Pitavastatin (Calcium)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.0497968
TMSB10 thymosin beta 10 0.0469766
RPS12 ribosomal protein S12 0.0424931
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0348948
RPL36 ribosomal protein L36 0.0320568
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0316264
RPL13A ribosomal protein L13a 0.0311974
TPI1 triosephosphate isomerase 1 0.0306689
RPL37A ribosomal protein L37a 0.0293591
RBM25 RNA binding motif protein 25 0.0292976
RPS3 ribosomal protein S3 0.0257679
KMT2E lysine (K)-specific methyltransferase 2E 0.0251908
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0247804
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0232881
KDM3A lysine (K)-specific demethylase 3A 0.0220352
NDRG1 N-myc downstream regulated 1 0.0206307
RPS19 ribosomal protein S19 0.020241
CNRIP1 cannabinoid receptor interacting protein 1 0.0197683
RPL7 ribosomal protein L7 0.0196891
PFDN2 prefoldin subunit 2 0.0194963
RHOB ras homolog family member B 0.0192183
DDIT4 DNA-damage-inducible transcript 4 0.0191441
SPAG9 sperm associated antigen 9 0.0183085
RPS27 ribosomal protein S27 0.0179858
RPLP1 ribosomal protein, large, P1 0.0177015
RPL3 ribosomal protein L3 0.0175091
TPM3 tropomyosin 3 0.0173167
INHBA inhibin, beta A 0.0172912
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0169593
RPS2 ribosomal protein S2 0.0167801
BHLHE40 basic helix-loop-helix family, member e40 0.0165969
RPS6 ribosomal protein S6 0.0165039
PA2G4 proliferation-associated 2G4, 38kDa 0.0159225
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0156995
ANXA1 annexin A1 0.0156971
SRRM1 serine/arginine repetitive matrix 1 0.0150603
NACA nascent polypeptide-associated complex alpha subunit 0.0148679
CD109 CD109 molecule 0.0147031
RPL9 ribosomal protein L9 0.0140594
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0140361
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0139946
RPS17 ribosomal protein S17 0.0139793
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0139295
FAM177A1 family with sequence similarity 177, member A1 0.0138564
SLC38A1 solute carrier family 38, member 1 0.0135672
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0133487
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0132041
GARS1 glycyl-tRNA synthetase 1 0.013163
RPLP2 ribosomal protein, large, P2 0.0130459
RPL31 ribosomal protein L31 0.0127499
IFITM3 interferon induced transmembrane protein 3 0.0127444
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0125815
GPX4 glutathione peroxidase 4 0.0123442
RPL18 ribosomal protein L18 0.0122851
HSPB1 heat shock 27kDa protein 1 0.0122107
RPL35 ribosomal protein L35 0.012088
RIOK3 RIO kinase 3 0.0120448
FAM168A family with sequence similarity 168, member A 0.0119592
TES testin LIM domain protein 0.0119295
H1-4 H1.4 linker histone, cluster member 0.0118928
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0118838
UBN1 ubinuclein 1 0.0118712
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0118359
COPA coatomer protein complex, subunit alpha 0.0118334
RNF38 ring finger protein 38 0.0118212
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0116661
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0114012
EIF1 eukaryotic translation initiation factor 1 0.0113042
PNN pinin, desmosome associated protein 0.0112547
TPR translocated promoter region, nuclear basket protein 0.0110673
RPL4 ribosomal protein L4 0.0109143
ISG15 ISG15 ubiquitin-like modifier 0.0109001
MYH9 myosin, heavy chain 9, non-muscle 0.0107046
RBM8A RNA binding motif protein 8A 0.0106899
ROMO1 reactive oxygen species modulator 1 0.0106059
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 0.0105761
HYOU1 hypoxia up-regulated 1 0.0105686
RPS14 ribosomal protein S14 0.0104776
CD44 CD44 molecule (Indian blood group) 0.0104489
ELF2 E74-like factor 2 (ets domain transcription factor) 0.010365
AFTPH aftiphilin 0.010359
RPS10 ribosomal protein S10 0.0103072
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0102476
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.0102114
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0101223
ATP5F1E ATP synthase F1 subunit epsilon 0.0100873
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0100769
CWC15 CWC15 spliceosome-associated protein 0.00998428
RPL41 ribosomal protein L41 0.00986815
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.00986091
RPL35A ribosomal protein L35a 0.0097996
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00979677
SRRT serrate, RNA effector molecule 0.00978161
RAB13 RAB13, member RAS oncogene family 0.00976298
MIS18BP1 MIS18 binding protein 1 0.0097544
RPS15A ribosomal protein S15a 0.00974334
NOP53 NOP53 ribosome biogenesis factor 0.00967632
RPL27 ribosomal protein L27 0.00966949
H1-2 H1.2 linker histone, cluster member 0.00963528
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.00954761

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.248829
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.236122
