Pirenzepine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/4848
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Genes

195 proteins with high or low expression in Pirenzepine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
KSR2 kinase suppressor of ras 2 1.66
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 1.55
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 1.12
MARCHF7 membrane associated ring-CH-type finger 7 1.1
MYO7B myosin VIIB 1.08
ADCY10 adenylate cyclase 10 (soluble) 1.05
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.89
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 0.87
BMT2 base methyltransferase of 25S rRNA 2 homolog 0.86
ZC3H12C zinc finger CCCH-type containing 12C 0.8
C12ORF60 chromosome 12 open reading frame 60 0.78
WWC3 WWC family member 3 0.77
LRRC7 leucine rich repeat containing 7 0.74
BCL2L12 BCL2-like 12 (proline rich) 0.72
ZNF226 zinc finger protein 226 0.72
IL6ST interleukin 6 signal transducer 0.7
ESAM endothelial cell adhesion molecule 0.7
LSM10 LSM10, U7 small nuclear RNA associated 0.67
KCTD12 potassium channel tetramerization domain containing 12 0.65
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 0.64
TTN titin 0.63
TRIM39 tripartite motif containing 39 0.63
STYK1 serine/threonine/tyrosine kinase 1 0.61
CALHM2 calcium homeostasis modulator 2 0.58
CCNDBP1 cyclin D-type binding-protein 1 0.58
PRKCH protein kinase C, eta 0.55
MTMR3 myotubularin related protein 3 0.55
KDM4D lysine (K)-specific demethylase 4D 0.54
DENND5A DENN/MADD domain containing 5A 0.54
FZD7 frizzled class receptor 7 0.53
FBXL17 F-box and leucine-rich repeat protein 17 0.53
PGS1 phosphatidylglycerophosphate synthase 1 0.52
B2M beta-2-microglobulin 0.51
KMT2B lysine (K)-specific methyltransferase 2B 0.49
YPEL5 yippee-like 5 (Drosophila) 0.49
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.48
PDGFA platelet-derived growth factor alpha polypeptide 0.47
RPS26 ribosomal protein S26 0.46
TMEM222 transmembrane protein 222 0.46
ADGRG6 adhesion G protein-coupled receptor G6 0.46
ACTBL2 actin, beta-like 2 0.45
LARP6 La ribonucleoprotein domain family, member 6 0.44
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.44
KLHL23 kelch-like family member 23 0.43
LRRC8B leucine rich repeat containing 8 family, member B 0.43
PIWIL2 piwi-like RNA-mediated gene silencing 2 0.43
NDFIP2 Nedd4 family interacting protein 2 0.42
HELQ helicase, POLQ-like 0.42
TMEM39B transmembrane protein 39B 0.42
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.42
FAM241B family with sequence similarity 241 member B 0.42
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 0.42
CCDC85B coiled-coil domain containing 85B 0.41
DNAH2 dynein, axonemal, heavy chain 2 0.41
ZSCAN26 zinc finger and SCAN domain containing 26 0.41
MCF2L MCF.2 cell line derived transforming sequence-like 0.4
ERI3 ERI1 exoribonuclease family member 3 0.4
RASA2 RAS p21 protein activator 2 0.4
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 0.39
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase 0.39
CCDC117 coiled-coil domain containing 117 0.39
DGKE diacylglycerol kinase, epsilon 64kDa 0.38
RNF139 ring finger protein 139 0.38
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.37
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.37
CREBZF CREB/ATF bZIP transcription factor 0.37
RAB36 RAB36, member RAS oncogene family 0.37
FBXO46 F-box protein 46 0.37
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.36
SON SON DNA binding protein 0.36
TMEM87B transmembrane protein 87B 0.36
SLC35A4 solute carrier family 35, member A4 0.35
KLHL15 kelch-like family member 15 0.35
ADM adrenomedullin 0.35
IL10RB interleukin 10 receptor, beta 0.35
ZNF101 zinc finger protein 101 0.35
KIAA0825 KIAA0825 0.35
PTMS parathymosin 0.34
CHMP4C charged multivesicular body protein 4C 0.34
PROS1 protein S (alpha) 0.34
SYTL3 synaptotagmin-like 3 0.34
CEP63 centrosomal protein 63kDa 0.34
BCL3 B-cell CLL/lymphoma 3 0.34
ZNF526 zinc finger protein 526 0.33
ZFP30 ZFP30 zinc finger protein 0.33
DOHH deoxyhypusine hydroxylase/monooxygenase 0.33
MPZL2 myelin protein zero-like 2 0.33
PKM pyruvate kinase, muscle 0.33
SESN1 sestrin 1 0.33
CLN3 ceroid-lipofuscinosis, neuronal 3 0.33
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.33
HYKK hydroxylysine kinase 0.33
TTC30A tetratricopeptide repeat domain 30A 0.32
TRIM23 tripartite motif containing 23 0.32
CIAO1 cytosolic iron-sulfur assembly component 1 0.32
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.32

