| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pitavastatin (Calcium) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pitavastatin (Calcium)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0434315 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0309218 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0223883 |
| PLEC | plectin | 0.0208867 |
| STC1 | stanniocalcin 1 | 0.0166474 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0150287 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0131527 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0130166 |
| MSN | moesin | 0.0107997 |
| RPL3 | ribosomal protein L3 | 0.0103173 |
| MT2A | metallothionein 2A | 0.0100975 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00904104 |
| ANGPTL4 | angiopoietin-like 4 | 0.00883331 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.00869511 |
| EZR | ezrin | 0.00839876 |
| KLF6 | Kruppel-like factor 6 | 0.00813557 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.00774242 |
| RHOB | ras homolog family member B | 0.00769565 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.00741228 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00713711 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.00701556 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.00697025 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00681599 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.00666503 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.00657539 |
| TPM3 | tropomyosin 3 | 0.00629514 |
| ANXA1 | annexin A1 | 0.00608141 |
| RPSA | ribosomal protein SA | 0.00588958 |
| H1-4 | H1.4 linker histone, cluster member | 0.00581488 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.00581103 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.00565351 |
| IER2 | immediate early response 2 | 0.00543161 |
| TNS1 | tensin 1 | 0.00532967 |
| HAS2 | hyaluronan synthase 2 | 0.00514375 |
| SMAD3 | SMAD family member 3 | 0.00514036 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0051238 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.00508263 |
| SEPTIN9 | septin 9 | 0.00504429 |
| RPS12 | ribosomal protein S12 | 0.00490358 |
| ARRDC3 | arrestin domain containing 3 | 0.00482762 |
| RPS2 | ribosomal protein S2 | 0.00473395 |
| INSIG1 | insulin induced gene 1 | 0.00469629 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.00461735 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | 0.0045857 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.00454713 |
| PLAUR | plasminogen activator, urokinase receptor | 0.00452696 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.00452421 |
| TPI1 | triosephosphate isomerase 1 | 0.00452285 |
| FLNB | filamin B, beta | 0.0044712 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.00433738 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.00432306 |
| RPS18 | ribosomal protein S18 | 0.00431679 |
| IGSF9B | immunoglobulin superfamily, member 9B | 0.00428616 |
| FLOT1 | flotillin 1 | 0.00424008 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0042313 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.00408166 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.00407476 |
| GRB10 | growth factor receptor-bound protein 10 | 0.00406727 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.00405449 |
| IL6 | interleukin 6 | 0.00400566 |
| DIAPH1 | diaphanous-related formin 1 | 0.00397783 |
| FOSL2 | FOS-like antigen 2 | 0.00395833 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.00393569 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00391971 |
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | 0.00388762 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.00388756 |
| RNF19B | ring finger protein 19B | 0.00387165 |
| BRD2 | bromodomain containing 2 | 0.00382576 |
| RPL13A | ribosomal protein L13a | 0.00377175 |
| SET | SET nuclear proto-oncogene | 0.00374334 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00373501 |
| SQLE | squalene epoxidase | 0.00373117 |
| STK38L | serine/threonine kinase 38 like | 0.00371788 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.00371 |
| RPS15A | ribosomal protein S15a | 0.00365062 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00362383 |
| H1-2 | H1.2 linker histone, cluster member | 0.00358712 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00356328 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0035623 |
| RHOA | ras homolog family member A | 0.0035578 |
| RRM2 | ribonucleotide reductase M2 | 0.00353276 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.00352781 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.00349551 |
| PLXNA1 | plexin A1 | 0.00348463 |
| TPR | translocated promoter region, nuclear basket protein | 0.00347336 |
| RPL21 | ribosomal protein L21 | 0.0034566 |
| IL1B | interleukin 1, beta | 0.00343621 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.00334079 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.00333168 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.00332981 |
| PTMA | prothymosin, alpha | 0.00331114 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.00329425 |
| CDC25B | cell division cycle 25B | 0.00327011 |
| KRT14 | keratin 14, type I | 0.00321382 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0031644 |
