Pioglitazone_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pioglitazone_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.140174
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0988985
MKI67 marker of proliferation Ki-67 0.0967225
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0940202
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0840013
CENPF centromere protein F, 350/400kDa 0.0798941
ZFAND3 zinc finger, AN1-type domain 3 0.0688077
ZEB2 zinc finger E-box binding homeobox 2 0.0645093
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0597765
CDC73 cell division cycle 73 0.0596105
TSC22D2 TSC22 domain family, member 2 0.0567116
TPX2 TPX2, microtubule-associated 0.0523001
TRIO trio Rho guanine nucleotide exchange factor 0.0515691
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0505547
DST dystonin 0.0503425
SRP54 signal recognition particle 54kDa 0.0496871
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0477923
NCOR1 nuclear receptor corepressor 1 0.0475316
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0467286
CENPE centromere protein E, 312kDa 0.0464679
SPAG9 sperm associated antigen 9 0.0450625
ZNF292 zinc finger protein 292 0.041351
SMC4 structural maintenance of chromosomes 4 0.0395092
NCKAP1 NCK-associated protein 1 0.0391096
PEG10 paternally expressed 10 0.0389285
WDR43 WD repeat domain 43 0.0389034
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0388415
KIF4A kinesin family member 4A 0.038765
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0387146
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0382993
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0376869
ZNF608 zinc finger protein 608 0.0375307
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0360193
ADAM9 ADAM metallopeptidase domain 9 0.0354733
HMGB2 high mobility group box 2 0.0354067
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0351355
MATR3 matrin 3 0.0350951
PUM1 pumilio RNA-binding family member 1 0.0341364
ENAH enabled homolog (Drosophila) 0.0337765
ANLN anillin, actin binding protein 0.0334899
MED13L mediator complex subunit 13-like 0.0331893
SFPQ splicing factor proline/glutamine-rich 0.0330909
RTN4 reticulon 4 0.0327746
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0327037
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.032544
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.032506
ANXA1 annexin A1 0.0325053
CHD1 chromodomain helicase DNA binding protein 1 0.0322832
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0320932
NUSAP1 nucleolar and spindle associated protein 1 0.0317488
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.031274
EMP1 epithelial membrane protein 1 0.0310293
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0308304
KDM6A lysine (K)-specific demethylase 6A 0.0305044
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0301707
FXR1 fragile X mental retardation, autosomal homolog 1 0.0300405
HDAC9 histone deacetylase 9 0.0298266
FIGN fidgetin 0.0294912
ECT2 epithelial cell transforming 2 0.029365
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0292392
ANXA2 annexin A2 0.0289505
STAG2 stromal antigen 2 0.0287984
CSDE1 cold shock domain containing E1, RNA-binding 0.0286311
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0285884
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0285075
CANX calnexin 0.0284283
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0281585
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0281242
KIF18B kinesin family member 18B 0.0275105
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0269704
PDGFC platelet derived growth factor C 0.026882
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0268644
MEMO1 mediator of cell motility 1 0.0266205
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0260825
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0259695
NAMPT nicotinamide phosphoribosyltransferase 0.0258831
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0258198
IGF1R insulin-like growth factor 1 receptor 0.0257587
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0257505
SPAG5 sperm associated antigen 5 0.0256849
FUS FUS RNA binding protein 0.0256291
FAM171B family with sequence similarity 171, member B 0.0255811
PCBP2 poly(rC) binding protein 2 0.0255055
CKAP5 cytoskeleton associated protein 5 0.0253475
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.025185
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0247558
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0247028
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0245309
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0245276
KAT6A K(lysine) acetyltransferase 6A 0.0239876
MTF2 metal response element binding transcription factor 2 0.0239345
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0236178
TRA2A transformer 2 alpha homolog (Drosophila) 0.0235775
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0235065
EWSR1 EWS RNA-binding protein 1 0.0233996
COL3A1 collagen, type III, alpha 1 0.0233945
KMT2E lysine (K)-specific methyltransferase 2E 0.0233748
