Pioglitazone_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pioglitazone_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.117556
CANX calnexin 0.102459
PHF3 PHD finger protein 3 0.102392
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0987985
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.087562
ZMYND8 zinc finger, MYND-type containing 8 0.074039
SPTBN1 spectrin, beta, non-erythrocytic 1 0.069499
MBNL2 muscleblind-like splicing regulator 2 0.0686008
TXNIP thioredoxin interacting protein 0.0623672
KIF16B kinesin family member 16B 0.0615196
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0593843
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0580209
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0568841
GOLGB1 golgin B1 0.0553916
FNDC3B fibronectin type III domain containing 3B 0.0552381
N4BP2L2 NEDD4 binding protein 2-like 2 0.0548152
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0547366
SMAD3 SMAD family member 3 0.0540755
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0527708
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0517315
MYH9 myosin, heavy chain 9, non-muscle 0.0511428
AHNAK AHNAK nucleoprotein 0.0496205
SPATA13 spermatogenesis associated 13 0.0492445
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0472578
AHI1 Abelson helper integration site 1 0.0442531
ENO1 enolase 1, (alpha) 0.0442061
ERRFI1 ERBB receptor feedback inhibitor 1 0.0435624
SAMD4A sterile alpha motif domain containing 4A 0.0416636
MLPH melanophilin 0.0411916
ARHGAP5 Rho GTPase activating protein 5 0.0407924
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0405108
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0405003
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0403292
TSC22D2 TSC22 domain family, member 2 0.0396847
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0393891
GOLGA2 golgin A2 0.0393113
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0384453
HELZ helicase with zinc finger 0.037661
IFNGR1 interferon gamma receptor 1 0.0371052
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0370788
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0367241
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0365531
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0357039
TM9SF3 transmembrane 9 superfamily member 3 0.0356876
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0355941
TPT1 tumor protein, translationally-controlled 1 0.0355703
DSPP dentin sialophosphoprotein 0.0353588
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0352618
FNIP1 folliculin interacting protein 1 0.0350453
KDM3A lysine (K)-specific demethylase 3A 0.0348588
FAT1 FAT atypical cadherin 1 0.0348422
FNDC3A fibronectin type III domain containing 3A 0.0346288
GRK3 G protein-coupled receptor kinase 3 0.0343299
COPA coatomer protein complex, subunit alpha 0.0331665
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0330741
MACC1 metastasis associated in colon cancer 1 0.0330733
MED13 mediator complex subunit 13 0.0329037
GOLGA3 golgin A3 0.0327285
RBM39 RNA binding motif protein 39 0.0324139
CLTC clathrin, heavy chain (Hc) 0.032286
RNF149 ring finger protein 149 0.0322318
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0321588
TMED2 transmembrane emp24 domain trafficking protein 2 0.031825
IGF1R insulin-like growth factor 1 receptor 0.0316962
TMEM39A transmembrane protein 39A 0.0315888
ATXN1 ataxin 1 0.0313468
ASPH aspartate beta-hydroxylase 0.0313108
TRIM2 tripartite motif containing 2 0.0311388
ZBTB20 zinc finger and BTB domain containing 20 0.0309627
PGK1 phosphoglycerate kinase 1 0.0309444
LURAP1L leucine rich adaptor protein 1-like 0.0307923
LRRC1 leucine rich repeat containing 1 0.0304644
ZMYM2 zinc finger, MYM-type 2 0.0301027
ESYT2 extended synaptotagmin-like protein 2 0.0298652
CGN cingulin 0.0298596
PADI1 peptidyl arginine deiminase, type I 0.0292239
UBAC2 UBA domain containing 2 0.029093
PRELID2 PRELI domain containing 2 0.0285025
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.0284964
AFF1 AF4/FMR2 family, member 1 0.0284461
TM9SF2 transmembrane 9 superfamily member 2 0.0282851
ADD3 adducin 3 (gamma) 0.0282674
COG6 component of oligomeric golgi complex 6 0.0281278
SPAG9 sperm associated antigen 9 0.0279303
PATJ PATJ crumbs cell polarity complex component 0.0278709
DENND4C DENN/MADD domain containing 4C 0.0277348
TTC3 tetratricopeptide repeat domain 3 0.0276151
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0276003
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0273587
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0272261
COPG1 coatomer protein complex, subunit gamma 1 0.0271885
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0271511
FDPS farnesyl diphosphate synthase 0.026976
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.026869
IQGAP1 IQ motif containing GTPase activating protein 1 0.0268289
