Piroxicam_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.18584
FTH1 ferritin, heavy polypeptide 1 0.0753117
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0597371
FTL ferritin, light polypeptide 0.0543967
HYOU1 hypoxia up-regulated 1 0.0543744
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0531439
CLDN4 claudin 4 0.0513701
RPS3 ribosomal protein S3 0.0481923
CST3 cystatin C 0.0425367
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0415074
KRT18 keratin 18, type I 0.0398997
PDIA6 protein disulfide isomerase family A, member 6 0.0376163
SRRM2 serine/arginine repetitive matrix 2 0.0367833
MYH9 myosin, heavy chain 9, non-muscle 0.0365079
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0354561
AREG amphiregulin 0.0341438
ANKRD11 ankyrin repeat domain 11 0.0340429
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0322129
AKAP9 A kinase (PRKA) anchor protein 9 0.0304898
GOLGA4 golgin A4 0.0296376
ITGB4 integrin, beta 4 0.029475
KLHL29 kelch-like family member 29 0.028681
PLEC plectin 0.0285854
RPL23 ribosomal protein L23 0.0285816
ANXA1 annexin A1 0.0276099
BRD2 bromodomain containing 2 0.0275385
PCDH1 protocadherin 1 0.0270383
CLDN7 claudin 7 0.0265688
PGM3 phosphoglucomutase 3 0.026564
CALR calreticulin 0.0263367
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0262503
SET SET nuclear proto-oncogene 0.0260823
EIF4H eukaryotic translation initiation factor 4H 0.0259012
SREBF2 sterol regulatory element binding transcription factor 2 0.0258433
NFE2L1 nuclear factor, erythroid 2-like 1 0.0248426
LRP5 low density lipoprotein receptor-related protein 5 0.0228522
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0223701
NUPR1 nuclear protein, transcriptional regulator, 1 0.0223542
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0219513
FAM13A family with sequence similarity 13, member A 0.0217495
TMED2 transmembrane emp24 domain trafficking protein 2 0.0217118
LRRC59 leucine rich repeat containing 59 0.0216815
RPS19 ribosomal protein S19 0.0210011
GARS1 glycyl-tRNA synthetase 1 0.0209936
PRPF8 pre-mRNA processing factor 8 0.0207331
BRD4 bromodomain containing 4 0.0207208
EEF2 eukaryotic translation elongation factor 2 0.0206939
RPL36 ribosomal protein L36 0.0205521
MUC3B mucin 3B, cell surface associated 0.0198966
RPS12 ribosomal protein S12 0.0197986
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0195707
RPL18 ribosomal protein L18 0.0192689
EIF4B eukaryotic translation initiation factor 4B 0.0190745
RPL37A ribosomal protein L37a 0.0189203
MBNL2 muscleblind-like splicing regulator 2 0.0189147
SSR1 signal sequence receptor, alpha 0.0187681
CAPN8 calpain 8 0.0187159
SEPTIN9 septin 9 0.0187127
S100A11 S100 calcium binding protein A11 0.0185572
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0184889
KMT2D lysine (K)-specific methyltransferase 2D 0.0184744
RPS2 ribosomal protein S2 0.0184324
ANXA11 annexin A11 0.0183645
LENG8 leukocyte receptor cluster (LRC) member 8 0.0182936
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0181622
UNC5B unc-5 homolog B (C. elegans) 0.018044
MMP24OS MMP24 opposite strand 0.0179702
BCL2L1 BCL2-like 1 0.0175739
MYOF myoferlin 0.0174627
RPS18 ribosomal protein S18 0.0174325
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0172377
NCOR2 nuclear receptor corepressor 2 0.0171667
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0171558
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0171027
PRRC2A proline-rich coiled-coil 2A 0.0169683
LAMA5 laminin, alpha 5 0.0169326
ZFP36 ZFP36 ring finger protein 0.0169158
SRRM1 serine/arginine repetitive matrix 1 0.0168735
APLP2 amyloid beta (A4) precursor-like protein 2 0.0166749
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0166426
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.0166076
PTPRH protein tyrosine phosphatase, receptor type, H 0.0165761
CTBP2 C-terminal binding protein 2 0.0165736
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0161003
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0160548
S100P S100 calcium binding protein P 0.0157696
TMF1 TATA element modulatory factor 1 0.0157188
RPS6 ribosomal protein S6 0.0156566
EPHA2 EPH receptor A2 0.0155193
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0153201
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0152171
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0151413
MLPH melanophilin 0.0149885
RPS17 ribosomal protein S17 0.0149272
RNPS1 RNA binding protein S1, serine-rich domain 0.0147465
MANF mesencephalic astrocyte-derived neurotrophic factor 0.0146049
RACK1 receptor for activated C kinase 1 0.014597
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.014498
OPTN optineurin 0.0144237
SERF2 small EDRK-rich factor 2 0.0142588

decreased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 -0.258897
NPSR1 neuropeptide S receptor 1 -0.18278
GMDS GDP-mannose 4,6-dehydratase -0.171958
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.171707