low expression

Symbol Name Standardized Value
DNAH6 dynein, axonemal, heavy chain 6 -1.12
MSRB2 methionine sulfoxide reductase B2 -0.91
KIAA1324L KIAA1324-like -0.69
MYO18B myosin XVIIIB -0.67
HIST2H2AA3 histone cluster 2, H2aa3 -0.65
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.65
ZNF236 zinc finger protein 236 -0.63
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -0.62
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -0.61
HIST3H2BB histone cluster 3, H2bb -0.61
MDM1 Mdm1 nuclear protein homolog (mouse) -0.59
MED8 mediator complex subunit 8 -0.58
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -0.58
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -0.58
DAP death-associated protein -0.57
RBKS ribokinase -0.56
TMPPE transmembrane protein with metallophosphoesterase domain -0.56
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.56
METTL7A methyltransferase like 7A -0.52
ZMYND19 zinc finger, MYND-type containing 19 -0.51
MPV17L2 MPV17 mitochondrial membrane protein-like 2 -0.51
MYORG myogenesis regulating glycosidase (putative) -0.5
PSEN2 presenilin 2 -0.5
TMEM231 transmembrane protein 231 -0.5
DERPC DERPC proline and glycine rich nuclear protein -0.49
TACSTD2 tumor-associated calcium signal transducer 2 -0.48
TSLIG1 tRNA splicing ligase complex subunit 1 -0.47
DPYSL2 dihydropyrimidinase-like 2 -0.46
FAM107B family with sequence similarity 107, member B -0.46
PDE4DIP phosphodiesterase 4D interacting protein -0.46
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -0.46
ADPRH ADP-ribosylarginine hydrolase -0.46
MYBPC1 myosin binding protein C, slow type -0.46
DUSP22 dual specificity phosphatase 22 -0.46
PHLDB3 pleckstrin homology-like domain, family B, member 3 -0.45
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.45
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.45
ZNF513 zinc finger protein 513 -0.45
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -0.44
MCEE methylmalonyl CoA epimerase -0.44
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -0.44
SIKE1 suppressor of IKBKE 1 -0.44
NDEL1 nudE neurodevelopment protein 1-like 1 -0.44
RGS3 regulator of G-protein signaling 3 -0.44
MAPKBP1 mitogen-activated protein kinase binding protein 1 -0.43
CD63 CD63 molecule -0.43
SPAG17 sperm associated antigen 17 -0.43
COX19 COX19 cytochrome c oxidase assembly factor -0.43
CALU calumenin -0.43
PITX2 paired-like homeodomain 2 -0.42
NCKAP1L NCK-associated protein 1-like -0.41
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.41
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted -0.41
CETN1 centrin, EF-hand protein, 1 -0.41
RAMAC RNA guanine-7 methyltransferase activating subunit -0.41
RMDN2 regulator of microtubule dynamics 2 -0.41
JPT2 Jupiter microtubule associated homolog 2 -0.4
DPY19L4 dpy-19-like 4 (C. elegans) -0.4
CIB1 calcium and integrin binding 1 (calmyrin) -0.4
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.4
MYOM2 myomesin 2 -0.4
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.39
SIX5 SIX homeobox 5 -0.39
CUEDC2 CUE domain containing 2 -0.39
FAT3 FAT atypical cadherin 3 -0.39
PSAP prosaposin -0.39
SPTBN5 spectrin, beta, non-erythrocytic 5 -0.39
TMEM248 transmembrane protein 248 -0.39
AMACR alpha-methylacyl-CoA racemase -0.39
OTUD5 OTU deubiquitinase 5 -0.39
SLC38A7 solute carrier family 38, member 7 -0.39
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -0.38
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -0.38
IGF1R insulin-like growth factor 1 receptor -0.38
ENSA endosulfine alpha -0.38
TULP4 tubby like protein 4 -0.38
FAM117A family with sequence similarity 117, member A -0.38
PON3 paraoxonase 3 -0.38
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -0.38
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.37
FOXP1 forkhead box P1 -0.37
ADIRF adipogenesis regulatory factor -0.37
PTPRD protein tyrosine phosphatase, receptor type, D -0.37
TMCC1 transmembrane and coiled-coil domain family 1 -0.36
ADSS1 adenylosuccinate synthase 1 -0.36
NR1H2 nuclear receptor subfamily 1, group H, member 2 -0.36
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.36
JARID2 jumonji, AT rich interactive domain 2 -0.36
ARG2 arginase 2 -0.36
MBP myelin basic protein -0.36
ZNF532 zinc finger protein 532 -0.35
KLHDC3 kelch domain containing 3 -0.35
COMTD1 catechol-O-methyltransferase domain containing 1 -0.35
ZFP64 ZFP64 zinc finger protein -0.35
KLF2 Kruppel-like factor 2 -0.35
DDAH2 dimethylarginine dimethylaminohydrolase 2 -0.35
ZNF503 zinc finger protein 503 -0.35
CNTRL centriolin -0.35
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit -0.35