Piroxicam_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.240979
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.161502
MT2A metallothionein 2A 0.155183
VEGFA vascular endothelial growth factor A 0.130388
C3 complement component 3 0.0744132
TIMP1 TIMP metallopeptidase inhibitor 1 0.0688118
NKD1 naked cuticle homolog 1 (Drosophila) 0.0636837
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0630713
BCL2L1 BCL2-like 1 0.0553727
AKAP12 A kinase (PRKA) anchor protein 12 0.0508935
DST dystonin 0.044602
NPAS2 neuronal PAS domain protein 2 0.0439601
FAT1 FAT atypical cadherin 1 0.0423978
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0413863
RPS19 ribosomal protein S19 0.0394884
FRMD5 FERM domain containing 5 0.0384176
ARHGAP9 Rho GTPase activating protein 9 0.0380121
APOA2 apolipoprotein A-II 0.036758
HMGA1 high mobility group AT-hook 1 0.0354987
ZMIZ1 zinc finger, MIZ-type containing 1 0.0352257
KRT18 keratin 18, type I 0.0342572
LIMS1 LIM and senescent cell antigen-like domains 1 0.0337304
STK17A serine/threonine kinase 17a 0.0327997
RPS3 ribosomal protein S3 0.0326948
SAMD4A sterile alpha motif domain containing 4A 0.0326042
DSPP dentin sialophosphoprotein 0.032537
VCL vinculin 0.0321835
RPS12 ribosomal protein S12 0.0321307
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0320951
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0312815
NACA nascent polypeptide-associated complex alpha subunit 0.0291386
ORM1 orosomucoid 1 0.0282067
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.027803
ACTN1 actinin, alpha 1 0.0277097
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0276589
SVIL supervillin 0.0275667
DLC1 DLC1 Rho GTPase activating protein 0.0273791
OSBPL10 oxysterol binding protein-like 10 0.0266297
RPL26 ribosomal protein L26 0.0256763
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0249896
KRT23 keratin 23, type I 0.0239907
ZFHX3 zinc finger homeobox 3 0.0238125
MYH9 myosin, heavy chain 9, non-muscle 0.0237952
RPL38 ribosomal protein L38 0.0231972
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0229478
RPL13A ribosomal protein L13a 0.022792
CST3 cystatin C 0.0223046
SRRM1 serine/arginine repetitive matrix 1 0.0222584
WWTR1 WW domain containing transcription regulator 1 0.0221824
ABTB3 ankyrin repeat and BTB domain containing 3 0.0221411
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0220049
MACF1 microtubule-actin crosslinking factor 1 0.0219877
PRRC2C proline-rich coiled-coil 2C 0.0217869
RPLP1 ribosomal protein, large, P1 0.0216422
MALT1 MALT1 paracaspase 0.0214541
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0213232
RPL11 ribosomal protein L11 0.0209899
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0206872
ITGB5 integrin, beta 5 0.0205485
COL7A1 collagen, type VII, alpha 1 0.0204963
NCOR2 nuclear receptor corepressor 2 0.0204411
DTNA dystrobrevin, alpha 0.0202561
MKI67 marker of proliferation Ki-67 0.0200932
PLIN2 perilipin 2 0.0200058
ENAH enabled homolog (Drosophila) 0.0198364
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0197305
MBNL2 muscleblind-like splicing regulator 2 0.0195046
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.019412
RPL36 ribosomal protein L36 0.0192234
RAD51B RAD51 paralog B 0.0189758
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0188636
KIAA1217 KIAA1217 0.0188183
SRRM2 serine/arginine repetitive matrix 2 0.0188006
FILIP1L filamin A interacting protein 1-like 0.0186826
ALPK2 alpha-kinase 2 0.0184508
AFF1 AF4/FMR2 family, member 1 0.018193
ETV4 ets variant 4 0.0181803
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0181508
LPP LIM domain containing preferred translocation partner in lipoma 0.0177459
FTH1 ferritin, heavy polypeptide 1 0.0175765
RACK1 receptor for activated C kinase 1 0.0175179
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0173568
PTPRF protein tyrosine phosphatase, receptor type, F 0.0171801
RPL18 ribosomal protein L18 0.0170933
WDR43 WD repeat domain 43 0.0170123
MYO1E myosin IE 0.016925
CREBBP CREB binding protein 0.0169065
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0168222
RPS10 ribosomal protein S10 0.0164385
UBASH3B ubiquitin associated and SH3 domain containing B 0.0163904
ITCH itchy E3 ubiquitin protein ligase 0.0163806
PPARD peroxisome proliferator-activated receptor delta 0.0163049
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0162908
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 0.0161589
RUNX1 runt-related transcription factor 1 0.0161468
SPRED2 sprouty-related, EVH1 domain containing 2 0.0159285
LMCD1 LIM and cysteine-rich domains 1 0.015912
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0158673
SHB Src homology 2 domain containing adaptor protein B 0.0158584
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0158566

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.237813
APOB apolipoprotein B -0.135718
ERRFI1 ERBB receptor feedback inhibitor 1 -0.132473
FBF1 Fas (TNFRSF6) binding factor 1 -0.131807
