Piroxicam_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.0717812
HSPA8 heat shock 70kDa protein 8 0.0604654
IGF2 insulin-like growth factor 2 0.0426608
AKAP12 A kinase (PRKA) anchor protein 12 0.0416696
FTL ferritin, light polypeptide 0.040208
RPL36 ribosomal protein L36 0.0377907
RPS3 ribosomal protein S3 0.0340125
MT2A metallothionein 2A 0.0323155
RPL23 ribosomal protein L23 0.0305999
RACK1 receptor for activated C kinase 1 0.0297838
PM20D1 peptidase M20 domain containing 1 0.0271161
MKI67 marker of proliferation Ki-67 0.0256502
NTN4 netrin 4 0.0244678
RPS19 ribosomal protein S19 0.0234737
GRAMD1B GRAM domain containing 1B 0.0214811
RNF213 ring finger protein 213 0.0210066
RPS2 ribosomal protein S2 0.0209844
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.020487
FLNA filamin A, alpha 0.0203933
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0194838
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0191806
WWOX WW domain containing oxidoreductase 0.0191556
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0191141
RPL3 ribosomal protein L3 0.0189675
MYH9 myosin, heavy chain 9, non-muscle 0.0184259
TUBB4B tubulin, beta 4B class IVb 0.0176536
RPS18 ribosomal protein S18 0.0171191
PRPF8 pre-mRNA processing factor 8 0.0168195
LAMA5 laminin, alpha 5 0.0168008
CST3 cystatin C 0.0162425
ARID1A AT rich interactive domain 1A (SWI-like) 0.0157285
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0155468
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0154861
RPL37A ribosomal protein L37a 0.0154777
EIF4H eukaryotic translation initiation factor 4H 0.015472
RNASEH2A ribonuclease H2, subunit A 0.0154061
FAT1 FAT atypical cadherin 1 0.0152002
RAD51B RAD51 paralog B 0.0151033
ZFP36 ZFP36 ring finger protein 0.0149571
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0146979
TMEM14C transmembrane protein 14C 0.014287
VEGFA vascular endothelial growth factor A 0.0141811
PRRC2A proline-rich coiled-coil 2A 0.0139406
NUCB1 nucleobindin 1 0.0138748
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0137937
EEF1G eukaryotic translation elongation factor 1 gamma 0.0134894
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0134849
NFE2L1 nuclear factor, erythroid 2-like 1 0.0134239
RPS17 ribosomal protein S17 0.0134081
RPS12 ribosomal protein S12 0.0130698
RPL18 ribosomal protein L18 0.0130557
PLEC plectin 0.012745
RPS27 ribosomal protein S27 0.0125651
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0123533
PCNT pericentrin 0.0123017
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0122029
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 0.0121284
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.0120883
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0117712
EGR1 early growth response 1 0.011588
BRD2 bromodomain containing 2 0.0115708
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.011415
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0113539
KMT2D lysine (K)-specific methyltransferase 2D 0.0112169
THSD4 thrombospondin, type I, domain containing 4 0.0111803
PRELID1 PRELI domain containing 1 0.011174
AHNAK2 AHNAK nucleoprotein 2 0.0111546
GPS2 G protein pathway suppressor 2 0.011125
PFN1 profilin 1 0.0111155
MDC1 mediator of DNA-damage checkpoint 1 0.0109816
CHMP7 charged multivesicular body protein 7 0.0107513
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.0107491
TMED9 transmembrane emp24 protein transport domain containing 9 0.0106396
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0106273
ZC3H18 zinc finger CCCH-type containing 18 0.0104955
GPX4 glutathione peroxidase 4 0.010443
MINK1 misshapen-like kinase 1 0.0104425
FBRSL1 fibrosin-like 1 0.0101831
PTBP1 polypyrimidine tract binding protein 1 0.0101171
TSPYL2 TSPY-like 2 0.0100985
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.0100717
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0100564
CTIF CBP80/20-dependent translation initiation factor 0.0100276
EIF4B eukaryotic translation initiation factor 4B 0.0100228
ROMO1 reactive oxygen species modulator 1 0.00999311
WDR62 WD repeat domain 62 0.00985051
SSR1 signal sequence receptor, alpha 0.00975328
ATP5MF ATP synthase membrane subunit f 0.00974056
STC2 stanniocalcin 2 0.00972299
CD68 CD68 molecule 0.009667
PABPN1 poly(A) binding protein, nuclear 1 0.00964925
RNPS1 RNA binding protein S1, serine-rich domain 0.00959866
STC1 stanniocalcin 1 0.00956975
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.00954165
KIFC1 kinesin family member C1 0.00953554
EEF2 eukaryotic translation elongation factor 2 0.00949867
UBE2C ubiquitin-conjugating enzyme E2C 0.00938584
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.0093739
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.00935726
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.00930791

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.150138
TXNRD1 thioredoxin reductase 1 -0.116234
ZFAND3 zinc finger, AN1-type domain 3 -0.10604
TM4SF1 transmembrane 4 L six family member 1 -0.0888542
RBM39 RNA binding motif protein 39 -0.0872132
