Pioglitazone_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pioglitazone_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.189364
ELL2 elongation factor, RNA polymerase II, 2 0.0979985
SOD2 superoxide dismutase 2, mitochondrial 0.0730453
ARRDC3 arrestin domain containing 3 0.0704499
HOOK2 hook microtubule-tethering protein 2 0.0688578
NAMPT nicotinamide phosphoribosyltransferase 0.060336
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0557992
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.054301
UGCG UDP-glucose ceramide glucosyltransferase 0.0520706
PDIA4 protein disulfide isomerase family A, member 4 0.0485139
KDM6A lysine (K)-specific demethylase 6A 0.0450029
ATP13A3 ATPase type 13A3 0.0448197
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0444819
UBE2H ubiquitin-conjugating enzyme E2H 0.0439364
ZNF292 zinc finger protein 292 0.0431024
ESYT2 extended synaptotagmin-like protein 2 0.0426172
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0422198
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0419119
ANXA5 annexin A5 0.0412702
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0408198
FAM13A family with sequence similarity 13, member A 0.0406388
CAVIN1 caveolae associated protein 1 0.0401188
SDC4 syndecan 4 0.0370817
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0369082
XPO1 exportin 1 0.03607
FRMD6 FERM domain containing 6 0.0359895
RAB8B RAB8B, member RAS oncogene family 0.0357917
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0349322
UBA6 ubiquitin-like modifier activating enzyme 6 0.0348252
CANX calnexin 0.0343935
MAP1B microtubule-associated protein 1B 0.0341127
OGA O-GlcNAcase 0.0340345
JARID2 jumonji, AT rich interactive domain 2 0.0333038
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0322836
SKIC3 SKI3 subunit of superkiller complex 0.0313523
SUCO SUN domain containing ossification factor 0.0303966
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0296973
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0295485
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0294206
DSCAM Down syndrome cell adhesion molecule 0.0293257
COL1A2 collagen, type I, alpha 2 0.0291608
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0285626
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.027674
KDM3A lysine (K)-specific demethylase 3A 0.0272473
PDIA3 protein disulfide isomerase family A, member 3 0.0272021
MARCHF6 membrane associated ring-CH-type finger 6 0.0268928
SFXN1 sideroflexin 1 0.0266371
DGKD diacylglycerol kinase, delta 130kDa 0.0266185
IGFBP7 insulin-like growth factor binding protein 7 0.0260703
NUMA1 nuclear mitotic apparatus protein 1 0.0260527
ITM2B integral membrane protein 2B 0.0259757
PRRC2C proline-rich coiled-coil 2C 0.0259269
CD47 CD47 molecule 0.0256609
SMAD3 SMAD family member 3 0.0255438
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0254384
DDIT4 DNA-damage-inducible transcript 4 0.0254267
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0252414
YME1L1 YME1-like 1 ATPase 0.0250346
IRAK2 interleukin-1 receptor-associated kinase 2 0.0250335
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0248381
CORO1C coronin, actin binding protein, 1C 0.0248023
ANLN anillin, actin binding protein 0.0245258
NUP58 nucleoporin 58 0.0245162
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0243304
FAM168B family with sequence similarity 168, member B 0.0243256
NEK7 NIMA-related kinase 7 0.0243096
ARHGAP17 Rho GTPase activating protein 17 0.0237915
ANO6 anoctamin 6 0.0237235
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0235862
SARAF store-operated calcium entry-associated regulatory factor 0.0235803
HMGB2 high mobility group box 2 0.0235105
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0235037
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0230126
GARS1 glycyl-tRNA synthetase 1 0.0229464
RNF145 ring finger protein 145 0.0227926
WDR43 WD repeat domain 43 0.0224874
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0223744
BHLHE40 basic helix-loop-helix family, member e40 0.0223404
MTF2 metal response element binding transcription factor 2 0.0222971
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0217626
PHF20 PHD finger protein 20 0.0216016
TENT2 terminal nucleotidyltransferase 2 0.0215878
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0215154
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0213527
IGF2R insulin-like growth factor 2 receptor 0.0213213
SLMAP sarcolemma associated protein 0.0212217
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0212158
RSRC2 arginine/serine-rich coiled-coil 2 0.021125
GLS2 glutaminase 2 (liver, mitochondrial) 0.0210789
CCDC93 coiled-coil domain containing 93 0.0210688
CDC73 cell division cycle 73 0.0210076
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0209849
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0208636
FOXJ3 forkhead box J3 0.0207872
RAD23B RAD23 homolog B (S. cerevisiae) 0.0206177
