Pioglitazone_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pioglitazone_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.114447
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0821706
CANX calnexin 0.0598053
SPAG9 sperm associated antigen 9 0.0596214
MCL1 myeloid cell leukemia 1 0.0548709
ELL2 elongation factor, RNA polymerase II, 2 0.0522775
TFPI2 tissue factor pathway inhibitor 2 0.0492276
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0491809
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.047508
ERRFI1 ERBB receptor feedback inhibitor 1 0.0442324
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0438328
SOD2 superoxide dismutase 2, mitochondrial 0.0428786
FMNL2 formin-like 2 0.0418852
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0411746
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0402482
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0399157
FNDC3A fibronectin type III domain containing 3A 0.0383611
PDIA3 protein disulfide isomerase family A, member 3 0.0359728
ESYT2 extended synaptotagmin-like protein 2 0.0352429
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0348874
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0336062
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0329173
KMT2C lysine (K)-specific methyltransferase 2C 0.0326365
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0317638
SMOC1 SPARC related modular calcium binding 1 0.0295647
CXCL8 chemokine (C-X-C motif) ligand 8 0.0291477
LIMCH1 LIM and calponin homology domains 1 0.0284424
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0278788
FNDC3B fibronectin type III domain containing 3B 0.0276625
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0275521
CTBP2 C-terminal binding protein 2 0.0269226
ANXA1 annexin A1 0.0268718
CD109 CD109 molecule 0.0262148
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0247087
OGA O-GlcNAcase 0.0246029
NUP58 nucleoporin 58 0.0243625
KDM6A lysine (K)-specific demethylase 6A 0.0243012
EEF2 eukaryotic translation elongation factor 2 0.0242719
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0240569
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0237565
FAM13A family with sequence similarity 13, member A 0.0237113
COPA coatomer protein complex, subunit alpha 0.0234469
USP9X ubiquitin specific peptidase 9, X-linked 0.022986
ITPRID2 ITPR interacting domain containing 2 0.0228082
CHD1 chromodomain helicase DNA binding protein 1 0.0227261
KMT2E lysine (K)-specific methyltransferase 2E 0.0226828
GRB10 growth factor receptor-bound protein 10 0.0226764
BZW1 basic leucine zipper and W2 domains 1 0.0225787
STC1 stanniocalcin 1 0.0220011
TGFBR1 transforming growth factor, beta receptor 1 0.0215781
PDLIM5 PDZ and LIM domain 5 0.0209912
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.020669
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0205115
CTSL cathepsin L 0.0204872
WAC WW domain containing adaptor with coiled-coil 0.0203582
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0202012
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0199986
AKAP13 A kinase (PRKA) anchor protein 13 0.0198055
EZR ezrin 0.0195973
OXSR1 oxidative stress responsive 1 0.0195185
SAMD4A sterile alpha motif domain containing 4A 0.0194964
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0194785
GOLGA4 golgin A4 0.0193193
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0191836
TM4SF1 transmembrane 4 L six family member 1 0.0190755
PDIA6 protein disulfide isomerase family A, member 6 0.0190256
NBAS neuroblastoma amplified sequence 0.0188638
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0188214
FLNB filamin B, beta 0.0187731
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0186576
ARRDC3 arrestin domain containing 3 0.0186282
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0186026
HELZ helicase with zinc finger 0.0185422
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0184827
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0184225
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0181788
DGKD diacylglycerol kinase, delta 130kDa 0.0181699
ATP13A3 ATPase type 13A3 0.0180153
ANXA5 annexin A5 0.0178843
DDIT4 DNA-damage-inducible transcript 4 0.017857
AHNAK AHNAK nucleoprotein 0.0176267
PDGFA platelet-derived growth factor alpha polypeptide 0.0175573
INHBA inhibin, beta A 0.0175538
ZC3H11A zinc finger CCCH-type containing 11A 0.0175238
CDC73 cell division cycle 73 0.0171672
UBA6 ubiquitin-like modifier activating enzyme 6 0.0170836
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0170438
CDH13 cadherin 13 0.0169063
FNIP1 folliculin interacting protein 1 0.0168756
STC2 stanniocalcin 2 0.0167912
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0167662
AUTS2 autism susceptibility candidate 2 0.0166462
RAB1A RAB1A, member RAS oncogene family 0.0165686
