| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pitavastatin (Calcium) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pitavastatin (Calcium)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.141862 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.123252 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.111442 |
| RHOA | ras homolog family member A | 0.0759626 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0659937 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0646316 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0545654 |
| MAP4 | microtubule-associated protein 4 | 0.0515743 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0513146 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0489541 |
| KLF6 | Kruppel-like factor 6 | 0.0485345 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0465122 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0446259 |
| NEBL | nebulette | 0.0445532 |
| SBF2 | SET binding factor 2 | 0.040444 |
| DSPP | dentin sialophosphoprotein | 0.0398891 |
| RPL3 | ribosomal protein L3 | 0.0393859 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0391934 |
| GOLGA4 | golgin A4 | 0.0388411 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0384309 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0374896 |
| RPL37A | ribosomal protein L37a | 0.036384 |
| SPAG9 | sperm associated antigen 9 | 0.0356695 |
| RPS3 | ribosomal protein S3 | 0.0345782 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0337655 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0335619 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0327936 |
| HMGB2 | high mobility group box 2 | 0.0312237 |
| HELZ | helicase with zinc finger | 0.030076 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0294828 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0293545 |
| ZNF292 | zinc finger protein 292 | 0.0292419 |
| SRP54 | signal recognition particle 54kDa | 0.0290538 |
| SEC24D | SEC24 family member D | 0.0286885 |
| RHOB | ras homolog family member B | 0.0282709 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0281961 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0279284 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0279055 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0276556 |
| DENND5A | DENN/MADD domain containing 5A | 0.027493 |
| OGA | O-GlcNAcase | 0.0273063 |
| RPS12 | ribosomal protein S12 | 0.0272182 |
| RBM39 | RNA binding motif protein 39 | 0.0269468 |
| FBXO42 | F-box protein 42 | 0.0267775 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0267291 |
| HYOU1 | hypoxia up-regulated 1 | 0.0264071 |
| ARGLU1 | arginine and glutamate rich 1 | 0.026365 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.026269 |
| B2M | beta-2-microglobulin | 0.0262376 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0262171 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0261297 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 0.0259705 |
| RPL23 | ribosomal protein L23 | 0.0258349 |
| YME1L1 | YME1-like 1 ATPase | 0.025825 |
| ATXN1 | ataxin 1 | 0.0255787 |
| XPOT | exportin, tRNA | 0.0253954 |
| RTN4 | reticulon 4 | 0.0247645 |
| KLC1 | kinesin light chain 1 | 0.0246395 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0243505 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0241679 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0241259 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0241046 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0240561 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0240432 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0239873 |
| SARS1 | seryl-tRNA synthetase 1 | 0.0238419 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.0238247 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0236178 |
| RPL19 | ribosomal protein L19 | 0.0235205 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0234706 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0232158 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0223815 |
| FOXO3 | forkhead box O3 | 0.0220754 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0219723 |
| TPI1 | triosephosphate isomerase 1 | 0.0219098 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.021665 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0216532 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0215806 |
| RPL31 | ribosomal protein L31 | 0.0215414 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0215341 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0214018 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0213794 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0212649 |
| SESN2 | sestrin 2 | 0.021258 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0212417 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0212148 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0210626 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0210525 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0210191 |
| FN1 | fibronectin 1 | 0.0209847 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0207673 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0207194 |
| SEPTIN7 | septin 7 | 0.0206076 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.020558 |
| RPSA | ribosomal protein SA | 0.0204799 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0204108 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0203886 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.020076 |
