Pitavastatin (Calcium)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.125527
PICALM phosphatidylinositol binding clathrin assembly protein 0.0863463
EPS8 epidermal growth factor receptor pathway substrate 8 0.0798335
KRT17 keratin 17, type I 0.0692668
NAMPT nicotinamide phosphoribosyltransferase 0.0687056
TSC22D2 TSC22 domain family, member 2 0.0663131
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0657227
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.057542
DSPP dentin sialophosphoprotein 0.0551321
PLAT plasminogen activator, tissue 0.0550523
ARRDC3 arrestin domain containing 3 0.0496261
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0483083
SPAG9 sperm associated antigen 9 0.0461505
LMO7 LIM domain 7 0.0454755
KYNU kynureninase 0.0451961
ZFAND3 zinc finger, AN1-type domain 3 0.0442917
DSCAM Down syndrome cell adhesion molecule 0.0441739
MUC4 mucin 4, cell surface associated 0.0439714
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0430942
CTNND1 catenin (cadherin-associated protein), delta 1 0.0423869
SOD2 superoxide dismutase 2, mitochondrial 0.0415813
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0403977
KDM3A lysine (K)-specific demethylase 3A 0.0389113
TC2N tandem C2 domains, nuclear 0.0379033
UBE2H ubiquitin-conjugating enzyme E2H 0.0374609
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.037392
MYH9 myosin, heavy chain 9, non-muscle 0.0370438
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0366787
KDM6A lysine (K)-specific demethylase 6A 0.0357139
EZR ezrin 0.034913
SMOC1 SPARC related modular calcium binding 1 0.0332705
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0331093
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0329202
WARS1 tryptophanyl-tRNA synthetase 1 0.0324589
USP9X ubiquitin specific peptidase 9, X-linked 0.0321183
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0320163
STK24 serine/threonine kinase 24 0.0318207
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.031609
NRIP1 nuclear receptor interacting protein 1 0.0314516
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0310832
MACF1 microtubule-actin crosslinking factor 1 0.0307839
TXNRD1 thioredoxin reductase 1 0.0307367
XPO1 exportin 1 0.0307083
UBA6 ubiquitin-like modifier activating enzyme 6 0.030346
PGK1 phosphoglycerate kinase 1 0.0298887
TFG TRK-fused gene 0.0293863
CCNY cyclin Y 0.0292924
FGD4 FYVE, RhoGEF and PH domain containing 4 0.028384
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0283359
OGA O-GlcNAcase 0.0283042
TNIP1 TNFAIP3 interacting protein 1 0.0281445
GRB10 growth factor receptor-bound protein 10 0.0266215
SPTBN1 spectrin, beta, non-erythrocytic 1 0.026366
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0262473
BHLHE40 basic helix-loop-helix family, member e40 0.0255718
TM9SF2 transmembrane 9 superfamily member 2 0.0253968
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0247241
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0246219
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0246204
ECT2 epithelial cell transforming 2 0.0243877
FOXO1 forkhead box O1 0.0242514
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0241271
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0241163
DAPK1 death-associated protein kinase 1 0.0240976
SMAD3 SMAD family member 3 0.0240621
SDC4 syndecan 4 0.0237853
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0234554
NCKAP1 NCK-associated protein 1 0.0232602
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0224738
H1-4 H1.4 linker histone, cluster member 0.0223865
WAC WW domain containing adaptor with coiled-coil 0.0223789
FXR1 fragile X mental retardation, autosomal homolog 1 0.0216787
AHR aryl hydrocarbon receptor 0.0216445
LRRC1 leucine rich repeat containing 1 0.0213729
MTAP methylthioadenosine phosphorylase 0.0213713
OXSR1 oxidative stress responsive 1 0.0213391
EFNA5 ephrin-A5 0.0213021
KMT2E lysine (K)-specific methyltransferase 2E 0.0212464
NDRG1 N-myc downstream regulated 1 0.0212413
KLF7 Kruppel-like factor 7 (ubiquitous) 0.021143
FAR1 fatty acyl CoA reductase 1 0.021055
RIOK3 RIO kinase 3 0.0210546
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0207272
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0207173
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0206213
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0205971
PTK2 protein tyrosine kinase 2 0.0202863
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0201301
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0200769
RNF149 ring finger protein 149 0.0198617
RYK receptor-like tyrosine kinase 0.0193133
DENND4C DENN/MADD domain containing 4C 0.0192598
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0192555
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0192122
NEK7 NIMA-related kinase 7 0.019135
KMT2C lysine (K)-specific methyltransferase 2C 0.0189791
