Piroxicam_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.181509
DST dystonin 0.0972848
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0725446
ANXA1 annexin A1 0.0684529
MKI67 marker of proliferation Ki-67 0.0555892
RPS3 ribosomal protein S3 0.0521593
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0502098
SRRM2 serine/arginine repetitive matrix 2 0.0458978
EIF4B eukaryotic translation initiation factor 4B 0.0409741
MAP1B microtubule-associated protein 1B 0.0406495
RACK1 receptor for activated C kinase 1 0.0401098
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0394812
CELF2 CUGBP, Elav-like family member 2 0.039164
DPYD dihydropyrimidine dehydrogenase 0.0390409
MARCHF4 membrane associated ring-CH-type finger 4 0.0354396
ARID1A AT rich interactive domain 1A (SWI-like) 0.0349076
SET SET nuclear proto-oncogene 0.0344809
HDGF hepatoma-derived growth factor 0.0329457
DLC1 DLC1 Rho GTPase activating protein 0.0290939
ANKRD12 ankyrin repeat domain 12 0.0284598
CMIP c-Maf inducing protein 0.0284464
CENPF centromere protein F, 350/400kDa 0.0278565
ACTG1 actin gamma 1 0.0265286
CCN2 cellular communication network factor 2 0.0264132
RPS2 ribosomal protein S2 0.025457
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.025363
AKAP12 A kinase (PRKA) anchor protein 12 0.0251513
BIRC3 baculoviral IAP repeat containing 3 0.0247466
RIMS2 regulating synaptic membrane exocytosis 2 0.0246924
PABPC1 poly(A) binding protein, cytoplasmic 1 0.024216
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0236295
RPL23 ribosomal protein L23 0.0228362
RPL3 ribosomal protein L3 0.0228158
TMEM14C transmembrane protein 14C 0.0209035
KMT2D lysine (K)-specific methyltransferase 2D 0.0207134
TPI1 triosephosphate isomerase 1 0.0206993
FAT1 FAT atypical cadherin 1 0.0203031
RPL36 ribosomal protein L36 0.0202719
MACF1 microtubule-actin crosslinking factor 1 0.020101
RPS12 ribosomal protein S12 0.0200783
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0196669
HSPA8 heat shock 70kDa protein 8 0.0194789
DOCK1 dedicator of cytokinesis 1 0.0194388
ATN1 atrophin 1 0.0193891
EIF4H eukaryotic translation initiation factor 4H 0.0192726
TRAPPC9 trafficking protein particle complex 9 0.0192524
TEAD4 TEA domain family member 4 0.0192452
PLK2 polo-like kinase 2 0.0186838
PFN1 profilin 1 0.0185979
FLNA filamin A, alpha 0.0185669
RPS8 ribosomal protein S8 0.0184751
EEF1G eukaryotic translation elongation factor 1 gamma 0.0183382
ZNF804A zinc finger protein 804A 0.0180112
EPHA6 EPH receptor A6 0.0179842
RPS19 ribosomal protein S19 0.0179014
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0177817
PABPN1 poly(A) binding protein, nuclear 1 0.0177762
RPS7 ribosomal protein S7 0.0176451
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0176193
EGR1 early growth response 1 0.0175339
TPM3 tropomyosin 3 0.0175028
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0173516
PRRC2A proline-rich coiled-coil 2A 0.0172213
RNF213 ring finger protein 213 0.0171907
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0171297
HMGA1 high mobility group AT-hook 1 0.0170914
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0168166
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0166928
SRRM1 serine/arginine repetitive matrix 1 0.0166394
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0165607
SESN2 sestrin 2 0.0165055
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0164839
GPX4 glutathione peroxidase 4 0.0162639
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0162092
RPL18 ribosomal protein L18 0.0160848
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0157912
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0157147
UBAP2L ubiquitin associated protein 2-like 0.0156975
BABAM2 BRISC and BRCA1 A complex member 2 0.0152173
ETV6 ets variant 6 0.0149845
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0149671
RNPS1 RNA binding protein S1, serine-rich domain 0.0148847
KSR2 kinase suppressor of ras 2 0.014771
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0147704
RPS26 ribosomal protein S26 0.0146769
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0142547
NEBL nebulette 0.0142034
NFE2L1 nuclear factor, erythroid 2-like 1 0.0141475
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.0141122
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0141075
INTS6 integrator complex subunit 6 0.014057
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0140344
IP6K2 inositol hexakisphosphate kinase 2 0.0140311
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0138431
NUMA1 nuclear mitotic apparatus protein 1 0.0137778
PRELID1 PRELI domain containing 1 0.0137771
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0137235
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0135512
RPTOR regulatory associated protein of MTOR, complex 1 0.0135269
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 0.0134033

decreased expression

Symbol Name Standardized Value
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.150101
VIM vimentin -0.119621
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0965921
