Pioglitazone_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pioglitazone_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.124953
TFPI2 tissue factor pathway inhibitor 2 0.112178
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.110839
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.107121
PABPC1 poly(A) binding protein, cytoplasmic 1 0.102298
EEF2 eukaryotic translation elongation factor 2 0.100522
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0913137
GRAMD1B GRAM domain containing 1B 0.0753231
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0613594
MKI67 marker of proliferation Ki-67 0.0604094
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0600718
CSDE1 cold shock domain containing E1, RNA-binding 0.0591919
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0591713
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.056792
MED13L mediator complex subunit 13-like 0.0558851
KDM2A lysine (K)-specific demethylase 2A 0.0527938
ERRFI1 ERBB receptor feedback inhibitor 1 0.0509059
TPM3 tropomyosin 3 0.0485825
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0475024
UBE2H ubiquitin-conjugating enzyme E2H 0.0459059
XPO1 exportin 1 0.0451313
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0444792
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0438759
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0434551
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0433092
EIF4B eukaryotic translation initiation factor 4B 0.0425099
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0422937
SMAD3 SMAD family member 3 0.0417911
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0411226
ANO6 anoctamin 6 0.0407554
ESYT2 extended synaptotagmin-like protein 2 0.0390277
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0388636
MYH9 myosin, heavy chain 9, non-muscle 0.0386976
PCBP2 poly(rC) binding protein 2 0.0385995
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0384932
CANX calnexin 0.0379464
RRM2 ribonucleotide reductase M2 0.037515
SRPK2 SRSF protein kinase 2 0.0369987
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0369346
ANKRD36 ankyrin repeat domain 36 0.0364004
ZCCHC7 zinc finger, CCHC domain containing 7 0.0356059
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0350225
ATXN2 ataxin 2 0.0345508
ZFAND3 zinc finger, AN1-type domain 3 0.0344953
KRT18 keratin 18, type I 0.0343891
MARCHF4 membrane associated ring-CH-type finger 4 0.034263
KMT2A lysine (K)-specific methyltransferase 2A 0.0340026
WNK1 WNK lysine deficient protein kinase 1 0.0339402
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0338575
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0336075
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.033542
KMT2C lysine (K)-specific methyltransferase 2C 0.0335356
CSNK1A1 casein kinase 1, alpha 1 0.0334279
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0332804
NCAPD2 non-SMC condensin I complex, subunit D2 0.0331493
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0329509
COPA coatomer protein complex, subunit alpha 0.0326127
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0324775
OGA O-GlcNAcase 0.0323006
ETNK1 ethanolamine kinase 1 0.0321985
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0321454
AFF4 AF4/FMR2 family, member 4 0.0320542
COG5 component of oligomeric golgi complex 5 0.0317134
PPME1 protein phosphatase methylesterase 1 0.0314231
ANKRD36B ankyrin repeat domain 36B 0.0313768
TRIO trio Rho guanine nucleotide exchange factor 0.0313217
ARL5B ADP-ribosylation factor-like 5B 0.0311703
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0310477
USP9X ubiquitin specific peptidase 9, X-linked 0.030849
KCMF1 potassium channel modulatory factor 1 0.0308102
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0307075
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0303261
MSH6 mutS homolog 6 0.0301829
MCL1 myeloid cell leukemia 1 0.0299034
MIS18BP1 MIS18 binding protein 1 0.029662
JAK1 Janus kinase 1 0.0295844
RASAL2 RAS protein activator like 2 0.0295299
PFKP phosphofructokinase, platelet 0.0294931
TMPO thymopoietin 0.029478
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.0291833
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0287926
DIAPH1 diaphanous-related formin 1 0.0287805
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0287476
PCNX1 pecanex 1 0.028469
PBX3 pre-B-cell leukemia homeobox 3 0.0282855
CAMTA1 calmodulin binding transcription activator 1 0.0278008
PHIP pleckstrin homology domain interacting protein 0.027799
SLMAP sarcolemma associated protein 0.0269825
TPM2 tropomyosin 2 (beta) 0.0268677
NOTCH2 notch 2 0.0267246
ANKRD36C ankyrin repeat domain 36C 0.0265495
NAMPT nicotinamide phosphoribosyltransferase 0.0265362
LCORL ligand dependent nuclear receptor corepressor-like 0.0265124
CEP250 centrosomal protein 250kDa 0.026442
GATAD2B GATA zinc finger domain containing 2B 0.0263739
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0263339
