Pitavastatin (Calcium)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.110724
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0688335
SPAG9 sperm associated antigen 9 0.0392825
ATXN1 ataxin 1 0.0348711
FMNL2 formin-like 2 0.0342135
SOD2 superoxide dismutase 2, mitochondrial 0.0334713
DSCAM Down syndrome cell adhesion molecule 0.0291512
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0268089
MYH9 myosin, heavy chain 9, non-muscle 0.0267882
ARHGAP32 Rho GTPase activating protein 32 0.0257934
EZR ezrin 0.0249867
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0230921
ATP13A3 ATPase type 13A3 0.0224376
ADAM17 ADAM metallopeptidase domain 17 0.0219409
AHNAK AHNAK nucleoprotein 0.0212963
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0211739
USP12 ubiquitin specific peptidase 12 0.0208545
DENND5A DENN/MADD domain containing 5A 0.0208296
PLEC plectin 0.0200608
MED13L mediator complex subunit 13-like 0.0193209
ESYT2 extended synaptotagmin-like protein 2 0.0190326
AFDN afadin, adherens junction formation factor 0.0187631
HSPA8 heat shock 70kDa protein 8 0.0176004
MBNL2 muscleblind-like splicing regulator 2 0.0171768
MACF1 microtubule-actin crosslinking factor 1 0.0170059
DPY19L1 dpy-19-like 1 (C. elegans) 0.0167626
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0165771
DST dystonin 0.0163642
LYST lysosomal trafficking regulator 0.0161856
CD109 CD109 molecule 0.015894
AFAP1 actin filament associated protein 1 0.014566
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0143351
IGF1R insulin-like growth factor 1 receptor 0.0142664
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0141839
NCKAP1 NCK-associated protein 1 0.0136451
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0135357
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0133653
APP amyloid beta (A4) precursor protein 0.0130979
KIF16B kinesin family member 16B 0.0129195
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0127779
RNF213 ring finger protein 213 0.0127547
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0126372
USP9X ubiquitin specific peptidase 9, X-linked 0.0123261
PATJ PATJ crumbs cell polarity complex component 0.0122466
FNIP1 folliculin interacting protein 1 0.0119346
TNIP1 TNFAIP3 interacting protein 1 0.011833
FRMD5 FERM domain containing 5 0.0116634
CAMTA1 calmodulin binding transcription activator 1 0.0116284
KLF6 Kruppel-like factor 6 0.011504
RHOB ras homolog family member B 0.011423
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0110976
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0110525
SMAD3 SMAD family member 3 0.011003
TENT2 terminal nucleotidyltransferase 2 0.0108969
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0108968
TFRC transferrin receptor 0.0108415
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0107493
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0107098
RHBDD1 rhomboid domain containing 1 0.0107054
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0106166
ELOVL5 ELOVL fatty acid elongase 5 0.0105256
ZCCHC7 zinc finger, CCHC domain containing 7 0.0103913
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0101531
TMEM123 transmembrane protein 123 0.0101176
KDM6A lysine (K)-specific demethylase 6A 0.0101091
ZDHHC14 zinc finger, DHHC-type containing 14 0.0100637
ZNF460 zinc finger protein 460 0.0100251
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.00995465
DMTF1 cyclin D binding myb-like transcription factor 1 0.00991697
TAOK1 TAO kinase 1 0.00985676
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.00980451
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00972335
PICALM phosphatidylinositol binding clathrin assembly protein 0.00970274
SPIRE1 spire-type actin nucleation factor 1 0.00967573
SUCO SUN domain containing ossification factor 0.00962233
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00959251
MRTFA myocardin related transcription factor A 0.00943713
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.00936256
PPARG peroxisome proliferator-activated receptor gamma 0.00921999
AHDC1 AT hook, DNA binding motif, containing 1 0.00908973
ANKRD10 ankyrin repeat domain 10 0.009043
RPL3 ribosomal protein L3 0.00898444
ZNF516 zinc finger protein 516 0.00897428
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.00880998
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00879462
ZFAND3 zinc finger, AN1-type domain 3 0.00865994
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0085869
LRRC49 leucine rich repeat containing 49 0.00839663
IRAK2 interleukin-1 receptor-associated kinase 2 0.00835415
GRB10 growth factor receptor-bound protein 10 0.00834737
PRKCA protein kinase C, alpha 0.00821962
KMT2C lysine (K)-specific methyltransferase 2C 0.00817293
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.00816955
CALCOCO2 calcium binding and coiled-coil domain 2 0.00809865
