Pimozide_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimozide_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.455072
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.192194
AKAP12 A kinase (PRKA) anchor protein 12 0.133366
LMTK2 lemur tyrosine kinase 2 0.12792
SMAD3 SMAD family member 3 0.124435
TMSB10 thymosin beta 10 0.120085
TPR translocated promoter region, nuclear basket protein 0.115723
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.103001
EFNA5 ephrin-A5 0.0984866
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.09589
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0947269
EGR1 early growth response 1 0.0917077
MICU1 mitochondrial calcium uptake 1 0.0888619
PGK1 phosphoglycerate kinase 1 0.0886201
ACTG1 actin gamma 1 0.0886027
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0839531
DST dystonin 0.0803533
MT2A metallothionein 2A 0.0797913
ARHGAP29 Rho GTPase activating protein 29 0.0781397
FTH1 ferritin, heavy polypeptide 1 0.0779351
EGFR epidermal growth factor receptor 0.0749051
HSPA8 heat shock 70kDa protein 8 0.0743928
YBX1 Y box binding protein 1 0.0709397
SND1 staphylococcal nuclease and tudor domain containing 1 0.0702537
TSC22D2 TSC22 domain family, member 2 0.0680111
RAB1A RAB1A, member RAS oncogene family 0.06709
FLNB filamin B, beta 0.0669987
PCBP2 poly(rC) binding protein 2 0.0640869
ERRFI1 ERBB receptor feedback inhibitor 1 0.0636377
ESYT2 extended synaptotagmin-like protein 2 0.0618776
VCL vinculin 0.0596599
FTL ferritin, light polypeptide 0.0576484
POTEF POTE ankyrin domain family, member F 0.0574955
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0574464
RUNX1 runt-related transcription factor 1 0.0571531
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0554571
ANKRD12 ankyrin repeat domain 12 0.0547954
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0515558
GOLGA4 golgin A4 0.0514907
RAP1B RAP1B, member of RAS oncogene family 0.0512649
KMT2E lysine (K)-specific methyltransferase 2E 0.050731
ITCH itchy E3 ubiquitin protein ligase 0.0499641
CUX1 cut-like homeobox 1 0.0493475
IQGAP1 IQ motif containing GTPase activating protein 1 0.049003
ARID1B AT rich interactive domain 1B (SWI1-like) 0.048982
SETD5 SET domain containing 5 0.0488371
ASPH aspartate beta-hydroxylase 0.0481013
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0458815
NRIP1 nuclear receptor interacting protein 1 0.0454942
ANKRD17 ankyrin repeat domain 17 0.0438554
PDIA3 protein disulfide isomerase family A, member 3 0.0427625
TPD52 tumor protein D52 0.042308
PKM pyruvate kinase, muscle 0.0422942
LMO7 LIM domain 7 0.0419994
SQSTM1 sequestosome 1 0.0411451
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0409779
SLTM SAFB-like, transcription modulator 0.0401942
ZBTB20 zinc finger and BTB domain containing 20 0.0394894
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0365815
HELZ helicase with zinc finger 0.0355756
FN1 fibronectin 1 0.0354029
TBC1D22A TBC1 domain family, member 22A 0.0350308
GPC6 glypican 6 0.0347466
LDHA lactate dehydrogenase A 0.0341174
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0335891
MORF4L2 mortality factor 4 like 2 0.0319662
FAM13A family with sequence similarity 13, member A 0.0301847
CD44 CD44 molecule (Indian blood group) 0.0278195
CANX calnexin 0.0241672
PRRC2C proline-rich coiled-coil 2C 0.0231985
SLC38A1 solute carrier family 38, member 1 0.02309
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0223565
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0222086
HILPDA hypoxia inducible lipid droplet-associated 0.0217441
SFTPA2 surfactant protein A2 0.0213593
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0195329
EEF2 eukaryotic translation elongation factor 2 0.0186921
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0186226
ENO1 enolase 1, (alpha) 0.0180399
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0173375
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0136701
RPL37 ribosomal protein L37 0.0126352
UBA6 ubiquitin-like modifier activating enzyme 6 0.0118612
NCOA3 nuclear receptor coactivator 3 0.0117542
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0109714
ZNF292 zinc finger protein 292 0.0103332
NIPBL Nipped-B homolog (Drosophila) 0.0102378
RTN4 reticulon 4 0.00975338
RAB2A RAB2A, member RAS oncogene family 0.00949321
SBF2 SET binding factor 2 0.00924582
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00818065
MEF2A myocyte enhancer factor 2A 0.00703235
TPM4 tropomyosin 4 0.00692475
RLF rearranged L-myc fusion 0.00471409
CXCL8 chemokine (C-X-C motif) ligand 8 0.00367404
ANKRD11 ankyrin repeat domain 11 0.00224752
ANXA2 annexin A2 0.00182064
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.00120689
NKTR natural killer cell triggering receptor 0.00110218
ARID4B AT rich interactive domain 4B (RBP1-like) 2.41178E-4

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.172396
