Piroxicam_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Piroxicam perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Piroxicam_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.181557
NRG1 neuregulin 1 0.180541
HMGA2 high mobility group AT-hook 2 0.114839
ITGA1 integrin, alpha 1 0.0919086
HLA-B major histocompatibility complex, class I, B 0.0881622
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0878886
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0848739
MT2A metallothionein 2A 0.0845455
PTMA prothymosin, alpha 0.0827427
NAMPT nicotinamide phosphoribosyltransferase 0.070102
EFNA5 ephrin-A5 0.0689148
FTL ferritin, light polypeptide 0.067606
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0645634
FTH1 ferritin, heavy polypeptide 1 0.0632431
VEGFA vascular endothelial growth factor A 0.0631377
GLIS3 GLIS family zinc finger 3 0.0630143
TMSB10 thymosin beta 10 0.0629139
HIPK2 homeodomain interacting protein kinase 2 0.0607535
PLIN2 perilipin 2 0.059663
ASPH aspartate beta-hydroxylase 0.0535923
STC2 stanniocalcin 2 0.0506828
TRIO trio Rho guanine nucleotide exchange factor 0.0503698
IFI27 interferon, alpha-inducible protein 27 0.0485272
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.047408
MKI67 marker of proliferation Ki-67 0.0440449
RACK1 receptor for activated C kinase 1 0.0431151
NRIP1 nuclear receptor interacting protein 1 0.0425754
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0425032
RPL37A ribosomal protein L37a 0.0421269
PRELID2 PRELI domain containing 2 0.0420931
DST dystonin 0.0419349
ZFP36L1 ZFP36 ring finger protein-like 1 0.0410473
SOX4 SRY (sex determining region Y)-box 4 0.0407023
AKAP12 A kinase (PRKA) anchor protein 12 0.0406138
SQSTM1 sequestosome 1 0.0405438
TNS3 tensin 3 0.0393222
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0382313
RPS3 ribosomal protein S3 0.0379772
TPT1 tumor protein, translationally-controlled 1 0.0378184
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0367605
IFI16 interferon, gamma-inducible protein 16 0.0367363
ETV6 ets variant 6 0.0364502
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0364346
LRMDA leucine rich melanocyte differentiation associated 0.0355745
S100A6 S100 calcium binding protein A6 0.0353982
S100A10 S100 calcium binding protein A10 0.0352772
RUNX2 runt-related transcription factor 2 0.0349942
RPS12 ribosomal protein S12 0.034941
H1-0 H1.0 linker histone 0.0346333
OSMR oncostatin M receptor 0.0346141
MAML2 mastermind-like 2 (Drosophila) 0.0344843
CST3 cystatin C 0.0343821
AHNAK2 AHNAK nucleoprotein 2 0.0343675
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0332773
RPL26 ribosomal protein L26 0.0331866
B2M beta-2-microglobulin 0.0331174
RPL38 ribosomal protein L38 0.0330277
LOXL2 lysyl oxidase-like 2 0.0330186
GRB10 growth factor receptor-bound protein 10 0.0329751
RAI14 retinoic acid induced 14 0.0320693
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0317281
RPL9 ribosomal protein L9 0.0315817
FAM13A family with sequence similarity 13, member A 0.0312479
ZMIZ1 zinc finger, MIZ-type containing 1 0.0311108
HPCAL1 hippocalcin-like 1 0.0308264
RAD51B RAD51 paralog B 0.0307018
RPL31 ribosomal protein L31 0.0304415
IER3 immediate early response 3 0.0300984
GLUL glutamate-ammonia ligase 0.0300949
CAPN2 calpain 2, (m/II) large subunit 0.0298626
RPS27 ribosomal protein S27 0.0295741
RPLP1 ribosomal protein, large, P1 0.0292484
RNF213 ring finger protein 213 0.0290505
RPL36 ribosomal protein L36 0.0290373
ZMYND8 zinc finger, MYND-type containing 8 0.0283903
LIMCH1 LIM and calponin homology domains 1 0.0277436
TPI1 triosephosphate isomerase 1 0.027214
PDE4D phosphodiesterase 4D, cAMP-specific 0.0266623
SSH1 slingshot protein phosphatase 1 0.025694
MACF1 microtubule-actin crosslinking factor 1 0.0256766
EGFR epidermal growth factor receptor 0.0256671
FAM20C family with sequence similarity 20, member C 0.0255892
RPL23 ribosomal protein L23 0.0254455
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.025339
FHIT fragile histidine triad 0.0250275
ZBTB20 zinc finger and BTB domain containing 20 0.0247892
TMEM156 transmembrane protein 156 0.0246599
LRP5 low density lipoprotein receptor-related protein 5 0.0244968
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.024443
RPS19 ribosomal protein S19 0.0237762
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0235737
RPL12 ribosomal protein L12 0.0235037
ENO1 enolase 1, (alpha) 0.0234866
IL6 interleukin 6 0.0234594
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.023222
RPS27A ribosomal protein S27a 0.0231741
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0231363
TAS2R14 taste receptor, type 2, member 14 0.0230186
RPS8 ribosomal protein S8 0.0229332
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0227074

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.165887
CANX calnexin -0.0774024
GOLGA4 golgin A4 -0.0597803
SUCO SUN domain containing ossification factor -0.057295
TM9SF3 transmembrane 9 superfamily member 3 -0.0564406
