Pioglitazone_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pioglitazone_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.107193
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0960038
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0852162
GOLGA4 golgin A4 0.0777029
ADAM10 ADAM metallopeptidase domain 10 0.0735855
FLNB filamin B, beta 0.0666668
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0654496
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0649689
ZNF292 zinc finger protein 292 0.0638802
DSCAM Down syndrome cell adhesion molecule 0.0620462
RTN4 reticulon 4 0.0593491
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0545172
ELOVL5 ELOVL fatty acid elongase 5 0.052423
EEF2 eukaryotic translation elongation factor 2 0.0509221
EIF4A2 eukaryotic translation initiation factor 4A2 0.0489974
ZFAND3 zinc finger, AN1-type domain 3 0.0484865
ADAM9 ADAM metallopeptidase domain 9 0.0477125
GARS1 glycyl-tRNA synthetase 1 0.0476434
RBM39 RNA binding motif protein 39 0.0469818
TXNRD1 thioredoxin reductase 1 0.0465963
NBAS neuroblastoma amplified sequence 0.045518
TMEM41B transmembrane protein 41B 0.0434554
ECT2 epithelial cell transforming 2 0.0434219
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0426796
ANK2 ankyrin 2, neuronal 0.0420004
VMP1 vacuole membrane protein 1 0.0415655
EXT1 exostosin glycosyltransferase 1 0.041496
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0414376
NCEH1 neutral cholesterol ester hydrolase 1 0.0410606
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0409603
RNF145 ring finger protein 145 0.0403079
NUP58 nucleoporin 58 0.0401672
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0395989
EZR ezrin 0.0394604
JMJD1C jumonji domain containing 1C 0.0390402
CDC73 cell division cycle 73 0.0387472
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0367742
NCKAP1 NCK-associated protein 1 0.0366949
EVI5 ecotropic viral integration site 5 0.0366707
EML4 echinoderm microtubule associated protein like 4 0.0366572
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0363312
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0357338
LDHA lactate dehydrogenase A 0.0357253
CAMTA1 calmodulin binding transcription activator 1 0.0355315
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0350968
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0350961
TFG TRK-fused gene 0.0350959
KMT2C lysine (K)-specific methyltransferase 2C 0.0349765
KDM3A lysine (K)-specific demethylase 3A 0.0349194
KMT2E lysine (K)-specific methyltransferase 2E 0.0347924
TMEM65 transmembrane protein 65 0.0346511
PNISR PNN-interacting serine/arginine-rich protein 0.0344871
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0343578
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.034007
PICALM phosphatidylinositol binding clathrin assembly protein 0.033852
CD47 CD47 molecule 0.0329517
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0329102
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.032814
TJP1 tight junction protein 1 0.0324311
SEC23A Sec23 homolog A (S. cerevisiae) 0.0322627
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0321736
QKI QKI, KH domain containing, RNA binding 0.031743
COG5 component of oligomeric golgi complex 5 0.031717
GSK3B glycogen synthase kinase 3 beta 0.0314082
TBC1D22A TBC1 domain family, member 22A 0.0309728
NAMPT nicotinamide phosphoribosyltransferase 0.0309276
CCNL1 cyclin L1 0.0300546
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0300079
GOLGA2 golgin A2 0.0297065
BIRC6 baculoviral IAP repeat containing 6 0.0297054
PTBP2 polypyrimidine tract binding protein 2 0.0291376
PDGFC platelet derived growth factor C 0.0287862
KDM6A lysine (K)-specific demethylase 6A 0.0285982
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0282808
ZEB1 zinc finger E-box binding homeobox 1 0.0282443
ANKRD11 ankyrin repeat domain 11 0.0281687
SEC63 SEC63 homolog (S. cerevisiae) 0.0280986
USP24 ubiquitin specific peptidase 24 0.0279598
HDLBP high density lipoprotein binding protein 0.0277808
TXNIP thioredoxin interacting protein 0.027748
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0276963
PLK2 polo-like kinase 2 0.0276329
SQSTM1 sequestosome 1 0.0274881
LPP LIM domain containing preferred translocation partner in lipoma 0.027291
PYGB phosphorylase, glycogen; brain 0.0271636
GLS2 glutaminase 2 (liver, mitochondrial) 0.0267816
ZCCHC7 zinc finger, CCHC domain containing 7 0.0267776
RBM26 RNA binding motif protein 26 0.0267663
FXR1 fragile X mental retardation, autosomal homolog 1 0.0265516
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0264152
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0262701
SRPK2 SRSF protein kinase 2 0.026243
RAB1A RAB1A, member RAS oncogene family 0.0262302
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0262299
SBF2 SET binding factor 2 0.0260307
