Pioglitazone_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pioglitazone_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.203959
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.168921
PCBP2 poly(rC) binding protein 2 0.0902152
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0900823
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0841913
SMAD3 SMAD family member 3 0.0826535
CANX calnexin 0.0819835
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0812595
NAMPT nicotinamide phosphoribosyltransferase 0.0797417
SOD2 superoxide dismutase 2, mitochondrial 0.0792353
KDM2A lysine (K)-specific demethylase 2A 0.0765782
EEF2 eukaryotic translation elongation factor 2 0.0761301
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0711196
EFNA5 ephrin-A5 0.0709096
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0659369
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0636537
NAV2 neuron navigator 2 0.0603234
GOLGA4 golgin A4 0.0579278
NGLY1 N-glycanase 1 0.0565112
PDIA3 protein disulfide isomerase family A, member 3 0.0557964
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0544174
MYH9 myosin, heavy chain 9, non-muscle 0.053271
OGA O-GlcNAcase 0.0528008
ESYT2 extended synaptotagmin-like protein 2 0.0527671
TTC3 tetratricopeptide repeat domain 3 0.0522669
CTNND1 catenin (cadherin-associated protein), delta 1 0.0515318
TRIO trio Rho guanine nucleotide exchange factor 0.0506972
PRELID2 PRELI domain containing 2 0.0489544
FLNB filamin B, beta 0.0488102
USP34 ubiquitin specific peptidase 34 0.0485652
DSCAM Down syndrome cell adhesion molecule 0.0481426
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0477837
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0473069
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0468238
FAM13A family with sequence similarity 13, member A 0.0457169
ARRDC3 arrestin domain containing 3 0.0449739
GRB10 growth factor receptor-bound protein 10 0.0446164
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0445313
ITCH itchy E3 ubiquitin protein ligase 0.0443151
YEATS2 YEATS domain containing 2 0.0441879
KMT2C lysine (K)-specific methyltransferase 2C 0.0441635
ELL2 elongation factor, RNA polymerase II, 2 0.0434142
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0433313
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0424673
SEC23A Sec23 homolog A (S. cerevisiae) 0.0422666
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0421821
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0421711
ATP13A3 ATPase type 13A3 0.0416007
PFKP phosphofructokinase, platelet 0.0400178
TGM2 transglutaminase 2 0.0398474
APLP2 amyloid beta (A4) precursor-like protein 2 0.0397754
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0375949
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0374326
RAB8B RAB8B, member RAS oncogene family 0.0374137
CEP250 centrosomal protein 250kDa 0.0371628
DLG1 discs, large homolog 1 (Drosophila) 0.0367245
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0366612
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0362018
YTHDC1 YTH domain containing 1 0.0358166
PIAS2 protein inhibitor of activated STAT, 2 0.0346582
FNDC3B fibronectin type III domain containing 3B 0.0346539
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0343584
DOCK5 dedicator of cytokinesis 5 0.0341031
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0339033
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.033031
PICALM phosphatidylinositol binding clathrin assembly protein 0.032858
NBAS neuroblastoma amplified sequence 0.0323044
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0322329
AKAP13 A kinase (PRKA) anchor protein 13 0.0319617
LIMCH1 LIM and calponin homology domains 1 0.0319038
NPC1 Niemann-Pick disease, type C1 0.0318503
KTN1 kinectin 1 (kinesin receptor) 0.0318051
UBA6 ubiquitin-like modifier activating enzyme 6 0.0317662
PRRC2C proline-rich coiled-coil 2C 0.0307944
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0307066
RUNX1 runt-related transcription factor 1 0.0306368
TM4SF1 transmembrane 4 L six family member 1 0.0303661
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0302426
TP53BP1 tumor protein p53 binding protein 1 0.0302253
GANAB glucosidase, alpha; neutral AB 0.0299928
SETD5 SET domain containing 5 0.0299736
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.02993
GOLGA2 golgin A2 0.0297533
CD109 CD109 molecule 0.0296884
AHR aryl hydrocarbon receptor 0.0293738
RICTOR RPTOR independent companion of MTOR, complex 2 0.0290897
ANKRD36 ankyrin repeat domain 36 0.0290816
CSDE1 cold shock domain containing E1, RNA-binding 0.0289685
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0289607
SBF2 SET binding factor 2 0.0289239
MYO1B myosin IB 0.0287705
PDE8A phosphodiesterase 8A 0.0285722
RARB retinoic acid receptor, beta 0.0284268
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0283939
