Piroxicam_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.211075
G0S2 G0/G1 switch 2 0.153187
PTMA prothymosin, alpha 0.114438
BHLHE40 basic helix-loop-helix family, member e40 0.11172
VEGFA vascular endothelial growth factor A 0.106543
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0855528
RPS3 ribosomal protein S3 0.0822327
HMGA1 high mobility group AT-hook 1 0.0803597
ZFP36L1 ZFP36 ring finger protein-like 1 0.0797581
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0788396
RACK1 receptor for activated C kinase 1 0.072831
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0642131
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0625267
CLDN4 claudin 4 0.0601769
TMSB10 thymosin beta 10 0.0589822
ACTG1 actin gamma 1 0.0585405
MT2A metallothionein 2A 0.0580726
LDHA lactate dehydrogenase A 0.0574204
LAMB3 laminin, beta 3 0.0516694
EEF2 eukaryotic translation elongation factor 2 0.0489365
IGFBP3 insulin-like growth factor binding protein 3 0.0477475
HSPA8 heat shock 70kDa protein 8 0.0471496
IFI27 interferon, alpha-inducible protein 27 0.0467775
PKM pyruvate kinase, muscle 0.046701
IFITM3 interferon induced transmembrane protein 3 0.0457124
IFI6 interferon, alpha-inducible protein 6 0.0456467
FOSL1 FOS-like antigen 1 0.0456297
ENO1 enolase 1, (alpha) 0.0448409
GPX4 glutathione peroxidase 4 0.0442446
RPS8 ribosomal protein S8 0.0437708
ISG15 ISG15 ubiquitin-like modifier 0.0436767
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0434704
RPS19 ribosomal protein S19 0.0421174
RPL12 ribosomal protein L12 0.0406906
CSTB cystatin B (stefin B) 0.0398004
RPL8 ribosomal protein L8 0.0389949
MKI67 marker of proliferation Ki-67 0.0383211
KRT18 keratin 18, type I 0.0377647
RPL23 ribosomal protein L23 0.0375506
RPL36 ribosomal protein L36 0.036933
RPLP1 ribosomal protein, large, P1 0.0364931
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0362866
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0352291
AREG amphiregulin 0.034458
CALR calreticulin 0.0343452
RPS14 ribosomal protein S14 0.0342917
SET SET nuclear proto-oncogene 0.0336753
RPS12 ribosomal protein S12 0.0336528
RPS17 ribosomal protein S17 0.0329668
RPS27 ribosomal protein S27 0.0323446
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0320016
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.031257
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0309563
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.0305385
RPS6 ribosomal protein S6 0.0302321
TPI1 triosephosphate isomerase 1 0.0301069
EEF1G eukaryotic translation elongation factor 1 gamma 0.0289964
IFITM1 interferon induced transmembrane protein 1 0.0287546
CST3 cystatin C 0.0286574
YBX1 Y box binding protein 1 0.0280948
MSN moesin 0.0278766
UBE2C ubiquitin-conjugating enzyme E2C 0.0274006
S100A11 S100 calcium binding protein A11 0.0271442
RPL28 ribosomal protein L28 0.0262613
RPS29 ribosomal protein S29 0.0260382
CD44 CD44 molecule (Indian blood group) 0.0258576
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0255765
HILPDA hypoxia inducible lipid droplet-associated 0.0254771
RPLP2 ribosomal protein, large, P2 0.0253815
S100A6 S100 calcium binding protein A6 0.0250986
RNF213 ring finger protein 213 0.0250201
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0248206
ARRDC3 arrestin domain containing 3 0.0248147
FTH1 ferritin, heavy polypeptide 1 0.024654
MX1 MX dynamin-like GTPase 1 0.0245624
LY6E lymphocyte antigen 6 complex, locus E 0.0244658
RPL37A ribosomal protein L37a 0.0241464
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0236367
OAZ1 ornithine decarboxylase antizyme 1 0.0234997
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0233827
B2M beta-2-microglobulin 0.0233313
NACA nascent polypeptide-associated complex alpha subunit 0.0228764
S100A10 S100 calcium binding protein A10 0.0228104
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0227801
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0224982
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.0224547
VIM vimentin 0.0224477
RPL34 ribosomal protein L34 0.0224252
PDIA6 protein disulfide isomerase family A, member 6 0.0221253
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0219067
RPL18 ribosomal protein L18 0.0216046
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0215462
IRF7 interferon regulatory factor 7 0.0214701
HLA-A major histocompatibility complex, class I, A 0.021429
COX7C cytochrome c oxidase subunit VIIc 0.0210208
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0209876
RPS10 ribosomal protein S10 0.020857
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0206576
SACK1A scaffolding CK1 anchoring protein A 0.0202903
PLAU plasminogen activator, urokinase 0.0197055

decreased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 -0.114574
FNDC3B fibronectin type III domain containing 3B -0.112895
FN1 fibronectin 1 -0.11188
