Pimozide_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimozide_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.13471
GRAMD1B GRAM domain containing 1B 0.127025
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0822115
OSMR oncostatin M receptor 0.0777891
EGR1 early growth response 1 0.0762176
RAD51B RAD51 paralog B 0.0753787
TXNRD1 thioredoxin reductase 1 0.073192
DOCK5 dedicator of cytokinesis 5 0.069511
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0676449
YBX3 Y box binding protein 3 0.0651506
ATP11A ATPase, class VI, type 11A 0.0633379
THSD4 thrombospondin, type I, domain containing 4 0.0630023
TRIO trio Rho guanine nucleotide exchange factor 0.0572444
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0540555
ERRFI1 ERBB receptor feedback inhibitor 1 0.052208
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0502718
MCL1 myeloid cell leukemia 1 0.0484042
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0478846
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0464144
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0450996
CDK17 cyclin-dependent kinase 17 0.0419507
PDE10A phosphodiesterase 10A 0.0415749
SLC38A2 solute carrier family 38, member 2 0.0408332
RICTOR RPTOR independent companion of MTOR, complex 2 0.0398925
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.039328
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0386666
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0385044
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0360813
PDE4D phosphodiesterase 4D, cAMP-specific 0.0339507
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0337341
CCNL1 cyclin L1 0.0336871
EEF2 eukaryotic translation elongation factor 2 0.033521
WNK1 WNK lysine deficient protein kinase 1 0.033446
NABP1 nucleic acid binding protein 1 0.0333177
ELL2 elongation factor, RNA polymerase II, 2 0.0331872
ACTN1 actinin, alpha 1 0.0325917
TM4SF1 transmembrane 4 L six family member 1 0.0324448
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0323599
EXT1 exostosin glycosyltransferase 1 0.0323056
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0320461
EEF1G eukaryotic translation elongation factor 1 gamma 0.0314385
MARCHF4 membrane associated ring-CH-type finger 4 0.0314322
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0313239
PRKCE protein kinase C, epsilon 0.0312848
IGF1R insulin-like growth factor 1 receptor 0.0303183
TRIP12 thyroid hormone receptor interactor 12 0.0297951
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0289524
PRPF8 pre-mRNA processing factor 8 0.0287698
ANKRD17 ankyrin repeat domain 17 0.0286305
EML4 echinoderm microtubule associated protein like 4 0.0283365
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0279649
EXOC4 exocyst complex component 4 0.0277638
PGK1 phosphoglycerate kinase 1 0.0275172
PHF14 PHD finger protein 14 0.0274191
SMAD3 SMAD family member 3 0.0272845
SFPQ splicing factor proline/glutamine-rich 0.0270352
LATS2 large tumor suppressor kinase 2 0.026896
SPRED2 sprouty-related, EVH1 domain containing 2 0.0267277
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0265518
EXOC6B exocyst complex component 6B 0.0265445
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0263874
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0262826
BRD2 bromodomain containing 2 0.0261976
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0259609
STC1 stanniocalcin 1 0.0259295
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0256423
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0254215
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0253033
RAB7A RAB7A, member RAS oncogene family 0.0252879
RTN4 reticulon 4 0.0252001
POTEF POTE ankyrin domain family, member F 0.0250311
CLTC clathrin, heavy chain (Hc) 0.0248794
YAP1 Yes-associated protein 1 0.0245363
FLNA filamin A, alpha 0.0243585
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0242367
ZFAND3 zinc finger, AN1-type domain 3 0.024226
CALD1 caldesmon 1 0.0239556
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0233887
NF1 neurofibromin 1 0.0233467
CCDC91 coiled-coil domain containing 91 0.0233383
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0227068
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0225545
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0225414
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0225283
KMT2D lysine (K)-specific methyltransferase 2D 0.0225191
FAF1 Fas (TNFRSF6) associated factor 1 0.0224918
RBM33 RNA binding motif protein 33 0.0223171
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0221733
ATXN1 ataxin 1 0.0221355
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0220419
NUP98 nucleoporin 98kDa 0.0220256
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0218235
ARID1A AT rich interactive domain 1A (SWI-like) 0.0216729
VCL vinculin 0.0214085
TMEM41B transmembrane protein 41B 0.0213651
