Pitavastatin (Calcium)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.112016
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0715761
LAMB3 laminin, beta 3 0.0577572
NUP58 nucleoporin 58 0.049457
USP3 ubiquitin specific peptidase 3 0.0480122
ZEB1 zinc finger E-box binding homeobox 1 0.046367
NAV2 neuron navigator 2 0.045869
KDM3A lysine (K)-specific demethylase 3A 0.0449194
KDM6A lysine (K)-specific demethylase 6A 0.0438797
ELL2 elongation factor, RNA polymerase II, 2 0.0409667
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0392749
USP9X ubiquitin specific peptidase 9, X-linked 0.0376911
ATP13A3 ATPase type 13A3 0.0370023
KMT2C lysine (K)-specific methyltransferase 2C 0.0369569
TPD52 tumor protein D52 0.0365293
RLF rearranged L-myc fusion 0.0354019
MYH9 myosin, heavy chain 9, non-muscle 0.0351534
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0349391
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0338785
AHNAK AHNAK nucleoprotein 0.0333628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0325114
RAD21 RAD21 homolog (S. pombe) 0.0313808
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0305929
BHLHE40 basic helix-loop-helix family, member e40 0.030218
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0298706
HSPA8 heat shock 70kDa protein 8 0.029761
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0297295
OGA O-GlcNAcase 0.0295644
RAB18 RAB18, member RAS oncogene family 0.0295305
PTK2 protein tyrosine kinase 2 0.0294328
STC1 stanniocalcin 1 0.0294306
RBM33 RNA binding motif protein 33 0.0291155
FLNB filamin B, beta 0.0288969
CNOT4 CCR4-NOT transcription complex, subunit 4 0.028541
SRPK2 SRSF protein kinase 2 0.0281065
NCKAP1 NCK-associated protein 1 0.0279738
OSBPL8 oxysterol binding protein-like 8 0.0273337
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0269958
BBX bobby sox homolog (Drosophila) 0.026942
BTBD9 BTB (POZ) domain containing 9 0.0268913
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0267815
UBA6 ubiquitin-like modifier activating enzyme 6 0.0266498
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0264135
PRRC2C proline-rich coiled-coil 2C 0.0259877
JMJD1C jumonji domain containing 1C 0.0256639
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0255816
RB1CC1 RB1-inducible coiled-coil 1 0.0252683
SPAG9 sperm associated antigen 9 0.0252372
ADAM17 ADAM metallopeptidase domain 17 0.0250189
XPO1 exportin 1 0.0248369
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.024595
KAT6A K(lysine) acetyltransferase 6A 0.0245835
CDK17 cyclin-dependent kinase 17 0.0244068
RBM39 RNA binding motif protein 39 0.0241347
ANXA5 annexin A5 0.0236123
ANK2 ankyrin 2, neuronal 0.0235339
ECPAS Ecm29 proteasome adaptor and scaffold 0.0231884
RPL3 ribosomal protein L3 0.0231384
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0231099
ZFAND3 zinc finger, AN1-type domain 3 0.023081
TSC22D2 TSC22 domain family, member 2 0.0230354
SBF2 SET binding factor 2 0.022882
CCNL1 cyclin L1 0.0228204
MAPK8 mitogen-activated protein kinase 8 0.0227474
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0223213
WSB1 WD repeat and SOCS box containing 1 0.0222543
NAMPT nicotinamide phosphoribosyltransferase 0.0222492
ABI1 abl-interactor 1 0.0220837
ANO6 anoctamin 6 0.0220013
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0218724
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0216768
TM9SF3 transmembrane 9 superfamily member 3 0.0216034
MTF2 metal response element binding transcription factor 2 0.0213874
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0213188
RNF145 ring finger protein 145 0.0208994
PTBP2 polypyrimidine tract binding protein 2 0.0206847
BRWD3 bromodomain and WD repeat domain containing 3 0.0205131
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0201963
ZFC3H1 zinc finger, C3H1-type containing 0.0199479
MAP2K1 mitogen-activated protein kinase kinase 1 0.0198345
PGK1 phosphoglycerate kinase 1 0.0196582
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0192111
APP amyloid beta (A4) precursor protein 0.0190708
OSBPL9 oxysterol binding protein-like 9 0.0189545
TEX10 testis expressed 10 0.0188897
FXR1 fragile X mental retardation, autosomal homolog 1 0.0188468
ZBTB43 zinc finger and BTB domain containing 43 0.0187592
PUM2 pumilio RNA-binding family member 2 0.0184569
CREB5 cAMP responsive element binding protein 5 0.0184379
GIGYF2 GRB10 interacting GYF protein 2 0.0183109
EZR ezrin 0.0182356
TMEM41B transmembrane protein 41B 0.0181719
MAST4 microtubule associated serine/threonine kinase family member 4 0.0181609
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0181486