DDIT4 DNA-damage-inducible transcript 4 0.0189579
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0189272
GARS1 glycyl-tRNA synthetase 1 0.0188916
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0186927

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162153
HMGA1 high mobility group AT-hook 1 -0.113894
MAML2 mastermind-like 2 (Drosophila) -0.0980768
ACTG1 actin gamma 1 -0.097415
LAMA4 laminin, alpha 4 -0.0789659
TPT1 tumor protein, translationally-controlled 1 -0.0732687
RPS6 ribosomal protein S6 -0.0716277
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0693384
POTEF POTE ankyrin domain family, member F -0.0675113
EGR1 early growth response 1 -0.0595703
RPL35A ribosomal protein L35a -0.0585323
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0563382
EMP1 epithelial membrane protein 1 -0.0561457
RPS8 ribosomal protein S8 -0.0536823
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0534791
EGFR epidermal growth factor receptor -0.0533809
ANXA2 annexin A2 -0.0530373
TMSB10 thymosin beta 10 -0.0523326
HLA-B major histocompatibility complex, class I, B -0.0520928
FN1 fibronectin 1 -0.0504865
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0481132
SVIL supervillin -0.0478542
RACK1 receptor for activated C kinase 1 -0.0470941
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0468022
INHBA inhibin, beta A -0.0463306
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0461853
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0458921
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0457
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0455526
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0451143
HDAC9 histone deacetylase 9 -0.0437738
RPS19 ribosomal protein S19 -0.0436821
KRT19 keratin 19, type I -0.0433763
RPLP1 ribosomal protein, large, P1 -0.0420894
RUNX1 runt-related transcription factor 1 -0.0412651
TM4SF1 transmembrane 4 L six family member 1 -0.0411613
ASPH aspartate beta-hydroxylase -0.0397798
F3 coagulation factor III (thromboplastin, tissue factor) -0.0395947
LAMB3 laminin, beta 3 -0.0395835
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0393418
RPL12 ribosomal protein L12 -0.0391528
KRT7 keratin 7, type II -0.038846
PLSCR1 phospholipid scramblase 1 -0.0386645
LAMC2 laminin, gamma 2 -0.0384416
HLA-A major histocompatibility complex, class I, A -0.0381984
TPM4 tropomyosin 4 -0.0379281
MT2A metallothionein 2A -0.0370914
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0367022
FOSL1 FOS-like antigen 1 -0.0365158
SAMD4A sterile alpha motif domain containing 4A -0.0357059
RPL19 ribosomal protein L19 -0.0354746
RNF213 ring finger protein 213 -0.0354043
ERBIN erbb2 interacting protein -0.0348717
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0344949
TJP1 tight junction protein 1 -0.034369
IFI27 interferon, alpha-inducible protein 27 -0.0343139
CD44 CD44 molecule (Indian blood group) -0.0341778
MACC1 metastasis associated in colon cancer 1 -0.0340875
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0338558
RPL37A ribosomal protein L37a -0.0336557
RAB7A RAB7A, member RAS oncogene family -0.0335033
INTS6 integrator complex subunit 6 -0.033389
TMSB4X thymosin beta 4, X-linked -0.0333747
RASAL2 RAS protein activator like 2 -0.0332153
EIF1 eukaryotic translation initiation factor 1 -0.0325404
RPS13 ribosomal protein S13 -0.0324306
VCL vinculin -0.0323808
RPL31 ribosomal protein L31 -0.0322719
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0315823
PLAU plasminogen activator, urokinase -0.0312076
FTL ferritin, light polypeptide -0.0311549
SLC35F3 solute carrier family 35, member F3 -0.0311305
SMYD3 SET and MYND domain containing 3 -0.0310916
B2M beta-2-microglobulin -0.0307373
RPL28 ribosomal protein L28 -0.0299299
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0299202
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0299183
RPS24 ribosomal protein S24 -0.0297953
G0S2 G0/G1 switch 2 -0.0297244
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0297228
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0296641
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0295262
HMGA2 high mobility group AT-hook 2 -0.0294678
RPL34 ribosomal protein L34 -0.0294365
SQSTM1 sequestosome 1 -0.0291782
CCND1 cyclin D1 -0.0291656
LOC102724023 ES1 protein homolog, mitochondrial -0.0286678
RPL23 ribosomal protein L23 -0.0284268
CDK6 cyclin-dependent kinase 6 -0.028343
LY6E lymphocyte antigen 6 complex, locus E -0.0282886
RPS3 ribosomal protein S3 -0.0281441
RPS23 ribosomal protein S23 -0.0277942
BACE2 beta-site APP-cleaving enzyme 2 -0.0277618
EHBP1 EH domain binding protein 1 -0.0276704
ARHGAP29 Rho GTPase activating protein 29 -0.0274029
BLZF1 basic leucine zipper nuclear factor 1 -0.0273527
ARHGAP5 Rho GTPase activating protein 5 -0.0269178
RPL37 ribosomal protein L37 -0.0268111
OSBPL3 oxysterol binding protein-like 3 -0.0265135
RPS29 ribosomal protein S29 -0.0265077