Piroxicam_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Piroxicam_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.238185
COL5A1 collagen, type V, alpha 1 0.140242
VEGFA vascular endothelial growth factor A 0.11453
BHLHE40 basic helix-loop-helix family, member e40 0.104265
AKAP12 A kinase (PRKA) anchor protein 12 0.0973759
CD44 CD44 molecule (Indian blood group) 0.0921076
TMSB10 thymosin beta 10 0.0911625
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0866855
TRIO trio Rho guanine nucleotide exchange factor 0.0829652
THBS2 thrombospondin 2 0.0824794
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0824082
MYH9 myosin, heavy chain 9, non-muscle 0.0753428
CALR calreticulin 0.0707684
UBC ubiquitin C 0.070608
HLA-B major histocompatibility complex, class I, B 0.0667416
AHNAK2 AHNAK nucleoprotein 2 0.0657899
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0638281
SQSTM1 sequestosome 1 0.0638123
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0632383
FLNA filamin A, alpha 0.0591613
NFE2L1 nuclear factor, erythroid 2-like 1 0.0582465
NAV1 neuron navigator 1 0.0559522
APP amyloid beta (A4) precursor protein 0.0556913
ZMIZ1 zinc finger, MIZ-type containing 1 0.0531283
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0523677
EIF4H eukaryotic translation initiation factor 4H 0.0522595
PTMA prothymosin, alpha 0.0514231
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0508521
LOXL2 lysyl oxidase-like 2 0.050615
FLNB filamin B, beta 0.0502168
LDHA lactate dehydrogenase A 0.049286
C1D C1D nuclear receptor corepressor 0.0456315
NAV2 neuron navigator 2 0.0447982
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0447931
UBAP2L ubiquitin associated protein 2-like 0.0441849
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0437289
PRRC2C proline-rich coiled-coil 2C 0.043225
EEF2 eukaryotic translation elongation factor 2 0.0406166
SRRM2 serine/arginine repetitive matrix 2 0.0399237
ACTG1 actin gamma 1 0.0378446
L1CAM L1 cell adhesion molecule 0.0373131
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0372107
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0371987
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.0370768
COL4A2 collagen, type IV, alpha 2 0.0366384
TMSB4X thymosin beta 4, X-linked 0.035596
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0355284
PLEC plectin 0.0351324
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0351141
ARRDC3 arrestin domain containing 3 0.0347751
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0345016
SFTPA2 surfactant protein A2 0.0342265
COL18A1 collagen, type XVIII, alpha 1 0.034102
LMNA lamin A/C 0.0328309
OPTN optineurin 0.0324118
CST3 cystatin C 0.0322063
ENO1 enolase 1, (alpha) 0.0320736
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.032016
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.031567
TNIP1 TNFAIP3 interacting protein 1 0.0314821
MB21D2 Mab-21 domain containing 2 0.0314654
SH3BP2 SH3-domain binding protein 2 0.0312645
B2M beta-2-microglobulin 0.031242
ANXA6 annexin A6 0.0309481
GPC1 glypican 1 0.0307803
CAPN2 calpain 2, (m/II) large subunit 0.0304994
ZFP36L1 ZFP36 ring finger protein-like 1 0.0303802
ANKRD11 ankyrin repeat domain 11 0.0296292
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0290483
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0288969
CTSB cathepsin B 0.0288623
CAVIN1 caveolae associated protein 1 0.0287377
BRD2 bromodomain containing 2 0.0286267
SLC22A23 solute carrier family 22, member 23 0.0285754
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.028322
ACTN4 actinin, alpha 4 0.0283013
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0282367
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0278039
RPS27A ribosomal protein S27a 0.0277013
TPR translocated promoter region, nuclear basket protein 0.0276556
FUS FUS RNA binding protein 0.0271398
HDLBP high density lipoprotein binding protein 0.0268242
COL7A1 collagen, type VII, alpha 1 0.0265387
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0264809
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0262713
TSPAN9 tetraspanin 9 0.0262369
TMED9 transmembrane emp24 protein transport domain containing 9 0.0258394
KDM3A lysine (K)-specific demethylase 3A 0.0255276
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0255118
RFTN1 raftlin, lipid raft linker 1 0.0254224
FAM107B family with sequence similarity 107, member B 0.0253567
RPS3 ribosomal protein S3 0.0253402
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0249219
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0248734
RACK1 receptor for activated C kinase 1 0.0245491
CSTB cystatin B (stefin B) 0.0244187
MED15 mediator complex subunit 15 0.0241121
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0236795
CERS2 ceramide synthase 2 0.0234666
SEC61G Sec61 gamma subunit 0.0234269

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.181385
NDRG1 N-myc downstream regulated 1 -0.134811
