| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pioglitazone perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pioglitazone_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.239514 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.189364 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.127835 |
| DSPP | dentin sialophosphoprotein | 0.0849545 |
| ENO1 | enolase 1, (alpha) | 0.0830913 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0755113 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0742873 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0697179 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0695259 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0681055 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0670075 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0643692 |
| FN1 | fibronectin 1 | 0.0609492 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0598274 |
| TF | transferrin | 0.0583267 |
| VEGFA | vascular endothelial growth factor A | 0.0582115 |
| AFDN | afadin, adherens junction formation factor | 0.0577175 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0540104 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0512595 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0510921 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0497182 |
| PEG3 | paternally expressed 3 | 0.0479907 |
| CANX | calnexin | 0.0467158 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0461566 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0459629 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0457276 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0441769 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0433119 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.041873 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0413113 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0409224 |
| TNS1 | tensin 1 | 0.040635 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0380596 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0378173 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0376483 |
| SDC4 | syndecan 4 | 0.0370292 |
| RPL11 | ribosomal protein L11 | 0.0354597 |
| PTK2 | protein tyrosine kinase 2 | 0.0354127 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0353485 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0343866 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0342384 |
| PGK1 | phosphoglycerate kinase 1 | 0.0337414 |
| TOP1 | topoisomerase (DNA) I | 0.0336167 |
| PHF3 | PHD finger protein 3 | 0.0334102 |
| INSIG2 | insulin induced gene 2 | 0.0333155 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.031626 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.031345 |
| MED13L | mediator complex subunit 13-like | 0.0307048 |
| C3 | complement component 3 | 0.0304562 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0300923 |
| ATRN | attractin | 0.0297683 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0297475 |
| ARFGEF3 | ARFGEF family member 3 | 0.0297042 |
| PRELID2 | PRELI domain containing 2 | 0.0294132 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0292775 |
| ASPH | aspartate beta-hydroxylase | 0.0289598 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0288963 |
| ITGA6 | integrin, alpha 6 | 0.0288066 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0284552 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.028305 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0281521 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0278649 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0278363 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0273731 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0271024 |
| QKI | QKI, KH domain containing, RNA binding | 0.026994 |
| SPAG9 | sperm associated antigen 9 | 0.0268997 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0267678 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0266664 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0265011 |
| HELZ | helicase with zinc finger | 0.0260495 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0259904 |
| FOXO1 | forkhead box O1 | 0.0257093 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0253068 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0249072 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0247388 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0246902 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0246752 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0246466 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0243621 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0243112 |
| HLF | hepatic leukemia factor | 0.0240057 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0239723 |
| PHIP | pleckstrin homology domain interacting protein | 0.0234736 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0233533 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0233445 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0233302 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0230455 |
| RBM25 | RNA binding motif protein 25 | 0.0229828 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0226286 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0225551 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0225243 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0223386 |
| KIF1B | kinesin family member 1B | 0.0222858 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0222405 |
| RREB1 | ras responsive element binding protein 1 | 0.0219324 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0216898 |
| MCL1 | myeloid cell leukemia 1 | 0.0214986 |
| SBF2 | SET binding factor 2 | 0.0214703 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0209778 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.353368 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.106745 |
| GPC6 | glypican 6 | -0.0717307 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0667536 |
| EHBP1 | EH domain binding protein 1 | -0.0646941 |
| APOA2 | apolipoprotein A-II | -0.062842 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.052563 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0479064 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.045979 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0433678 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0422735 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0395444 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0388968 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0378197 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0371157 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.035741 |
| GPC3 | glypican 3 | -0.0335746 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0333045 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0324827 |
| PTCHD4 | patched domain containing 4 | -0.0316905 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0312078 |
| APOB | apolipoprotein B | -0.030745 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0305275 |
| EGR1 | early growth response 1 | -0.029482 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0288295 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0282019 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0281092 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.027576 |
| TRIM26 | tripartite motif containing 26 | -0.0273324 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.02689 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0251968 |
| TMSB10 | thymosin beta 10 | -0.0249049 |
| FRMD5 | FERM domain containing 5 | -0.0241401 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0234445 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0234394 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0233451 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0226241 |
| ITGAV | integrin, alpha V | -0.0224242 |
| FAM135A | family with sequence similarity 135, member A | -0.0222389 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.02189 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0215838 |
| DST | dystonin | -0.021552 |
| ZFHX3 | zinc finger homeobox 3 | -0.0214793 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0210941 |
| NHSL1 | NHS-like 1 | -0.0205106 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0202023 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0201856 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0194161 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0192997 |
| HMGA2 | high mobility group AT-hook 2 | -0.0192872 |
| ACTN4 | actinin, alpha 4 | -0.0190593 |
| TMEM123 | transmembrane protein 123 | -0.0189775 |
| CNKSR3 | CNKSR family member 3 | -0.0189523 |
| CDK6 | cyclin-dependent kinase 6 | -0.0187006 |
| SYN3 | synapsin III | -0.0186996 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0185511 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0185223 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0180717 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.0180477 |
| HDAC4 | histone deacetylase 4 | -0.0179806 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0178383 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0178012 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0177367 |
| PHF21A | PHD finger protein 21A | -0.0175611 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0173895 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0172054 |
| DCDC2 | doublecortin domain containing 2 | -0.0171773 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.016829 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0167618 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0167157 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0166813 |
| FTL | ferritin, light polypeptide | -0.0165504 |
| RTN4 | reticulon 4 | -0.0163798 |
| CADM1 | cell adhesion molecule 1 | -0.0163529 |
| RPL36 | ribosomal protein L36 | -0.0163006 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0162503 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0161867 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0161285 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | -0.0159831 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0157894 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0157843 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0157124 |
| RASAL2 | RAS protein activator like 2 | -0.0156786 |
| AHR | aryl hydrocarbon receptor | -0.0155983 |
| RIC8B | RIC8 guanine nucleotide exchange factor B | -0.0153871 |
| RRBP1 | ribosome binding protein 1 | -0.0153447 |
| FABP1 | fatty acid binding protein 1, liver | -0.0153142 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0152906 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0152014 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.015163 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0147017 |
| SMYD3 | SET and MYND domain containing 3 | -0.0145403 |
| IER3 | immediate early response 3 | -0.0143418 |
| NABP1 | nucleic acid binding protein 1 | -0.0143237 |
| BLCAP | bladder cancer associated protein | -0.0142724 |
| MAP4 | microtubule-associated protein 4 | -0.014203 |
| CP | ceruloplasmin (ferroxidase) | -0.0137759 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.013633 |
| SH3D19 | SH3 domain containing 19 | -0.0136084 |
| THBS1 | thrombospondin 1 | -0.0135817 |
