Pioglitazone_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pioglitazone perturbation in SW 900 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pioglitazone_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.0782747
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0715789
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0578328
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0571609
RNF145 ring finger protein 145 0.0555889
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0548652
CANX calnexin 0.0526461
SOD2 superoxide dismutase 2, mitochondrial 0.0489112
NAMPT nicotinamide phosphoribosyltransferase 0.0479335
OGA O-GlcNAcase 0.0438406
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0430612
FAM13A family with sequence similarity 13, member A 0.0420082
CD109 CD109 molecule 0.0403257
PRRC2C proline-rich coiled-coil 2C 0.0400563
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0396322
SEC23A Sec23 homolog A (S. cerevisiae) 0.0390714
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0380962
RICTOR RPTOR independent companion of MTOR, complex 2 0.0373724
SUCO SUN domain containing ossification factor 0.0356993
NDRG1 N-myc downstream regulated 1 0.0356135
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0350679
WAC WW domain containing adaptor with coiled-coil 0.0343631
APLP2 amyloid beta (A4) precursor-like protein 2 0.0342472
TFG TRK-fused gene 0.0341996
ARRDC3 arrestin domain containing 3 0.0340095
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.033462
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0327017
HELZ helicase with zinc finger 0.0322077
NEK7 NIMA-related kinase 7 0.0319176
NUP58 nucleoporin 58 0.0315945
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0314332
RAB8B RAB8B, member RAS oncogene family 0.0311133
ZNF292 zinc finger protein 292 0.0308475
TFPI2 tissue factor pathway inhibitor 2 0.0308244
NAP1L1 nucleosome assembly protein 1-like 1 0.0304221
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0297882
TENT2 terminal nucleotidyltransferase 2 0.0288823
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0288744
EEF2 eukaryotic translation elongation factor 2 0.0286588
KMT2E lysine (K)-specific methyltransferase 2E 0.0279629
ETNK1 ethanolamine kinase 1 0.0277869
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0277718
RAB6A RAB6A, member RAS oncogene family 0.027571
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0274827
TXNIP thioredoxin interacting protein 0.0274812
MARCHF6 membrane associated ring-CH-type finger 6 0.0270569
WDR45B WD repeat domain 45B 0.0266793
RAB18 RAB18, member RAS oncogene family 0.0258517
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0258
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0256895
MYO1B myosin IB 0.025223
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0251332
ADAM9 ADAM metallopeptidase domain 9 0.0250652
XPO1 exportin 1 0.0245094
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0244011
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.024291
FAT1 FAT atypical cadherin 1 0.0242189
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0240182
EPS8 epidermal growth factor receptor pathway substrate 8 0.0239608
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0236866
AFTPH aftiphilin 0.0232295
COG5 component of oligomeric golgi complex 5 0.0231068
COPA coatomer protein complex, subunit alpha 0.0230507
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0229369
KDM6A lysine (K)-specific demethylase 6A 0.0226942
VEGFA vascular endothelial growth factor A 0.0226911
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0225022
UBA6 ubiquitin-like modifier activating enzyme 6 0.0223943
GOLT1B golgi transport 1B 0.0221198
CDC73 cell division cycle 73 0.0219468
SMAD3 SMAD family member 3 0.0218529
CUL3 cullin 3 0.0217746
YME1L1 YME1-like 1 ATPase 0.0216937
MIS18BP1 MIS18 binding protein 1 0.0216768
RAB1A RAB1A, member RAS oncogene family 0.0216747
FAM168B family with sequence similarity 168, member B 0.0216312
PUM2 pumilio RNA-binding family member 2 0.0216243
USP3 ubiquitin specific peptidase 3 0.0215693
GPBP1 GC-rich promoter binding protein 1 0.0214648
UGCG UDP-glucose ceramide glucosyltransferase 0.0212837
DSCAM Down syndrome cell adhesion molecule 0.0211889
TRAM1 translocation associated membrane protein 1 0.0209488
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0206688
LCORL ligand dependent nuclear receptor corepressor-like 0.0206666
CTNND1 catenin (cadherin-associated protein), delta 1 0.0205717
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0205284
BIRC6 baculoviral IAP repeat containing 6 0.0205049
ELL2 elongation factor, RNA polymerase II, 2 0.0204727
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0203649
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0202995
ESYT2 extended synaptotagmin-like protein 2 0.0201426
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0200088
GOLGA4 golgin A4 0.0199502
SFXN1 sideroflexin 1 0.0197622