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0258373
TTC3 tetratricopeptide repeat domain 3 0.0257233
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0256229
CALR calreticulin 0.025369
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0253024

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.159792
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0863641
BMP10 bone morphogenetic protein 10 -0.0860954
RPS6 ribosomal protein S6 -0.0749141
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0656027
RPS8 ribosomal protein S8 -0.0609772
FOXP1 forkhead box P1 -0.0575088
RPL35A ribosomal protein L35a -0.0563289
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0476453
MYO5C myosin VC -0.0421238
GLI3 GLI family zinc finger 3 -0.0412837
HSPB1 heat shock 27kDa protein 1 -0.0410354
RPLP1 ribosomal protein, large, P1 -0.0389713
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0387721
ACTG1 actin gamma 1 -0.0358597
TPT1 tumor protein, translationally-controlled 1 -0.0354097
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0343613
RPL34 ribosomal protein L34 -0.0340944
RPL26 ribosomal protein L26 -0.0325862
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0319978
RPS19 ribosomal protein S19 -0.0318838
RPS3 ribosomal protein S3 -0.0307135
MKI67 marker of proliferation Ki-67 -0.0299799
S100A4 S100 calcium binding protein A4 -0.0294503
TMSB10 thymosin beta 10 -0.0291
EBNA1BP2 EBNA1 binding protein 2 -0.0287292
CCND1 cyclin D1 -0.0286817
PKM pyruvate kinase, muscle -0.0282659
ZNF438 zinc finger protein 438 -0.0280354
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0279163
DIAPH3 diaphanous-related formin 3 -0.0276897
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0274323
RPS13 ribosomal protein S13 -0.0270554
RPL9 ribosomal protein L9 -0.0269986
RPS27A ribosomal protein S27a -0.0267403
RPLP2 ribosomal protein, large, P2 -0.0265992
RPL19 ribosomal protein L19 -0.0257172
DLG1 discs, large homolog 1 (Drosophila) -0.0255527
TUBB4B tubulin, beta 4B class IVb -0.0253944
PDE4B phosphodiesterase 4B, cAMP-specific -0.024961
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0245739
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0237087
RPS25 ribosomal protein S25 -0.0233838
RPL36 ribosomal protein L36 -0.0232821
RPL31 ribosomal protein L31 -0.0230721
CUX1 cut-like homeobox 1 -0.0220377
RPS24 ribosomal protein S24 -0.0219969
RPL37A ribosomal protein L37a -0.021517
NPAS2 neuronal PAS domain protein 2 -0.0212728
IFITM3 interferon induced transmembrane protein 3 -0.0211899
RPL38 ribosomal protein L38 -0.0210405
RPL37 ribosomal protein L37 -0.0210396
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0209916
ZMYND8 zinc finger, MYND-type containing 8 -0.0207352
S100A9 S100 calcium binding protein A9 -0.0206808
RPL12 ribosomal protein L12 -0.0205443
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.020522
RPS5 ribosomal protein S5 -0.0204763
RACK1 receptor for activated C kinase 1 -0.0197801
SPRY4 sprouty homolog 4 (Drosophila) -0.0197516
HMGB1 high mobility group box 1 -0.0194761
RPS12 ribosomal protein S12 -0.0194182
RPL7A ribosomal protein L7a -0.0193916
RPL32 ribosomal protein L32 -0.019265
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0190518
LOC102724023 ES1 protein homolog, mitochondrial -0.0190107
ARL4C ADP-ribosylation factor-like 4C -0.0189897
S100A10 S100 calcium binding protein A10 -0.0189814
RPL8 ribosomal protein L8 -0.0188602
RPL18 ribosomal protein L18 -0.0187488
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.018683
MACROD2 MACRO domain containing 2 -0.0185167
RPS21 ribosomal protein S21 -0.0185074
RPS27 ribosomal protein S27 -0.0184361
BCOR BCL6 corepressor -0.0183456
RPL30 ribosomal protein L30 -0.0183406
UNC13A unc-13 homolog A (C. elegans) -0.0182583
RPS23 ribosomal protein S23 -0.0181995
IFI6 interferon, alpha-inducible protein 6 -0.0178801
CAMKMT calmodulin-lysine N-methyltransferase -0.0177841
TUBA1B tubulin, alpha 1b -0.0177692
TPI1 triosephosphate isomerase 1 -0.017152
PDE7B phosphodiesterase 7B -0.0171302
ITGA10 integrin, alpha 10 -0.0170057
MYL12B myosin, light chain 12B, regulatory -0.0169761
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0169442
PA2G4 proliferation-associated 2G4, 38kDa -0.0168271
RPS14 ribosomal protein S14 -0.0167386
RPL28 ribosomal protein L28 -0.0167113
SDK1 sidekick cell adhesion molecule 1 -0.0166114
THBD thrombomodulin -0.0165532
RIGI RNA sensor RIG-I -0.0163307
GSE1 Gse1 coiled-coil protein -0.0162952
CENPF centromere protein F, 350/400kDa -0.0161019
RPLP0 ribosomal protein, large, P0 -0.0159757
NAV2 neuron navigator 2 -0.0158978
EXOC4 exocyst complex component 4 -0.0157878
PLSCR1 phospholipid scramblase 1 -0.0157633
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0156671
HLA-B major histocompatibility complex, class I, B -0.0156292