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108201
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.105175
FNDC3B fibronectin type III domain containing 3B -0.0952257
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0888838
GPC3 glypican 3 -0.0827697
SDC4 syndecan 4 -0.0746304
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0722029
FN1 fibronectin 1 -0.0692327
SOD2 superoxide dismutase 2, mitochondrial -0.0664391
ENO1 enolase 1, (alpha) -0.0588091
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0586728
SLC38A2 solute carrier family 38, member 2 -0.0581446
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0580524
CANX calnexin -0.0566894
AHSG alpha-2-HS-glycoprotein -0.0542816
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0521889
KDM3A lysine (K)-specific demethylase 3A -0.051799
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.051466
CP ceruloplasmin (ferroxidase) -0.049846
RBM39 RNA binding motif protein 39 -0.0481491
CPE carboxypeptidase E -0.0458702
NDRG1 N-myc downstream regulated 1 -0.0449703
TF transferrin -0.0441533
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0433114
SOS1 son of sevenless homolog 1 (Drosophila) -0.0429944
INSIG2 insulin induced gene 2 -0.0411757
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0406915
JMJD1C jumonji domain containing 1C -0.0405765
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0404876
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0398229
LOC112694756 uncharaterized LOC112694756 -0.0384019
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0382405
PDIA3 protein disulfide isomerase family A, member 3 -0.0381355
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0378933
IGFBP1 insulin-like growth factor binding protein 1 -0.0378216
LYZ lysozyme -0.0371826
TRIM26 tripartite motif containing 26 -0.0368568
EML4 echinoderm microtubule associated protein like 4 -0.0361751
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0357142
TPT1 tumor protein, translationally-controlled 1 -0.0345725
PERP PERP, TP53 apoptosis effector -0.0336265
ERBIN erbb2 interacting protein -0.0330182
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0324873
GPC6 glypican 6 -0.031769
ASPH aspartate beta-hydroxylase -0.0311599
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0311215
GLG1 golgi glycoprotein 1 -0.0310696
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0309813
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0307194
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0306743
TFRC transferrin receptor -0.0305382
ICAM1 intercellular adhesion molecule 1 -0.030401
SPAG9 sperm associated antigen 9 -0.0300699
ZFAND3 zinc finger, AN1-type domain 3 -0.0294321
PEG3 paternally expressed 3 -0.0292857
WDR45B WD repeat domain 45B -0.0287601
VMP1 vacuole membrane protein 1 -0.0286659
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0283877
BIRC6 baculoviral IAP repeat containing 6 -0.0283795
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0275533
SCAF11 SR-related CTD-associated factor 11 -0.0272628
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0271833
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0271764
SLF2 SMC5-SMC6 complex localization factor 2 -0.0270862
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0269704
GK glycerol kinase -0.0268841
GNAS GNAS complex locus -0.0266752
MCL1 myeloid cell leukemia 1 -0.0263705
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0261941
MBNL3 muscleblind-like splicing regulator 3 -0.0260047
UBC ubiquitin C -0.0258368
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0255933
DDIT4 DNA-damage-inducible transcript 4 -0.0255506
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0254871
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0250374
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0248551
MAPK14 mitogen-activated protein kinase 14 -0.0248008
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0247038
NAP1L1 nucleosome assembly protein 1-like 1 -0.0245599
ELL2 elongation factor, RNA polymerase II, 2 -0.0243431
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0240246
AMBP alpha-1-microglobulin/bikunin precursor -0.0237938
MYO6 myosin VI -0.0234213
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0233986
TM4SF1 transmembrane 4 L six family member 1 -0.0232908
ZBTB20 zinc finger and BTB domain containing 20 -0.023136
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0231016
CFB complement factor B -0.0230639
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0228283
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0224417
MTSS1 metastasis suppressor 1 -0.0224177
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0222692
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0220238
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0219735
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0219639
CFAP73 cilia and flagella associated protein 73 -0.0218953