Piroxicam_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.117438
TSC22D1 TSC22 domain family, member 1 0.0841684
MLPH melanophilin 0.059205
MYH9 myosin, heavy chain 9, non-muscle 0.0453703
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0413474
MKI67 marker of proliferation Ki-67 0.0382742
RNF43 ring finger protein 43 0.0373281
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0371972
ARRDC3 arrestin domain containing 3 0.036789
BHLHE40 basic helix-loop-helix family, member e40 0.033853
SREBF2 sterol regulatory element binding transcription factor 2 0.0319512
SRRM2 serine/arginine repetitive matrix 2 0.0308102
FAT1 FAT atypical cadherin 1 0.0307454
HLA-B major histocompatibility complex, class I, B 0.0303199
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0278298
NRIP1 nuclear receptor interacting protein 1 0.027372
PADI1 peptidyl arginine deiminase, type I 0.026544
SHB Src homology 2 domain containing adaptor protein B 0.0264172
H1-0 H1.0 linker histone 0.0263179
OARD1 O-acyl-ADP-ribose deacylase 1 0.0261975
PRRC2C proline-rich coiled-coil 2C 0.02587
TMPRSS4 transmembrane protease, serine 4 0.0243085
CST3 cystatin C 0.023889
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0234114
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.022824
EIF4B eukaryotic translation initiation factor 4B 0.0228134
EIF4H eukaryotic translation initiation factor 4H 0.0224485
LRP5 low density lipoprotein receptor-related protein 5 0.0224037
NCOR2 nuclear receptor corepressor 2 0.0219459
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0216015
PRELID2 PRELI domain containing 2 0.0206503
SPRED2 sprouty-related, EVH1 domain containing 2 0.019852
EHF ets homologous factor 0.0195721
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0195711
PTPRF protein tyrosine phosphatase, receptor type, F 0.019041
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0189839
MATR3 matrin 3 0.0187252
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.0186859
HPCAL1 hippocalcin-like 1 0.0186649
SPRED1 sprouty-related, EVH1 domain containing 1 0.0184693
OGA O-GlcNAcase 0.0183009
LMTK2 lemur tyrosine kinase 2 0.0181789
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 0.017903
ZNF160 zinc finger protein 160 0.0174969
ERRFI1 ERBB receptor feedback inhibitor 1 0.0174301
TSPYL2 TSPY-like 2 0.0173219
MACF1 microtubule-actin crosslinking factor 1 0.0172919
EFHD2 EF-hand domain family, member D2 0.0172478
NFE2L1 nuclear factor, erythroid 2-like 1 0.0172428
TPR translocated promoter region, nuclear basket protein 0.0168138
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0166436
CLDN4 claudin 4 0.0163976
PRPF8 pre-mRNA processing factor 8 0.0162095
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0161393
MINK1 misshapen-like kinase 1 0.0160898
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0158349
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0158041
UBAP2L ubiquitin associated protein 2-like 0.0157867
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0156757
TMED2 transmembrane emp24 domain trafficking protein 2 0.0156253
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0155545
BRD9 bromodomain containing 9 0.0155145
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0153707
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0153331
DNM2 dynamin 2 0.0153201
AHDC1 AT hook, DNA binding motif, containing 1 0.0147332
AOPEP aminopeptidase O (putative) 0.0147008
SMAD3 SMAD family member 3 0.014548
ARGLU1 arginine and glutamate rich 1 0.0145185
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0144953
PRRC2B proline-rich coiled-coil 2B 0.0143584
CD68 CD68 molecule 0.0143536
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0142962
ZNF841 zinc finger protein 841 0.014151
CENPF centromere protein F, 350/400kDa 0.0140151
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0138344
MYO5B myosin VB 0.0138264
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.013798
ATP10B ATPase, class V, type 10B 0.0137505
CTTN cortactin 0.0136636
FEM1C fem-1 homolog c (C. elegans) 0.0135133
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0134758
SET SET nuclear proto-oncogene 0.0133968
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0133378
ZBTB7A zinc finger and BTB domain containing 7A 0.0133004
SH3BP2 SH3-domain binding protein 2 0.0131416
CIZ1 CDKN1A interacting zinc finger protein 1 0.0130825
PLXNB2 plexin B2 0.0130149
USPL1 ubiquitin specific peptidase like 1 0.0128438
LDHA lactate dehydrogenase A 0.0128381
RB1CC1 RB1-inducible coiled-coil 1 0.0127426
TCF25 transcription factor 25 (basic helix-loop-helix) 0.0127286
USP47 ubiquitin specific peptidase 47 0.0127087
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0126672
SELENOF selenoprotein F 0.012658
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0125622
QRICH1 glutamine-rich 1 0.0124065
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0123268
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0123104
NKD1 naked cuticle homolog 1 (Drosophila) 0.0120873