PDE4D phosphodiesterase 4D, cAMP-specific -0.182047
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.154371
TM4SF1 transmembrane 4 L six family member 1 -0.149424
DOCK4 dedicator of cytokinesis 4 -0.128985
PM20D1 peptidase M20 domain containing 1 -0.126367
TXNRD1 thioredoxin reductase 1 -0.106855
AKAP12 A kinase (PRKA) anchor protein 12 -0.0883418
UBC ubiquitin C -0.0823333
NRG1 neuregulin 1 -0.0733489
MCL1 myeloid cell leukemia 1 -0.0720689
VIM vimentin -0.0716185
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.068954
THSD4 thrombospondin, type I, domain containing 4 -0.0685476
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0661516
CMIP c-Maf inducing protein -0.0637142
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0616397
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0608037
RPS27A ribosomal protein S27a -0.059914
SAMD4A sterile alpha motif domain containing 4A -0.0579172
PARD3 par-3 family cell polarity regulator -0.0561986
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0553803
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0549118
POTEF POTE ankyrin domain family, member F -0.0536258
PDLIM5 PDZ and LIM domain 5 -0.0502223
MAML3 mastermind-like 3 (Drosophila) -0.050077
AHNAK AHNAK nucleoprotein -0.0492276
STC1 stanniocalcin 1 -0.0485966
ACTG1 actin gamma 1 -0.0476174
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.045309
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0453014
DOCK5 dedicator of cytokinesis 5 -0.0429036
GLS2 glutaminase 2 (liver, mitochondrial) -0.041237
BICC1 BicC family RNA binding protein 1 -0.0407393
IGF2 insulin-like growth factor 2 -0.0405896
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0401301
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0400556
FGB fibrinogen beta chain -0.0397678
UBASH3B ubiquitin associated and SH3 domain containing B -0.0394973
FAM107B family with sequence similarity 107, member B -0.0394411
VMP1 vacuole membrane protein 1 -0.0378521
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0376602
WWOX WW domain containing oxidoreductase -0.0368374
GLIS3 GLIS family zinc finger 3 -0.0361108
NEBL nebulette -0.0358802
SLC38A2 solute carrier family 38, member 2 -0.0351469
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0351377
ASPH aspartate beta-hydroxylase -0.0348975
EXT1 exostosin glycosyltransferase 1 -0.0347474
MACF1 microtubule-actin crosslinking factor 1 -0.0347114
APP amyloid beta (A4) precursor protein -0.0346266
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0344783
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0344751
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0337333
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0336766
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0335347
OSMR oncostatin M receptor -0.0330695
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0326586
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0323733
EEF2 eukaryotic translation elongation factor 2 -0.0323503
BMP6 bone morphogenetic protein 6 -0.03223
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.031908
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0315178
USP34 ubiquitin specific peptidase 34 -0.0309819
AKAP13 A kinase (PRKA) anchor protein 13 -0.0307965
BIRC3 baculoviral IAP repeat containing 3 -0.0303694
KYNU kynureninase -0.0297463
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0290041
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0289739
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0274906
TPD52 tumor protein D52 -0.0273922
ZMYND8 zinc finger, MYND-type containing 8 -0.0272891
TMEM131 transmembrane protein 131 -0.0271628
BASP1 brain abundant, membrane attached signal protein 1 -0.0262126
EFNA5 ephrin-A5 -0.0261813
DENND4A DENN/MADD domain containing 4A -0.0261547
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0260223
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0254115
ENO1 enolase 1, (alpha) -0.0253566
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0253239
ANXA2 annexin A2 -0.0252683
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0249562
PLS3 plastin 3 -0.0249488
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0249041
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0248621
AK1 adenylate kinase 1 -0.0247418
IGF1R insulin-like growth factor 1 receptor -0.0246831
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0244363
DSCAM Down syndrome cell adhesion molecule -0.0240949
DENND5B DENN/MADD domain containing 5B -0.0240329
FTH1 ferritin, heavy polypeptide 1 -0.024009
CALU calumenin -0.0237473
ZNF207 zinc finger protein 207 -0.0236252
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0236086
GLG1 golgi glycoprotein 1 -0.0236036
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0234572
JMJD1C jumonji domain containing 1C -0.0233397
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0232596
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0231187