VMP1 vacuole membrane protein 1 -0.0545741
BIRC6 baculoviral IAP repeat containing 6 -0.0544736
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0539649
NUP58 nucleoporin 58 -0.0495278
COPA coatomer protein complex, subunit alpha -0.0492322
ETNK1 ethanolamine kinase 1 -0.045797
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0453889
COG5 component of oligomeric golgi complex 5 -0.0440865
NOP58 NOP58 ribonucleoprotein -0.0423646
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.041877
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0418687
SPAG9 sperm associated antigen 9 -0.041787
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0411626
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0402727
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0401994
TFG TRK-fused gene -0.0390461
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0388564
WAC WW domain containing adaptor with coiled-coil -0.0382096
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0380866
ACBD3 acyl-CoA binding domain containing 3 -0.0377812
ZC3H11A zinc finger CCCH-type containing 11A -0.0374921
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0371564
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.037072
SOD2 superoxide dismutase 2, mitochondrial -0.0370298
SEC23A Sec23 homolog A (S. cerevisiae) -0.0369009
VCL vinculin -0.0367638
RBM39 RNA binding motif protein 39 -0.0367618
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0360897
HELZ helicase with zinc finger -0.0359029
UBE2K ubiquitin-conjugating enzyme E2K -0.0359027
PUM2 pumilio RNA-binding family member 2 -0.0352737
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0350656
USP3 ubiquitin specific peptidase 3 -0.0347882
WDR43 WD repeat domain 43 -0.0342375
RNF145 ring finger protein 145 -0.0342096
TRA2A transformer 2 alpha homolog (Drosophila) -0.0339444
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0339346
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0336824
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0333444
RAB1A RAB1A, member RAS oncogene family -0.0333178
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0329764
CLINT1 clathrin interactor 1 -0.0328563
NDRG1 N-myc downstream regulated 1 -0.032828
ZFAND3 zinc finger, AN1-type domain 3 -0.031867
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.031529
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0314869
STRN3 striatin, calmodulin binding protein 3 -0.030913
WDR45B WD repeat domain 45B -0.0304359
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0302549
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0300092
ANXA5 annexin A5 -0.0299018
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0297995
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0296091
FOXO3 forkhead box O3 -0.0296056
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0294895
SEC31A SEC31 homolog A (S. cerevisiae) -0.0294843
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0290614
CUL3 cullin 3 -0.0290556
NDEL1 nudE neurodevelopment protein 1-like 1 -0.0287987
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0287347
PNPLA8 patatin-like phospholipase domain containing 8 -0.0285418
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.028354
AKAP9 A kinase (PRKA) anchor protein 9 -0.0282461
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0282212
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0279542
KMT2E lysine (K)-specific methyltransferase 2E -0.0278841
ADAM17 ADAM metallopeptidase domain 17 -0.027867
DUSP5 dual specificity phosphatase 5 -0.0273353
SAR1A secretion associated, Ras related GTPase 1A -0.0272634
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0271461
KDM2A lysine (K)-specific demethylase 2A -0.027129
PICALM phosphatidylinositol binding clathrin assembly protein -0.0270909
LCORL ligand dependent nuclear receptor corepressor-like -0.0270587
SEC24A SEC24 family member A -0.0268223
FNDC3A fibronectin type III domain containing 3A -0.0265701
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0265659
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0263947
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0263904
CDC73 cell division cycle 73 -0.0262975
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0262076
TENT2 terminal nucleotidyltransferase 2 -0.025838
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0257563
ZMYM2 zinc finger, MYM-type 2 -0.0256776
RAB6A RAB6A, member RAS oncogene family -0.0254257
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0254251
EWSR1 EWS RNA-binding protein 1 -0.0254041
TTC3 tetratricopeptide repeat domain 3 -0.0254012
PCBP2 poly(rC) binding protein 2 -0.0253948
GLG1 golgi glycoprotein 1 -0.0253585
NUMB numb homolog (Drosophila) -0.025291
CCNL1 cyclin L1 -0.025103
ARF4 ADP-ribosylation factor 4 -0.0250549
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0250235
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0249824
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0249626