Pitavastatin (Calcium)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.212469
DST dystonin 0.105198
CREB5 cAMP responsive element binding protein 5 0.10026
HDAC9 histone deacetylase 9 0.0996065
AUTS2 autism susceptibility candidate 2 0.0985928
PTMA prothymosin, alpha 0.0926179
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0910596
HSPB1 heat shock 27kDa protein 1 0.0858771
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0778775
SORBS2 sorbin and SH3 domain containing 2 0.0776771
TMSB10 thymosin beta 10 0.0755169
KLF6 Kruppel-like factor 6 0.0707552
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0673153
SPAG9 sperm associated antigen 9 0.0660487
LMNA lamin A/C 0.065301
TRIO trio Rho guanine nucleotide exchange factor 0.0630685
EZR ezrin 0.0619822
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0611437
CSTB cystatin B (stefin B) 0.0527727
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0523408
MYH9 myosin, heavy chain 9, non-muscle 0.0502587
RHOB ras homolog family member B 0.0497339
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0495346
NDRG1 N-myc downstream regulated 1 0.0484972
MEF2A myocyte enhancer factor 2A 0.0463225
ANKRD11 ankyrin repeat domain 11 0.0451172
ANXA1 annexin A1 0.0448214
TMOD1 tropomodulin 1 0.044559
GRB10 growth factor receptor-bound protein 10 0.0437671
KLF7 Kruppel-like factor 7 (ubiquitous) 0.04373
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0432586
AHNAK AHNAK nucleoprotein 0.0420611
MAP4 microtubule-associated protein 4 0.0418777
FBN1 fibrillin 1 0.0417983
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0416235
ATXN1 ataxin 1 0.0411604
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0406554
DLG1 discs, large homolog 1 (Drosophila) 0.0394355
MAP1B microtubule-associated protein 1B 0.0393457
APP amyloid beta (A4) precursor protein 0.0389998
ABI1 abl-interactor 1 0.0385741
TNIP1 TNFAIP3 interacting protein 1 0.0384149
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0380468
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0372539
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0369904
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0369815
RHOA ras homolog family member A 0.0359778
MSI2 musashi RNA-binding protein 2 0.0356478
PSD3 pleckstrin and Sec7 domain containing 3 0.0352774
UBE2H ubiquitin-conjugating enzyme E2H 0.0347257
DENND5A DENN/MADD domain containing 5A 0.0345235
TMSB4X thymosin beta 4, X-linked 0.0343123
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0341648
STC1 stanniocalcin 1 0.0335408
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.033221
IQGAP1 IQ motif containing GTPase activating protein 1 0.0331747
MSN moesin 0.0329638
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0327439
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0324207
CD109 CD109 molecule 0.0318879
FMNL2 formin-like 2 0.0318141
CLIC4 chloride intracellular channel 4 0.0315714
FLNB filamin B, beta 0.0315683
CYLD cylindromatosis (turban tumor syndrome) 0.0312103
SPIRE1 spire-type actin nucleation factor 1 0.0305065
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0304951
EIF1 eukaryotic translation initiation factor 1 0.0303657
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0303087
MXI1 MAX interactor 1, dimerization protein 0.0302667
ARL15 ADP-ribosylation factor-like 15 0.029959
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0299441
TIMP3 TIMP metallopeptidase inhibitor 3 0.0297201
KDM3A lysine (K)-specific demethylase 3A 0.0296735
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0296297
APAF1 apoptotic peptidase activating factor 1 0.029117
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0289025
OPTN optineurin 0.0284867
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.027884
GARS1 glycyl-tRNA synthetase 1 0.0276737
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0276387
S100A6 S100 calcium binding protein A6 0.027329
PLEC plectin 0.0272666
SDK1 sidekick cell adhesion molecule 1 0.0271816
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0268435
S100A10 S100 calcium binding protein A10 0.026827
ZMIZ1 zinc finger, MIZ-type containing 1 0.0266703
OXSR1 oxidative stress responsive 1 0.0263171
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0261555
LDHA lactate dehydrogenase A 0.0258738
ANXA2 annexin A2 0.0258177
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0256958
CCNY cyclin Y 0.0255477
ESYT2 extended synaptotagmin-like protein 2 0.025422
KALRN kalirin, RhoGEF kinase 0.0252225
RABGAP1L RAB GTPase activating protein 1-like 0.0247137
SQSTM1 sequestosome 1 0.0245257
FAM107B family with sequence similarity 107, member B 0.0244977
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.024332
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0242636
PRRC2C proline-rich coiled-coil 2C 0.0241164

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.189903