CCNL1 cyclin L1 0.0233116
SAFB scaffold attachment factor B 0.023114
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0227386

decreased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 -0.200729
CDH10 cadherin 10, type 2 (T2-cadherin) -0.166104
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.137074
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.131683
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.13068
TMSB10 thymosin beta 10 -0.11466
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.111726
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100096
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0925527
CADM2 cell adhesion molecule 2 -0.0853525
WSB1 WD repeat and SOCS box containing 1 -0.0797122
PHIP pleckstrin homology domain interacting protein -0.0713696
PCDH9 protocadherin 9 -0.0665739
RPS16 ribosomal protein S16 -0.0665216
NTM neurotrimin -0.0629939
LRRC4C leucine rich repeat containing 4C -0.0607047
ADGRL2 adhesion G protein-coupled receptor L2 -0.060681
RPS6 ribosomal protein S6 -0.0605901
PARD3B par-3 family cell polarity regulator beta -0.0590722
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0578848
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0573974
ACTG1 actin gamma 1 -0.0554277
ADGRV1 adhesion G protein-coupled receptor V1 -0.0551269
VIM vimentin -0.0551252
GNAS GNAS complex locus -0.0545272
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.054025
PCLO piccolo presynaptic cytomatrix protein -0.0529614
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0525955
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.051944
ITGAV integrin, alpha V -0.0514225
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0513576
NCAM2 neural cell adhesion molecule 2 -0.0496074
RPS8 ribosomal protein S8 -0.0489042
SOX2 SRY (sex determining region Y)-box 2 -0.0477001
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0467238
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0442042
RPS12 ribosomal protein S12 -0.0421247
TENM3 teneurin transmembrane protein 3 -0.041846
RPL35A ribosomal protein L35a -0.0411256
MDK midkine (neurite growth-promoting factor 2) -0.04005
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0392603
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0390282
NEBL nebulette -0.0389832
CSMD3 CUB and Sushi multiple domains 3 -0.0382014
RAD51B RAD51 paralog B -0.0380063
GPC3 glypican 3 -0.0377087
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0375409
PGK1 phosphoglycerate kinase 1 -0.0367678
MRPS6 mitochondrial ribosomal protein S6 -0.0365921
TOX thymocyte selection-associated high mobility group box -0.0365917
RPL9 ribosomal protein L9 -0.0365511
LDHA lactate dehydrogenase A -0.0363936
PTMA prothymosin, alpha -0.0352179
SLC44A5 solute carrier family 44, member 5 -0.0351685
RPL37A ribosomal protein L37a -0.0346817
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0329599
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0320897
PGAP1 post-GPI attachment to proteins 1 -0.0315882
RPS3 ribosomal protein S3 -0.0312869
RPLP1 ribosomal protein, large, P1 -0.0312266
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0309817
RPL19 ribosomal protein L19 -0.0308555
CNRIP1 cannabinoid receptor interacting protein 1 -0.0305441
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0302548
FBXL17 F-box and leucine-rich repeat protein 17 -0.0300445
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0299216
SLIT2 slit homolog 2 (Drosophila) -0.0298361
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0297188
PRTG protogenin -0.0295462
DOCK5 dedicator of cytokinesis 5 -0.028928
SNX6 sorting nexin 6 -0.0289046
BMPR1A bone morphogenetic protein receptor, type IA -0.028801
RPL28 ribosomal protein L28 -0.0285455
RPS13 ribosomal protein S13 -0.0280262
S100A9 S100 calcium binding protein A9 -0.0278524
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0277586
MAML2 mastermind-like 2 (Drosophila) -0.027728
TTC3 tetratricopeptide repeat domain 3 -0.0276816
NF1 neurofibromin 1 -0.0276494
FOXG1 forkhead box G1 -0.0276427
RNF213 ring finger protein 213 -0.0273144
CUX1 cut-like homeobox 1 -0.0272002
RPS21 ribosomal protein S21 -0.0269465
LOC102724023 ES1 protein homolog, mitochondrial -0.0268993
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.026784
TUT4 terminal uridylyl transferase 4 -0.0266172
RPL37 ribosomal protein L37 -0.0264782
ZC3H12B zinc finger CCCH-type containing 12B -0.0264559
ISG15 ISG15 ubiquitin-like modifier -0.0263729
SETD5 SET domain containing 5 -0.0263284
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0260642
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0255963
FN1 fibronectin 1 -0.0254288
BRWD1 bromodomain and WD repeat domain containing 1 -0.0254066
RPS24 ribosomal protein S24 -0.0251474
NBEAL1 neurobeachin-like 1 -0.024886
NCOR2 nuclear receptor corepressor 2 -0.0247938
GREB1L growth regulation by estrogen in breast cancer-like -0.0246145
MEIS2 Meis homeobox 2 -0.0246055
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0245723