TNIP1 TNFAIP3 interacting protein 1 0.0282057
HDAC9 histone deacetylase 9 0.0278292
VEGFA vascular endothelial growth factor A 0.0277008
SAMD4A sterile alpha motif domain containing 4A 0.0276755
GIGYF2 GRB10 interacting GYF protein 2 0.027641
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0276008

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228963
TMSB10 thymosin beta 10 -0.185439
VIM vimentin -0.132481
FTL ferritin, light polypeptide -0.126146
RPLP1 ribosomal protein, large, P1 -0.0961081
GLCCI1 glucocorticoid induced 1 -0.0901319
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0721385
FTH1 ferritin, heavy polypeptide 1 -0.0719867
PTMA prothymosin, alpha -0.0671208
NRG1 neuregulin 1 -0.0661985
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0645832
IER3 immediate early response 3 -0.0616328
RPS19 ribosomal protein S19 -0.0548332
RPL35A ribosomal protein L35a -0.0538222
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0514116
CDH13 cadherin 13 -0.0513734
MT2A metallothionein 2A -0.0498421
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0494149
RPS21 ribosomal protein S21 -0.0492543
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0483887
EGR1 early growth response 1 -0.047604
RPS6 ribosomal protein S6 -0.0465178
STC1 stanniocalcin 1 -0.0464634
NTN4 netrin 4 -0.0450101
DDIT3 DNA-damage-inducible transcript 3 -0.0434457
RPL36 ribosomal protein L36 -0.0395726
CD44 CD44 molecule (Indian blood group) -0.0395499
RPLP0 ribosomal protein, large, P0 -0.0391314
RPL28 ribosomal protein L28 -0.038993
HMGA2 high mobility group AT-hook 2 -0.0389512
S100A10 S100 calcium binding protein A10 -0.0380387
RPL34 ribosomal protein L34 -0.0377523
S100A6 S100 calcium binding protein A6 -0.0376879
DPYD dihydropyrimidine dehydrogenase -0.0375268
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0371967
GNAS GNAS complex locus -0.0363263
SLC38A1 solute carrier family 38, member 1 -0.0355767
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0351156
LOC102724023 ES1 protein homolog, mitochondrial -0.0345043
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0343987
RPL23 ribosomal protein L23 -0.0342244
RPL37A ribosomal protein L37a -0.0342222
RPL37 ribosomal protein L37 -0.0340265
HMGA1 high mobility group AT-hook 1 -0.0336508
RPLP2 ribosomal protein, large, P2 -0.0330939
GLIS3 GLIS family zinc finger 3 -0.0328195
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0323002
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0322047
RPL32 ribosomal protein L32 -0.0313041
RPS24 ribosomal protein S24 -0.0311715
RPL30 ribosomal protein L30 -0.0310364
RPS25 ribosomal protein S25 -0.0309421
RPL19 ribosomal protein L19 -0.0307487
ACTG1 actin gamma 1 -0.0301199
TMSB4X thymosin beta 4, X-linked -0.0300069
RPS5 ribosomal protein S5 -0.029628
SOS1 son of sevenless homolog 1 (Drosophila) -0.0293988
SYT1 synaptotagmin I -0.0293589
RPS12 ribosomal protein S12 -0.0289752
LOC112694756 uncharaterized LOC112694756 -0.0289502
HLA-B major histocompatibility complex, class I, B -0.0284084
RPS16 ribosomal protein S16 -0.0283926
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0276051
RPL31 ribosomal protein L31 -0.0274595
ANKRD28 ankyrin repeat domain 28 -0.0272435
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0269341
MTSS1 metastasis suppressor 1 -0.026489
ZNF804A zinc finger protein 804A -0.0257048
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0251751
RPL9 ribosomal protein L9 -0.0247337
CDK14 cyclin-dependent kinase 14 -0.024479
RPS29 ribosomal protein S29 -0.0244349
RPS14 ribosomal protein S14 -0.024322
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0240737
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0240376
B2M beta-2-microglobulin -0.0236519
RPL27A ribosomal protein L27a -0.0235379
RPS8 ribosomal protein S8 -0.0234187
TGFB1 transforming growth factor, beta 1 -0.0227679
PRRX1 paired related homeobox 1 -0.0226888
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0226839
TMEM131 transmembrane protein 131 -0.0226333
TPT1 tumor protein, translationally-controlled 1 -0.0224842
MAP1B microtubule-associated protein 1B -0.0223953
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0223467
RPS20 ribosomal protein S20 -0.0223415
MORF4L2 mortality factor 4 like 2 -0.0223289
SAMD9 sterile alpha motif domain containing 9 -0.0223216
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0221329
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0220685
NRP1 neuropilin 1 -0.0219269
MX2 MX dynamin-like GTPase 2 -0.0218873
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.021881
RASAL2 RAS protein activator like 2 -0.0217559
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0217475
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0217101
TNNC1 troponin C type 1 (slow) -0.0211387
IFI6 interferon, alpha-inducible protein 6 -0.0210075
RPS3 ribosomal protein S3 -0.0209135
RPS23 ribosomal protein S23 -0.0208941