Pitavastatin (Calcium)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.197933
TXNRD1 thioredoxin reductase 1 0.123585
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0847088
CLIP1 CAP-GLY domain containing linker protein 1 0.0435985
CREB5 cAMP responsive element binding protein 5 0.0419827
RTN4 reticulon 4 0.0400456
VIM vimentin 0.034132
SPAG9 sperm associated antigen 9 0.0321627
EZR ezrin 0.0309421
ATXN1 ataxin 1 0.0308845
PABPC1 poly(A) binding protein, cytoplasmic 1 0.027436
MAP7 microtubule-associated protein 7 0.0262797
RB1CC1 RB1-inducible coiled-coil 1 0.025475
HSPB1 heat shock 27kDa protein 1 0.0233973
RHOB ras homolog family member B 0.0230817
RHOA ras homolog family member A 0.0228
HSPA8 heat shock 70kDa protein 8 0.0215919
JMJD1C jumonji domain containing 1C 0.0208113
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0207791
RHOQ ras homolog family member Q 0.0198984
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0198464
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.019425
UBE2H ubiquitin-conjugating enzyme E2H 0.0194197
DUSP16 dual specificity phosphatase 16 0.0188316
CSDE1 cold shock domain containing E1, RNA-binding 0.0186899
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0185365
KMT2C lysine (K)-specific methyltransferase 2C 0.0177705
EXOC6B exocyst complex component 6B 0.0173466
ANXA5 annexin A5 0.0171049
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.0169697
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0162899
KMT2A lysine (K)-specific methyltransferase 2A 0.0162811
ITPRID2 ITPR interacting domain containing 2 0.0160899
ADAM17 ADAM metallopeptidase domain 17 0.0159474
COL4A5 collagen, type IV, alpha 5 0.0155692
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0154193
ENAH enabled homolog (Drosophila) 0.0148405
NPEPPS aminopeptidase puromycin sensitive 0.0140947
IQGAP3 IQ motif containing GTPase activating protein 3 0.0140918
MAP4 microtubule-associated protein 4 0.0139596
SERINC3 serine incorporator 3 0.0139099
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0138955
ADAM9 ADAM metallopeptidase domain 9 0.0137393
UBC ubiquitin C 0.0137283
TPI1 triosephosphate isomerase 1 0.0132316
FKBP4 FK506 binding protein 4, 59kDa 0.0130471
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0127323
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0126714
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0126502
ESYT2 extended synaptotagmin-like protein 2 0.0124987
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0124455
IQGAP1 IQ motif containing GTPase activating protein 1 0.0123571
ENO1 enolase 1, (alpha) 0.0123547
CLU clusterin 0.0123493
RANBP2 RAN binding protein 2 0.0123431
NCKAP1 NCK-associated protein 1 0.0122304
HSPA1A heat shock 70kDa protein 1A 0.0122199
CHD1 chromodomain helicase DNA binding protein 1 0.0120905
SRPK2 SRSF protein kinase 2 0.012048
FBXL2 F-box and leucine-rich repeat protein 2 0.0120114
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0119948
KCTD20 potassium channel tetramerization domain containing 20 0.0119298
S100A10 S100 calcium binding protein A10 0.011856
NCOA6 nuclear receptor coactivator 6 0.0118268
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0116868
CEP70 centrosomal protein 70kDa 0.0115923
ZBTB10 zinc finger and BTB domain containing 10 0.0114951
DAAM1 dishevelled associated activator of morphogenesis 1 0.0111912
KCMF1 potassium channel modulatory factor 1 0.0111222
TMEM41B transmembrane protein 41B 0.0110946
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0109628
MYO5A myosin VA (heavy chain 12, myoxin) 0.0108931
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0107603
RHOF ras homolog family member F (in filopodia) 0.0107566
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0107466
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0107305
ANXA1 annexin A1 0.0106757
ERGIC3 ERGIC and golgi 3 0.0106031
RPL3 ribosomal protein L3 0.0105329
MEF2A myocyte enhancer factor 2A 0.0105268
EIF1 eukaryotic translation initiation factor 1 0.0103473
KIF5B kinesin family member 5B 0.0103176
SDC4 syndecan 4 0.0102204
RAB10 RAB10, member RAS oncogene family 0.0101965
MKRN1 makorin ring finger protein 1 0.0101251
XPO1 exportin 1 0.0100733
RIOK3 RIO kinase 3 0.0100069
ATF3 activating transcription factor 3 0.00999804
BLTP3B bridge-like lipid transfer protein family member 3B 0.00994725
KDM3A lysine (K)-specific demethylase 3A 0.00994405
CD109 CD109 molecule 0.00993047
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.00992455
RPS20 ribosomal protein S20 0.00990062
RUBCN rubicon autophagy regulator 0.00987924
RAB6A RAB6A, member RAS oncogene family 0.00986178
ZBTB20 zinc finger and BTB domain containing 20 0.00984884
PKM pyruvate kinase, muscle 0.00983845
SPDYA speedy/RINGO cell cycle regulator family member A 0.00978049
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.00977187
WEE1 WEE1 G2 checkpoint kinase 0.00970961

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.291127
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.121295
RAD51B RAD51 paralog B -0.105679