PSME4 proteasome (prosome, macropain) activator subunit 4 0.018082
UBXN7 UBX domain protein 7 0.0179641
NPEPPS aminopeptidase puromycin sensitive 0.0177371
HELZ helicase with zinc finger 0.0176482
KMT2E lysine (K)-specific methyltransferase 2E 0.0175259
OTUD4 OTU deubiquitinase 4 0.0174191

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157234
MT2A metallothionein 2A -0.155353
RPL35A ribosomal protein L35a -0.112792
RPS6 ribosomal protein S6 -0.109759
DLC1 DLC1 Rho GTPase activating protein -0.100736
RPS8 ribosomal protein S8 -0.0987906
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0848765
FTL ferritin, light polypeptide -0.082093
POTEF POTE ankyrin domain family, member F -0.0804525
RPS13 ribosomal protein S13 -0.0803835
RPL8 ribosomal protein L8 -0.0797957
ACTG1 actin gamma 1 -0.0792198
RPL37A ribosomal protein L37a -0.0756172
RPL12 ribosomal protein L12 -0.0719087
RPL11 ribosomal protein L11 -0.0717226
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0711544
RPS23 ribosomal protein S23 -0.0704588
RPL31 ribosomal protein L31 -0.0702443
TPT1 tumor protein, translationally-controlled 1 -0.0697486
RPS19 ribosomal protein S19 -0.0685363
HMGA1 high mobility group AT-hook 1 -0.0684929
RPLP2 ribosomal protein, large, P2 -0.0677841
FRMD6 FERM domain containing 6 -0.0676171
RPLP1 ribosomal protein, large, P1 -0.0628546
RPS29 ribosomal protein S29 -0.0621257
RPS12 ribosomal protein S12 -0.0615061
RPL9 ribosomal protein L9 -0.0602939
RPL7A ribosomal protein L7a -0.0601917
ZNF438 zinc finger protein 438 -0.0590494
RPS20 ribosomal protein S20 -0.0586409
NAV3 neuron navigator 3 -0.0582025
PFN1 profilin 1 -0.0565246
RPS3 ribosomal protein S3 -0.0548813
RPL19 ribosomal protein L19 -0.0535421
PTMA prothymosin, alpha -0.0519763
RPS25 ribosomal protein S25 -0.0516403
RPS15 ribosomal protein S15 -0.050696
EGR1 early growth response 1 -0.0499084
RPL5 ribosomal protein L5 -0.0492049
RPL7 ribosomal protein L7 -0.0478912
RPS10 ribosomal protein S10 -0.0478247
P4HB prolyl 4-hydroxylase, beta polypeptide -0.047796
RPS21 ribosomal protein S21 -0.046632
RPS17 ribosomal protein S17 -0.0454962
NABP1 nucleic acid binding protein 1 -0.0451111
RPL34 ribosomal protein L34 -0.0443591
RPL30 ribosomal protein L30 -0.0439157
TPM4 tropomyosin 4 -0.0421298
RPL35 ribosomal protein L35 -0.041103
RPS27 ribosomal protein S27 -0.0405283
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0397013
RPLP0 ribosomal protein, large, P0 -0.0393225
RPL23 ribosomal protein L23 -0.039093
EEF2 eukaryotic translation elongation factor 2 -0.0383206
CALD1 caldesmon 1 -0.0379985
INTS6 integrator complex subunit 6 -0.0375094
EIF1 eukaryotic translation initiation factor 1 -0.0372614
HDAC9 histone deacetylase 9 -0.0366588
RPS24 ribosomal protein S24 -0.0365592
B2M beta-2-microglobulin -0.0363959
RAD51B RAD51 paralog B -0.0361296
DIAPH3 diaphanous-related formin 3 -0.035768
RPS27A ribosomal protein S27a -0.0352768
RPL38 ribosomal protein L38 -0.0350569
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0349315
RPL36A ribosomal protein L36a -0.0346643
RPL28 ribosomal protein L28 -0.0345625
RPL37 ribosomal protein L37 -0.0343665
PA2G4 proliferation-associated 2G4, 38kDa -0.0338111
RAB7A RAB7A, member RAS oncogene family -0.0337319
RPS11 ribosomal protein S11 -0.0336989
RPL27 ribosomal protein L27 -0.0332154
GLRX glutaredoxin (thioltransferase) -0.0331531
RPL32 ribosomal protein L32 -0.0327135
RACK1 receptor for activated C kinase 1 -0.032268
PDIA3 protein disulfide isomerase family A, member 3 -0.0320847
FRMD4A FERM domain containing 4A -0.0318015
RPS14 ribosomal protein S14 -0.0315847
KPNB1 karyopherin (importin) beta 1 -0.0314317
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0309716
ARHGAP22 Rho GTPase activating protein 22 -0.0308486
S100A9 S100 calcium binding protein A9 -0.0301417
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0300722
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0300005
ATP5F1B ATP synthase F1 subunit beta -0.0295755
VIM vimentin -0.0292517
KTN1 kinectin 1 (kinesin receptor) -0.0291111
GPHN gephyrin -0.0290962
TMSB10 thymosin beta 10 -0.0289359
EXT1 exostosin glycosyltransferase 1 -0.0284381
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0283551
IFI6 interferon, alpha-inducible protein 6 -0.0282796
TBCA tubulin folding cofactor A -0.0281153
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0280787
RPL10A ribosomal protein L10a -0.0275438
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0274188
PCNX4 pecanex 4 -0.0262828
BPTF bromodomain PHD finger transcription factor -0.0261851
RPS16 ribosomal protein S16 -0.0259829
SP100 SP100 nuclear antigen -0.0258248