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.111447
LPP LIM domain containing preferred translocation partner in lipoma -0.103025
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0913787
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0863511
SAMD4A sterile alpha motif domain containing 4A -0.0821071
EFNA5 ephrin-A5 -0.0753782
TRIO trio Rho guanine nucleotide exchange factor -0.0733516
ERBIN erbb2 interacting protein -0.0716338
LIMCH1 LIM and calponin homology domains 1 -0.0687964
MYO6 myosin VI -0.0634245
GOLGA4 golgin A4 -0.0557752
SEC31A SEC31 homolog A (S. cerevisiae) -0.0540418
PDLIM5 PDZ and LIM domain 5 -0.0537767
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0516589
AHNAK AHNAK nucleoprotein -0.0515316
VCL vinculin -0.051454
RCOR1 REST corepressor 1 -0.0495776
CANX calnexin -0.0487921
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0479416
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0476133
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0474786
ARID4B AT rich interactive domain 4B (RBP1-like) -0.047421
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0453361
FNIP1 folliculin interacting protein 1 -0.0449499
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0443737
UBE2H ubiquitin-conjugating enzyme E2H -0.0426137
STRN3 striatin, calmodulin binding protein 3 -0.0425192
ZFAND3 zinc finger, AN1-type domain 3 -0.041656
SLC38A1 solute carrier family 38, member 1 -0.0415857
NF1 neurofibromin 1 -0.0412047
ALCAM activated leukocyte cell adhesion molecule -0.0407013
CD2AP CD2-associated protein -0.0405617
DSCAM Down syndrome cell adhesion molecule -0.0405451
FBXO32 F-box protein 32 -0.0400925
AKAP13 A kinase (PRKA) anchor protein 13 -0.0396887
CLTC clathrin, heavy chain (Hc) -0.0394112
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0382132
NIPBL Nipped-B homolog (Drosophila) -0.0382122
OGA O-GlcNAcase -0.0378276
PTK2 protein tyrosine kinase 2 -0.0377574
RAB1A RAB1A, member RAS oncogene family -0.0372866
FBXO34 F-box protein 34 -0.0369864
TTC3 tetratricopeptide repeat domain 3 -0.0368518
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0365073
ZNF292 zinc finger protein 292 -0.0354886
NPEPPS aminopeptidase puromycin sensitive -0.0353559
TXNRD1 thioredoxin reductase 1 -0.0353454
TNPO1 transportin 1 -0.0350006
NUMB numb homolog (Drosophila) -0.0345106
AFF1 AF4/FMR2 family, member 1 -0.0343865
KDM3A lysine (K)-specific demethylase 3A -0.0341965
MYO1E myosin IE -0.0341773
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0338456
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.033638
DTNA dystrobrevin, alpha -0.0334967
ARHGAP5 Rho GTPase activating protein 5 -0.0327275
BIRC6 baculoviral IAP repeat containing 6 -0.032674
RBM39 RNA binding motif protein 39 -0.0326678
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0326561
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0326474
KDM6A lysine (K)-specific demethylase 6A -0.0325936
UBAP1 ubiquitin associated protein 1 -0.0324828
OCLN occludin -0.0323606
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0322325
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0320993
COPA coatomer protein complex, subunit alpha -0.0319705
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0319245
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0318635
ANKRD17 ankyrin repeat domain 17 -0.0318282
KMT2C lysine (K)-specific methyltransferase 2C -0.0318234
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0318073
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0317798
COPB1 coatomer protein complex, subunit beta 1 -0.031748
ACBD3 acyl-CoA binding domain containing 3 -0.0314345
CDK13 cyclin-dependent kinase 13 -0.0313459
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0312193
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0311902
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0310729
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0308426
VMP1 vacuole membrane protein 1 -0.0307597
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0306019
ITCH itchy E3 ubiquitin protein ligase -0.0304362
MON2 MON2 homolog (S. cerevisiae) -0.0300882
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0300445
GSK3B glycogen synthase kinase 3 beta -0.0299046
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0298874
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0297752
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0295876
ARHGAP20 Rho GTPase activating protein 20 -0.0295146
HELZ helicase with zinc finger -0.0294566
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0294428
ZNF148 zinc finger protein 148 -0.0294302
PICALM phosphatidylinositol binding clathrin assembly protein -0.0291929
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0290661
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0287732
LMO7 LIM domain 7 -0.0286449
MARCHF6 membrane associated ring-CH-type finger 6 -0.0285493