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.185879
LMO7 LIM domain 7 -0.166659
PERP PERP, TP53 apoptosis effector -0.119686
TPT1 tumor protein, translationally-controlled 1 -0.117498
GCLC glutamate-cysteine ligase, catalytic subunit -0.109777
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.109309
ANXA2 annexin A2 -0.109154
LYZ lysozyme -0.107384
EGR1 early growth response 1 -0.10633
RNF213 ring finger protein 213 -0.102101
EZR ezrin -0.0959425
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0941266
RIGI RNA sensor RIG-I -0.0929204
BTBD9 BTB (POZ) domain containing 9 -0.0874998
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0861942
SP100 SP100 nuclear antigen -0.085735
MX1 MX dynamin-like GTPase 1 -0.0840557
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0813533
MACC1 metastasis associated in colon cancer 1 -0.0807117
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0799052
ERBIN erbb2 interacting protein -0.079592
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0786154
GMDS GDP-mannose 4,6-dehydratase -0.0768786
PLSCR1 phospholipid scramblase 1 -0.0749932
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0746381
INTS6 integrator complex subunit 6 -0.0733916
ZBTB20 zinc finger and BTB domain containing 20 -0.0708223
NDRG1 N-myc downstream regulated 1 -0.0660463
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0649943
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0648421
MX2 MX dynamin-like GTPase 2 -0.0637852
AHI1 Abelson helper integration site 1 -0.0622066
CANX calnexin -0.060991
NPSR1 neuropeptide S receptor 1 -0.0609075
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0604232
MYO1E myosin IE -0.0581902
ZNF292 zinc finger protein 292 -0.0572091
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0566036
RABGAP1L RAB GTPase activating protein 1-like -0.0549147
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0545116
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0526723
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0525406
SEC31A SEC31 homolog A (S. cerevisiae) -0.0525268
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.052526
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.052467
EXT1 exostosin glycosyltransferase 1 -0.0510278
TJP1 tight junction protein 1 -0.0508506
TSHZ2 teashirt zinc finger homeobox 2 -0.0505898
AREG amphiregulin -0.0499488
STS steroid sulfatase (microsomal), isozyme S -0.0490752
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0490483
SPAG9 sperm associated antigen 9 -0.0487987
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0474638
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0473567
VCL vinculin -0.0472192
VMP1 vacuole membrane protein 1 -0.0471393
UBC ubiquitin C -0.0469198
MAML2 mastermind-like 2 (Drosophila) -0.046197
XAF1 XIAP associated factor 1 -0.0444182
CATSPERB catsper channel auxiliary subunit beta -0.0435095
ABLIM1 actin binding LIM protein 1 -0.0421929
DSCAM Down syndrome cell adhesion molecule -0.0421704
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0417702
AKAP13 A kinase (PRKA) anchor protein 13 -0.0417672
IFIH1 interferon induced with helicase C domain 1 -0.0408159
TMC5 transmembrane channel-like 5 -0.0407382
MAP7 microtubule-associated protein 7 -0.0407014
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0406913
ANKRD10 ankyrin repeat domain 10 -0.0402276
ARHGAP26 Rho GTPase activating protein 26 -0.0398867
PIBF1 progesterone immunomodulatory binding factor 1 -0.0395428
PHACTR4 phosphatase and actin regulator 4 -0.0395287
IGFBP3 insulin-like growth factor binding protein 3 -0.0391447
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.038956
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0388871
PKM pyruvate kinase, muscle -0.0388353
PDIA3 protein disulfide isomerase family A, member 3 -0.0386971
EIF1 eukaryotic translation initiation factor 1 -0.0386896
IRF1 interferon regulatory factor 1 -0.0385259
LOC112694756 uncharaterized LOC112694756 -0.0382313
HLA-E major histocompatibility complex, class I, E -0.0381127
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.03784
PLSCR2 phospholipid scramblase 2 -0.0376345
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0375866
ITGA6 integrin, alpha 6 -0.0370083
LOC102724023 ES1 protein homolog, mitochondrial -0.0370081
ZMYND8 zinc finger, MYND-type containing 8 -0.0366409
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0362244
MCL1 myeloid cell leukemia 1 -0.0360778
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0360721
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0357563
RBM47 RNA binding motif protein 47 -0.0356268
NCOA7 nuclear receptor coactivator 7 -0.0355691
SPDYA speedy/RINGO cell cycle regulator family member A -0.0355236
C6ORF132 chromosome 6 open reading frame 132 -0.0354256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0354203
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0354108
SERINC5 serine incorporator 5 -0.0341983
DGKH diacylglycerol kinase, eta -0.0339116
JUN jun proto-oncogene -0.0338262