Pioglitazone_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pioglitazone_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANXA1 annexin A1 0.0604071
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0582514
EEF2 eukaryotic translation elongation factor 2 0.0546051
AHNAK AHNAK nucleoprotein 0.0544557
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0398863
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0350398
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0306528
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0285945
ZBTB20 zinc finger and BTB domain containing 20 0.0268491
CKAP5 cytoskeleton associated protein 5 0.0239825
CCDC47 coiled-coil domain containing 47 0.0232305
GSK3B glycogen synthase kinase 3 beta 0.0213789
BRWD1 bromodomain and WD repeat domain containing 1 0.0199769
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0195502
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0192192
USP9X ubiquitin specific peptidase 9, X-linked 0.0189121
ARRDC3 arrestin domain containing 3 0.01883
ARHGAP12 Rho GTPase activating protein 12 0.0186205
EIF4B eukaryotic translation initiation factor 4B 0.0185002
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0182033
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0176705
PHF3 PHD finger protein 3 0.0173051
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.017146
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0168333
LARS1 leucyl-tRNA synthetase 1 0.0165498
TXNRD1 thioredoxin reductase 1 0.0162624
ANKRD36 ankyrin repeat domain 36 0.0162198
EIF4A2 eukaryotic translation initiation factor 4A2 0.0161858
NEBL nebulette 0.0161348
MARCHF6 membrane associated ring-CH-type finger 6 0.0158267
CPOX coproporphyrinogen oxidase 0.0158256
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.015765
GANAB glucosidase, alpha; neutral AB 0.0155462
DCTN1 dynactin 1 0.0155279
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0155101
KIF5B kinesin family member 5B 0.0154852
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0153234
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0149988
CEP250 centrosomal protein 250kDa 0.0149665
DSPP dentin sialophosphoprotein 0.0149389
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0144167
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0142543
FMNL2 formin-like 2 0.0141982
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0140738
ESYT2 extended synaptotagmin-like protein 2 0.0138995
CHD1 chromodomain helicase DNA binding protein 1 0.0137129
PCBP2 poly(rC) binding protein 2 0.0136712
NCEH1 neutral cholesterol ester hydrolase 1 0.0134944
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.013421
GIGYF2 GRB10 interacting GYF protein 2 0.0133664
RHBDD1 rhomboid domain containing 1 0.0133336
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0133208
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0132857
RPL41 ribosomal protein L41 0.0132107
PPP1R21 protein phosphatase 1, regulatory subunit 21 0.0131553
FER fer (fps/fes related) tyrosine kinase 0.0131025
SERINC1 serine incorporator 1 0.0130012
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0128571
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0128215
MED13L mediator complex subunit 13-like 0.0127856
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0126551
AHCTF1 AT hook containing transcription factor 1 0.0125698
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0125533
SPAG9 sperm associated antigen 9 0.0123885
HELB helicase (DNA) B 0.0123309
PLK2 polo-like kinase 2 0.0123123
TNRC6B trinucleotide repeat containing 6B 0.0120352
YTHDC1 YTH domain containing 1 0.0119052
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0118758
FNBP1L formin binding protein 1-like 0.0118448
ZFC3H1 zinc finger, C3H1-type containing 0.0118426
EPS15 epidermal growth factor receptor pathway substrate 15 0.0117016
KLHL24 kelch-like family member 24 0.0116804
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0116431
CDK19 cyclin-dependent kinase 19 0.0116088
KMT2C lysine (K)-specific methyltransferase 2C 0.0115829
CEP350 centrosomal protein 350kDa 0.0115069
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0114654
MYH9 myosin, heavy chain 9, non-muscle 0.0114445
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0113899
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0113091
ZNF292 zinc finger protein 292 0.0112611
PLEC plectin 0.0112602
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0112336
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.011181
AFDN afadin, adherens junction formation factor 0.0111646
AXIN2 axin 2 0.011093
KDM3A lysine (K)-specific demethylase 3A 0.011076
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0109828
ATRN attractin 0.0109827
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0109564
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0109427
CLDND1 claudin domain containing 1 0.0108697
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0108539