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0708909
TMSB10 thymosin beta 10 -0.0681406
BIRC6 baculoviral IAP repeat containing 6 -0.0655967
VMP1 vacuole membrane protein 1 -0.0646124
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0635888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0623285
TXNRD1 thioredoxin reductase 1 -0.0615943
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0546314
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0532554
AREG amphiregulin -0.0530805
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0513309
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0510907
MGAT4C MGAT4 family, member C -0.0508434
MYL12B myosin, light chain 12B, regulatory -0.0503964
USP34 ubiquitin specific peptidase 34 -0.0487428
CXADR coxsackie virus and adenovirus receptor -0.0466997
KDM3A lysine (K)-specific demethylase 3A -0.0460057
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0438296
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0421416
CANX calnexin -0.0407123
SMYD3 SET and MYND domain containing 3 -0.040107
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0399997
TMEM41B transmembrane protein 41B -0.0397601
CAMKMT calmodulin-lysine N-methyltransferase -0.0395359
XPO1 exportin 1 -0.0395336
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0394123
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0386417
ZBTB20 zinc finger and BTB domain containing 20 -0.0385431
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0366028
CPOX coproporphyrinogen oxidase -0.0363867
FBXO11 F-box protein 11 -0.0361976
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0360961
RAB1A RAB1A, member RAS oncogene family -0.0359989
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0358348
RRM2 ribonucleotide reductase M2 -0.0356076
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.034988
VDAC1 voltage-dependent anion channel 1 -0.0349452
MED13L mediator complex subunit 13-like -0.0347927
SPAG9 sperm associated antigen 9 -0.033722
NAP1L1 nucleosome assembly protein 1-like 1 -0.0334271
ETNK1 ethanolamine kinase 1 -0.0333795
TPT1 tumor protein, translationally-controlled 1 -0.0332018
OGA O-GlcNAcase -0.0328087
PGK1 phosphoglycerate kinase 1 -0.0326779
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0322655
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0317983
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0315079
SLC38A2 solute carrier family 38, member 2 -0.0313176
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0311658
CDK17 cyclin-dependent kinase 17 -0.03112
CLTC clathrin, heavy chain (Hc) -0.0309877
TAS2R14 taste receptor, type 2, member 14 -0.0302405
MEMO1 mediator of cell motility 1 -0.0297741
MARCHF6 membrane associated ring-CH-type finger 6 -0.0294177
EIF1 eukaryotic translation initiation factor 1 -0.029155
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0291193
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0290279
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0288292
PTMA prothymosin, alpha -0.0288006
PUM2 pumilio RNA-binding family member 2 -0.0287161
BCAS3 breast carcinoma amplified sequence 3 -0.0283939
GPHN gephyrin -0.0282501
ADAM17 ADAM metallopeptidase domain 17 -0.0278394
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.027668
SLC38A1 solute carrier family 38, member 1 -0.0276335
SEC31A SEC31 homolog A (S. cerevisiae) -0.0275802
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0275255
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0273952
TNPO1 transportin 1 -0.0272162
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0271595
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.027043
MBD5 methyl-CpG binding domain protein 5 -0.0270076
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0268852
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0265992
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.026504
ADGRG6 adhesion G protein-coupled receptor G6 -0.0261176
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0258237
FBXL20 F-box and leucine-rich repeat protein 20 -0.0257392
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0257002
PCNP PEST proteolytic signal containing nuclear protein -0.0256736
ZNF207 zinc finger protein 207 -0.0254568
BIRC2 baculoviral IAP repeat containing 2 -0.0253904
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.025315
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -0.0249062
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0247995
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0247798
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0247259
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.024622
RPL35A ribosomal protein L35a -0.0243812
RPS24 ribosomal protein S24 -0.0239432
TRIO trio Rho guanine nucleotide exchange factor -0.0233696
CDK19 cyclin-dependent kinase 19 -0.0232898
FNIP1 folliculin interacting protein 1 -0.0231635
ATP5F1B ATP synthase F1 subunit beta -0.0230631
SPDYA speedy/RINGO cell cycle regulator family member A -0.0227301
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0226569
GLG1 golgi glycoprotein 1 -0.0225953