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114478
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0773299
ZBTB20 zinc finger and BTB domain containing 20 -0.0694495
VIM vimentin -0.0639979
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0613332
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0609078
POTEF POTE ankyrin domain family, member F -0.0549586
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0527249
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0506813
DLG1 discs, large homolog 1 (Drosophila) -0.0506269
COL1A2 collagen, type I, alpha 2 -0.0506106
MYADM myeloid-associated differentiation marker -0.0503286
S100A10 S100 calcium binding protein A10 -0.047823
COL8A1 collagen, type VIII, alpha 1 -0.0476123
FBN1 fibrillin 1 -0.0446213
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0444749
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0440313
GPC6 glypican 6 -0.0398566
MX2 MX dynamin-like GTPase 2 -0.039446
IFIH1 interferon induced with helicase C domain 1 -0.0391237
PDIA3 protein disulfide isomerase family A, member 3 -0.0390214
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0389658
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0388434
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0346438
VCL vinculin -0.0336834
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0334841
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0333085
FNDC3A fibronectin type III domain containing 3A -0.0332915
SUCNR1 succinate receptor 1 -0.0330748
RTN4 reticulon 4 -0.0324161
CUX1 cut-like homeobox 1 -0.0322138
SOD2 superoxide dismutase 2, mitochondrial -0.0320355
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0319946
TAGLN2 transgelin 2 -0.0315725
TAOK1 TAO kinase 1 -0.0315304
MED13L mediator complex subunit 13-like -0.0296453
SRPK2 SRSF protein kinase 2 -0.0294245
SLC38A1 solute carrier family 38, member 1 -0.0289364
ARL4C ADP-ribosylation factor-like 4C -0.0288102
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0284192
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0282377
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0275541
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.027462
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0269786
PICALM phosphatidylinositol binding clathrin assembly protein -0.0269398
SBF2 SET binding factor 2 -0.0266294
PBX3 pre-B-cell leukemia homeobox 3 -0.0263729
RHOBTB3 Rho-related BTB domain containing 3 -0.0262897
TRAM1 translocation associated membrane protein 1 -0.0261922
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0261824
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0260643
SLC38A2 solute carrier family 38, member 2 -0.0259859
RIGI RNA sensor RIG-I -0.0258502
SETD5 SET domain containing 5 -0.0258396
TAPBP TAP binding protein (tapasin) -0.0257703
ZNF207 zinc finger protein 207 -0.0255556
RPS24 ribosomal protein S24 -0.0254645
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0251646
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0244054
SEPTIN7 septin 7 -0.0243656
ITM2B integral membrane protein 2B -0.0241685
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.024161
NF1 neurofibromin 1 -0.0240316
PIAS1 protein inhibitor of activated STAT, 1 -0.0238147
USP34 ubiquitin specific peptidase 34 -0.0235758
RPL35A ribosomal protein L35a -0.0235312
PARD3 par-3 family cell polarity regulator -0.0234074
SAMD9 sterile alpha motif domain containing 9 -0.02339
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0232869
NBEAL1 neurobeachin-like 1 -0.0231226
FADS2 fatty acid desaturase 2 -0.022671
KIF13A kinesin family member 13A -0.0226588
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0222226
PDE4D phosphodiesterase 4D, cAMP-specific -0.022195
WARS1 tryptophanyl-tRNA synthetase 1 -0.0220594
FRMD5 FERM domain containing 5 -0.0220311
BPTF bromodomain PHD finger transcription factor -0.0217944
ESYT2 extended synaptotagmin-like protein 2 -0.0217335
TUBA1B tubulin, alpha 1b -0.0217301
MT1X metallothionein 1X -0.021644
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0215239
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0214258
MYOF myoferlin -0.0212449
PRSS23 protease, serine, 23 -0.021214
ZNF148 zinc finger protein 148 -0.021192
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0211546
ANKRD12 ankyrin repeat domain 12 -0.0209872
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0208553
IFITM3 interferon induced transmembrane protein 3 -0.0207489
XPO1 exportin 1 -0.0205965
PGK1 phosphoglycerate kinase 1 -0.0205867
PERP PERP, TP53 apoptosis effector -0.0205243
ADAM10 ADAM metallopeptidase domain 10 -0.0204588
TPM4 tropomyosin 4 -0.0203947
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.020279
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0200974
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0200964
TENT5A terminal nucleotidyltransferase 5A -0.0200232