Pitavastatin (Calcium)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0829227
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.074643
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0626425
MBNL2 muscleblind-like splicing regulator 2 0.04132
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0387113
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0353632
FDPS farnesyl diphosphate synthase 0.0330962
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0327207
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0326635
SREBF2 sterol regulatory element binding transcription factor 2 0.031728
NDRG1 N-myc downstream regulated 1 0.0312333
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0292823
PDIA3 protein disulfide isomerase family A, member 3 0.0292161
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0270333
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0263378
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0252408
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0241853
BTBD9 BTB (POZ) domain containing 9 0.0234832
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0219536
RNF149 ring finger protein 149 0.021917
NEBL nebulette 0.0202438
COPA coatomer protein complex, subunit alpha 0.020237
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0202131
GOLGA4 golgin A4 0.020098
MSMO1 methylsterol monooxygenase 1 0.0200753
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0200166
ERRFI1 ERBB receptor feedback inhibitor 1 0.0198147
ANXA1 annexin A1 0.0194288
FEM1C fem-1 homolog c (C. elegans) 0.0192136
HYOU1 hypoxia up-regulated 1 0.0189155
ABHD2 abhydrolase domain containing 2 0.0188992
KMT2C lysine (K)-specific methyltransferase 2C 0.0188815
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0187197
RAB6A RAB6A, member RAS oncogene family 0.0180801
TTC3 tetratricopeptide repeat domain 3 0.0178669
TSC22D2 TSC22 domain family, member 2 0.0178291
RTN4 reticulon 4 0.0178193
ACSL3 acyl-CoA synthetase long-chain family member 3 0.017808
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0176879
SACK1B scaffolding CK1 anchoring protein B 0.0176798
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0174049
SEC24D SEC24 family member D 0.0171657
PADI1 peptidyl arginine deiminase, type I 0.0170031
ESYT2 extended synaptotagmin-like protein 2 0.0169255
KLF6 Kruppel-like factor 6 0.0168535
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0167714
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0167435
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0165011
AKAP13 A kinase (PRKA) anchor protein 13 0.0164988
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0164483
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.016353
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0157117
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0156542
MXD1 MAX dimerization protein 1 0.0154675
BHLHE40 basic helix-loop-helix family, member e40 0.015424
INSIG1 insulin induced gene 1 0.0154081
CYTH1 cytohesin 1 0.0152296
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0152177
SRRM2 serine/arginine repetitive matrix 2 0.0150946
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0149177
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0147603
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0145292
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0144314
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0143904
ADAM17 ADAM metallopeptidase domain 17 0.0142971
DDIT4 DNA-damage-inducible transcript 4 0.0141867
CDCP1 CUB domain containing protein 1 0.0141482
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.014133
RREB1 ras responsive element binding protein 1 0.0140759
FOSL2 FOS-like antigen 2 0.0138795
RNF145 ring finger protein 145 0.0136999
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0133326
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0131603
NUP58 nucleoporin 58 0.0131285
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0130877
HELZ helicase with zinc finger 0.0129565
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0128941
MYO5B myosin VB 0.0127409
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0126414
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0126062
DST dystonin 0.0125912
AHNAK AHNAK nucleoprotein 0.0125318
NFE2L1 nuclear factor, erythroid 2-like 1 0.0124998
MCTP2 multiple C2 domains, transmembrane 2 0.012464
UBA6 ubiquitin-like modifier activating enzyme 6 0.0120621
NDEL1 nudE neurodevelopment protein 1-like 1 0.012052
KDM6A lysine (K)-specific demethylase 6A 0.0120386
SSR1 signal sequence receptor, alpha 0.0119983
TENT2 terminal nucleotidyltransferase 2 0.0119661
LMTK2 lemur tyrosine kinase 2 0.0119595
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.0117467
GRB10 growth factor receptor-bound protein 10 0.0116156
SNX13 sorting nexin 13 0.0115602
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0115082
SERP1 stress-associated endoplasmic reticulum protein 1 0.0115058
LPIN1 lipin 1 0.0114843
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0114453