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.14887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.139903
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.133129
LAMA4 laminin, alpha 4 -0.11338
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.110677
NKD1 naked cuticle homolog 1 (Drosophila) -0.105832
PTMA prothymosin, alpha -0.103513
EXT1 exostosin glycosyltransferase 1 -0.0985953
FNDC3A fibronectin type III domain containing 3A -0.0938171
JMJD1C jumonji domain containing 1C -0.0896034
SEC31A SEC31 homolog A (S. cerevisiae) -0.0865458
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0859579
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0814971
PDE10A phosphodiesterase 10A -0.0812935
SMC5 structural maintenance of chromosomes 5 -0.0806469
PIBF1 progesterone immunomodulatory binding factor 1 -0.077404
PDE4D phosphodiesterase 4D, cAMP-specific -0.0759963
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0754072
HMGA2 high mobility group AT-hook 2 -0.0732065
RPS6 ribosomal protein S6 -0.0718024
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0701618
PDLIM5 PDZ and LIM domain 5 -0.0694237
PSD3 pleckstrin and Sec7 domain containing 3 -0.0678019
GOLGB1 golgin B1 -0.0647173
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0644059
KMT2C lysine (K)-specific methyltransferase 2C -0.0643453
TPT1 tumor protein, translationally-controlled 1 -0.0632158
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0628919
DSCAM Down syndrome cell adhesion molecule -0.0616457
RAB7A RAB7A, member RAS oncogene family -0.0586876
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0584206
RORA RAR-related orphan receptor A -0.0567205
CLTC clathrin, heavy chain (Hc) -0.0554666
VIM vimentin -0.0552092
BPTF bromodomain PHD finger transcription factor -0.0526907
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0509421
PTK2 protein tyrosine kinase 2 -0.04902
KTN1 kinectin 1 (kinesin receptor) -0.048699
JARID2 jumonji, AT rich interactive domain 2 -0.0480704
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0478489
INHBA inhibin, beta A -0.0476421
EIF1 eukaryotic translation initiation factor 1 -0.0475171
RPL23 ribosomal protein L23 -0.0446311
RNF213 ring finger protein 213 -0.0432789
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0430288
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0406481
ATF6 activating transcription factor 6 -0.0397888
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0388386
RSF1 remodeling and spacing factor 1 -0.0381683
MACF1 microtubule-actin crosslinking factor 1 -0.0370279
NAMPT nicotinamide phosphoribosyltransferase -0.0357609
FNIP1 folliculin interacting protein 1 -0.0356307
IGF2 insulin-like growth factor 2 -0.0338738
GPHN gephyrin -0.0329065
NF1 neurofibromin 1 -0.0320534
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0318329
B2M beta-2-microglobulin -0.0296823
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0280676
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0251417
MMP1 matrix metallopeptidase 1 -0.0246195
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0240082
PRELID2 PRELI domain containing 2 -0.0223687
NUP58 nucleoporin 58 -0.0206841
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0194254
BBX bobby sox homolog (Drosophila) -0.0180965
SRP54 signal recognition particle 54kDa -0.017866
TXNRD1 thioredoxin reductase 1 -0.0177064
SPAG9 sperm associated antigen 9 -0.0169079
XRN2 5'-3' exoribonuclease 2 -0.0166173
RPL11 ribosomal protein L11 -0.0164788
PUM1 pumilio RNA-binding family member 1 -0.0163742
FNDC3B fibronectin type III domain containing 3B -0.0162128
RPS19 ribosomal protein S19 -0.0159596
LAMB3 laminin, beta 3 -0.0153998
NALF1 NALCN channel auxiliary factor 1 -0.0144998
ATXN1 ataxin 1 -0.0140818
PARD3 par-3 family cell polarity regulator -0.0133851
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0129956
TGFBI transforming growth factor, beta-induced, 68kDa -0.0129872
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0127095
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0121805
EZR ezrin -0.0114433
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0109776
MCL1 myeloid cell leukemia 1 -0.0102028
GMDS GDP-mannose 4,6-dehydratase -0.00920785
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.00890074
WSB1 WD repeat and SOCS box containing 1 -0.00886568
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.00879
SEPTIN7 septin 7 -0.00582369
FMN1 formin 1 -0.00495043
TRIO trio Rho guanine nucleotide exchange factor -0.0048574
ELL2 elongation factor, RNA polymerase II, 2 -0.00467108
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.00443158
ATP11A ATPase, class VI, type 11A -0.00409625
MYO1E myosin IE -0.00336488
ZFAND3 zinc finger, AN1-type domain 3 -0.00333298
PHF3 PHD finger protein 3 -0.00321111
YEATS2 YEATS domain containing 2 -0.00238563
NDRG1 N-myc downstream regulated 1 -0.00213828