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0212897
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0212841
WWTR1 WW domain containing transcription regulator 1 0.021239
BABAM2 BRISC and BRCA1 A complex member 2 0.020952
ZNF207 zinc finger protein 207 0.0207998

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.18606
PTMA prothymosin, alpha -0.139597
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.13893
TMSB10 thymosin beta 10 -0.103888
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102071
VIM vimentin -0.100686
RPS8 ribosomal protein S8 -0.0818257
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0713211
RPL23 ribosomal protein L23 -0.0674046
TPT1 tumor protein, translationally-controlled 1 -0.0549815
RPLP1 ribosomal protein, large, P1 -0.0539456
RPS19 ribosomal protein S19 -0.0534897
RPL35A ribosomal protein L35a -0.0531064
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0522418
RPS29 ribosomal protein S29 -0.0518716
RPS3 ribosomal protein S3 -0.0513009
RPL12 ribosomal protein L12 -0.0508199
CANX calnexin -0.0504321
RPL37A ribosomal protein L37a -0.0497942
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0495955
RPL34 ribosomal protein L34 -0.0449617
GNAS GNAS complex locus -0.0449359
EIF1 eukaryotic translation initiation factor 1 -0.0447161
RPS21 ribosomal protein S21 -0.0446462
RPS27 ribosomal protein S27 -0.0430839
RPL19 ribosomal protein L19 -0.0427396
RPS25 ribosomal protein S25 -0.0397898
RPL37 ribosomal protein L37 -0.0395773
YBX1 Y box binding protein 1 -0.039166
RPL26 ribosomal protein L26 -0.0381239
RPS15 ribosomal protein S15 -0.0380925
MYL12B myosin, light chain 12B, regulatory -0.0379004
OGA O-GlcNAcase -0.0350591
RPS27A ribosomal protein S27a -0.0349485
RPS6 ribosomal protein S6 -0.0347004
RPL36 ribosomal protein L36 -0.0346368
TOP2A topoisomerase (DNA) II alpha 170kDa -0.034285
RPL32 ribosomal protein L32 -0.0330543
RPS14 ribosomal protein S14 -0.0329743
RPS12 ribosomal protein S12 -0.0329076
PDIA4 protein disulfide isomerase family A, member 4 -0.0317789
RPS24 ribosomal protein S24 -0.0317298
FTL ferritin, light polypeptide -0.0313599
CALR calreticulin -0.0309297
MT2A metallothionein 2A -0.0304526
RPL31 ribosomal protein L31 -0.0302142
RPL8 ribosomal protein L8 -0.0297789
S100A10 S100 calcium binding protein A10 -0.0291403
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0284503
NAP1L1 nucleosome assembly protein 1-like 1 -0.0283801
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0278183
RPS10 ribosomal protein S10 -0.0274038
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0268944
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.026519
RPL5 ribosomal protein L5 -0.0264302
RPLP2 ribosomal protein, large, P2 -0.0259287
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0254659
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0253768
RSL1D1 ribosomal L1 domain containing 1 -0.0252838
RPS20 ribosomal protein S20 -0.0246827
RPL9 ribosomal protein L9 -0.0246241
GARS1 glycyl-tRNA synthetase 1 -0.0245945
RPL35 ribosomal protein L35 -0.0245109
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0245087
AHNAK AHNAK nucleoprotein -0.0241126
KTN1 kinectin 1 (kinesin receptor) -0.0240735
SRP72 signal recognition particle 72kDa -0.0235571
PDIA6 protein disulfide isomerase family A, member 6 -0.0234771
RPL11 ribosomal protein L11 -0.0230796
RPL7A ribosomal protein L7a -0.022953
RPL38 ribosomal protein L38 -0.0228421
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.022497
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0224895
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0220738
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0219301
RPS17 ribosomal protein S17 -0.0218805
GOLGA4 golgin A4 -0.0218054
ENO1 enolase 1, (alpha) -0.0217599
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0214954
RPS16 ribosomal protein S16 -0.0213518
KDM3A lysine (K)-specific demethylase 3A -0.0212528
RSF1 remodeling and spacing factor 1 -0.0210594
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0205916
RPS13 ribosomal protein S13 -0.0205731
DEK DEK proto-oncogene -0.0205427
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0205173
TPI1 triosephosphate isomerase 1 -0.0204928
RPLP0 ribosomal protein, large, P0 -0.0204921
UBB ubiquitin B -0.0200296
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0198669
RPS26 ribosomal protein S26 -0.0195168
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0193335
RPL18 ribosomal protein L18 -0.0188889
RLF rearranged L-myc fusion -0.0187319
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.018702
RPL36A ribosomal protein L36a -0.0186382
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0183868
RPS4X ribosomal protein S4, X-linked -0.0182496
ATP5F1E ATP synthase F1 subunit epsilon -0.0179904
PRRC2C proline-rich coiled-coil 2C -0.0178208