IGFBP3 insulin-like growth factor binding protein 3 -0.150648
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.136856
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.134606
LOX lysyl oxidase -0.130945
PODXL podocalyxin-like -0.118092
COL8A1 collagen, type VIII, alpha 1 -0.112859
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.098765
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0877258
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.070147
POTEF POTE ankyrin domain family, member F -0.0690751
CDH13 cadherin 13 -0.0678779
EGFR epidermal growth factor receptor -0.0617361
SUCNR1 succinate receptor 1 -0.0595781
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0572746
RUNX1 runt-related transcription factor 1 -0.0567881
EFNA5 ephrin-A5 -0.0542752
DCLK2 doublecortin-like kinase 2 -0.0536854
MX2 MX dynamin-like GTPase 2 -0.0529939
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0490419
GLIS3 GLIS family zinc finger 3 -0.0462296
MEIS2 Meis homeobox 2 -0.0446409
COL5A2 collagen, type V, alpha 2 -0.0425533
FRMD4A FERM domain containing 4A -0.0414966
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0410744
NAV1 neuron navigator 1 -0.0397724
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0392118
CD44 CD44 molecule (Indian blood group) -0.0388614
TPM1 tropomyosin 1 (alpha) -0.0379122
SMYD3 SET and MYND domain containing 3 -0.0370747
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0355131
PBX3 pre-B-cell leukemia homeobox 3 -0.0354282
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0346771
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.03436
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0337471
CDK6 cyclin-dependent kinase 6 -0.0332658
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0331814
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0307248
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0303753
COL5A1 collagen, type V, alpha 1 -0.0302754
FTH1 ferritin, heavy polypeptide 1 -0.0301293
MRPS6 mitochondrial ribosomal protein S6 -0.0299843
ANTXR1 anthrax toxin receptor 1 -0.0295893
AFF3 AF4/FMR2 family, member 3 -0.0287581
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0285489
CCND1 cyclin D1 -0.0285474
EHBP1 EH domain binding protein 1 -0.0284406
MYADM myeloid-associated differentiation marker -0.0281846
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.028127
VIM vimentin -0.028099
TAPBP TAP binding protein (tapasin) -0.0268814
TENM3 teneurin transmembrane protein 3 -0.0263245
TNS3 tensin 3 -0.0261256
SP3 Sp3 transcription factor -0.0256462
DOCK5 dedicator of cytokinesis 5 -0.025616
TIMP2 TIMP metallopeptidase inhibitor 2 -0.025306
COL1A2 collagen, type I, alpha 2 -0.0248218
IFI16 interferon, gamma-inducible protein 16 -0.0245912
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0244957
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0243845
PRELID2 PRELI domain containing 2 -0.0238511
DGKG diacylglycerol kinase, gamma 90kDa -0.023149
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0229227
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0227694
TENT5A terminal nucleotidyltransferase 5A -0.0226394
RIGI RNA sensor RIG-I -0.022578
PDE4D phosphodiesterase 4D, cAMP-specific -0.0224703
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0222933
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0221913
ZNF217 zinc finger protein 217 -0.0220856
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0220483
IFI44 interferon-induced protein 44 -0.0218448
MBNL2 muscleblind-like splicing regulator 2 -0.0216577
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0212754
NRP1 neuropilin 1 -0.0208484
SPDL1 spindle apparatus coiled-coil protein 1 -0.020806
ASPH aspartate beta-hydroxylase -0.0207454
PLSCR1 phospholipid scramblase 1 -0.0206327
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0203923
WWTR1 WW domain containing transcription regulator 1 -0.020353
MBNL1 muscleblind-like splicing regulator 1 -0.0202712
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0201302
TOX thymocyte selection-associated high mobility group box -0.020038
AKAP9 A kinase (PRKA) anchor protein 9 -0.0198358
CUX1 cut-like homeobox 1 -0.0196927
BPTF bromodomain PHD finger transcription factor -0.0195057
LOC112694756 uncharaterized LOC112694756 -0.0188481
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0188136
AGRN agrin -0.0186879
MYOF myoferlin -0.0185064
CHD9 chromodomain helicase DNA binding protein 9 -0.0184786
SEPTIN11 septin 11 -0.0184362
MBD5 methyl-CpG binding domain protein 5 -0.0180529
CEP170 centrosomal protein 170kDa -0.018001
MAML2 mastermind-like 2 (Drosophila) -0.017942
VEGFC vascular endothelial growth factor C -0.0177296
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.017647
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0175861
NEK7 NIMA-related kinase 7 -0.0175814
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0175478