Pimozide_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimozide_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0689886
ZEB2 zinc finger E-box binding homeobox 2 0.0688518
PABPC1 poly(A) binding protein, cytoplasmic 1 0.060834
KMT2C lysine (K)-specific methyltransferase 2C 0.0522391
PDGFC platelet derived growth factor C 0.0449379
EEF1G eukaryotic translation elongation factor 1 gamma 0.0439108
ZFAND3 zinc finger, AN1-type domain 3 0.0412081
FBXO11 F-box protein 11 0.0411027
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0370374
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0360863
SLC38A2 solute carrier family 38, member 2 0.0353306
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0338293
WDR43 WD repeat domain 43 0.0333089
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0318747
PGAP1 post-GPI attachment to proteins 1 0.0313897
HMGA1 high mobility group AT-hook 1 0.0313214
RERE arginine-glutamic acid dipeptide (RE) repeats 0.03126
COTL1 coactosin-like F-actin binding protein 1 0.0300097
FAM171B family with sequence similarity 171, member B 0.0299879
LONP1 lon peptidase 1, mitochondrial 0.0299705
PDIA3 protein disulfide isomerase family A, member 3 0.0297239
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0296353
PDS5A PDS5 cohesin associated factor A 0.02939
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0290334
ENAH enabled homolog (Drosophila) 0.028308
TRPS1 trichorhinophalangeal syndrome I 0.0282408
SPAG9 sperm associated antigen 9 0.0274843
NTM neurotrimin 0.0273045
PLPP1 phospholipid phosphatase 1 0.0272327
ZNF608 zinc finger protein 608 0.0268945
TSC22D2 TSC22 domain family, member 2 0.0262633
SPRED2 sprouty-related, EVH1 domain containing 2 0.0262418
FNDC3B fibronectin type III domain containing 3B 0.0260265
NUP98 nucleoporin 98kDa 0.0255142
ANXA5 annexin A5 0.0253202
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0251526
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0249989
PCNX1 pecanex 1 0.024739
ZNF217 zinc finger protein 217 0.0246884
RAI1 retinoic acid induced 1 0.0246181
NAMPT nicotinamide phosphoribosyltransferase 0.0245772
TENM3 teneurin transmembrane protein 3 0.0244751
JMJD1C jumonji domain containing 1C 0.024374
RPS2 ribosomal protein S2 0.0240151
PDS5B PDS5 cohesin associated factor B 0.0237927
FLNA filamin A, alpha 0.0237883
CCN2 cellular communication network factor 2 0.0236361
ADGRG6 adhesion G protein-coupled receptor G6 0.0231469
NCOR1 nuclear receptor corepressor 1 0.0228418
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0227382
ECT2 epithelial cell transforming 2 0.0226606
ELOVL5 ELOVL fatty acid elongase 5 0.0226557
ANXA2 annexin A2 0.0226386
RBM33 RNA binding motif protein 33 0.0225403
AGO3 argonaute RISC catalytic component 3 0.0225263
PCDH18 protocadherin 18 0.0222566
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.0222518
RNASEH2A ribonuclease H2, subunit A 0.0220753
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0218174
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.021767
BCLAF1 BCL2-associated transcription factor 1 0.0216548
RHOH ras homolog family member H 0.021596
CEP170 centrosomal protein 170kDa 0.0215909
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.021511
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0214751
USP15 ubiquitin specific peptidase 15 0.0214428
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.0213438
GOLM2 golgi membrane protein 2 0.0211224
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0209936
WNK1 WNK lysine deficient protein kinase 1 0.0208054
CDC14A cell division cycle 14A 0.0207068
ADGRL2 adhesion G protein-coupled receptor L2 0.0205416
NEK7 NIMA-related kinase 7 0.020531
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0202106
SF1 splicing factor 1 0.0201302
CEP95 centrosomal protein 95kDa 0.0201085
GRB2 growth factor receptor-bound protein 2 0.0199219
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.019811
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0197742
SCAF4 SR-related CTD-associated factor 4 0.019646
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0196274
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0194
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0190741
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0189554
TTC28 tetratricopeptide repeat domain 28 0.0189334
SIK3 SIK family kinase 3 0.0188893
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0188799
WAC WW domain containing adaptor with coiled-coil 0.0187247
CDC5L cell division cycle 5-like 0.0187233
ZFC3H1 zinc finger, C3H1-type containing 0.0184401
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.0181262
AHCTF1 AT hook containing transcription factor 1 0.0181143
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0180392
CALCR calcitonin receptor 0.0180219
ANXA1 annexin A1 0.0180042
MKI67 marker of proliferation Ki-67 0.0179641
