Piroxicam_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.100693
MT2A metallothionein 2A 0.0812188
FAM13A family with sequence similarity 13, member A 0.0732154
FTH1 ferritin, heavy polypeptide 1 0.0724499
NAMPT nicotinamide phosphoribosyltransferase 0.0677653
PRRC2C proline-rich coiled-coil 2C 0.045578
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0429395
SEC61G Sec61 gamma subunit 0.0426531
FTL ferritin, light polypeptide 0.0409829
TMEM165 transmembrane protein 165 0.0409428
NGLY1 N-glycanase 1 0.0390387
MKI67 marker of proliferation Ki-67 0.0373862
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0360008
RUNX1 runt-related transcription factor 1 0.035875
GCLC glutamate-cysteine ligase, catalytic subunit 0.034619
ARRDC3 arrestin domain containing 3 0.0341645
RPS3 ribosomal protein S3 0.0338577
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0337888
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0332344
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0330562
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.032795
TMSB10 thymosin beta 10 0.0324222
TXNRD1 thioredoxin reductase 1 0.0319415
CES1 carboxylesterase 1 0.0314837
LAMA4 laminin, alpha 4 0.0299683
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0291332
SRRM2 serine/arginine repetitive matrix 2 0.0287899
CAMTA1 calmodulin binding transcription activator 1 0.0286111
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0265708
RNF145 ring finger protein 145 0.0260185
ADAM17 ADAM metallopeptidase domain 17 0.0253582
OGA O-GlcNAcase 0.0250821
CST3 cystatin C 0.0250455
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0249455
TOP1 topoisomerase (DNA) I 0.0244444
EEF2 eukaryotic translation elongation factor 2 0.0238765
UBA6 ubiquitin-like modifier activating enzyme 6 0.0235913
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0227335
RTN4 reticulon 4 0.0222739
SREBF2 sterol regulatory element binding transcription factor 2 0.022099
RNF149 ring finger protein 149 0.022091
TSC22D2 TSC22 domain family, member 2 0.0220548
ATP13A3 ATPase type 13A3 0.0216882
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0213155
VEGFA vascular endothelial growth factor A 0.0212401
BRWD1 bromodomain and WD repeat domain containing 1 0.0210903
SMTN smoothelin 0.020988
HELZ helicase with zinc finger 0.0209536
DTNA dystrobrevin, alpha 0.0209309
BRWD3 bromodomain and WD repeat domain containing 3 0.0205308
RNMT RNA (guanine-7-) methyltransferase 0.0204893
MATR3 matrin 3 0.0195344
YEATS2 YEATS domain containing 2 0.019465
TNRC6A trinucleotide repeat containing 6A 0.019216
MT1X metallothionein 1X 0.018966
CSNK1E casein kinase 1, epsilon 0.0187531
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0185783
WDR45B WD repeat domain 45B 0.0185523
KDM2A lysine (K)-specific demethylase 2A 0.0183214
TPD52 tumor protein D52 0.0179705
NDRG1 N-myc downstream regulated 1 0.0179449
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0178589
RPS6 ribosomal protein S6 0.0176777
RICTOR RPTOR independent companion of MTOR, complex 2 0.0174571
VEZT vezatin, adherens junctions transmembrane protein 0.0174294
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0171047
RAB7A RAB7A, member RAS oncogene family 0.0170959
CIB1 calcium and integrin binding 1 (calmyrin) 0.0168811
BLZF1 basic leucine zipper nuclear factor 1 0.0168608
MXI1 MAX interactor 1, dimerization protein 0.0165945
SYAP1 synapse associated protein 1 0.0163659
EP300 E1A binding protein p300 0.0162667
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0158509
TBC1D22A TBC1 domain family, member 22A 0.015812
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0156776
ZNF292 zinc finger protein 292 0.0155934
SPRED2 sprouty-related, EVH1 domain containing 2 0.0155025
SEPTIN2 septin 2 0.015433
KMT2D lysine (K)-specific methyltransferase 2D 0.0153045
HILPDA hypoxia inducible lipid droplet-associated 0.0152597
RAP1B RAP1B, member of RAS oncogene family 0.0150898
HYOU1 hypoxia up-regulated 1 0.0150865
CCNL1 cyclin L1 0.0150196
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0150066
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0148536
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0148264
GOLGA4 golgin A4 0.0148068
TMEM87A transmembrane protein 87A 0.0147853
YTHDC1 YTH domain containing 1 0.0147758
MYH9 myosin, heavy chain 9, non-muscle 0.0147195
SON SON DNA binding protein 0.0147078
TBK1 TANK-binding kinase 1 0.0146079
EIF1 eukaryotic translation initiation factor 1 0.0145352
ZFR zinc finger RNA binding protein 0.0144761
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.014155
PUM2 pumilio RNA-binding family member 2 0.0140769
FOSL1 FOS-like antigen 1 0.0140628
RBM25 RNA binding motif protein 25 0.0139984
KMT2E lysine (K)-specific methyltransferase 2E 0.013955
MGST1 microsomal glutathione S-transferase 1 0.0139119

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.315328
ASPH aspartate beta-hydroxylase -0.169947
PTPRM protein tyrosine phosphatase, receptor type, M -0.114515