PGK1 phosphoglycerate kinase 1 0.0262282
UBXN7 UBX domain protein 7 0.026181
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0261653
GIGYF2 GRB10 interacting GYF protein 2 0.0260367

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.2234
AKAP12 A kinase (PRKA) anchor protein 12 -0.208184
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.119265
TMSB10 thymosin beta 10 -0.103084
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0758807
RPL35A ribosomal protein L35a -0.0721066
VIM vimentin -0.0720318
OSMR oncostatin M receptor -0.0673661
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0635784
RPL37A ribosomal protein L37a -0.0601364
RPS8 ribosomal protein S8 -0.0576701
RPL37 ribosomal protein L37 -0.057124
ACTG1 actin gamma 1 -0.0548541
PTMA prothymosin, alpha -0.0539228
AFF3 AF4/FMR2 family, member 3 -0.0532062
EGR1 early growth response 1 -0.0529166
RPL26 ribosomal protein L26 -0.052758
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0527445
GNAS GNAS complex locus -0.050813
HLA-B major histocompatibility complex, class I, B -0.047405
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0465833
RPL38 ribosomal protein L38 -0.044737
HMGA2 high mobility group AT-hook 2 -0.0445975
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0421223
RPS12 ribosomal protein S12 -0.0420189
TPM4 tropomyosin 4 -0.0417479
IER3 immediate early response 3 -0.0405618
RPS3 ribosomal protein S3 -0.0401754
IFI6 interferon, alpha-inducible protein 6 -0.040076
RPS6 ribosomal protein S6 -0.0365418
RPLP1 ribosomal protein, large, P1 -0.0363874
MORF4L2 mortality factor 4 like 2 -0.0363231
LOC102724023 ES1 protein homolog, mitochondrial -0.0356418
EIF5B eukaryotic translation initiation factor 5B -0.0355091
FBXO11 F-box protein 11 -0.0354617
TPT1 tumor protein, translationally-controlled 1 -0.0347829
RACK1 receptor for activated C kinase 1 -0.0343715
IGF2 insulin-like growth factor 2 -0.03374
FTL ferritin, light polypeptide -0.0332326
RIMS2 regulating synaptic membrane exocytosis 2 -0.0327863
THSD4 thrombospondin, type I, domain containing 4 -0.0322456
RPL5 ribosomal protein L5 -0.0322382
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0311532
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0308146
RPL34 ribosomal protein L34 -0.0305925
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -0.0301187
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0300242
WSB1 WD repeat and SOCS box containing 1 -0.029806
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0297276
RPLP2 ribosomal protein, large, P2 -0.0297246
NCOA7 nuclear receptor coactivator 7 -0.0294923
RPL9 ribosomal protein L9 -0.0294818
RPS24 ribosomal protein S24 -0.0294215
RPL31 ribosomal protein L31 -0.0293814
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0293452
S100A11 S100 calcium binding protein A11 -0.0287466
S100A10 S100 calcium binding protein A10 -0.0285606
RYR3 ryanodine receptor 3 -0.0281153
ATP11A ATPase, class VI, type 11A -0.0275112
POTEF POTE ankyrin domain family, member F -0.0272465
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.02696
RPS17 ribosomal protein S17 -0.0266938
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0260196
RPS20 ribosomal protein S20 -0.0258159
CAVIN1 caveolae associated protein 1 -0.0254116
RPL23 ribosomal protein L23 -0.0251718
FTH1 ferritin, heavy polypeptide 1 -0.0248395
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0237524
TRA2A transformer 2 alpha homolog (Drosophila) -0.0234591
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0234488
RPS27A ribosomal protein S27a -0.0232799
RPS23 ribosomal protein S23 -0.0231178
RPL36A ribosomal protein L36a -0.0231056
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0227876
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0227784
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0227507
RPS27 ribosomal protein S27 -0.0226966
SEC61G Sec61 gamma subunit -0.0224707
RPS10 ribosomal protein S10 -0.0222133
SEPTIN7 septin 7 -0.0221847
RPL32 ribosomal protein L32 -0.021977
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0219566
RPL27 ribosomal protein L27 -0.0216387
MT2A metallothionein 2A -0.0216275
PA2G4 proliferation-associated 2G4, 38kDa -0.021505
RPS25 ribosomal protein S25 -0.0214218
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0208921
RPL30 ribosomal protein L30 -0.0207175
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0206556
DOCK5 dedicator of cytokinesis 5 -0.0205691
SUMF1 sulfatase modifying factor 1 -0.0205467
ATG7 autophagy related 7 -0.0205041
POGZ pogo transposable element with ZNF domain -0.0203495
RPL19 ribosomal protein L19 -0.0203362
SENP6 SUMO1/sentrin specific peptidase 6 -0.0202984
EIF3J eukaryotic translation initiation factor 3, subunit J -0.0200738
WNT2B wingless-type MMTV integration site family, member 2B -0.019829
CLDN1 claudin 1 -0.0196021
RNF213 ring finger protein 213 -0.0195969
RPL35 ribosomal protein L35 -0.0193539