TMX4 thioredoxin-related transmembrane protein 4 0.0163507
EIF4B eukaryotic translation initiation factor 4B 0.0162312
CSNK1A1 casein kinase 1, alpha 1 0.0161986
TPM3 tropomyosin 3 0.0161504
PTK2 protein tyrosine kinase 2 0.0159575
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0159304
MYH9 myosin, heavy chain 9, non-muscle 0.0159127

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.179064
TMSB10 thymosin beta 10 -0.105131
RPLP1 ribosomal protein, large, P1 -0.0809726
FTL ferritin, light polypeptide -0.0682143
PDE4D phosphodiesterase 4D, cAMP-specific -0.0639381
RPS6 ribosomal protein S6 -0.0621388
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0615163
MT2A metallothionein 2A -0.0596796
TXNRD1 thioredoxin reductase 1 -0.0585352
RPL35A ribosomal protein L35a -0.0523518
RPS19 ribosomal protein S19 -0.0447503
RPS24 ribosomal protein S24 -0.0441401
PSD3 pleckstrin and Sec7 domain containing 3 -0.0433096
RPS23 ribosomal protein S23 -0.0410327
RPL31 ribosomal protein L31 -0.0407204
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0402305
RPL37A ribosomal protein L37a -0.038896
RPL19 ribosomal protein L19 -0.0387227
ACTG1 actin gamma 1 -0.0382515
RPL23 ribosomal protein L23 -0.0381721
RPL26 ribosomal protein L26 -0.037762
PTMA prothymosin, alpha -0.0376356
RPS8 ribosomal protein S8 -0.0369008
VIM vimentin -0.0362341
RPL9 ribosomal protein L9 -0.0361855
RPLP2 ribosomal protein, large, P2 -0.0354187
RPS4X ribosomal protein S4, X-linked -0.0331369
NALF1 NALCN channel auxiliary factor 1 -0.0327164
RPL12 ribosomal protein L12 -0.0323015
GRAMD1B GRAM domain containing 1B -0.0312296
COL4A5 collagen, type IV, alpha 5 -0.0311077
PRDX1 peroxiredoxin 1 -0.0309383
RPS12 ribosomal protein S12 -0.0305223
RPS29 ribosomal protein S29 -0.0296866
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0295162
RPS21 ribosomal protein S21 -0.0293419
SRGN serglycin -0.0292286
RPL37 ribosomal protein L37 -0.0291131
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0288139
NRCAM neuronal cell adhesion molecule -0.0285316
SMYD3 SET and MYND domain containing 3 -0.0282155
PDE10A phosphodiesterase 10A -0.0278675
RPL36A ribosomal protein L36a -0.0277332
RPL34 ribosomal protein L34 -0.0273217
AKR1C1 aldo-keto reductase family 1, member C1 -0.0272608
RPL36 ribosomal protein L36 -0.0267842
RPL7A ribosomal protein L7a -0.0266666
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.026541
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0251803
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0249272
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0246893
RPLP0 ribosomal protein, large, P0 -0.0245512
RPL28 ribosomal protein L28 -0.0241288
RPS16 ribosomal protein S16 -0.0240171
PTGR1 prostaglandin reductase 1 -0.0236987
RPS27A ribosomal protein S27a -0.0235823
ATP5F1E ATP synthase F1 subunit epsilon -0.02275
MT1X metallothionein 1X -0.0227315
RACK1 receptor for activated C kinase 1 -0.0226949
RPL32 ribosomal protein L32 -0.0225658
GNAS GNAS complex locus -0.0223054
RPS14 ribosomal protein S14 -0.0222022
RPL35 ribosomal protein L35 -0.0221294
RPS3 ribosomal protein S3 -0.0220209
RPL5 ribosomal protein L5 -0.0215762
RPL13A ribosomal protein L13a -0.0214363
EIF1 eukaryotic translation initiation factor 1 -0.0212731
COL8A1 collagen, type VIII, alpha 1 -0.021139
MAML3 mastermind-like 3 (Drosophila) -0.0209557
RPL27 ribosomal protein L27 -0.0203036
RPL30 ribosomal protein L30 -0.0200789
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0200044
RPS13 ribosomal protein S13 -0.0197407
RPS28 ribosomal protein S28 -0.0196777
LOC112694756 uncharaterized LOC112694756 -0.0195297
S100A10 S100 calcium binding protein A10 -0.0190688
COL5A2 collagen, type V, alpha 2 -0.0183258
RPL38 ribosomal protein L38 -0.0183048
RPS25 ribosomal protein S25 -0.0182503
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0181123
RPS27 ribosomal protein S27 -0.0178906
VDAC1 voltage-dependent anion channel 1 -0.0178587
RPS20 ribosomal protein S20 -0.0178293
ASPH aspartate beta-hydroxylase -0.0174588
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0172935
RTN1 reticulon 1 -0.016828
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0166044
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0165895
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0162018
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0160008
PRKN parkin RBR E3 ubiquitin protein ligase -0.0159185
PFN1 profilin 1 -0.0157835
HMGB1 high mobility group box 1 -0.0155169
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0154763
HLA-B major histocompatibility complex, class I, B -0.0154691
RPS15 ribosomal protein S15 -0.0153603
MFF mitochondrial fission factor -0.0150075
NCOA7 nuclear receptor coactivator 7 -0.014961
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0149494
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0149044