Piroxicam_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.20186
MYH9 myosin, heavy chain 9, non-muscle 0.193816
EEF2 eukaryotic translation elongation factor 2 0.151984
CD44 CD44 molecule (Indian blood group) 0.110687
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0899702
LDHA lactate dehydrogenase A 0.0873741
COL6A3 collagen, type VI, alpha 3 0.0842289
RPS3 ribosomal protein S3 0.0784782
SFTPA2 surfactant protein A2 0.0709077
ZMIZ1 zinc finger, MIZ-type containing 1 0.0642365
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0600512
AKAP12 A kinase (PRKA) anchor protein 12 0.0572452
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0567122
HLA-B major histocompatibility complex, class I, B 0.0553021
FN1 fibronectin 1 0.053075
COL5A1 collagen, type V, alpha 1 0.0514078
APP amyloid beta (A4) precursor protein 0.0497191
HLA-A major histocompatibility complex, class I, A 0.0496266
PDE10A phosphodiesterase 10A 0.0476932
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0462728
CALR calreticulin 0.0458242
FLNA filamin A, alpha 0.0452121
RPS27A ribosomal protein S27a 0.0451282
ENO1 enolase 1, (alpha) 0.0416764
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0408507
RPL23 ribosomal protein L23 0.0407186
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0403544
RPL26 ribosomal protein L26 0.0401335
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0398133
RPS12 ribosomal protein S12 0.039476
SMAD3 SMAD family member 3 0.0394233
MLPH melanophilin 0.0393723
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0391135
TMSB10 thymosin beta 10 0.039104
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.039044
IER3 immediate early response 3 0.0374543
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0359021
TMSB4X thymosin beta 4, X-linked 0.0347541
RAB7A RAB7A, member RAS oncogene family 0.0347159
RACK1 receptor for activated C kinase 1 0.0343375
HSPA8 heat shock 70kDa protein 8 0.0342912
HLA-C major histocompatibility complex, class I, C 0.0342081
MKI67 marker of proliferation Ki-67 0.0338707
RPL37A ribosomal protein L37a 0.0338642
VCAN versican 0.0332338
OPTN optineurin 0.0327875
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0327564
SQSTM1 sequestosome 1 0.0324882
WTAP Wilms tumor 1 associated protein 0.0323895
RPS4X ribosomal protein S4, X-linked 0.0322472
BHLHE40 basic helix-loop-helix family, member e40 0.0321739
MACF1 microtubule-actin crosslinking factor 1 0.0321564
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0306343
THBS2 thrombospondin 2 0.0301667
COL4A2 collagen, type IV, alpha 2 0.029755
SET SET nuclear proto-oncogene 0.0293965
EIF4H eukaryotic translation initiation factor 4H 0.0285289
RPS18 ribosomal protein S18 0.0283365
C3 complement component 3 0.0281488
KDM3A lysine (K)-specific demethylase 3A 0.0280961
HDLBP high density lipoprotein binding protein 0.027897
CDH13 cadherin 13 0.0278462
RPLP2 ribosomal protein, large, P2 0.0275182
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0272387
CTSB cathepsin B 0.0268672
GADD45B growth arrest and DNA-damage-inducible, beta 0.025993
FRMPD4 FERM and PDZ domain containing 4 0.0259683
AFDN afadin, adherens junction formation factor 0.0259265
FAM20C family with sequence similarity 20, member C 0.0257062
ICAM1 intercellular adhesion molecule 1 0.0256145
EEF1G eukaryotic translation elongation factor 1 gamma 0.0250544
ACTN1 actinin, alpha 1 0.0249423
RPL3 ribosomal protein L3 0.0246307
ARRDC3 arrestin domain containing 3 0.0243712
B2M beta-2-microglobulin 0.024059
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0240393
RPS2 ribosomal protein S2 0.0239004
RPL13A ribosomal protein L13a 0.0238093
UBAP2L ubiquitin associated protein 2-like 0.0234991
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0233489
NACA nascent polypeptide-associated complex alpha subunit 0.0232795
PGK1 phosphoglycerate kinase 1 0.0231483
DST dystonin 0.0231454
RPS8 ribosomal protein S8 0.022801
ZFAND3 zinc finger, AN1-type domain 3 0.0223896
DDIT4 DNA-damage-inducible transcript 4 0.0222927
AHNAK AHNAK nucleoprotein 0.0222166
PDIA6 protein disulfide isomerase family A, member 6 0.022062
CD70 CD70 molecule 0.0216951
PTMA prothymosin, alpha 0.0214581
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0213399
RPS10 ribosomal protein S10 0.0212157
CUL4B cullin 4B 0.0211034
PHF3 PHD finger protein 3 0.0210118
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0209715
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0207033
AHDC1 AT hook, DNA binding motif, containing 1 0.0206537
NRN1 neuritin 1 0.0206035
RPL11 ribosomal protein L11 0.0205103
IGFBP3 insulin-like growth factor binding protein 3 0.0204504

decreased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial -0.100138
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0762327
JMJD1C jumonji domain containing 1C -0.0606237
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0519341
