Piroxicam_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.201165
FLNB filamin B, beta 0.141005
KRT6A keratin 6A, type II 0.137319
IGF2 insulin-like growth factor 2 0.134328
LDHA lactate dehydrogenase A 0.112304
ANXA1 annexin A1 0.108655
TRIO trio Rho guanine nucleotide exchange factor 0.100002
MYH9 myosin, heavy chain 9, non-muscle 0.0972967
MSN moesin 0.095235
VEGFA vascular endothelial growth factor A 0.0940611
BHLHE40 basic helix-loop-helix family, member e40 0.0935716
CD44 CD44 molecule (Indian blood group) 0.0906366
NDRG1 N-myc downstream regulated 1 0.0781091
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0758846
LAMA5 laminin, alpha 5 0.0741789
EZR ezrin 0.0739497
PGK1 phosphoglycerate kinase 1 0.0701688
PLEC plectin 0.0695104
EEF2 eukaryotic translation elongation factor 2 0.0671593
HSPG2 heparan sulfate proteoglycan 2 0.0658621
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0636426
ENO1 enolase 1, (alpha) 0.0615717
FLNA filamin A, alpha 0.0615269
RPS3 ribosomal protein S3 0.0593144
KRT17 keratin 17, type I 0.0583485
PCDH1 protocadherin 1 0.0577815
LMO7 LIM domain 7 0.0556524
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0547555
SRRM2 serine/arginine repetitive matrix 2 0.0546355
EFHD2 EF-hand domain family, member D2 0.0545926
APLP2 amyloid beta (A4) precursor-like protein 2 0.054049
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0539909
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0528114
SQLE squalene epoxidase 0.0527837
SQSTM1 sequestosome 1 0.0527329
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0526445
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0483209
PTMA prothymosin, alpha 0.0482622
CLU clusterin 0.0478416
SLK STE20-like kinase 0.0474952
FTH1 ferritin, heavy polypeptide 1 0.0469412
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0466108
CST3 cystatin C 0.0461225
NCOR2 nuclear receptor corepressor 2 0.0458543
TPM3 tropomyosin 3 0.0451827
ITGB4 integrin, beta 4 0.0434456
ZMIZ1 zinc finger, MIZ-type containing 1 0.0428201
PLS3 plastin 3 0.0426862
ARRDC3 arrestin domain containing 3 0.0426794
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0416792
ACTN4 actinin, alpha 4 0.0390012
EGR1 early growth response 1 0.038938
CALB1 calbindin 1, 28kDa 0.0383445
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0378408
AHDC1 AT hook, DNA binding motif, containing 1 0.0376124
CALR calreticulin 0.0372198
MACF1 microtubule-actin crosslinking factor 1 0.0368943
RPL3 ribosomal protein L3 0.0367021
SET SET nuclear proto-oncogene 0.0360189
TGM2 transglutaminase 2 0.036014
MATR3 matrin 3 0.0354694
UBAP2L ubiquitin associated protein 2-like 0.0353683
HSPA8 heat shock 70kDa protein 8 0.0353132
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0352937
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0347314
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0345332
SULF2 sulfatase 2 0.0344915
FSCN1 fascin actin-bundling protein 1 0.0339829
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.033897
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0338677
C1D C1D nuclear receptor corepressor 0.0333991
TSC22D1 TSC22 domain family, member 1 0.033293
HLA-B major histocompatibility complex, class I, B 0.0328669
OPTN optineurin 0.0328445
EPHA2 EPH receptor A2 0.0324707
TPR translocated promoter region, nuclear basket protein 0.032324
PRRC2C proline-rich coiled-coil 2C 0.031663
ADRB2 adrenoceptor beta 2, surface 0.0316158
GRB10 growth factor receptor-bound protein 10 0.0311892
MKI67 marker of proliferation Ki-67 0.0308015
CYB5R3 cytochrome b5 reductase 3 0.0304433
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0300127
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0294054
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.029358
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.0293307
NAMPT nicotinamide phosphoribosyltransferase 0.0292397
RPS2 ribosomal protein S2 0.0291873
FXYD5 FXYD domain containing ion transport regulator 5 0.0287573
COL17A1 collagen, type XVII, alpha 1 0.0287544
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0285536
SUN1 Sad1 and UNC84 domain containing 1 0.0282868
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0281606
SRRM1 serine/arginine repetitive matrix 1 0.0281199
HDGF hepatoma-derived growth factor 0.0275962
PGM3 phosphoglucomutase 3 0.0270979
RACK1 receptor for activated C kinase 1 0.0268483
PFN1 profilin 1 0.0266279
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0265713
LMNA lamin A/C 0.026437
ECE1 endothelin converting enzyme 1 0.0262721

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.127651
TPT1 tumor protein, translationally-controlled 1 -0.0902136
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0825675
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.08017
DPYD dihydropyrimidine dehydrogenase -0.0692194