HILPDA hypoxia inducible lipid droplet-associated 0.0196395
COLEC11 collectin sub-family member 11 0.0196363
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0195249
RYBP RING1 and YY1 binding protein 0.0194118
EIF4B eukaryotic translation initiation factor 4B 0.0193689
TPD52 tumor protein D52 0.0193084

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.343763
FN1 fibronectin 1 -0.285688
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.239297
HMGA2 high mobility group AT-hook 2 -0.183615
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.162628
ASPH aspartate beta-hydroxylase -0.115775
GLIS3 GLIS family zinc finger 3 -0.115014
SYT1 synaptotagmin I -0.102363
EFNA5 ephrin-A5 -0.0959699
EXT1 exostosin glycosyltransferase 1 -0.0943532
TMSB10 thymosin beta 10 -0.0842532
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.079675
SQSTM1 sequestosome 1 -0.0768134
TMEM156 transmembrane protein 156 -0.0662257
IFI27 interferon, alpha-inducible protein 27 -0.0632215
RAI14 retinoic acid induced 14 -0.0619606
PTMA prothymosin, alpha -0.0602442
VCL vinculin -0.0591939
HLA-B major histocompatibility complex, class I, B -0.0568512
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0557705
ITGA1 integrin, alpha 1 -0.0526667
TMSB4X thymosin beta 4, X-linked -0.0513521
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0494181
PDE4D phosphodiesterase 4D, cAMP-specific -0.048762
S100A6 S100 calcium binding protein A6 -0.0478601
ZBTB20 zinc finger and BTB domain containing 20 -0.0478404
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0455011
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0444942
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0443586
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0438511
NRP1 neuropilin 1 -0.0435341
ETV1 ets variant 1 -0.0431431
MAML2 mastermind-like 2 (Drosophila) -0.0429016
ACTG1 actin gamma 1 -0.0426943
LOC102724023 ES1 protein homolog, mitochondrial -0.0424748
IFI16 interferon, gamma-inducible protein 16 -0.0421579
SOX4 SRY (sex determining region Y)-box 4 -0.0412121
NTN4 netrin 4 -0.0404852
RNF213 ring finger protein 213 -0.0397108
DNAH5 dynein, axonemal, heavy chain 5 -0.0394466
TNS3 tensin 3 -0.0389619
HIPK2 homeodomain interacting protein kinase 2 -0.0387192
TAS2R14 taste receptor, type 2, member 14 -0.0385942
PLIN2 perilipin 2 -0.0382486
TSC22D1 TSC22 domain family, member 1 -0.0379478
MBD5 methyl-CpG binding domain protein 5 -0.037461
FOXP1 forkhead box P1 -0.0374391
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0373923
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0369962
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0369592
OSMR oncostatin M receptor -0.0367795
KLHL5 kelch-like family member 5 -0.0365076
LRMDA leucine rich melanocyte differentiation associated -0.0364544
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0357551
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0355387
POTEF POTE ankyrin domain family, member F -0.0351258
ETV6 ets variant 6 -0.0347166
EGR1 early growth response 1 -0.0345532
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.033528
ZMYND8 zinc finger, MYND-type containing 8 -0.0326206
BICD1 bicaudal D homolog 1 (Drosophila) -0.0320446
MAP1B microtubule-associated protein 1B -0.0318534
MX2 MX dynamin-like GTPase 2 -0.0314872
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0311884
SLC35F3 solute carrier family 35, member F3 -0.0311323
RANBP17 RAN binding protein 17 -0.0307569
DST dystonin -0.0304885
RASAL2 RAS protein activator like 2 -0.029983
FTL ferritin, light polypeptide -0.0292403
EXOC4 exocyst complex component 4 -0.0292118
AEBP2 AE binding protein 2 -0.0287696
HPCAL1 hippocalcin-like 1 -0.028627
IFI6 interferon, alpha-inducible protein 6 -0.0283392
GPC6 glypican 6 -0.027622
BABAM2 BRISC and BRCA1 A complex member 2 -0.0274579
SLC38A2 solute carrier family 38, member 2 -0.026545
TTC28 tetratricopeptide repeat domain 28 -0.0259374
FTH1 ferritin, heavy polypeptide 1 -0.0257251
NCOA7 nuclear receptor coactivator 7 -0.02567
ENO2 enolase 2 (gamma, neuronal) -0.0254817
RBM47 RNA binding motif protein 47 -0.0254256
PRKCA protein kinase C, alpha -0.0251149
RAD51B RAD51 paralog B -0.0247302
BPTF bromodomain PHD finger transcription factor -0.0245829
RPL35A ribosomal protein L35a -0.024441
INTS6 integrator complex subunit 6 -0.0241734
GLUL glutamate-ammonia ligase -0.0241727
PRH1 proline-rich protein HaeIII subfamily 1 -0.0241549
SP100 SP100 nuclear antigen -0.0239715
MRPS6 mitochondrial ribosomal protein S6 -0.0237412
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0237051
TMEM131 transmembrane protein 131 -0.0236445
IER3 immediate early response 3 -0.0230875
RUNX2 runt-related transcription factor 2 -0.0230584
TBC1D22A TBC1 domain family, member 22A -0.0227163
LY6E lymphocyte antigen 6 complex, locus E -0.0224717
SSH1 slingshot protein phosphatase 1 -0.0223885
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0223691
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0221494
RIGI RNA sensor RIG-I -0.0217774