Pitavastatin (Calcium)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0886816
NAMPT nicotinamide phosphoribosyltransferase 0.0400775
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0399225
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0380978
CREB5 cAMP responsive element binding protein 5 0.0334754
KYNU kynureninase 0.0319116
NRIP1 nuclear receptor interacting protein 1 0.0298962
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.026618
PCBP3 poly(rC) binding protein 3 0.024683
KLF6 Kruppel-like factor 6 0.0244693
SP3 Sp3 transcription factor 0.0230683
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0226134
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0224207
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0218626
SMAD3 SMAD family member 3 0.021801
DSCAM Down syndrome cell adhesion molecule 0.0216362
RIPK2 receptor-interacting serine-threonine kinase 2 0.0209554
TSHZ2 teashirt zinc finger homeobox 2 0.0208135
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0206036
APP amyloid beta (A4) precursor protein 0.0205784
NFE2L2 nuclear factor, erythroid 2-like 2 0.0204915
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0198969
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0194782
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0193401
ASPH aspartate beta-hydroxylase 0.0188064
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0187878
HSPA8 heat shock 70kDa protein 8 0.0187627
GDA guanine deaminase 0.0185015
ANXA1 annexin A1 0.0183188
ARHGAP26 Rho GTPase activating protein 26 0.0182842
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0180036
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0178487
AGFG1 ArfGAP with FG repeats 1 0.0177577
PDE4D phosphodiesterase 4D, cAMP-specific 0.0173954
LHFPL2 lipoma HMGIC fusion partner-like 2 0.017302
MTAP methylthioadenosine phosphorylase 0.0169255
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.0167574
CFLAR CASP8 and FADD-like apoptosis regulator 0.0165077
SOD2 superoxide dismutase 2, mitochondrial 0.0162476
KDM3A lysine (K)-specific demethylase 3A 0.0160238
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0160206
ARRDC3 arrestin domain containing 3 0.0159438
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0157723
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0150506
PLEC plectin 0.0145923
RPL3 ribosomal protein L3 0.014561
ATXN1 ataxin 1 0.0144145
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0143541
USP12 ubiquitin specific peptidase 12 0.0141578
PSD3 pleckstrin and Sec7 domain containing 3 0.0140544
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0139596
NRP2 neuropilin 2 0.0136205
CDK14 cyclin-dependent kinase 14 0.0134587
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0128794
DAPK1 death-associated protein kinase 1 0.0128415
EZR ezrin 0.0125787
RALB v-ral simian leukemia viral oncogene homolog B 0.0125486
SLFN5 schlafen family member 5 0.0123572
IGF2R insulin-like growth factor 2 receptor 0.0122284
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0120934
CLDN12 claudin 12 0.0119005
FNDC3B fibronectin type III domain containing 3B 0.0118382
ANKRD10 ankyrin repeat domain 10 0.0118019
DENND2B DENN domain containing 2B 0.0115928
SEPTIN9 septin 9 0.0115009
OSBPL3 oxysterol binding protein-like 3 0.0114419
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0111278
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0109683
AHNAK AHNAK nucleoprotein 0.0108829
HMGB2 high mobility group box 2 0.0108089
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0107916
TNIP1 TNFAIP3 interacting protein 1 0.0107706
GOLGA3 golgin A3 0.0107061
RPS15A ribosomal protein S15a 0.0106411
ETV6 ets variant 6 0.0105532
NCAM1 neural cell adhesion molecule 1 0.0103672
IQGAP3 IQ motif containing GTPase activating protein 3 0.0102425
ABTB3 ankyrin repeat and BTB domain containing 3 0.0102198
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0101482
CPAP centrosome assembly and centriole elongation protein 0.0100773
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0100729
LIF leukemia inhibitory factor 0.00988285
CYTH1 cytohesin 1 0.00987135
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.00985759
TNS1 tensin 1 0.00975249
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00974306
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.00962244
RHOB ras homolog family member B 0.00952947
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00952664
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00947297
DOCK5 dedicator of cytokinesis 5 0.00926585
FAM20C family with sequence similarity 20, member C 0.00921961
MACF1 microtubule-actin crosslinking factor 1 0.00918766
BIRC3 baculoviral IAP repeat containing 3 0.00911375
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.009064
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0090344
KIF16B kinesin family member 16B 0.00899293
