Piroxicam_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.132275
CEMIP cell migration inducing protein, hyaluronan binding 0.119899
VEGFA vascular endothelial growth factor A 0.116091
PTMA prothymosin, alpha 0.113888
ONECUT3 one cut homeobox 3 0.107711
NPSR1 neuropeptide S receptor 1 0.0968396
FLNB filamin B, beta 0.0913084
KRT18 keratin 18, type I 0.0910903
TNS4 tensin 4 0.0775664
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0590109
MT2A metallothionein 2A 0.0585807
PTPRR protein tyrosine phosphatase, receptor type, R 0.0568791
TMSB10 thymosin beta 10 0.0557955
MYO1E myosin IE 0.0547139
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0542488
MACF1 microtubule-actin crosslinking factor 1 0.0534983
GREB1L growth regulation by estrogen in breast cancer-like 0.0520372
CALB1 calbindin 1, 28kDa 0.0518422
ITGB4 integrin, beta 4 0.0509733
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0507671
SRRM2 serine/arginine repetitive matrix 2 0.0501586
NALF1 NALCN channel auxiliary factor 1 0.0494072
CADPS Ca++-dependent secretion activator 0.049313
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.047773
FTH1 ferritin, heavy polypeptide 1 0.04548
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0445916
TMEM45B transmembrane protein 45B 0.0389783
RPS3 ribosomal protein S3 0.0350646
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.034957
AUTS2 autism susceptibility candidate 2 0.0344434
SVIL supervillin 0.0335291
CD44 CD44 molecule (Indian blood group) 0.0327991
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0317881
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0316867
EHBP1 EH domain binding protein 1 0.0314482
PRSS3 protease, serine, 3 0.0313377
SEPTIN9 septin 9 0.0305245
GMDS GDP-mannose 4,6-dehydratase 0.0300197
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0299648
RPL18 ribosomal protein L18 0.0297843
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.0296795
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0294264
RNF217 ring finger protein 217 0.0283442
MLPH melanophilin 0.0282349
MT1E metallothionein 1E 0.0280059
ANTXR2 anthrax toxin receptor 2 0.0276712
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0274656
PRELID2 PRELI domain containing 2 0.0273672
RPS12 ribosomal protein S12 0.0269538
CLDN4 claudin 4 0.0269246
FERMT1 fermitin family member 1 0.0268292
TBC1D22A TBC1 domain family, member 22A 0.026691
SSR1 signal sequence receptor, alpha 0.0263192
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0259829
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0258939
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0257879
MPRIP myosin phosphatase Rho interacting protein 0.0252609
GPR39 G protein-coupled receptor 39 0.0250916
SHB Src homology 2 domain containing adaptor protein B 0.0248959
ICA1 islet cell autoantigen 1, 69kDa 0.0244689
SH3D19 SH3 domain containing 19 0.0236319
RPL26 ribosomal protein L26 0.0236077
RPL37A ribosomal protein L37a 0.0233389
SLC35F3 solute carrier family 35, member F3 0.0230928
IGFL2 IGF-like family member 2 0.0230267
NCOR2 nuclear receptor corepressor 2 0.0227644
RPS18 ribosomal protein S18 0.0226679
BACE2 beta-site APP-cleaving enzyme 2 0.0222593
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0220154
CST3 cystatin C 0.0219918
PATJ PATJ crumbs cell polarity complex component 0.0218768
DERA deoxyribose-phosphate aldolase (putative) 0.0216483
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0215391
TSC22D1 TSC22 domain family, member 1 0.0212274
MYH9 myosin, heavy chain 9, non-muscle 0.0209246
MYH14 myosin, heavy chain 14, non-muscle 0.0209017
MINK1 misshapen-like kinase 1 0.0208205
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0207234
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0203578
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0202762
ACTG1 actin gamma 1 0.0202324
RPS19 ribosomal protein S19 0.020129
RAD51B RAD51 paralog B 0.0201097
KIZ kizuna centrosomal protein 0.0200947
TRAPPC9 trafficking protein particle complex 9 0.0199681
PTPRB protein tyrosine phosphatase, receptor type, B 0.0199538
FAM120B family with sequence similarity 120B 0.0198474
TC2N tandem C2 domains, nuclear 0.0198153
GAK cyclin G associated kinase 0.0197818
RPS8 ribosomal protein S8 0.0197573
PLEC plectin 0.0197345
ALCAM activated leukocyte cell adhesion molecule 0.0195356
CMIP c-Maf inducing protein 0.0193879
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0193765
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0193409
PTPRF protein tyrosine phosphatase, receptor type, F 0.0193096
KIAA1217 KIAA1217 0.0189392
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0188988
ITGB5 integrin, beta 5 0.0188286
NPAS2 neuronal PAS domain protein 2 0.0187566

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115146
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113535
EZR ezrin -0.104985
TXNIP thioredoxin interacting protein -0.103339
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0791928