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0823185
TFPI2 tissue factor pathway inhibitor 2 -0.0806141
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0802978
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.080222
PTK2 protein tyrosine kinase 2 -0.0784294
FNDC3B fibronectin type III domain containing 3B -0.0742134
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.069971
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0662683
EIF1 eukaryotic translation initiation factor 1 -0.0658168
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0657874
DENND4A DENN/MADD domain containing 4A -0.0643301
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0620391
PDE4D phosphodiesterase 4D, cAMP-specific -0.0617686
ERBIN erbb2 interacting protein -0.0612688
RAB1A RAB1A, member RAS oncogene family -0.061154
ZNF207 zinc finger protein 207 -0.0596013
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0592738
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0587708
NOP58 NOP58 ribonucleoprotein -0.0575081
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.057251
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0572294
WAC WW domain containing adaptor with coiled-coil -0.0569365
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.055802
SLC38A1 solute carrier family 38, member 1 -0.0557778
FBXO11 F-box protein 11 -0.0554454
USP3 ubiquitin specific peptidase 3 -0.0552858
RBM25 RNA binding motif protein 25 -0.0544531
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0544004
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0542531
KMT2E lysine (K)-specific methyltransferase 2E -0.0536877
FMNL2 formin-like 2 -0.0532952
RTN4 reticulon 4 -0.0526998
SPAG9 sperm associated antigen 9 -0.0510463
ZNF292 zinc finger protein 292 -0.0504897
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0501391
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0491068
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0489191
FAM168A family with sequence similarity 168, member A -0.048645
TRIO trio Rho guanine nucleotide exchange factor -0.0475649
POTEF POTE ankyrin domain family, member F -0.0472524
SLC38A2 solute carrier family 38, member 2 -0.047119
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0469757
IER3 immediate early response 3 -0.0468625
TRA2A transformer 2 alpha homolog (Drosophila) -0.045461
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0446886
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0446439
CANX calnexin -0.0444851
USP34 ubiquitin specific peptidase 34 -0.0440907
KDM3A lysine (K)-specific demethylase 3A -0.0440454
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0432984
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0429597
PDIA3 protein disulfide isomerase family A, member 3 -0.0426359
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.042447
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0424305
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0423241
KTN1 kinectin 1 (kinesin receptor) -0.0421356
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0419312
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0418239
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0416026
WTAP Wilms tumor 1 associated protein -0.0414191
ADAM17 ADAM metallopeptidase domain 17 -0.0411514
AFF4 AF4/FMR2 family, member 4 -0.0410636
MYOF myoferlin -0.0410428
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0409809
PARD3 par-3 family cell polarity regulator -0.0409531
RAD21 RAD21 homolog (S. pombe) -0.040855
NAP1L1 nucleosome assembly protein 1-like 1 -0.0408479
KIF5B kinesin family member 5B -0.0403934
RHOA ras homolog family member A -0.0399076
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.039792
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0396695
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0393949
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.039282
SEPTIN7 septin 7 -0.0392414
PDLIM5 PDZ and LIM domain 5 -0.0389683
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0386367
ANKRD11 ankyrin repeat domain 11 -0.0382784
TPD52 tumor protein D52 -0.0379527
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0377249
YBX3 Y box binding protein 3 -0.0374952
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0372639
TFG TRK-fused gene -0.0371898
WDR43 WD repeat domain 43 -0.0370938
MARCHF6 membrane associated ring-CH-type finger 6 -0.0369879
FAM107B family with sequence similarity 107, member B -0.0369059
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0367524
PCBP2 poly(rC) binding protein 2 -0.0364672
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0363357
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0362768
CAMTA1 calmodulin binding transcription activator 1 -0.0362696
JMJD1C jumonji domain containing 1C -0.0362131
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.035577
BIRC6 baculoviral IAP repeat containing 6 -0.0355326
RBM33 RNA binding motif protein 33 -0.0352165
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0351516