0779234
STAU1 staufen double-stranded RNA binding protein 1 -0.07288
ATOSA atos homolog A -0.0718515
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0713966
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0676398
SLC38A1 solute carrier family 38, member 1 -0.0634581
AHNAK AHNAK nucleoprotein -0.0602955
DSCAM Down syndrome cell adhesion molecule -0.0595453
RPL35A ribosomal protein L35a -0.0590219
FBXO11 F-box protein 11 -0.058894
NPTN neuroplastin -0.0569009
PKM pyruvate kinase, muscle -0.0567297
NPEPPS aminopeptidase puromycin sensitive -0.0563465
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0562875
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0557787
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0557736
NALF1 NALCN channel auxiliary factor 1 -0.0525135
PTK2 protein tyrosine kinase 2 -0.0516371
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0513425
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0513358
NAMPT nicotinamide phosphoribosyltransferase -0.0510436
IFIH1 interferon induced with helicase C domain 1 -0.0482753
RPS29 ribosomal protein S29 -0.0479857
GRB10 growth factor receptor-bound protein 10 -0.0479276
USP53 ubiquitin specific peptidase 53 -0.0474083
KDM5B lysine (K)-specific demethylase 5B -0.0469279
RPL26 ribosomal protein L26 -0.0467594
TMOD3 tropomodulin 3 (ubiquitous) -0.0461439
RIOK3 RIO kinase 3 -0.0454468
CAMTA1 calmodulin binding transcription activator 1 -0.044936
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0448731
MTUS1 microtubule associated tumor suppressor 1 -0.0447418
RNF145 ring finger protein 145 -0.0440547
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0439452
DICER1 dicer 1, ribonuclease type III -0.0434542
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0429797
AFF1 AF4/FMR2 family, member 1 -0.0425896
UBE2H ubiquitin-conjugating enzyme E2H -0.0420683
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0416239
CANX calnexin -0.0414986
ACVR1 activin A receptor, type I -0.0412878
S100A10 S100 calcium binding protein A10 -0.0411644
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.04097
LAMC2 laminin, gamma 2 -0.0404377
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0401829
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0399077
RBM15 RNA binding motif protein 15 -0.0398079
GPBP1 GC-rich promoter binding protein 1 -0.0397734
FN1 fibronectin 1 -0.0395858
FTH1 ferritin, heavy polypeptide 1 -0.039457
RPS24 ribosomal protein S24 -0.0391178
SOX4 SRY (sex determining region Y)-box 4 -0.0390704
F3 coagulation factor III (thromboplastin, tissue factor) -0.0388407
RPLP1 ribosomal protein, large, P1 -0.0385188
FOXO3 forkhead box O3 -0.0383005
EMP1 epithelial membrane protein 1 -0.038053
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0376176
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0375671
FNDC3A fibronectin type III domain containing 3A -0.0372265
LIMCH1 LIM and calponin homology domains 1 -0.037083
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0363443
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.036334
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0359329
KMT2C lysine (K)-specific methyltransferase 2C -0.035496
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0350476
RPL31 ribosomal protein L31 -0.0349677
PICALM phosphatidylinositol binding clathrin assembly protein -0.0347965
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0342644
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.034243
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0341956
SDCBP syndecan binding protein (syntenin) -0.0339797
RRBP1 ribosome binding protein 1 -0.0334347
ZNF292 zinc finger protein 292 -0.0333555
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0328557
KTN1 kinectin 1 (kinesin receptor) -0.0325878
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0324452
RPL37A ribosomal protein L37a -0.0324372
SRPK2 SRSF protein kinase 2 -0.03218
ZNFX1 zinc finger, NFX1-type containing 1 -0.032082
MCL1 myeloid cell leukemia 1 -0.0318173
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0317615
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0317574
NEK7 NIMA-related kinase 7 -0.0316155
TMSB4X thymosin beta 4, X-linked -0.0315405
ABI1 abl-interactor 1 -0.0314386
FAM13A family with sequence similarity 13, member A -0.0312399