Pimozide_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimozide_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.188688
FTH1 ferritin, heavy polypeptide 1 0.148785
COL6A3 collagen, type VI, alpha 3 0.0978949
TGFBI transforming growth factor, beta-induced, 68kDa 0.0925164
TENT5A terminal nucleotidyltransferase 5A 0.0767705
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0733161
ATP13A3 ATPase type 13A3 0.0730287
STC1 stanniocalcin 1 0.0719335
AKAP9 A kinase (PRKA) anchor protein 9 0.0656026
IL6 interleukin 6 0.0569318
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0508986
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.050842
CEMIP cell migration inducing protein, hyaluronan binding 0.0493806
YEATS2 YEATS domain containing 2 0.0483576
HOOK2 hook microtubule-tethering protein 2 0.0466557
FOXJ3 forkhead box J3 0.0459169
FNIP1 folliculin interacting protein 1 0.0444326
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0424145
UGCG UDP-glucose ceramide glucosyltransferase 0.0419726
EEF1G eukaryotic translation elongation factor 1 gamma 0.041771
LOC112694756 uncharaterized LOC112694756 0.0416325
DSCAM Down syndrome cell adhesion molecule 0.0414953
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0409366
EGR1 early growth response 1 0.0408833
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0404365
NKD1 naked cuticle homolog 1 (Drosophila) 0.0403369
C1D C1D nuclear receptor corepressor 0.0397861
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.039639
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0394145
UBA6 ubiquitin-like modifier activating enzyme 6 0.0391811
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0391341
NAMPT nicotinamide phosphoribosyltransferase 0.0389591
MYADM myeloid-associated differentiation marker 0.0386846
ELL2 elongation factor, RNA polymerase II, 2 0.038257
STK10 serine/threonine kinase 10 0.0365717
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0364282
TM4SF1 transmembrane 4 L six family member 1 0.0358514
ARRDC3 arrestin domain containing 3 0.0355922
AKAP12 A kinase (PRKA) anchor protein 12 0.0351957
NDRG1 N-myc downstream regulated 1 0.0351196
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0350461
PNISR PNN-interacting serine/arginine-rich protein 0.0349622
TMEM165 transmembrane protein 165 0.0345999
KDM5B lysine (K)-specific demethylase 5B 0.0345312
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0339779
BIRC6 baculoviral IAP repeat containing 6 0.0339696
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0338425
MARCHF7 membrane associated ring-CH-type finger 7 0.0332883
RAB6A RAB6A, member RAS oncogene family 0.0332557
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.033159
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0330126
YTHDC1 YTH domain containing 1 0.0325323
AFF4 AF4/FMR2 family, member 4 0.0323176
OXSR1 oxidative stress responsive 1 0.0322656
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0320626
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0319991
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0319648
L1CAM L1 cell adhesion molecule 0.0316142
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0315353
TANK TRAF family member-associated NFKB activator 0.0309963
MARCHF6 membrane associated ring-CH-type finger 6 0.030872
FAM13A family with sequence similarity 13, member A 0.0305686
VEGFA vascular endothelial growth factor A 0.0303818
INSIG2 insulin induced gene 2 0.0302682
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0299032
TMEM263 transmembrane protein 263 0.0295627
NSD3 nuclear receptor binding SET domain protein 3 0.0293596
COG6 component of oligomeric golgi complex 6 0.0291959
SRP72 signal recognition particle 72kDa 0.0288155
SRP54 signal recognition particle 54kDa 0.0287849
COG5 component of oligomeric golgi complex 5 0.0286179
CIRSR corepressor of RBPJ and splicing regulator 0.0285215
SFTPA2 surfactant protein A2 0.0282868
BUB3 BUB3 mitotic checkpoint protein 0.028035
TBC1D23 TBC1 domain family, member 23 0.0279599
DIDO1 death inducer-obliterator 1 0.0279325
USP48 ubiquitin specific peptidase 48 0.0276579
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0276033
ANKRD17 ankyrin repeat domain 17 0.0274749
LASP1 LIM and SH3 protein 1 0.0273272
TNRC6A trinucleotide repeat containing 6A 0.027268
YME1L1 YME1-like 1 ATPase 0.0271092
SUCO SUN domain containing ossification factor 0.0271082
PCNX1 pecanex 1 0.0270341
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.0269283
TNPO3 transportin 3 0.0267423
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0267376
USP15 ubiquitin specific peptidase 15 0.0267015
ANLN anillin, actin binding protein 0.0267005
ERRFI1 ERBB receptor feedback inhibitor 1 0.026635
COPA coatomer protein complex, subunit alpha 0.0266037
MMP2 matrix metallopeptidase 2 0.0265506
EIF1 eukaryotic translation initiation factor 1 0.0261268
BCAR1 breast cancer anti-estrogen resistance 1 0.0260178
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0259956
FAM13B family with sequence similarity 13, member B 0.0259394