RPS24 ribosomal protein S24 -0.0619429
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0551058
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0522146
CEMIP cell migration inducing protein, hyaluronan binding -0.0440667
OSMR oncostatin M receptor -0.0430855
FNIP1 folliculin interacting protein 1 -0.0425365
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0422674
FOXP1 forkhead box P1 -0.041496
ASPH aspartate beta-hydroxylase -0.040741
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0401493
MTSS1 metastasis suppressor 1 -0.0399173
RPS25 ribosomal protein S25 -0.0397827
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0395489
PRELID2 PRELI domain containing 2 -0.0385291
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0383452
VDAC1 voltage-dependent anion channel 1 -0.0375093
METTL15 methyltransferase like 15 -0.0373959
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0367369
SMYD3 SET and MYND domain containing 3 -0.0358858
RPLP0 ribosomal protein, large, P0 -0.0354593
ANKRD10 ankyrin repeat domain 10 -0.0350674
CANX calnexin -0.0341243
IFI16 interferon, gamma-inducible protein 16 -0.0337084
DLG1 discs, large homolog 1 (Drosophila) -0.0335198
S100A6 S100 calcium binding protein A6 -0.0327655
NF1 neurofibromin 1 -0.0325246
PTK2 protein tyrosine kinase 2 -0.0322165
RPL35A ribosomal protein L35a -0.0316815
PDE4D phosphodiesterase 4D, cAMP-specific -0.0316155
RPLP1 ribosomal protein, large, P1 -0.0315413
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0304519
TXNRD1 thioredoxin reductase 1 -0.0296954
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0293303
NT5C2 5'-nucleotidase, cytosolic II -0.0293115
TAS2R14 taste receptor, type 2, member 14 -0.0289213
SOD2 superoxide dismutase 2, mitochondrial -0.0287648
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.028231
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0281391
ARHGAP5 Rho GTPase activating protein 5 -0.0277345
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0277213
OSBPL3 oxysterol binding protein-like 3 -0.0271451
RPL27A ribosomal protein L27a -0.0271075
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0265811
BMAL2 basic helix-loop-helix ARNT like 2 -0.026479
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0263504
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0259322
AVL9 AVL9 homolog (S. cerevisiase) -0.0258362
DENND4C DENN/MADD domain containing 4C -0.0258356
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0257954
TKT transketolase -0.0255027
PHF20 PHD finger protein 20 -0.0253328
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0252256
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0251279
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.02509
MYO9A myosin IXA -0.0248971
RPLP2 ribosomal protein, large, P2 -0.024859
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0248031
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0247273
MRPS6 mitochondrial ribosomal protein S6 -0.0245556
HDAC8 histone deacetylase 8 -0.0244969
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0239692
ANKRD12 ankyrin repeat domain 12 -0.0237882
NPEPPS aminopeptidase puromycin sensitive -0.0236454
NFIA nuclear factor I/A -0.0233572
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0231102
EFNA5 ephrin-A5 -0.0230422
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0229896
FNDC3B fibronectin type III domain containing 3B -0.0227585
EXOC6B exocyst complex component 6B -0.0225919
MBD5 methyl-CpG binding domain protein 5 -0.0225795
S100A10 S100 calcium binding protein A10 -0.0224333
NRCAM neuronal cell adhesion molecule -0.0222756
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0222403
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0221386
RAB1A RAB1A, member RAS oncogene family -0.0220552
NRIP1 nuclear receptor interacting protein 1 -0.0219923
RABGAP1L RAB GTPase activating protein 1-like -0.0218931
RPL36A ribosomal protein L36a -0.0216918
MON2 MON2 homolog (S. cerevisiae) -0.0216618
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0216552
ATXN1 ataxin 1 -0.0214514
XRN1 5'-3' exoribonuclease 1 -0.0213813
MAML2 mastermind-like 2 (Drosophila) -0.0212993
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0212546
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0212347
COG5 component of oligomeric golgi complex 5 -0.0211474
JMJD1C jumonji domain containing 1C -0.0210855
RIN2 Ras and Rab interactor 2 -0.021057
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0209015
LIFR leukemia inhibitory factor receptor alpha -0.0208762
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0208514
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0208105
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.020806
SLC38A2 solute carrier family 38, member 2 -0.0207228
ADAM10 ADAM metallopeptidase domain 10 -0.0207133