PRPF8 pre-mRNA processing factor 8 0.0179138
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0178459
CCNA2 cyclin A2 0.0178294
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0177981

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.162459
VIM vimentin -0.116467
COL11A1 collagen, type XI, alpha 1 -0.112648
CADM2 cell adhesion molecule 2 -0.100386
PTMA prothymosin, alpha -0.0866502
GPC3 glypican 3 -0.0800138
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0712255
PCDH9 protocadherin 9 -0.0662401
RPS8 ribosomal protein S8 -0.0659095
PHIP pleckstrin homology domain interacting protein -0.0655854
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0647112
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0625139
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0608121
UBC ubiquitin C -0.0548515
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0543152
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0535473
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0522822
RPS27A ribosomal protein S27a -0.05122
RPLP1 ribosomal protein, large, P1 -0.0500268
RPL31 ribosomal protein L31 -0.0470712
ITGAV integrin, alpha V -0.0458709
GNAS GNAS complex locus -0.0450097
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0447899
MAP4 microtubule-associated protein 4 -0.042664
FN1 fibronectin 1 -0.0415529
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0414791
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0407552
ENO1 enolase 1, (alpha) -0.0397316
RPLP2 ribosomal protein, large, P2 -0.0389472
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0385306
RPS6 ribosomal protein S6 -0.0380197
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0379046
RPS16 ribosomal protein S16 -0.037469
RPL23 ribosomal protein L23 -0.036053
LRRC4C leucine rich repeat containing 4C -0.0358188
ADGRV1 adhesion G protein-coupled receptor V1 -0.0352878
RPS3 ribosomal protein S3 -0.0352412
COL1A2 collagen, type I, alpha 2 -0.0352406
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0351644
ANK2 ankyrin 2, neuronal -0.0350765
APOE apolipoprotein E -0.0348962
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0347105
S100A10 S100 calcium binding protein A10 -0.0336507
SLC44A5 solute carrier family 44, member 5 -0.0336433
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0322301
AKAP12 A kinase (PRKA) anchor protein 12 -0.0319724
MDK midkine (neurite growth-promoting factor 2) -0.0316786
RPL32 ribosomal protein L32 -0.0316176
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0313548
RPL37A ribosomal protein L37a -0.0311255
TPT1 tumor protein, translationally-controlled 1 -0.0310028
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0292448
RPL12 ribosomal protein L12 -0.0292312
PCDH7 protocadherin 7 -0.0291445
KMT2E lysine (K)-specific methyltransferase 2E -0.0291201
SET SET nuclear proto-oncogene -0.0289251
NRG1 neuregulin 1 -0.0287388
COL3A1 collagen, type III, alpha 1 -0.0285765
S100A9 S100 calcium binding protein A9 -0.0284953
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0280473
RPL5 ribosomal protein L5 -0.0276527
RPS25 ribosomal protein S25 -0.0275186
PCLO piccolo presynaptic cytomatrix protein -0.0272762
TRIO trio Rho guanine nucleotide exchange factor -0.0269314
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0266684
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0265548
TMSB4X thymosin beta 4, X-linked -0.0264753
RPS14 ribosomal protein S14 -0.026401
ADGRL3 adhesion G protein-coupled receptor L3 -0.0262231
EEF2 eukaryotic translation elongation factor 2 -0.0258
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0257515
RPL19 ribosomal protein L19 -0.025634
HMGB1 high mobility group box 1 -0.0255219
CBX3 chromobox homolog 3 -0.0252857
RPL36 ribosomal protein L36 -0.0252075
RPL8 ribosomal protein L8 -0.0249406
SON SON DNA binding protein -0.0249246
RPS10 ribosomal protein S10 -0.0249134
SNX6 sorting nexin 6 -0.0247702
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0244094
HMGB2 high mobility group box 2 -0.0242812
ZNF638 zinc finger protein 638 -0.0241599
TPM4 tropomyosin 4 -0.024006
RAD51B RAD51 paralog B -0.0239104
RPS5 ribosomal protein S5 -0.0238734
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0237734
KCTD16 potassium channel tetramerization domain containing 16 -0.0237621
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.023753
RSF1 remodeling and spacing factor 1 -0.023668
SBF2 SET binding factor 2 -0.0233117
RPS12 ribosomal protein S12 -0.0231083
CALU calumenin -0.0228601
RSRC1 arginine/serine-rich coiled-coil 1 -0.0228405
RPL9 ribosomal protein L9 -0.0227358
NAP1L1 nucleosome assembly protein 1-like 1 -0.0223602
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.022326
UBE2K ubiquitin-conjugating enzyme E2K -0.0222848
WSB1 WD repeat and SOCS box containing 1 -0.022204
FTL ferritin, light polypeptide -0.0221614
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0221342