AFF3 AF4/FMR2 family, member 3 -0.0805356
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0708182
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0701651
TAS2R14 taste receptor, type 2, member 14 -0.068137
YBX3 Y box binding protein 3 -0.0668625
HMGA2 high mobility group AT-hook 2 -0.06515
DOCK5 dedicator of cytokinesis 5 -0.0639186
MCL1 myeloid cell leukemia 1 -0.0628256
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0622539
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0605065
THSD4 thrombospondin, type I, domain containing 4 -0.0577507
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0576273
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0559329
PDE4D phosphodiesterase 4D, cAMP-specific -0.0515864
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0513742
EXT1 exostosin glycosyltransferase 1 -0.0512804
GRAMD1B GRAM domain containing 1B -0.0506175
GPHN gephyrin -0.0503901
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0497503
VCL vinculin -0.0484219
NABP1 nucleic acid binding protein 1 -0.048106
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0479417
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0475329
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0457189
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0448852
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0440712
SMAD3 SMAD family member 3 -0.0427848
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0421347
SMYD3 SET and MYND domain containing 3 -0.0419303
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0410579
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0410535
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0409473
NF1 neurofibromin 1 -0.040813
AEBP2 AE binding protein 2 -0.0400445
RNF213 ring finger protein 213 -0.0392562
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0385835
YAP1 Yes-associated protein 1 -0.0373729
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0373302
ZNF638 zinc finger protein 638 -0.0369962
INTS6 integrator complex subunit 6 -0.0367858
EGR1 early growth response 1 -0.0364594
EGFR epidermal growth factor receptor -0.036124
ACTN1 actinin, alpha 1 -0.036032
SDK1 sidekick cell adhesion molecule 1 -0.0360204
MACF1 microtubule-actin crosslinking factor 1 -0.0349701
PDLIM5 PDZ and LIM domain 5 -0.0347447
RBM39 RNA binding motif protein 39 -0.0344909
MCTP1 multiple C2 domains, transmembrane 1 -0.0344447
ATG7 autophagy related 7 -0.034328
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0342937
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0340976
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0324497
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0322606
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0320156
OSMR oncostatin M receptor -0.0319742
PRH1 proline-rich protein HaeIII subfamily 1 -0.0318697
EXOC4 exocyst complex component 4 -0.0318603
PRKCE protein kinase C, epsilon -0.0316112
DIAPH2 diaphanous-related formin 2 -0.0314182
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0313577
SPIDR scaffolding protein involved in DNA repair -0.0313432
CDK17 cyclin-dependent kinase 17 -0.0310259
KTN1 kinectin 1 (kinesin receptor) -0.0305791
SAMD4A sterile alpha motif domain containing 4A -0.0304451
NAP1L1 nucleosome assembly protein 1-like 1 -0.0302645
FBXO11 F-box protein 11 -0.030186
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0300843
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0300207
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.02975
NCOA7 nuclear receptor coactivator 7 -0.0297327
LOXL2 lysyl oxidase-like 2 -0.0296788
R3HDM2 R3H domain containing 2 -0.0296109
SHB Src homology 2 domain containing adaptor protein B -0.0294307
MBD5 methyl-CpG binding domain protein 5 -0.0293469
EML4 echinoderm microtubule associated protein like 4 -0.0291984
BPTF bromodomain PHD finger transcription factor -0.0290388
STAT1 signal transducer and activator of transcription 1, 91kDa -0.029015
E2F3 E2F transcription factor 3 -0.0284368
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0283784
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0282347
PRELID2 PRELI domain containing 2 -0.0278139
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0270342
ELL2 elongation factor, RNA polymerase II, 2 -0.0269618
BASP1 brain abundant, membrane attached signal protein 1 -0.026914
ZFAND3 zinc finger, AN1-type domain 3 -0.0269043
USP34 ubiquitin specific peptidase 34 -0.0268113
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0266971
WDPCP WD repeat containing planar cell polarity effector -0.0266866
TFPI2 tissue factor pathway inhibitor 2 -0.0265965
EPAS1 endothelial PAS domain protein 1 -0.0261904
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0254218
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.025195
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.025161
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0250829
CCNL1 cyclin L1 -0.0249482
WDR70 WD repeat domain 70 -0.0248624
WNT2B wingless-type MMTV integration site family, member 2B -0.0248391