Pimozide_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimozide_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.0936265
FN1 fibronectin 1 0.0876566
NAMPT nicotinamide phosphoribosyltransferase 0.0840172
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0768402
EFNA5 ephrin-A5 0.0750279
TRIO trio Rho guanine nucleotide exchange factor 0.0628081
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.049239
FNDC3B fibronectin type III domain containing 3B 0.0459977
MYOF myoferlin 0.0443644
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0434284
LIMCH1 LIM and calponin homology domains 1 0.042712
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0418063
NPAS2 neuronal PAS domain protein 2 0.0399971
NEK7 NIMA-related kinase 7 0.0396552
PGK1 phosphoglycerate kinase 1 0.03938
ASPH aspartate beta-hydroxylase 0.0391051
ZEB2 zinc finger E-box binding homeobox 2 0.0386651
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0375758
NRCAM neuronal cell adhesion molecule 0.0374799
TGFBI transforming growth factor, beta-induced, 68kDa 0.0365969
ELL2 elongation factor, RNA polymerase II, 2 0.036052
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0357064
TM4SF1 transmembrane 4 L six family member 1 0.0350515
TXNRD1 thioredoxin reductase 1 0.0345154
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0335921
SPTBN1 spectrin, beta, non-erythrocytic 1 0.032825
SAMD4A sterile alpha motif domain containing 4A 0.0307193
KYNU kynureninase 0.0307181
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0306745
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0303353
COL8A1 collagen, type VIII, alpha 1 0.0288665
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.028678
PDLIM5 PDZ and LIM domain 5 0.02864
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0286081
COL5A2 collagen, type V, alpha 2 0.0285806
CD109 CD109 molecule 0.027677
RTN4 reticulon 4 0.0271158
CXCL8 chemokine (C-X-C motif) ligand 8 0.0267408
GRAMD1B GRAM domain containing 1B 0.0265532
FLNB filamin B, beta 0.0262525
TGFBR1 transforming growth factor, beta receptor 1 0.023991
DOCK4 dedicator of cytokinesis 4 0.0232904
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0227985
AGFG1 ArfGAP with FG repeats 1 0.0222135
CTSC cathepsin C 0.0217471
OSMR oncostatin M receptor 0.0216068
ENAH enabled homolog (Drosophila) 0.0213581
ESYT2 extended synaptotagmin-like protein 2 0.0209939
COL4A6 collagen, type IV, alpha 6 0.0204599
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0202149
BIRC6 baculoviral IAP repeat containing 6 0.019858
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0193008
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0187073
ANKRD28 ankyrin repeat domain 28 0.0185118
TFPI2 tissue factor pathway inhibitor 2 0.0181963
FTH1 ferritin, heavy polypeptide 1 0.0180382
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0179594
MFF mitochondrial fission factor 0.017887
SLC38A2 solute carrier family 38, member 2 0.0176522
BCAR3 breast cancer anti-estrogen resistance 3 0.0175825
ARHGAP29 Rho GTPase activating protein 29 0.0174823
ATP13A3 ATPase type 13A3 0.0174407
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0174062
EEF1G eukaryotic translation elongation factor 1 gamma 0.0173585
TNPO1 transportin 1 0.0172045
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0166815
SPAG9 sperm associated antigen 9 0.0165823
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0165637
AVL9 AVL9 homolog (S. cerevisiase) 0.0165381
PRRC2C proline-rich coiled-coil 2C 0.0164481
PM20D1 peptidase M20 domain containing 1 0.016259
IGFBP3 insulin-like growth factor binding protein 3 0.0160594
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0160504
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0159261
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0158606
PTEN phosphatase and tensin homolog 0.0158208
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0157527
LDHA lactate dehydrogenase A 0.0154838
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0154261
COL4A5 collagen, type IV, alpha 5 0.0152194
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0148281
SH3KBP1 SH3-domain kinase binding protein 1 0.0145727
BRWD3 bromodomain and WD repeat domain containing 3 0.014561
USP9X ubiquitin specific peptidase 9, X-linked 0.0144956
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0144013
MKI67 marker of proliferation Ki-67 0.0143506
AKAP13 A kinase (PRKA) anchor protein 13 0.0142976
BMERB1 bMERB domain containing 1 0.0140322
ANKRD17 ankyrin repeat domain 17 0.0139096
PDE10A phosphodiesterase 10A 0.0137818
CARD16 caspase recruitment domain family, member 16 0.0136127
TMX4 thioredoxin-related transmembrane protein 4 0.0136113
NBAS neuroblastoma amplified sequence 0.0134969