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.0089904
PARP4 poly (ADP-ribose) polymerase family, member 4 0.00897491
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0088359

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.249661
FRMD4A FERM domain containing 4A -0.186109
VIM vimentin -0.149013
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.127448
GPC6 glypican 6 -0.0968798
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0787353
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0755859
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0752337
FTL ferritin, light polypeptide -0.0671947
ZCCHC7 zinc finger, CCHC domain containing 7 -0.066144
NDRG1 N-myc downstream regulated 1 -0.0660033
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0654824
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0636707
B2M beta-2-microglobulin -0.0623465
POTEF POTE ankyrin domain family, member F -0.0619313
PFN1 profilin 1 -0.0597443
RPS6 ribosomal protein S6 -0.0556842
HLA-B major histocompatibility complex, class I, B -0.0554127
TMSB10 thymosin beta 10 -0.0503267
CTSD cathepsin D -0.0473133
TRAM1 translocation associated membrane protein 1 -0.044823
RND3 Rho family GTPase 3 -0.0439993
MAP1B microtubule-associated protein 1B -0.0419702
MTDH metadherin -0.0411934
GLS2 glutaminase 2 (liver, mitochondrial) -0.0397133
LITAF lipopolysaccharide-induced TNF factor -0.039108
GARS1 glycyl-tRNA synthetase 1 -0.0384589
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0382588
DSTN destrin (actin depolymerizing factor) -0.0378923
PTBP3 polypyrimidine tract binding protein 3 -0.0374811
NOP58 NOP58 ribonucleoprotein -0.037335
TPM1 tropomyosin 1 (alpha) -0.0373094
PRRC2C proline-rich coiled-coil 2C -0.0365651
TPM4 tropomyosin 4 -0.0364587
GDF15 growth differentiation factor 15 -0.0361276
PLK2 polo-like kinase 2 -0.0356301
CALR calreticulin -0.0354709
UBA6 ubiquitin-like modifier activating enzyme 6 -0.035177
HSPB1 heat shock 27kDa protein 1 -0.035177
MYADM myeloid-associated differentiation marker -0.0347536
ACBD3 acyl-CoA binding domain containing 3 -0.0347211
FTH1 ferritin, heavy polypeptide 1 -0.0344342
RTN4 reticulon 4 -0.0339433
ACTG1 actin gamma 1 -0.0337796
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0332224
CALD1 caldesmon 1 -0.0331484
PDIA3 protein disulfide isomerase family A, member 3 -0.0326524
UBC ubiquitin C -0.0321946
UGCG UDP-glucose ceramide glucosyltransferase -0.0321311
RAB1A RAB1A, member RAS oncogene family -0.0315972
ADAM9 ADAM metallopeptidase domain 9 -0.0315377
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0313265
IARS1 isoleucyl-tRNA synthetase 1 -0.0308061
CALU calumenin -0.0303442
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0302495
RPL35A ribosomal protein L35a -0.0299666
TFPI2 tissue factor pathway inhibitor 2 -0.0299396
MT2A metallothionein 2A -0.0295285
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0287887
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0282497
PDIA6 protein disulfide isomerase family A, member 6 -0.0276849
FUS FUS RNA binding protein -0.0274708
RPL28 ribosomal protein L28 -0.0271619
KPNB1 karyopherin (importin) beta 1 -0.0266207
ADAM10 ADAM metallopeptidase domain 10 -0.0263471
MRPS6 mitochondrial ribosomal protein S6 -0.0261662
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0260732
WDR43 WD repeat domain 43 -0.0260469
GOLGA4 golgin A4 -0.0258673
VEGFA vascular endothelial growth factor A -0.0256064
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0255793
ICAM1 intercellular adhesion molecule 1 -0.0255075
EIF5B eukaryotic translation initiation factor 5B -0.0253194
SRPK2 SRSF protein kinase 2 -0.0252162
RAB7A RAB7A, member RAS oncogene family -0.0251536
CMIP c-Maf inducing protein -0.0250857
RPS8 ribosomal protein S8 -0.0249183
ATP13A3 ATPase type 13A3 -0.0248635
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0247895
HM13 histocompatibility (minor) 13 -0.024708
CBX3 chromobox homolog 3 -0.024525
LMAN1 lectin, mannose-binding, 1 -0.0243557
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0242885
RHEB Ras homolog enriched in brain -0.0242471
RPL8 ribosomal protein L8 -0.0242323
BNC2 basonuclin 2 -0.0241836
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0238977
RPS13 ribosomal protein S13 -0.0237719
HMGA1 high mobility group AT-hook 1 -0.0237338
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0236129
RAP1B RAP1B, member of RAS oncogene family -0.023588
EIF1 eukaryotic translation initiation factor 1 -0.0234824
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0234183
ARL4C ADP-ribosylation factor-like 4C -0.0233728
DLG1 discs, large homolog 1 (Drosophila) -0.0232217
PTMA prothymosin, alpha -0.02302
TIMP2 TIMP metallopeptidase inhibitor 2 -0.02297
CXXC1 CXXC finger protein 1 -0.0228214
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0227725
ATP5F1B ATP synthase F1 subunit beta -0.0227416