Pitavastatin (Calcium)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.146495
FTL ferritin, light polypeptide 0.10012
MYH9 myosin, heavy chain 9, non-muscle 0.084626
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0706118
HLA-B major histocompatibility complex, class I, B 0.0697402
ENO1 enolase 1, (alpha) 0.0639695
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0565192
PTMA prothymosin, alpha 0.0554796
TPT1 tumor protein, translationally-controlled 1 0.051957
TMSB10 thymosin beta 10 0.0485603
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0447332
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.040113
AKAP12 A kinase (PRKA) anchor protein 12 0.0397609
VIM vimentin 0.0392198
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0380089
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0350175
FLNB filamin B, beta 0.0345055
CAVIN1 caveolae associated protein 1 0.033594
RPL35A ribosomal protein L35a 0.0333866
RPS6 ribosomal protein S6 0.0329564
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0322212
RPS3 ribosomal protein S3 0.0318631
B2M beta-2-microglobulin 0.0315734
CALR calreticulin 0.0303484
RPS8 ribosomal protein S8 0.0295849
PGK1 phosphoglycerate kinase 1 0.0295085
RPLP2 ribosomal protein, large, P2 0.0293046
ADM adrenomedullin 0.0287787
RPL26 ribosomal protein L26 0.028768
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0282908
EIF1 eukaryotic translation initiation factor 1 0.028242
NAMPT nicotinamide phosphoribosyltransferase 0.0278971
SET SET nuclear proto-oncogene 0.027809
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0277123
TMSB4X thymosin beta 4, X-linked 0.0265506
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0260379
TPI1 triosephosphate isomerase 1 0.0258223
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0256744
AHNAK AHNAK nucleoprotein 0.0255661
RPL37 ribosomal protein L37 0.0252951
RPL12 ribosomal protein L12 0.025249
PLEC plectin 0.0251204
PLIN2 perilipin 2 0.0251011
LMNA lamin A/C 0.0248204
RPL23 ribosomal protein L23 0.0247666
RPL7A ribosomal protein L7a 0.0241446
H1-4 H1.4 linker histone, cluster member 0.0233617
ZNF841 zinc finger protein 841 0.023335
NAP1L1 nucleosome assembly protein 1-like 1 0.0231236
INTS6 integrator complex subunit 6 0.0230782
RPL11 ribosomal protein L11 0.0230234
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0230204
RPL31 ribosomal protein L31 0.0219666
RPLP1 ribosomal protein, large, P1 0.0216481
EZR ezrin 0.0213202
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.02097
RPL37A ribosomal protein L37a 0.0209598
CD44 CD44 molecule (Indian blood group) 0.0206228
RPL35 ribosomal protein L35 0.0197018
HLA-A major histocompatibility complex, class I, A 0.0196325
HLA-E major histocompatibility complex, class I, E 0.019543
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0195113
PKM pyruvate kinase, muscle 0.019406
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0193278
ANXA1 annexin A1 0.0186188
COL5A1 collagen, type V, alpha 1 0.017987
SEPTIN9 septin 9 0.0176668
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.017517
TPM4 tropomyosin 4 0.0174138
RPS12 ribosomal protein S12 0.0173355
KRT18 keratin 18, type I 0.0171521
LDHA lactate dehydrogenase A 0.0171239
KPNB1 karyopherin (importin) beta 1 0.0171149
ANGPTL4 angiopoietin-like 4 0.017045
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0169993
PTPRF protein tyrosine phosphatase, receptor type, F 0.0169912
HMGB2 high mobility group box 2 0.0169101
TPM3 tropomyosin 3 0.0168807
IFI6 interferon, alpha-inducible protein 6 0.016831
S100A6 S100 calcium binding protein A6 0.0165297
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0163902
KLF6 Kruppel-like factor 6 0.016193
SRRM2 serine/arginine repetitive matrix 2 0.0161193
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0161097
GOLGB1 golgin B1 0.0160968
RPS17 ribosomal protein S17 0.0156829
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0156186
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0154974
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0154444
RPS27A ribosomal protein S27a 0.015238
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0152084
KRT8 keratin 8, type II 0.0151574
RRBP1 ribosome binding protein 1 0.0151397
RPS29 ribosomal protein S29 0.0150725
TLN1 talin 1 0.0150397
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0150114
RPS16 ribosomal protein S16 0.0149102
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0147241
EDF1 endothelial differentiation-related factor 1 0.0146117
BZW1 basic leucine zipper and W2 domains 1 0.0145334

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.0805711
FTH1 ferritin, heavy polypeptide 1 -0.074828
TRIO trio Rho guanine nucleotide exchange factor -0.0532821
ERBIN erbb2 interacting protein -0.0454069
POTEF POTE ankyrin domain family, member F -0.0381626
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0327456