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0480742
NDRG1 N-myc downstream regulated 1 -0.0460312
TAPBP TAP binding protein (tapasin) -0.0435347
TENT5A terminal nucleotidyltransferase 5A -0.0417803
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0378586
BICC1 BicC family RNA binding protein 1 -0.037844
RTN4 reticulon 4 -0.0365271
EGR1 early growth response 1 -0.035598
TXNIP thioredoxin interacting protein -0.0340571
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0330896
FNDC3B fibronectin type III domain containing 3B -0.0328915
CCNL1 cyclin L1 -0.0320581
VCL vinculin -0.031027
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0300594
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0298041
SBF2 SET binding factor 2 -0.0286688
EXT1 exostosin glycosyltransferase 1 -0.0285271
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0283185
PDIA3 protein disulfide isomerase family A, member 3 -0.0276493
TSC22D2 TSC22 domain family, member 2 -0.0270014
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.027001
DLG1 discs, large homolog 1 (Drosophila) -0.0268111
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0265093
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0262184
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0252418
RPS24 ribosomal protein S24 -0.0250692
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0249923
UBE2H ubiquitin-conjugating enzyme E2H -0.0244004
VMP1 vacuole membrane protein 1 -0.0243242
MAGT1 magnesium transporter 1 -0.0242077
NPEPPS aminopeptidase puromycin sensitive -0.024107
ZNFX1 zinc finger, NFX1-type containing 1 -0.0239111
WASF2 WAS protein family, member 2 -0.0237513
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0226595
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0226141
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0225283
ERBIN erbb2 interacting protein -0.0224903
AVL9 AVL9 homolog (S. cerevisiase) -0.0222523
WDR45B WD repeat domain 45B -0.0221807
ZMYND8 zinc finger, MYND-type containing 8 -0.021823
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.021711
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0213757
BTG1 B-cell translocation gene 1, anti-proliferative -0.0213346
SETD5 SET domain containing 5 -0.0211013
RPL35A ribosomal protein L35a -0.021069
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0210639
NKTR natural killer cell triggering receptor -0.0209029
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.020738
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -0.0203873
TMEM41B transmembrane protein 41B -0.0203143
CDCP1 CUB domain containing protein 1 -0.020298
CTSD cathepsin D -0.0200962
MX1 MX dynamin-like GTPase 1 -0.0200903
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0198779
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0198654
FRMD5 FERM domain containing 5 -0.0198184
SCFD1 sec1 family domain containing 1 -0.0197719
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0196522
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0195395
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0194131
ARF4 ADP-ribosylation factor 4 -0.0194059
TXNRD1 thioredoxin reductase 1 -0.0192172
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.019141
BIRC6 baculoviral IAP repeat containing 6 -0.0191327
USP34 ubiquitin specific peptidase 34 -0.0189943
PHIP pleckstrin homology domain interacting protein -0.018991
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0187152
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0185255
PTBP3 polypyrimidine tract binding protein 3 -0.0185136
KTN1 kinectin 1 (kinesin receptor) -0.0183896
CLIC4 chloride intracellular channel 4 -0.0183496
ANKRD12 ankyrin repeat domain 12 -0.0183372
DIAPH3 diaphanous-related formin 3 -0.0182409
GRN granulin -0.0179583
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0179544
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0179337
RAB1A RAB1A, member RAS oncogene family -0.0177516
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0177444
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0177209
AKAP9 A kinase (PRKA) anchor protein 9 -0.0176845
ESYT2 extended synaptotagmin-like protein 2 -0.0176734
ECPAS Ecm29 proteasome adaptor and scaffold -0.0175543
CD2AP CD2-associated protein -0.017505
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0173834
NAMPT nicotinamide phosphoribosyltransferase -0.0173395
IFI16 interferon, gamma-inducible protein 16 -0.0172933
RAP1B RAP1B, member of RAS oncogene family -0.0170865
CALD1 caldesmon 1 -0.0170702
CDK19 cyclin-dependent kinase 19 -0.0169712
KYNU kynureninase -0.0169101
NBEAL1 neurobeachin-like 1 -0.0167578
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0167226
KDM2A lysine (K)-specific demethylase 2A -0.0166804
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0166716
LCOR ligand dependent nuclear receptor corepressor -0.0166674
CD46 CD46 molecule, complement regulatory protein -0.0165923