SREBF2 sterol regulatory element binding transcription factor 2 0.0267976
KMT2C lysine (K)-specific methyltransferase 2C 0.0266368
USPL1 ubiquitin specific peptidase like 1 0.0265828
MON2 MON2 homolog (S. cerevisiae) 0.0264476
CEP95 centrosomal protein 95kDa 0.0263465

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.199539
LCN2 lipocalin 2 -0.142196
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138558
C6ORF132 chromosome 6 open reading frame 132 -0.125813
EGR1 early growth response 1 -0.114595
IFI6 interferon, alpha-inducible protein 6 -0.097838
LOC102724023 ES1 protein homolog, mitochondrial -0.073649
IFI27 interferon, alpha-inducible protein 27 -0.0716686
GCLC glutamate-cysteine ligase, catalytic subunit -0.0703099
RPL35A ribosomal protein L35a -0.0675746
TMSB10 thymosin beta 10 -0.0670582
FTL ferritin, light polypeptide -0.0661633
HLA-B major histocompatibility complex, class I, B -0.0632232
MX2 MX dynamin-like GTPase 2 -0.0623857
RPS6 ribosomal protein S6 -0.0608923
MT2A metallothionein 2A -0.0604149
RPLP1 ribosomal protein, large, P1 -0.0602123
PERP PERP, TP53 apoptosis effector -0.0593748
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0578219
RUNX1 runt-related transcription factor 1 -0.0549099
IRF1 interferon regulatory factor 1 -0.0518024
RPL23 ribosomal protein L23 -0.0477911
ACTG1 actin gamma 1 -0.0476604
RIGI RNA sensor RIG-I -0.0472281
MUC13 mucin 13, cell surface associated -0.046148
RPS19 ribosomal protein S19 -0.0436821
MX1 MX dynamin-like GTPase 1 -0.0434026
CCNL1 cyclin L1 -0.042506
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0420345
POTEF POTE ankyrin domain family, member F -0.0407065
CST3 cystatin C -0.0405384
RPS8 ribosomal protein S8 -0.0395974
RPS27 ribosomal protein S27 -0.0379108
IFITM3 interferon induced transmembrane protein 3 -0.0375572
RPL37A ribosomal protein L37a -0.0370568
NAMPT nicotinamide phosphoribosyltransferase -0.035869
LOC112694756 uncharaterized LOC112694756 -0.0356707
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0351544
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0348015
DSTN destrin (actin depolymerizing factor) -0.0346095
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0345458
RPLP2 ribosomal protein, large, P2 -0.033098
PKM pyruvate kinase, muscle -0.0322158
CLDN4 claudin 4 -0.0321588
ANXA2 annexin A2 -0.0312804
PTMA prothymosin, alpha -0.0312053
FTH1 ferritin, heavy polypeptide 1 -0.0310255
RPS3 ribosomal protein S3 -0.0310233
S100A10 S100 calcium binding protein A10 -0.0309868
TXNRD1 thioredoxin reductase 1 -0.0307925
POMP proteasome maturation protein -0.0307899
RPL31 ribosomal protein L31 -0.029548
ITPKC inositol-trisphosphate 3-kinase C -0.0292575
RPL36 ribosomal protein L36 -0.0289124
TRERF1 transcriptional regulating factor 1 -0.0288494
FOSL1 FOS-like antigen 1 -0.02883
S100A11 S100 calcium binding protein A11 -0.0287225
RPL34 ribosomal protein L34 -0.028616
OASL 2'-5'-oligoadenylate synthetase-like -0.028585
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0285323
RPL28 ribosomal protein L28 -0.0283292
ATF4 activating transcription factor 4 -0.0279637
WSB1 WD repeat and SOCS box containing 1 -0.0275994
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.027297
RPL9 ribosomal protein L9 -0.0271018
S100A6 S100 calcium binding protein A6 -0.027089
PMP22 peripheral myelin protein 22 -0.0270855
EIF1 eukaryotic translation initiation factor 1 -0.0269176
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0268244
S100P S100 calcium binding protein P -0.0267744
VCL vinculin -0.026442
RPL19 ribosomal protein L19 -0.0263853
NCOA7 nuclear receptor coactivator 7 -0.0263134
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0257366
RPL32 ribosomal protein L32 -0.025553
MT1X metallothionein 1X -0.0254657
HMGB1 high mobility group box 1 -0.0253911
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0252925
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.025266
RPS29 ribosomal protein S29 -0.0250589
TJP1 tight junction protein 1 -0.0249414
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0249331
TC2N tandem C2 domains, nuclear -0.0248982
MEIS2 Meis homeobox 2 -0.0247538
IRS2 insulin receptor substrate 2 -0.0245708
RPS23 ribosomal protein S23 -0.024404
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0241383
RPL37 ribosomal protein L37 -0.0241059
LY6E lymphocyte antigen 6 complex, locus E -0.0241058
SP100 SP100 nuclear antigen -0.0240787
SAA2 serum amyloid A2 -0.0240398
RPL30 ribosomal protein L30 -0.0239677
RPL35 ribosomal protein L35 -0.0238443
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0237892
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0237815
RPS25 ribosomal protein S25 -0.0237688
RPS12 ribosomal protein S12 -0.0235347
BLZF1 basic leucine zipper nuclear factor 1 -0.0232314
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0228567
MTDH metadherin -0.0227874