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0309112
TXNRD1 thioredoxin reductase 1 -0.0292371
EXT1 exostosin glycosyltransferase 1 -0.029217
NALF1 NALCN channel auxiliary factor 1 -0.0291714
DLG1 discs, large homolog 1 (Drosophila) -0.0287988
FOSL1 FOS-like antigen 1 -0.0242872
OSMR oncostatin M receptor -0.0239806
PTBP3 polypyrimidine tract binding protein 3 -0.0235876
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0234201
GLS2 glutaminase 2 (liver, mitochondrial) -0.0229552
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0226665
LATS2 large tumor suppressor kinase 2 -0.0214579
FN1 fibronectin 1 -0.0210324
UGCG UDP-glucose ceramide glucosyltransferase -0.0209886
F3 coagulation factor III (thromboplastin, tissue factor) -0.0205546
TGFB2 transforming growth factor, beta 2 -0.0205375
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0203311
PLCB4 phospholipase C, beta 4 -0.0192796
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0192102
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0191978
VEGFC vascular endothelial growth factor C -0.0186129
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0180209
VGLL3 vestigial-like family member 3 -0.0180203
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0178876
DIAPH3 diaphanous-related formin 3 -0.0176497
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0175836
CCNL1 cyclin L1 -0.017569
TSC22D2 TSC22 domain family, member 2 -0.0174912
LIMCH1 LIM and calponin homology domains 1 -0.0174378
SAMD12 sterile alpha motif domain containing 12 -0.0173662
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0172188
ADAM9 ADAM metallopeptidase domain 9 -0.0169884
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0169266
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0168693
NEK7 NIMA-related kinase 7 -0.0159646
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.015725
TPM1 tropomyosin 1 (alpha) -0.0155257
ABI3BP ABI family, member 3 (NESH) binding protein -0.0155181
ANKRD28 ankyrin repeat domain 28 -0.0151307
CCBE1 collagen and calcium binding EGF domains 1 -0.015064
FRMD6 FERM domain containing 6 -0.0147028
TMEM178B transmembrane protein 178B -0.0143577
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0143002
PPME1 protein phosphatase methylesterase 1 -0.014077
TAPBP TAP binding protein (tapasin) -0.0137838
ZNF207 zinc finger protein 207 -0.0137437
ZNF91 zinc finger protein 91 -0.0130635
U2SURP U2 snRNP-associated SURP domain containing -0.012784
NF1 neurofibromin 1 -0.0127533
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.012744
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0126539
CCDC14 coiled-coil domain containing 14 -0.0125667
TENT4A terminal nucleotidyltransferase 4A -0.0124335
SULF1 sulfatase 1 -0.0123011
MARCHF7 membrane associated ring-CH-type finger 7 -0.0120847
IL6ST interleukin 6 signal transducer -0.0120369
PDS5B PDS5 cohesin associated factor B -0.0119558
ELL2 elongation factor, RNA polymerase II, 2 -0.0118179
GRAMD2B GRAM domain containing 2B -0.0118167
PBX3 pre-B-cell leukemia homeobox 3 -0.0117878
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0116429
NECTIN3 nectin cell adhesion molecule 3 -0.0116227
FNDC3B fibronectin type III domain containing 3B -0.0115158
ZNF462 zinc finger protein 462 -0.0115002
MAML2 mastermind-like 2 (Drosophila) -0.011395
AXL AXL receptor tyrosine kinase -0.0112471
PKP4 plakophilin 4 -0.0112094
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0111634
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.011153
MBNL2 muscleblind-like splicing regulator 2 -0.0110539
ZMYM2 zinc finger, MYM-type 2 -0.010858
PRRC2A proline-rich coiled-coil 2A -0.0108347
EGFR epidermal growth factor receptor -0.0108297
ECT2 epithelial cell transforming 2 -0.0107947
PIAS2 protein inhibitor of activated STAT, 2 -0.0107822
WAC WW domain containing adaptor with coiled-coil -0.0107017
NUP153 nucleoporin 153kDa -0.0104962
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0104817
GMPS guanine monphosphate synthase -0.0104166
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0103547
ITCH itchy E3 ubiquitin protein ligase -0.0103505
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0103046
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0102378
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0102334
FNIP1 folliculin interacting protein 1 -0.0100972
SCAF11 SR-related CTD-associated factor 11 -0.00998472
FXR1 fragile X mental retardation, autosomal homolog 1 -0.00998035
GLIS3 GLIS family zinc finger 3 -0.00990727
WNT5B wingless-type MMTV integration site family, member 5B -0.00988313
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.00964897
HP1BP3 heterochromatin protein 1, binding protein 3 -0.009629
NUP58 nucleoporin 58 -0.00961161
PTBP2 polypyrimidine tract binding protein 2 -0.00960846
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.00940019