SEC24A SEC24 family member A 0.0205915
MIGA1 mitoguardin 1 0.0205582
WDR45B WD repeat domain 45B 0.0205227
MYH9 myosin, heavy chain 9, non-muscle 0.0205128
MORC3 MORC family CW-type zinc finger 3 0.0204864

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.231341
TGFBI transforming growth factor, beta-induced, 68kDa -0.21561
TMSB10 thymosin beta 10 -0.17904
VIM vimentin -0.177527
MT2A metallothionein 2A -0.145306
IGFBP3 insulin-like growth factor binding protein 3 -0.136535
FTL ferritin, light polypeptide -0.119236
TIMP3 TIMP metallopeptidase inhibitor 3 -0.118468
ACTG1 actin gamma 1 -0.0919973
EGFR epidermal growth factor receptor -0.0845191
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0795556
PTMA prothymosin, alpha -0.0711026
RPL35A ribosomal protein L35a -0.0698499
CDH13 cadherin 13 -0.0661144
POTEF POTE ankyrin domain family, member F -0.0642785
RPS6 ribosomal protein S6 -0.0633257
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0612366
CADM1 cell adhesion molecule 1 -0.0607744
PSD3 pleckstrin and Sec7 domain containing 3 -0.058337
NDRG1 N-myc downstream regulated 1 -0.0535274
COL6A1 collagen, type VI, alpha 1 -0.0525453
HLA-B major histocompatibility complex, class I, B -0.0522487
HLA-A major histocompatibility complex, class I, A -0.0503057
COL1A1 collagen, type I, alpha 1 -0.0501096
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0487095
RPS8 ribosomal protein S8 -0.0482019
RPLP1 ribosomal protein, large, P1 -0.0478076
PKM pyruvate kinase, muscle -0.0477591
LMNA lamin A/C -0.0475958
RPL34 ribosomal protein L34 -0.0466051
S100A9 S100 calcium binding protein A9 -0.0451008
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0445615
RPS19 ribosomal protein S19 -0.0441301
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0435829
FN1 fibronectin 1 -0.0420768
TPM4 tropomyosin 4 -0.0408593
TPT1 tumor protein, translationally-controlled 1 -0.0406563
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0406301
RPL23 ribosomal protein L23 -0.0398442
RPS3 ribosomal protein S3 -0.0392825
FTH1 ferritin, heavy polypeptide 1 -0.0391039
VEGFA vascular endothelial growth factor A -0.0389791
RPS14 ribosomal protein S14 -0.0375146
FBXO11 F-box protein 11 -0.0370372
RPS27A ribosomal protein S27a -0.0366776
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0363398
ATXN1 ataxin 1 -0.0356243
INTS6 integrator complex subunit 6 -0.0352924
CA12 carbonic anhydrase XII -0.0348452
RPS25 ribosomal protein S25 -0.0346254
RPS23 ribosomal protein S23 -0.0344879
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0344713
RPL31 ribosomal protein L31 -0.0341773
RPL9 ribosomal protein L9 -0.033844
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0322291
ZBTB20 zinc finger and BTB domain containing 20 -0.0322025
FNDC3B fibronectin type III domain containing 3B -0.0320571
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0319304
GNAS GNAS complex locus -0.031269
ECE1 endothelin converting enzyme 1 -0.0310084
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0308075
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0302543
RRBP1 ribosome binding protein 1 -0.0302322
ATF4 activating transcription factor 4 -0.0301504
TIMP2 TIMP metallopeptidase inhibitor 2 -0.030094
VDAC1 voltage-dependent anion channel 1 -0.0297684
DPYD dihydropyrimidine dehydrogenase -0.0297416
RPL38 ribosomal protein L38 -0.0293968
HMGA2 high mobility group AT-hook 2 -0.0293723
HM13 histocompatibility (minor) 13 -0.0290221
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0289363
BPTF bromodomain PHD finger transcription factor -0.0288742
ZMYND8 zinc finger, MYND-type containing 8 -0.0284226
RPL37A ribosomal protein L37a -0.0282125
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0280764
CDK6 cyclin-dependent kinase 6 -0.0276737
PUM2 pumilio RNA-binding family member 2 -0.0276501
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0275946
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0274647
RPS11 ribosomal protein S11 -0.0273034
TTC3 tetratricopeptide repeat domain 3 -0.0272837
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0272565
CALD1 caldesmon 1 -0.0272393
PRMT2 protein arginine methyltransferase 2 -0.0270244
EIF1 eukaryotic translation initiation factor 1 -0.0267911
FAF1 Fas (TNFRSF6) associated factor 1 -0.0262975
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0262658
RPS16 ribosomal protein S16 -0.0260796
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0259857
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0259367
ANKRD28 ankyrin repeat domain 28 -0.0258154
ENO2 enolase 2 (gamma, neuronal) -0.0255921
PTPRM protein tyrosine phosphatase, receptor type, M -0.0253337
IL6 interleukin 6 -0.0248231
RPL36 ribosomal protein L36 -0.0244825
TNS3 tensin 3 -0.0244648
PTPRG protein tyrosine phosphatase, receptor type, G -0.0244555
MORF4L2 mortality factor 4 like 2 -0.0242953
KTN1 kinectin 1 (kinesin receptor) -0.0241382
SEC61G Sec61 gamma subunit -0.0240912