| ATF3 | activating transcription factor 3 | 0.0200591 |
| ANK2 | ankyrin 2, neuronal | 0.0198861 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.264261 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.263 |
| NDRG1 | N-myc downstream regulated 1 | -0.148497 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.110486 |
| AHNAK | AHNAK nucleoprotein | -0.109435 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0906148 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0819089 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0783409 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0701573 |
| EGR1 | early growth response 1 | -0.0658962 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0650346 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0602587 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0593256 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0586522 |
| POTEF | POTE ankyrin domain family, member F | -0.0581066 |
| TENM3 | teneurin transmembrane protein 3 | -0.0560535 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0558768 |
| SMYD3 | SET and MYND domain containing 3 | -0.0550387 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0542871 |
| MCL1 | myeloid cell leukemia 1 | -0.0528611 |
| EGFR | epidermal growth factor receptor | -0.0519537 |
| ASPH | aspartate beta-hydroxylase | -0.0512175 |
| FLNB | filamin B, beta | -0.0500267 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.046938 |
| WWC1 | WW and C2 domain containing 1 | -0.0465559 |
| HMGA1 | high mobility group AT-hook 1 | -0.046013 |
| VCL | vinculin | -0.0459321 |
| ACTG1 | actin gamma 1 | -0.04592 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0458599 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0442106 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0431952 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.042457 |
| TPM4 | tropomyosin 4 | -0.0420011 |
| MKI67 | marker of proliferation Ki-67 | -0.0419142 |
| CDCP1 | CUB domain containing protein 1 | -0.0400463 |
| KIAA1217 | KIAA1217 | -0.0392419 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0391343 |
| WWC2 | WW and C2 domain containing 2 | -0.0385677 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0367524 |
| SERINC5 | serine incorporator 5 | -0.0363531 |
| EHBP1 | EH domain binding protein 1 | -0.0362253 |
| PARD3 | par-3 family cell polarity regulator | -0.0359062 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0358306 |
| PKM | pyruvate kinase, muscle | -0.0357449 |
| KRT8 | keratin 8, type II | -0.0357268 |
| FRMD5 | FERM domain containing 5 | -0.0353725 |
| PKP2 | plakophilin 2 | -0.0352991 |
| MED13L | mediator complex subunit 13-like | -0.0351618 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0348651 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0347859 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0346784 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0345755 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0345608 |
| ATM | ATM serine/threonine kinase | -0.0345098 |
| ZNF638 | zinc finger protein 638 | -0.0344301 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0340662 |
| CCND1 | cyclin D1 | -0.0339 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0337186 |
| NF1 | neurofibromin 1 | -0.0336551 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0334905 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0330787 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0322015 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0321091 |
| RCOR1 | REST corepressor 1 | -0.0315294 |
| TAPBP | TAP binding protein (tapasin) | -0.031438 |
| FUS | FUS RNA binding protein | -0.0314361 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0313818 |
| SMAD3 | SMAD family member 3 | -0.0313808 |
| CMIP | c-Maf inducing protein | -0.0313505 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0311945 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0308411 |
| ERBIN | erbb2 interacting protein | -0.0303689 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0303282 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0302427 |
| ITGB4 | integrin, beta 4 | -0.0301906 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0294003 |
| TMSB10 | thymosin beta 10 | -0.0293536 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.02921 |
| S100A10 | S100 calcium binding protein A10 | -0.0289164 |
| KRT18 | keratin 18, type I | -0.0282862 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0278374 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.027825 |
| MSI2 | musashi RNA-binding protein 2 | -0.0278148 |
| SEPTIN9 | septin 9 | -0.0276635 |
| SDC4 | syndecan 4 | -0.0275737 |
| TCF12 | transcription factor 12 | -0.0274609 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.027307 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0272849 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0272738 |
| TMEM123 | transmembrane protein 123 | -0.027124 |
| KRT19 | keratin 19, type I | -0.0270561 |
| WWOX | WW domain containing oxidoreductase | -0.0269242 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0265153 |
| BPTF | bromodomain PHD finger transcription factor | -0.0264428 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0264166 |
| ADD3 | adducin 3 (gamma) | -0.0263519 |
| GPHN | gephyrin | -0.0261902 |
| ARF4 | ADP-ribosylation factor 4 | -0.0261605 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0260948 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.026084 |
