Piroxicam_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.104861
VEGFA vascular endothelial growth factor A 0.0983258
TMSB10 thymosin beta 10 0.0677043
AKAP12 A kinase (PRKA) anchor protein 12 0.0610464
CD44 CD44 molecule (Indian blood group) 0.0530471
SMAD3 SMAD family member 3 0.0515508
RPS3 ribosomal protein S3 0.0431996
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0430852
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.041682
EEF2 eukaryotic translation elongation factor 2 0.0403995
EIF4H eukaryotic translation initiation factor 4H 0.0387238
RPLP1 ribosomal protein, large, P1 0.0377654
RPS12 ribosomal protein S12 0.0373836
HLA-B major histocompatibility complex, class I, B 0.0348279
RPS21 ribosomal protein S21 0.0339802
BHLHE40 basic helix-loop-helix family, member e40 0.0333454
NAV2 neuron navigator 2 0.0331654
RPS29 ribosomal protein S29 0.0329665
RPL23 ribosomal protein L23 0.0322591
RPL36 ribosomal protein L36 0.0320384
RPL13A ribosomal protein L13a 0.0304765
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0302813
FAM20C family with sequence similarity 20, member C 0.0299964
ACTG1 actin gamma 1 0.0296926
RPLP2 ribosomal protein, large, P2 0.0296292
RPL37A ribosomal protein L37a 0.0295954
RPS19 ribosomal protein S19 0.0294943
RPL31 ribosomal protein L31 0.0286478
TMSB4X thymosin beta 4, X-linked 0.0283732
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0278989
KLF6 Kruppel-like factor 6 0.0270723
EIF1 eukaryotic translation initiation factor 1 0.0260018
RACK1 receptor for activated C kinase 1 0.0255666
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.025457
RPL32 ribosomal protein L32 0.0252763
RPL12 ribosomal protein L12 0.0241649
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0225203
OPTN optineurin 0.0223471
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0219083
IER3 immediate early response 3 0.0211159
RPL38 ribosomal protein L38 0.0210601
MYH9 myosin, heavy chain 9, non-muscle 0.020876
HSPA8 heat shock 70kDa protein 8 0.0203712
MLPH melanophilin 0.0199936
RPL11 ribosomal protein L11 0.0199382
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0194526
H1-0 H1.0 linker histone 0.0189959
BACE2 beta-site APP-cleaving enzyme 2 0.0189224
RPL18 ribosomal protein L18 0.018831
ABI1 abl-interactor 1 0.0180104
FAM107B family with sequence similarity 107, member B 0.0179292
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0179024
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0178086
PRRC2C proline-rich coiled-coil 2C 0.0178044
CD59 CD59 molecule, complement regulatory protein 0.0174924
RPL34 ribosomal protein L34 0.0173987
CST3 cystatin C 0.0173782
RPS18 ribosomal protein S18 0.0172909
TM4SF1 transmembrane 4 L six family member 1 0.0169574
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0167273
RPL26 ribosomal protein L26 0.0167092
PTMA prothymosin, alpha 0.0167075
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0166571
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0165553
ATP5MC2 ATP synthase membrane subunit c locus 2 0.0164346
BRD2 bromodomain containing 2 0.0162866
ICAM1 intercellular adhesion molecule 1 0.0162747
SFTPA2 surfactant protein A2 0.0161436
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.016114
CNOT12 CCR4-NOT transcription complex subunit 12 0.0159638
G0S2 G0/G1 switch 2 0.0158855
ZMIZ1 zinc finger, MIZ-type containing 1 0.0157798
LAMB3 laminin, beta 3 0.0156368
CEP250 centrosomal protein 250kDa 0.0155189
RPL7A ribosomal protein L7a 0.0155123
RPS17 ribosomal protein S17 0.0152018
RPL5 ribosomal protein L5 0.0151893
CALR calreticulin 0.0150019
AMPD3 adenosine monophosphate deaminase 3 0.0148762
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.014775
SUN1 Sad1 and UNC84 domain containing 1 0.0147266
NACA nascent polypeptide-associated complex alpha subunit 0.0146994
RPL14 ribosomal protein L14 0.0146816
DNMBP dynamin binding protein 0.0146736
EMP1 epithelial membrane protein 1 0.0146468
RPS10 ribosomal protein S10 0.0146161
UBAP2L ubiquitin associated protein 2-like 0.0146153
SEC61G Sec61 gamma subunit 0.0145408
MARS1 methionyl-tRNA synthetase 1 0.0145292
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 0.0145168
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0144602
CAVIN1 caveolae associated protein 1 0.0144363
PTPRM protein tyrosine phosphatase, receptor type, M 0.0144144
KDM3A lysine (K)-specific demethylase 3A 0.0143003
CTNND1 catenin (cadherin-associated protein), delta 1 0.0142751
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0142438
FLNA filamin A, alpha 0.0141898
TMED9 transmembrane emp24 protein transport domain containing 9 0.0141201
APP amyloid beta (A4) precursor protein 0.0138308
NECTIN2 nectin cell adhesion molecule 2 0.0136507

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.275141
FNDC3B fibronectin type III domain containing 3B -0.147249
PCBP2 poly(rC) binding protein 2 -0.136904
SDK1 sidekick cell adhesion molecule 1 -0.129878
SOD2 superoxide dismutase 2, mitochondrial -0.129118