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0751355
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0678332
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0628885
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0604513
RAB1A RAB1A, member RAS oncogene family -0.0588521
MED13L mediator complex subunit 13-like -0.0585245
EREG epiregulin -0.0577521
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0571596
GOLGA4 golgin A4 -0.0533557
CANX calnexin -0.0517304
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.051692
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0506773
KMT2E lysine (K)-specific methyltransferase 2E -0.0504776
IARS1 isoleucyl-tRNA synthetase 1 -0.0498264
WAC WW domain containing adaptor with coiled-coil -0.0462465
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0457133
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0449938
RBM39 RNA binding motif protein 39 -0.0443439
CD46 CD46 molecule, complement regulatory protein -0.0433285
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0427398
SETD5 SET domain containing 5 -0.0417614
MBNL1 muscleblind-like splicing regulator 1 -0.0410527
ARID4B AT rich interactive domain 4B (RBP1-like) -0.040955
INSIG1 insulin induced gene 1 -0.0406452
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0406287
BIRC6 baculoviral IAP repeat containing 6 -0.0402407
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0394419
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0392627
DSCAM Down syndrome cell adhesion molecule -0.0390179
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0388939
AFF1 AF4/FMR2 family, member 1 -0.0386744
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0383637
CCNL1 cyclin L1 -0.0377595
RYBP RING1 and YY1 binding protein -0.0377279
LOC112694756 uncharaterized LOC112694756 -0.0370619
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0367776
USP3 ubiquitin specific peptidase 3 -0.0367109
SLMAP sarcolemma associated protein -0.0367054
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0366901
SLC38A2 solute carrier family 38, member 2 -0.036527
ARF4 ADP-ribosylation factor 4 -0.0364276
COG5 component of oligomeric golgi complex 5 -0.0363667
MUC13 mucin 13, cell surface associated -0.0363666
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0361748
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0360624
PTBP3 polypyrimidine tract binding protein 3 -0.0360605
RLF rearranged L-myc fusion -0.0360462
GRB10 growth factor receptor-bound protein 10 -0.0356863
CD2AP CD2-associated protein -0.0354038
GARS1 glycyl-tRNA synthetase 1 -0.0353372
RAD21 RAD21 homolog (S. pombe) -0.0352094
NEK7 NIMA-related kinase 7 -0.0350944
TFG TRK-fused gene -0.035087
PHIP pleckstrin homology domain interacting protein -0.0345043
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.034479
STRN3 striatin, calmodulin binding protein 3 -0.0342281
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0342211
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0341522
KDM3A lysine (K)-specific demethylase 3A -0.034132
ZFAND3 zinc finger, AN1-type domain 3 -0.0341246
ADAM9 ADAM metallopeptidase domain 9 -0.0341155
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0340381
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0337986
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0337964
TXNRD1 thioredoxin reductase 1 -0.0332231
MARCHF6 membrane associated ring-CH-type finger 6 -0.0327099
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0323634
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0323077
TRA2A transformer 2 alpha homolog (Drosophila) -0.0319164
FNDC3B fibronectin type III domain containing 3B -0.0317705
VMP1 vacuole membrane protein 1 -0.0317235
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0313572
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0311935
ARL5B ADP-ribosylation factor-like 5B -0.0310784
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0309168
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0304144
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0300648
TFRC transferrin receptor -0.0298851
WDR45B WD repeat domain 45B -0.0298349
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0297747
PDIA3 protein disulfide isomerase family A, member 3 -0.0297539
PICALM phosphatidylinositol binding clathrin assembly protein -0.0295547
JMJD1C jumonji domain containing 1C -0.0292157
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0291492
TES testin LIM domain protein -0.0291263
PIGR polymeric immunoglobulin receptor -0.028971
EGR1 early growth response 1 -0.0289639
JUN jun proto-oncogene -0.0288896
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0288326
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing -0.0287895
TPD52 tumor protein D52 -0.0287378
STAG2 stromal antigen 2 -0.0287096
ANKRD11 ankyrin repeat domain 11 -0.0286344
ERBIN erbb2 interacting protein -0.0286284
ANKRD17 ankyrin repeat domain 17 -0.0285332