DSCAM Down syndrome cell adhesion molecule 0.011435
TPM3 tropomyosin 3 0.0114144
ITPKA inositol-trisphosphate 3-kinase A 0.0113334

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.120942
STAT1 signal transducer and activator of transcription 1, 91kDa -0.115679
RNF213 ring finger protein 213 -0.0987733
B2M beta-2-microglobulin -0.0921088
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0911546
VCL vinculin -0.0883857
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0879571
SP100 SP100 nuclear antigen -0.0784471
TPT1 tumor protein, translationally-controlled 1 -0.0777835
RIGI RNA sensor RIG-I -0.0747288
LCN2 lipocalin 2 -0.0743675
XAF1 XIAP associated factor 1 -0.0637985
MX1 MX dynamin-like GTPase 1 -0.0610586
PTMA prothymosin, alpha -0.0596599
HLA-B major histocompatibility complex, class I, B -0.0592186
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0570604
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0569288
EXT1 exostosin glycosyltransferase 1 -0.0560884
EGR1 early growth response 1 -0.0557153
SQSTM1 sequestosome 1 -0.0536793
INTS6 integrator complex subunit 6 -0.0534
IFI6 interferon, alpha-inducible protein 6 -0.0526204
MX2 MX dynamin-like GTPase 2 -0.0523647
GMDS GDP-mannose 4,6-dehydratase -0.0491596
EPHB2 EPH receptor B2 -0.0484243
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0482793
ACTG1 actin gamma 1 -0.04657
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0463115
RAD51B RAD51 paralog B -0.0463058
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.045909
ZMYND8 zinc finger, MYND-type containing 8 -0.0449495
ARHGAP26 Rho GTPase activating protein 26 -0.0445378
STS steroid sulfatase (microsomal), isozyme S -0.0434014
PLSCR1 phospholipid scramblase 1 -0.0431464
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0422979
RPL7L1 ribosomal protein L7-like 1 -0.0419099
MACC1 metastasis associated in colon cancer 1 -0.0414342
C6ORF132 chromosome 6 open reading frame 132 -0.0412906
NCKAP5 NCK-associated protein 5 -0.041114
TM4SF1 transmembrane 4 L six family member 1 -0.0404402
ATP11A ATPase, class VI, type 11A -0.0388766
LOC102724023 ES1 protein homolog, mitochondrial -0.0384385
RABGAP1L RAB GTPase activating protein 1-like -0.038248
PMP22 peripheral myelin protein 22 -0.0376696
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0370467
ANXA2 annexin A2 -0.0367806
LYZ lysozyme -0.0364004
PHF3 PHD finger protein 3 -0.0363972
NCOA7 nuclear receptor coactivator 7 -0.0361847
SERINC5 serine incorporator 5 -0.0360973
MYO1E myosin IE -0.036074
ANKRD10 ankyrin repeat domain 10 -0.0359562
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0359371
PERP PERP, TP53 apoptosis effector -0.0357678
RAB7A RAB7A, member RAS oncogene family -0.034772
MUC20 mucin 20, cell surface associated -0.0341805
JUN jun proto-oncogene -0.0336743
SPATA13 spermatogenesis associated 13 -0.0334626
GCLC glutamate-cysteine ligase, catalytic subunit -0.0330597
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0330357
HLA-E major histocompatibility complex, class I, E -0.0318105
FOXP1 forkhead box P1 -0.0314082
RHOBTB3 Rho-related BTB domain containing 3 -0.0312914
MEIS2 Meis homeobox 2 -0.0312502
TRERF1 transcriptional regulating factor 1 -0.0311776
AREG amphiregulin -0.0305045
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0295024
RSAD2 radical S-adenosyl methionine domain containing 2 -0.029481
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.029231
WSB1 WD repeat and SOCS box containing 1 -0.0292284
ABLIM1 actin binding LIM protein 1 -0.029019
MAML2 mastermind-like 2 (Drosophila) -0.0289778
ACTN4 actinin, alpha 4 -0.0289539
RPL34 ribosomal protein L34 -0.0288996
RUNX1 runt-related transcription factor 1 -0.0284717
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0282441
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0280991
NKD1 naked cuticle homolog 1 (Drosophila) -0.0279507
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.027335
ETV6 ets variant 6 -0.0267069
IFIH1 interferon induced with helicase C domain 1 -0.0261383
CATSPERB catsper channel auxiliary subunit beta -0.0251993
HLA-C major histocompatibility complex, class I, C -0.0249399
TJP1 tight junction protein 1 -0.0249271
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0248358
PLSCR2 phospholipid scramblase 2 -0.0247152
SAMD12 sterile alpha motif domain containing 12 -0.0244788
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0243945
TRIM56 tripartite motif containing 56 -0.0241514
RPS24 ribosomal protein S24 -0.0241167
ERBIN erbb2 interacting protein -0.0237353
VMP1 vacuole membrane protein 1 -0.0234383
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0234124
CLYBL citrate lyase beta like -0.023211
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0229325
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0227269
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0225631
ZNFX1 zinc finger, NFX1-type containing 1 -0.0224323
TMC5 transmembrane channel-like 5 -0.022419
ZBTB20 zinc finger and BTB domain containing 20 -0.0221707