PARD3 par-3 family cell polarity regulator 0.0258952
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0258175
ARFIP1 ADP-ribosylation factor interacting protein 1 0.025814
MT2A metallothionein 2A 0.0254868

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.248398
TMSB10 thymosin beta 10 -0.205128
VIM vimentin -0.143352
FN1 fibronectin 1 -0.109168
COL1A1 collagen, type I, alpha 1 -0.107164
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0971565
PTMA prothymosin, alpha -0.096759
CALD1 caldesmon 1 -0.0898869
COL1A2 collagen, type I, alpha 2 -0.0875719
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0786293
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.078485
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0758267
CD44 CD44 molecule (Indian blood group) -0.075249
PSD3 pleckstrin and Sec7 domain containing 3 -0.073317
EXT1 exostosin glycosyltransferase 1 -0.0695835
CDK6 cyclin-dependent kinase 6 -0.069466
AHNAK AHNAK nucleoprotein -0.0667605
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0657805
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0623417
ENO1 enolase 1, (alpha) -0.0601576
POTEF POTE ankyrin domain family, member F -0.0592525
DPYD dihydropyrimidine dehydrogenase -0.0591934
RRBP1 ribosome binding protein 1 -0.0578898
F3 coagulation factor III (thromboplastin, tissue factor) -0.0568446
GRB10 growth factor receptor-bound protein 10 -0.0563711
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0555891
CAV1 caveolin 1, caveolae protein, 22kDa -0.0516693
SDC4 syndecan 4 -0.0513602
GLS2 glutaminase 2 (liver, mitochondrial) -0.0505093
TRIO trio Rho guanine nucleotide exchange factor -0.0490285
CALU calumenin -0.0485417
DST dystonin -0.0482449
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0478453
FBXL7 F-box and leucine-rich repeat protein 7 -0.0468681
TPT1 tumor protein, translationally-controlled 1 -0.0449143
ZFAND3 zinc finger, AN1-type domain 3 -0.0448153
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0446677
RTN4 reticulon 4 -0.0441027
RAD51B RAD51 paralog B -0.0440126
GLIS3 GLIS family zinc finger 3 -0.0428014
VEGFC vascular endothelial growth factor C -0.0427768
PRKCA protein kinase C, alpha -0.0422979
ASPH aspartate beta-hydroxylase -0.0421921
TAS2R14 taste receptor, type 2, member 14 -0.0420654
ATXN1 ataxin 1 -0.0382339
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.037505
MACF1 microtubule-actin crosslinking factor 1 -0.0374887
TPM4 tropomyosin 4 -0.0373559
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0366303
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0365859
MYO10 myosin X -0.0362362
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0356889
TXNIP thioredoxin interacting protein -0.0355468
MEF2A myocyte enhancer factor 2A -0.0352791
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0346725
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.034333
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0341478
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0341285
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0339161
COL4A2 collagen, type IV, alpha 2 -0.033568
COL5A1 collagen, type V, alpha 1 -0.0333995
UBC ubiquitin C -0.0329956
FBN1 fibrillin 1 -0.0327338
PLCB4 phospholipase C, beta 4 -0.0326993
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0325955
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0325737
TRPS1 trichorhinophalangeal syndrome I -0.0325523
CDH13 cadherin 13 -0.0322808
MYLK myosin light chain kinase -0.0322549
MYOF myoferlin -0.0317014
PRELID2 PRELI domain containing 2 -0.0316543
WTAP Wilms tumor 1 associated protein -0.0312824
PRSS23 protease, serine, 23 -0.0312726
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0312662
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0311789
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0307723
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.030513
BASP1 brain abundant, membrane attached signal protein 1 -0.0301074
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0300348
TNS3 tensin 3 -0.0297023
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0296419
COL5A2 collagen, type V, alpha 2 -0.0295078
MAP4 microtubule-associated protein 4 -0.0291181
IGFBP5 insulin-like growth factor binding protein 5 -0.0289669
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0287135
SSBP2 single-stranded DNA binding protein 2 -0.028343
ITGAV integrin, alpha V -0.0283096
QKI QKI, KH domain containing, RNA binding -0.0282918
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0281133
ACTG1 actin gamma 1 -0.0278386
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0277706
TMSB4X thymosin beta 4, X-linked -0.0277514
TPM1 tropomyosin 1 (alpha) -0.0276217
GSE1 Gse1 coiled-coil protein -0.0271951
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0270265
PTPRK protein tyrosine phosphatase, receptor type, K -0.0268856
PTPRM protein tyrosine phosphatase, receptor type, M -0.0267499
CLIC4 chloride intracellular channel 4 -0.0265803
CHD9 chromodomain helicase DNA binding protein 9 -0.0265002
EXOC4 exocyst complex component 4 -0.026473