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.00796287
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00794986
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00792947
STRN3 striatin, calmodulin binding protein 3 0.00792549
USP24 ubiquitin specific peptidase 24 0.00792474
AKAP12 A kinase (PRKA) anchor protein 12 0.00786304

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.395565
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.272778
VIM vimentin -0.262377
MT2A metallothionein 2A -0.120588
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0972167
RPLP1 ribosomal protein, large, P1 -0.0939614
TMSB10 thymosin beta 10 -0.0920391
RPLP2 ribosomal protein, large, P2 -0.0887082
VCL vinculin -0.078313
FBL fibrillarin -0.0778257
RPL35A ribosomal protein L35a -0.075028
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0729135
SAMD4B sterile alpha motif domain containing 4B -0.0690767
FTL ferritin, light polypeptide -0.0660275
FOSL1 FOS-like antigen 1 -0.0656613
ACTG1 actin gamma 1 -0.0609887
RPLP0 ribosomal protein, large, P0 -0.0601668
RPS8 ribosomal protein S8 -0.0595638
RPS12 ribosomal protein S12 -0.0578244
ZFP36 ZFP36 ring finger protein -0.0567288
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0553746
EIF1 eukaryotic translation initiation factor 1 -0.0535603
ACTN4 actinin, alpha 4 -0.05293
RPS3 ribosomal protein S3 -0.0517147
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0515866
TM4SF1 transmembrane 4 L six family member 1 -0.0514682
RPL11 ribosomal protein L11 -0.0506775
KTN1 kinectin 1 (kinesin receptor) -0.0505346
PTMA prothymosin, alpha -0.0499416
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0475096
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0467271
YBX1 Y box binding protein 1 -0.0466446
RPL28 ribosomal protein L28 -0.0451341
RPS19 ribosomal protein S19 -0.0451337
RPL12 ribosomal protein L12 -0.0447386
RPS6 ribosomal protein S6 -0.0424217
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0424008
RPS25 ribosomal protein S25 -0.0423681
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0423152
B2M beta-2-microglobulin -0.0416333
S100A6 S100 calcium binding protein A6 -0.0413074
RPS13 ribosomal protein S13 -0.0404615
RPL36A ribosomal protein L36a -0.040403
RPL37A ribosomal protein L37a -0.040075
ASPH aspartate beta-hydroxylase -0.0378803
SEPTIN7 septin 7 -0.0377058
RPS5 ribosomal protein S5 -0.0374924
RBM25 RNA binding motif protein 25 -0.0369245
LOC102724023 ES1 protein homolog, mitochondrial -0.0364915
RPL27A ribosomal protein L27a -0.0362131
LOC112694756 uncharaterized LOC112694756 -0.0361426
NAP1L1 nucleosome assembly protein 1-like 1 -0.0361391
RPS24 ribosomal protein S24 -0.0359586
SMYD3 SET and MYND domain containing 3 -0.0354269
THOC2 THO complex 2 -0.0352082
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.034939
RTN4 reticulon 4 -0.0348164
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0345501
TOP2A topoisomerase (DNA) II alpha 170kDa -0.034459
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.034078
FHL2 four and a half LIM domains 2 -0.0339751
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0339346
MED29 mediator complex subunit 29 -0.0337254
RPL31 ribosomal protein L31 -0.0335758
PFN1 profilin 1 -0.0334729
EFNA5 ephrin-A5 -0.0333877
RPL9 ribosomal protein L9 -0.0333425
SLC35F3 solute carrier family 35, member F3 -0.0332695
EGR1 early growth response 1 -0.0332263
RACK1 receptor for activated C kinase 1 -0.0331385
DSTN destrin (actin depolymerizing factor) -0.0331105
SMC4 structural maintenance of chromosomes 4 -0.0331085
IFITM3 interferon induced transmembrane protein 3 -0.0330974
RPS27A ribosomal protein S27a -0.0330459
ITGB5 integrin, beta 5 -0.0330251
RPS23 ribosomal protein S23 -0.0327402
MKI67 marker of proliferation Ki-67 -0.0327309
CENPF centromere protein F, 350/400kDa -0.0324621
ANGPTL4 angiopoietin-like 4 -0.0323584
RPL26 ribosomal protein L26 -0.0321366
DEK DEK proto-oncogene -0.0319257
RPL8 ribosomal protein L8 -0.0318901
GARS1 glycyl-tRNA synthetase 1 -0.0317593
MCL1 myeloid cell leukemia 1 -0.0317087
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0313575
RPS21 ribosomal protein S21 -0.0309487
ANXA2 annexin A2 -0.0303642
RPS17 ribosomal protein S17 -0.030324
RPL23 ribosomal protein L23 -0.0300632
RPL37 ribosomal protein L37 -0.0299342
RPS14 ribosomal protein S14 -0.0298697
RPL32 ribosomal protein L32 -0.0296515
RPL38 ribosomal protein L38 -0.0295734
HMGA1 high mobility group AT-hook 1 -0.0295049
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0294463
CCDC88A coiled-coil domain containing 88A -0.0294042
CD44 CD44 molecule (Indian blood group) -0.0292837
MCTP1 multiple C2 domains, transmembrane 1 -0.0292731
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0291679
CBX3 chromobox homolog 3 -0.0283418