USP34 ubiquitin specific peptidase 34 -0.100164
KDM2A lysine (K)-specific demethylase 2A -0.0975502
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0825092
PDIA3 protein disulfide isomerase family A, member 3 -0.0804639
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0787985
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0776216
IGFBP3 insulin-like growth factor binding protein 3 -0.0751251
FN1 fibronectin 1 -0.0708707
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0708096
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0691031
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0677103
NRG1 neuregulin 1 -0.0663088
GPC6 glypican 6 -0.0649236
HMGA2 high mobility group AT-hook 2 -0.0640542
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0639507
RAB1A RAB1A, member RAS oncogene family -0.0610291
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0601039
PSD3 pleckstrin and Sec7 domain containing 3 -0.0596035
DPYD dihydropyrimidine dehydrogenase -0.0592053
DLG1 discs, large homolog 1 (Drosophila) -0.0575653
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0569204
MEF2A myocyte enhancer factor 2A -0.0568243
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0566377
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0552562
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0551446
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0537566
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0528998
JMJD1C jumonji domain containing 1C -0.0524039
GRB10 growth factor receptor-bound protein 10 -0.0522339
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0511415
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0509197
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0491215
SETD5 SET domain containing 5 -0.0487282
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0484144
ASPH aspartate beta-hydroxylase -0.0482802
RIOK3 RIO kinase 3 -0.0475164
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.047187
LOX lysyl oxidase -0.0463109
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0462336
RAI14 retinoic acid induced 14 -0.0457305
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0444658
DDIT3 DNA-damage-inducible transcript 3 -0.0443741
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0443305
DST dystonin -0.0435143
FTH1 ferritin, heavy polypeptide 1 -0.0433982
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0432977
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0423376
PTK2 protein tyrosine kinase 2 -0.0421991
VMP1 vacuole membrane protein 1 -0.0419765
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0416543
KYNU kynureninase -0.0416358
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0413045
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0410689
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0410415
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0404632
CDCP1 CUB domain containing protein 1 -0.0403746
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0397587
ITCH itchy E3 ubiquitin protein ligase -0.039745
ZFAND3 zinc finger, AN1-type domain 3 -0.039553
CANX calnexin -0.0388482
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0385426
NGLY1 N-glycanase 1 -0.0383594
PIAS2 protein inhibitor of activated STAT, 2 -0.0379562
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0376913
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0375524
RAD51B RAD51 paralog B -0.0375256
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0374848
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0371881
MRPS6 mitochondrial ribosomal protein S6 -0.0371065
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0370907
CLIC4 chloride intracellular channel 4 -0.0366394
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0365743
MBNL1 muscleblind-like splicing regulator 1 -0.0365552
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0365456
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0361348
GLCCI1 glucocorticoid induced 1 -0.0361148
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0359023
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0358095
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0357522
DIAPH2 diaphanous-related formin 2 -0.0357085
NDRG1 N-myc downstream regulated 1 -0.0354607
FAM13A family with sequence similarity 13, member A -0.0353157
FBN1 fibrillin 1 -0.0351656
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0349499
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0348086
ETV6 ets variant 6 -0.0347059
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0345286
RNF24 ring finger protein 24 -0.0345234
BTG1 B-cell translocation gene 1, anti-proliferative -0.0342494
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0342107
TAS2R14 taste receptor, type 2, member 14 -0.0341554
RBM39 RNA binding motif protein 39 -0.0341091
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0339014
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0336415
MAML3 mastermind-like 3 (Drosophila) -0.0334496