WDFY2 WD repeat and FYVE domain containing 2 0.0132289
ERRFI1 ERBB receptor feedback inhibitor 1 0.0131814
GLIS3 GLIS family zinc finger 3 0.0130875
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0129488
MCL1 myeloid cell leukemia 1 0.0129055
CLTC clathrin, heavy chain (Hc) 0.0125605
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0125037

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.0475049
TMSB10 thymosin beta 10 -0.0421335
TPT1 tumor protein, translationally-controlled 1 -0.0390033
RPS6 ribosomal protein S6 -0.03713
PTMA prothymosin, alpha -0.0369654
RPL31 ribosomal protein L31 -0.0359604
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0349821
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0347116
RPS8 ribosomal protein S8 -0.033055
RPS19 ribosomal protein S19 -0.0273543
RPLP1 ribosomal protein, large, P1 -0.0267559
RPL37A ribosomal protein L37a -0.0266505
FTL ferritin, light polypeptide -0.0262738
RPS12 ribosomal protein S12 -0.025238
RPS24 ribosomal protein S24 -0.0246911
RPL35A ribosomal protein L35a -0.024683
RPS23 ribosomal protein S23 -0.0238272
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0236044
CDH13 cadherin 13 -0.0220173
RPS29 ribosomal protein S29 -0.0210228
RPL34 ribosomal protein L34 -0.0200438
RPS3 ribosomal protein S3 -0.019288
RPS27A ribosomal protein S27a -0.0192114
PRKN parkin RBR E3 ubiquitin protein ligase -0.0190858
RPL7A ribosomal protein L7a -0.0190319
RPL9 ribosomal protein L9 -0.0189155
RPL23 ribosomal protein L23 -0.0188952
RPL26 ribosomal protein L26 -0.0181553
RPL19 ribosomal protein L19 -0.0176992
RPS13 ribosomal protein S13 -0.0173333
RPS25 ribosomal protein S25 -0.0170559
NALF1 NALCN channel auxiliary factor 1 -0.0165863
RPS27 ribosomal protein S27 -0.0162907
LSAMP limbic system-associated membrane protein -0.0162621
RPLP2 ribosomal protein, large, P2 -0.0161577
PTPRM protein tyrosine phosphatase, receptor type, M -0.0155101
RPS17 ribosomal protein S17 -0.0154216
AUTS2 autism susceptibility candidate 2 -0.0153177
RPS14 ribosomal protein S14 -0.0151493
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0150997
MT2A metallothionein 2A -0.0149359
RPL36 ribosomal protein L36 -0.0148367
PDE4D phosphodiesterase 4D, cAMP-specific -0.0145716
RPS10 ribosomal protein S10 -0.0132918
S100A10 S100 calcium binding protein A10 -0.0132479
B2M beta-2-microglobulin -0.0132382
RPL37 ribosomal protein L37 -0.0132079
RPL38 ribosomal protein L38 -0.0131314
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0130157
CADM2 cell adhesion molecule 2 -0.0128781
RPL36A ribosomal protein L36a -0.0124848
INTS6 integrator complex subunit 6 -0.0124843
RPL12 ribosomal protein L12 -0.0121799
RPS16 ribosomal protein S16 -0.0121278
RPS21 ribosomal protein S21 -0.0120413
RPL28 ribosomal protein L28 -0.0119092
EIF1 eukaryotic translation initiation factor 1 -0.011734
CUX1 cut-like homeobox 1 -0.0115507
HLA-B major histocompatibility complex, class I, B -0.0115324
XYLT1 xylosyltransferase I -0.0114221
PRELID2 PRELI domain containing 2 -0.011347
AEBP2 AE binding protein 2 -0.011304
RPL5 ribosomal protein L5 -0.0112584
SQSTM1 sequestosome 1 -0.0109039
GLRX glutaredoxin (thioltransferase) -0.0108873
RPL11 ribosomal protein L11 -0.0107333
MAML3 mastermind-like 3 (Drosophila) -0.0106614
LMNA lamin A/C -0.0105745
HLA-A major histocompatibility complex, class I, A -0.0105281
PCDH15 protocadherin-related 15 -0.0105198
RPL27 ribosomal protein L27 -0.0104535
RPL35 ribosomal protein L35 -0.0104529
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0104115
RPS11 ribosomal protein S11 -0.0103451
ASTN2 astrotactin 2 -0.0102851
DENND1A DENN/MADD domain containing 1A -0.0101506
RAD51B RAD51 paralog B -0.0101245
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0101212
GNAS GNAS complex locus -0.0100871
SMAD2 SMAD family member 2 -0.00992385
RPS15 ribosomal protein S15 -0.00979226
RPS5 ribosomal protein S5 -0.00967926
SOX6 SRY (sex determining region Y)-box 6 -0.00959771
WARS1 tryptophanyl-tRNA synthetase 1 -0.00950673
NCKAP5 NCK-associated protein 5 -0.00949867
PCDH9 protocadherin 9 -0.00947194
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00927379
RPL13A ribosomal protein L13a -0.0091929
RACK1 receptor for activated C kinase 1 -0.00872279
MAP7 microtubule-associated protein 7 -0.0083674
KIAA0825 KIAA0825 -0.00801984
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.00788018
VCL vinculin -0.00785099
ENO2 enolase 2 (gamma, neuronal) -0.00782603
RPL15 ribosomal protein L15 -0.00778542
C9ORF153 chromosome 9 open reading frame 153 -0.00773901
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.00772034
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.00751307
RPL32 ribosomal protein L32 -0.00749085
ISG15 ISG15 ubiquitin-like modifier -0.0074401