Piroxicam_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.16946
TM4SF1 transmembrane 4 L six family member 1 0.0914277
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0723188
BCAR3 breast cancer anti-estrogen resistance 3 0.0681692
TXNRD1 thioredoxin reductase 1 0.0596604
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0571274
WWTR1 WW domain containing transcription regulator 1 0.0538305
EEF2 eukaryotic translation elongation factor 2 0.0513829
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0506414
RACK1 receptor for activated C kinase 1 0.0494608
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0483175
MKI67 marker of proliferation Ki-67 0.0469005
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0468945
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0449486
CAPN2 calpain 2, (m/II) large subunit 0.0443711
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0436324
PODXL podocalyxin-like 0.0427521
MACF1 microtubule-actin crosslinking factor 1 0.0423745
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0423477
FTH1 ferritin, heavy polypeptide 1 0.0422427
ACTG1 actin gamma 1 0.0415233
PRRC2C proline-rich coiled-coil 2C 0.0412342
RPL23 ribosomal protein L23 0.0408106
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0401814
RTN4 reticulon 4 0.0393755
SPRY4 sprouty homolog 4 (Drosophila) 0.0382012
TMEM41B transmembrane protein 41B 0.0358289
HSPA8 heat shock 70kDa protein 8 0.0351303
SPRED2 sprouty-related, EVH1 domain containing 2 0.0344026
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0342511
UPP1 uridine phosphorylase 1 0.0338582
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0325888
AHNAK2 AHNAK nucleoprotein 2 0.0321689
RPS3 ribosomal protein S3 0.031362
EMP1 epithelial membrane protein 1 0.0312495
MT1E metallothionein 1E 0.0310503
RPL12 ribosomal protein L12 0.0309586
RPS18 ribosomal protein S18 0.0309521
EIF4H eukaryotic translation initiation factor 4H 0.0306369
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0306316
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0301978
VEGFA vascular endothelial growth factor A 0.030179
RAI1 retinoic acid induced 1 0.0295394
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0294439
MYH9 myosin, heavy chain 9, non-muscle 0.0289394
AREG amphiregulin 0.0282723
EGR1 early growth response 1 0.028198
SET SET nuclear proto-oncogene 0.0280223
ZFP36L1 ZFP36 ring finger protein-like 1 0.0278048
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0272623
KRT18 keratin 18, type I 0.0269011
UBAP2L ubiquitin associated protein 2-like 0.0268338
MT1X metallothionein 1X 0.0264511
SRRM2 serine/arginine repetitive matrix 2 0.0263647
CENPF centromere protein F, 350/400kDa 0.0260758
BHLHE40 basic helix-loop-helix family, member e40 0.0258426
RPS8 ribosomal protein S8 0.0254353
RPS2 ribosomal protein S2 0.0254286
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0247013
NECTIN2 nectin cell adhesion molecule 2 0.0241004
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0240268
KLF6 Kruppel-like factor 6 0.0239361
PRRC2B proline-rich coiled-coil 2B 0.0236221
RB1CC1 RB1-inducible coiled-coil 1 0.0234592
ERRFI1 ERBB receptor feedback inhibitor 1 0.0233003
MATR3 matrin 3 0.0231147
ACTN1 actinin, alpha 1 0.0221788
ERCC1 excision repair cross-complementation group 1 0.021566
F2R coagulation factor II (thrombin) receptor 0.0214478
NAMPT nicotinamide phosphoribosyltransferase 0.0211697
YBX3 Y box binding protein 3 0.0209829
CXCL8 chemokine (C-X-C motif) ligand 8 0.0208889
EZR ezrin 0.020727
MSN moesin 0.0205973
MLPH melanophilin 0.0205184
FERMT1 fermitin family member 1 0.0204461
ZNF160 zinc finger protein 160 0.0199635
FHL2 four and a half LIM domains 2 0.0197849
RPS12 ribosomal protein S12 0.0197505
RPL36 ribosomal protein L36 0.0195939
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0190729
CDCP1 CUB domain containing protein 1 0.0189008
HPCAL1 hippocalcin-like 1 0.0188921
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0187856
FOSL1 FOS-like antigen 1 0.018427
EPHA2 EPH receptor A2 0.0182273
AMPD3 adenosine monophosphate deaminase 3 0.0180904
EP300 E1A binding protein p300 0.0179827
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0179488
NACA nascent polypeptide-associated complex alpha subunit 0.0178156
ANGPTL4 angiopoietin-like 4 0.0177216
BMERB1 bMERB domain containing 1 0.0177175
NTSR1 neurotensin receptor 1 (high affinity) 0.017682
PRRC2A proline-rich coiled-coil 2A 0.0175852
USP22 ubiquitin specific peptidase 22 0.0175684
BARX2 BARX homeobox 2 0.0175284
PYGB phosphorylase, glycogen; brain 0.0174072
NT5E 5'-nucleotidase, ecto (CD73) 0.0172391
STX1A syntaxin 1A (brain) 0.0172265
CUL4B cullin 4B 0.0171429

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.168534
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.135215
CADM2 cell adhesion molecule 2 -0.123715
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.118137
DLG1 discs, large homolog 1 (Drosophila) -0.113471