APLP2 amyloid beta (A4) precursor-like protein 2 0.0108081
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0107743
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0107395
ECT2 epithelial cell transforming 2 0.0107159
APOLD1 apolipoprotein L domain containing 1 0.0106754
RREB1 ras responsive element binding protein 1 0.0105306

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.226211
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.152102
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.139557
TMSB10 thymosin beta 10 -0.134253
VIM vimentin -0.126519
NLGN1 neuroligin 1 -0.116476
ACTG1 actin gamma 1 -0.110111
HMGA2 high mobility group AT-hook 2 -0.0765739
RPS6 ribosomal protein S6 -0.0735536
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.06154
RAB7A RAB7A, member RAS oncogene family -0.0595745
MYL12B myosin, light chain 12B, regulatory -0.0589519
TPI1 triosephosphate isomerase 1 -0.05833
TUBA1B tubulin, alpha 1b -0.0572284
ANKRD12 ankyrin repeat domain 12 -0.057153
AREG amphiregulin -0.0561203
PDE4D phosphodiesterase 4D, cAMP-specific -0.0554797
PFN1 profilin 1 -0.0529103
PTMA prothymosin, alpha -0.0528775
HMGA1 high mobility group AT-hook 1 -0.0517532
RPL35A ribosomal protein L35a -0.0514081
FTL ferritin, light polypeptide -0.0511078
ZNF804A zinc finger protein 804A -0.0504601
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0495869
EGR1 early growth response 1 -0.0495182
RTN4 reticulon 4 -0.0493489
RPS8 ribosomal protein S8 -0.0477727
RPS12 ribosomal protein S12 -0.0474827
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0474681
PCDH7 protocadherin 7 -0.0472284
RPS2 ribosomal protein S2 -0.0442783
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0432884
POTEF POTE ankyrin domain family, member F -0.0431683
ATP5F1B ATP synthase F1 subunit beta -0.0429117
JMJD1C jumonji domain containing 1C -0.0424503
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0406611
YBX3 Y box binding protein 3 -0.0390227
YAP1 Yes-associated protein 1 -0.0390207
SMC4 structural maintenance of chromosomes 4 -0.0386578
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0379585
RPL37A ribosomal protein L37a -0.0379472
RASAL2 RAS protein activator like 2 -0.037704
TMEM41B transmembrane protein 41B -0.0361941
CCND1 cyclin D1 -0.0360956
RPS21 ribosomal protein S21 -0.0356705
RPS23 ribosomal protein S23 -0.0350443
RPL37 ribosomal protein L37 -0.0348597
RPS3 ribosomal protein S3 -0.0348112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0346264
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0341851
MMP12 matrix metallopeptidase 12 -0.0338035
RPL23 ribosomal protein L23 -0.0337438
CELF2 CUGBP, Elav-like family member 2 -0.0333163
RPLP2 ribosomal protein, large, P2 -0.0332806
RPL19 ribosomal protein L19 -0.0331991
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0330705
RPS19 ribosomal protein S19 -0.0327444
RPL9 ribosomal protein L9 -0.032665
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0320471
RPLP1 ribosomal protein, large, P1 -0.0320431
MGAT4C MGAT4 family, member C -0.0318481
RPS13 ribosomal protein S13 -0.0316673
PRDX1 peroxiredoxin 1 -0.0316116
RPL26 ribosomal protein L26 -0.0311087
RRM2 ribonucleotide reductase M2 -0.0302559
MAP1B microtubule-associated protein 1B -0.0295844
LDHB lactate dehydrogenase B -0.0295042
LOC102724023 ES1 protein homolog, mitochondrial -0.0291872
RPS29 ribosomal protein S29 -0.0285981
IFIH1 interferon induced with helicase C domain 1 -0.0284365
RPS14 ribosomal protein S14 -0.0281098
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0279958
KPNB1 karyopherin (importin) beta 1 -0.0277719
GNAS GNAS complex locus -0.0273683
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0271465
CNRIP1 cannabinoid receptor interacting protein 1 -0.0264473
CCN2 cellular communication network factor 2 -0.0264415
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0262023
VDAC1 voltage-dependent anion channel 1 -0.0261408
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0260443
RPL11 ribosomal protein L11 -0.0256469
RPL12 ribosomal protein L12 -0.0253483
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0252304
NAP1L1 nucleosome assembly protein 1-like 1 -0.0246485
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0242334
S100A10 S100 calcium binding protein A10 -0.0241775
DLC1 DLC1 Rho GTPase activating protein -0.0241518
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0241289
TENM3 teneurin transmembrane protein 3 -0.0237151
RPLP0 ribosomal protein, large, P0 -0.0235638
SLC38A2 solute carrier family 38, member 2 -0.0234764
RPL27 ribosomal protein L27 -0.0233891
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0232873
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0231354
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0229104
HSPB1 heat shock 27kDa protein 1 -0.0226953
CBX3 chromobox homolog 3 -0.0225612
RPS20 ribosomal protein S20 -0.0223707
RPS24 ribosomal protein S24 -0.0222249
TUBA1C tubulin, alpha 1c -0.0221069