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.133
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.120867
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.106868
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0879216
PGK1 phosphoglycerate kinase 1 -0.0797184
CANX calnexin -0.0785314
AHNAK AHNAK nucleoprotein -0.0754316
MAML2 mastermind-like 2 (Drosophila) -0.0648589
TMEM123 transmembrane protein 123 -0.0633121
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0632458
TPT1 tumor protein, translationally-controlled 1 -0.062224
CDK6 cyclin-dependent kinase 6 -0.0605725
ANXA2 annexin A2 -0.0602483
CD2AP CD2-associated protein -0.0600732
LMO7 LIM domain 7 -0.058709
LPP LIM domain containing preferred translocation partner in lipoma -0.0583928
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0573658
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0541919
EHBP1 EH domain binding protein 1 -0.0538676
AHR aryl hydrocarbon receptor -0.0502442
INSIG1 insulin induced gene 1 -0.0486519
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0485792
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0485402
PTPRK protein tyrosine phosphatase, receptor type, K -0.0480294
CEMIP cell migration inducing protein, hyaluronan binding -0.0479831
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0472548
TRPS1 trichorhinophalangeal syndrome I -0.0462123
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0458895
ACACA acetyl-CoA carboxylase alpha -0.0454804
CD46 CD46 molecule, complement regulatory protein -0.0451775
EMP1 epithelial membrane protein 1 -0.0449594
SAMD12 sterile alpha motif domain containing 12 -0.0449365
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0444682
PTMA prothymosin, alpha -0.0443594
PDIA3 protein disulfide isomerase family A, member 3 -0.0436475
MCU mitochondrial calcium uniporter -0.0414049
LOC112694756 uncharaterized LOC112694756 -0.0411312
NF1 neurofibromin 1 -0.0406931
PHF14 PHD finger protein 14 -0.0406186
EPCAM epithelial cell adhesion molecule -0.0405999
EXOC4 exocyst complex component 4 -0.0396962
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0392507
ASPH aspartate beta-hydroxylase -0.0391135
MECOM MDS1 and EVI1 complex locus -0.0388757
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0388037
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0385023
S100A6 S100 calcium binding protein A6 -0.0383166
PRKCA protein kinase C, alpha -0.0370383
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0366155
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0363827
RTN3 reticulon 3 -0.0357947
FRMD5 FERM domain containing 5 -0.0354363
PTK2 protein tyrosine kinase 2 -0.0353015
RPS24 ribosomal protein S24 -0.0345881
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0343835
RAB1A RAB1A, member RAS oncogene family -0.0341344
TFRC transferrin receptor -0.034126
TM4SF1 transmembrane 4 L six family member 1 -0.0339889
DIAPH2 diaphanous-related formin 2 -0.0338792
HLA-E major histocompatibility complex, class I, E -0.0336135
TCF12 transcription factor 12 -0.0331545
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0327531
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0324957
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0324882
RPL35A ribosomal protein L35a -0.0324248
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.032183
AGR2 anterior gradient 2 -0.031994
ARHGAP32 Rho GTPase activating protein 32 -0.0319213
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.031641
COBL cordon-bleu WH2 repeat protein -0.0316305
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0313675
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0313163
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0310712
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0309361
XPO1 exportin 1 -0.0307697
TNIK TRAF2 and NCK interacting kinase -0.0306352
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0304642
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0304163
PERP PERP, TP53 apoptosis effector -0.0301858
MTUS1 microtubule associated tumor suppressor 1 -0.030151
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0301448
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0298877
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0298657
USP34 ubiquitin specific peptidase 34 -0.0295524
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0295047
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0291945
DLG1 discs, large homolog 1 (Drosophila) -0.0290081
POF1B premature ovarian failure, 1B -0.0285349
GNAS GNAS complex locus -0.0282628
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0281819
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0281389
KRT8 keratin 8, type II -0.0280271
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0278333
SETX senataxin -0.0274439
NCOA7 nuclear receptor coactivator 7 -0.02733
TAS2R14 taste receptor, type 2, member 14 -0.0272663