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113404
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.112964
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.106087
EFNA5 ephrin-A5 -0.0956122
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0937531
DST dystonin -0.0924198
DPYD dihydropyrimidine dehydrogenase -0.0864242
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0855287
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.081813
EPHA4 EPH receptor A4 -0.0815413
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0805753
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0803699
CANX calnexin -0.0802703
TNS3 tensin 3 -0.0788305
HDAC9 histone deacetylase 9 -0.0768343
CSMD3 CUB and Sushi multiple domains 3 -0.0756702
MYOF myoferlin -0.0731487
EHBP1 EH domain binding protein 1 -0.0699357
TSC22D1 TSC22 domain family, member 1 -0.0668347
PSD3 pleckstrin and Sec7 domain containing 3 -0.0657844
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0642587
POTEF POTE ankyrin domain family, member F -0.0625402
FNIP1 folliculin interacting protein 1 -0.0620232
EXOC4 exocyst complex component 4 -0.0612782
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0560993
PIAS2 protein inhibitor of activated STAT, 2 -0.0556412
FMNL2 formin-like 2 -0.0542731
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0528184
CFAP299 cilia and flagella associated protein 299 -0.0526487
LRPPRC leucine-rich pentatricopeptide repeat containing -0.052219
PTK2 protein tyrosine kinase 2 -0.048651
PGK1 phosphoglycerate kinase 1 -0.0482953
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0482275
SLC38A2 solute carrier family 38, member 2 -0.048175
TAOK1 TAO kinase 1 -0.0468605
LPP LIM domain containing preferred translocation partner in lipoma -0.0468598
KDM4C lysine (K)-specific demethylase 4C -0.0463488
TMEM123 transmembrane protein 123 -0.0463221
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0454766
ESYT2 extended synaptotagmin-like protein 2 -0.0448379
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0445849
SP100 SP100 nuclear antigen -0.0445451
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.044355
BIRC6 baculoviral IAP repeat containing 6 -0.0440649
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0440223
ZNF292 zinc finger protein 292 -0.0438269
TTC3 tetratricopeptide repeat domain 3 -0.0427831
TRIO trio Rho guanine nucleotide exchange factor -0.042498
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0424529
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0417603
ADAM10 ADAM metallopeptidase domain 10 -0.0411669
TXNIP thioredoxin interacting protein -0.0410662
PRELID2 PRELI domain containing 2 -0.0404578
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0401463
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0400353
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0400141
ENO2 enolase 2 (gamma, neuronal) -0.0390082
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0385651
FNDC3B fibronectin type III domain containing 3B -0.0384843
KDM3A lysine (K)-specific demethylase 3A -0.0379754
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0374215
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0373326
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0367339
GLG1 golgi glycoprotein 1 -0.036691
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0363069
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0357744
MBD5 methyl-CpG binding domain protein 5 -0.0355766
DNER delta/notch-like EGF repeat containing -0.0354395
FAF1 Fas (TNFRSF6) associated factor 1 -0.0353368
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0351927
UBE3C ubiquitin protein ligase E3C -0.0349956
LYST lysosomal trafficking regulator -0.0345713
USP34 ubiquitin specific peptidase 34 -0.0343563
SPDYA speedy/RINGO cell cycle regulator family member A -0.0342065
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0341795
PDIA3 protein disulfide isomerase family A, member 3 -0.0340765
COL5A2 collagen, type V, alpha 2 -0.0337001
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0336088
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0333775
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0332313
NDRG1 N-myc downstream regulated 1 -0.0329744
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.032729
CUX1 cut-like homeobox 1 -0.0326256
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0326034
MBNL2 muscleblind-like splicing regulator 2 -0.0325698
ATXN2 ataxin 2 -0.0324264
NBEAL1 neurobeachin-like 1 -0.0322608
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0320057
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0317113
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0317088
EPB41 erythrocyte membrane protein band 4.1 -0.0316769
SOD2 superoxide dismutase 2, mitochondrial -0.0314254
ZNF638 zinc finger protein 638 -0.0312534
WSB1 WD repeat and SOCS box containing 1 -0.0308783
RSF1 remodeling and spacing factor 1 -0.0306285