THSD4 thrombospondin, type I, domain containing 4 -0.105844
INTS6 integrator complex subunit 6 -0.100203
LMO7 LIM domain 7 -0.0792747
EFNA5 ephrin-A5 -0.0685598
PDLIM5 PDZ and LIM domain 5 -0.0665931
SOD2 superoxide dismutase 2, mitochondrial -0.0605871
AHNAK AHNAK nucleoprotein -0.0602318
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0584246
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0581558
SLTM SAFB-like, transcription modulator -0.0568135
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0567331
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0560193
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0542882
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0537017
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.053656
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0523909
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0522349
LPP LIM domain containing preferred translocation partner in lipoma -0.0494717
HOMER1 homer scaffolding protein 1 -0.0482498
LRP1B low density lipoprotein receptor-related protein 1B -0.0481236
NABP1 nucleic acid binding protein 1 -0.0472053
MYO1E myosin IE -0.0470917
FNDC3B fibronectin type III domain containing 3B -0.0455206
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0454114
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0434432
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0395074
RNF213 ring finger protein 213 -0.038646
CAV1 caveolin 1, caveolae protein, 22kDa -0.0382329
ANXA2 annexin A2 -0.0372925
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0369902
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0366528
PDE4D phosphodiesterase 4D, cAMP-specific -0.0363297
SP100 SP100 nuclear antigen -0.03611
CUX1 cut-like homeobox 1 -0.0360468
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0358801
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0353341
BZW1 basic leucine zipper and W2 domains 1 -0.034333
VCL vinculin -0.0339978
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0335683
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0334393
MYOF myoferlin -0.0332327
MCTP1 multiple C2 domains, transmembrane 1 -0.032956
NCOA7 nuclear receptor coactivator 7 -0.0318034
CATSPERB catsper channel auxiliary subunit beta -0.0317009
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0315168
MAML3 mastermind-like 3 (Drosophila) -0.031111
LOC112694756 uncharaterized LOC112694756 -0.0308736
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0304454
CCSER1 coiled-coil serine-rich protein 1 -0.0302044
PM20D1 peptidase M20 domain containing 1 -0.0295076
SCEL sciellin -0.0293478
PRKCA protein kinase C, alpha -0.0286181
DSCAM Down syndrome cell adhesion molecule -0.0284958
BIRC3 baculoviral IAP repeat containing 3 -0.0282742
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0280179
CCND1 cyclin D1 -0.0279249
SLC38A2 solute carrier family 38, member 2 -0.0277428
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0274775
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0273435
FBXO11 F-box protein 11 -0.0270335
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0264999
GRAMD1B GRAM domain containing 1B -0.0264207
RAD51B RAD51 paralog B -0.0262672
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0259795
TNS3 tensin 3 -0.0255633
LDHA lactate dehydrogenase A -0.0254339
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0250015
RIMS2 regulating synaptic membrane exocytosis 2 -0.0247017
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0246773
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0245298
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0244956
CMIP c-Maf inducing protein -0.0243073
CEMIP cell migration inducing protein, hyaluronan binding -0.0242191
SMOC1 SPARC related modular calcium binding 1 -0.023984
NSUN6 NOP2/Sun domain family, member 6 -0.0236175
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0234332
PATJ PATJ crumbs cell polarity complex component -0.0234129
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0233176
GM2A GM2 ganglioside activator -0.0231997
LIMCH1 LIM and calponin homology domains 1 -0.0231707
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0230712
DOCK5 dedicator of cytokinesis 5 -0.022959
NRIP1 nuclear receptor interacting protein 1 -0.022899
NPAS2 neuronal PAS domain protein 2 -0.0226021
AEBP2 AE binding protein 2 -0.0225444
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0225361
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0224632
USP53 ubiquitin specific peptidase 53 -0.0223755
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0223444
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0221147
FOXP1 forkhead box P1 -0.0219854
KRT86 keratin 86, type II -0.0218766
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0217768
MCU mitochondrial calcium uniporter -0.0215784
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0213561
ANKRD10 ankyrin repeat domain 10 -0.0213552
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.021209