| TGM2 | transglutaminase 2 | 0.00315942 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.00315174 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.00313182 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.00312618 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0030906 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.279383 |
| FN1 | fibronectin 1 | -0.216158 |
| COL1A1 | collagen, type I, alpha 1 | -0.133129 |
| COL6A3 | collagen, type VI, alpha 3 | -0.131377 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106077 |
| COL1A2 | collagen, type I, alpha 2 | -0.0824618 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0814603 |
| VIM | vimentin | -0.079923 |
| NDRG1 | N-myc downstream regulated 1 | -0.0782425 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0688795 |
| CDH13 | cadherin 13 | -0.0684195 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0542266 |
| ASPH | aspartate beta-hydroxylase | -0.050481 |
| FBN1 | fibrillin 1 | -0.0498026 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0467919 |
| LOX | lysyl oxidase | -0.0462542 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0455802 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0437226 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0423648 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0403294 |
| TPM4 | tropomyosin 4 | -0.0397816 |
| COL5A1 | collagen, type V, alpha 1 | -0.0374378 |
| LOXL2 | lysyl oxidase-like 2 | -0.0367351 |
| VCAN | versican | -0.0360009 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0338977 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0330544 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0328216 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0326112 |
| ACTG1 | actin gamma 1 | -0.0322356 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0317059 |
| GLIS3 | GLIS family zinc finger 3 | -0.0304454 |
| CANX | calnexin | -0.030273 |
| HMGA2 | high mobility group AT-hook 2 | -0.0296862 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0291311 |
| CALD1 | caldesmon 1 | -0.0290024 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0288275 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.027405 |
| PDE10A | phosphodiesterase 10A | -0.0264396 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0264039 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0257572 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0238764 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0225136 |
| IER3 | immediate early response 3 | -0.022497 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.022491 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0222859 |
| CALU | calumenin | -0.0220865 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0220812 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0219194 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.021909 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0214888 |
| CALR | calreticulin | -0.0208204 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0205316 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0205277 |
| NRP1 | neuropilin 1 | -0.019976 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0199036 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0198761 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0193192 |
| UBC | ubiquitin C | -0.0190181 |
| HLA-B | major histocompatibility complex, class I, B | -0.0189885 |
| SMYD3 | SET and MYND domain containing 3 | -0.0188496 |
| OSMR | oncostatin M receptor | -0.0185617 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0183579 |
| GOLGA4 | golgin A4 | -0.0182767 |
| RUNX1 | runt-related transcription factor 1 | -0.0182206 |
| IL6ST | interleukin 6 signal transducer | -0.0179446 |
| RRBP1 | ribosome binding protein 1 | -0.0179336 |
| ANXA2 | annexin A2 | -0.0171411 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0168308 |
| PTK2 | protein tyrosine kinase 2 | -0.016788 |
| MTDH | metadherin | -0.0164803 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0164687 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0163999 |
| EGFR | epidermal growth factor receptor | -0.0163403 |
| CD44 | CD44 molecule (Indian blood group) | -0.016045 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0160407 |
| SDC2 | syndecan 2 | -0.0160357 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.016019 |
| MYO10 | myosin X | -0.0159516 |
| VCL | vinculin | -0.0157764 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0156666 |
| MAP4 | microtubule-associated protein 4 | -0.0156284 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0155968 |
| TPM1 | tropomyosin 1 (alpha) | -0.0155527 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0155327 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0154143 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0153578 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0153212 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0152922 |
| COL3A1 | collagen, type III, alpha 1 | -0.0152837 |
| OXR1 | oxidation resistance 1 | -0.0152315 |
| BNC2 | basonuclin 2 | -0.0150484 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0150066 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0149838 |
| AHNAK | AHNAK nucleoprotein | -0.014942 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.014874 |
| GOLGB1 | golgin B1 | -0.0147817 |
| MAP1B | microtubule-associated protein 1B | -0.014766 |
| CADM1 | cell adhesion molecule 1 | -0.0146836 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0145073 |
| PXDN | peroxidasin | -0.0144809 |
