Pitavastatin (Calcium)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TENM1 teneurin transmembrane protein 1 0.0956977
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0837453
SLC35F4 solute carrier family 35, member F4 0.0830047
PSD3 pleckstrin and Sec7 domain containing 3 0.0765879
RHOA ras homolog family member A 0.0752987
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0710061
EZR ezrin 0.0618609
MYH9 myosin, heavy chain 9, non-muscle 0.0596196
MAP1B microtubule-associated protein 1B 0.0530311
TRIO trio Rho guanine nucleotide exchange factor 0.0527241
CREB5 cAMP responsive element binding protein 5 0.049236
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.046985
LMO7 LIM domain 7 0.0425081
MAST4 microtubule associated serine/threonine kinase family member 4 0.040823
ZFHX3 zinc finger homeobox 3 0.0391556
HSPB1 heat shock 27kDa protein 1 0.0388505
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0381912
DST dystonin 0.0379984
RHOB ras homolog family member B 0.0379895
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0374764
SCG2 secretogranin II 0.0374625
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.036359
PGM2L1 phosphoglucomutase 2-like 1 0.0358538
MACF1 microtubule-actin crosslinking factor 1 0.0345128
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0343613
CEMIP cell migration inducing protein, hyaluronan binding 0.0323951
ERRFI1 ERBB receptor feedback inhibitor 1 0.0319092
IQGAP3 IQ motif containing GTPase activating protein 3 0.030869
TPD52 tumor protein D52 0.0304071
TPM3 tropomyosin 3 0.0298272
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0297935
RIMS2 regulating synaptic membrane exocytosis 2 0.0286057
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0280259
FNDC3B fibronectin type III domain containing 3B 0.0276313
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.0273505
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0272165
FAM13A family with sequence similarity 13, member A 0.0270888
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0270668
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0264941
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0240207
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0237995
TACC2 transforming, acidic coiled-coil containing protein 2 0.0235211
BACE2 beta-site APP-cleaving enzyme 2 0.0234564
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0234161
ANKH ANKH inorganic pyrophosphate transport regulator 0.0233941
APP amyloid beta (A4) precursor protein 0.0231159
MPRIP myosin phosphatase Rho interacting protein 0.023095
SLC22A23 solute carrier family 22, member 23 0.0221593
GPC5 glypican 5 0.0219854
ANXA2 annexin A2 0.0218649
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0215655
LMNB1 lamin B1 0.0214542
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.021278
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0212637
PLPP1 phospholipid phosphatase 1 0.0209991
RPH3AL rabphilin 3A-like (without C2 domains) 0.0209319
DTNA dystrobrevin, alpha 0.0208995
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0208201
JUN jun proto-oncogene 0.0200769
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0199955
TMCO3 transmembrane and coiled-coil domains 3 0.0197766
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.0194668
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0194547
AFF1 AF4/FMR2 family, member 1 0.0193997
NUMA1 nuclear mitotic apparatus protein 1 0.019326
XPO1 exportin 1 0.0192505
HSPA8 heat shock 70kDa protein 8 0.0192256
CKAP5 cytoskeleton associated protein 5 0.0191501
MED13L mediator complex subunit 13-like 0.0190393
MAP4 microtubule-associated protein 4 0.0188904
FNBP1L formin binding protein 1-like 0.0187143
DPYSL2 dihydropyrimidinase-like 2 0.0186544
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.018416
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0183813
ECPAS Ecm29 proteasome adaptor and scaffold 0.0178563
ACACA acetyl-CoA carboxylase alpha 0.017836
ACTN4 actinin, alpha 4 0.0176681
PCBP3 poly(rC) binding protein 3 0.0176028
DSPP dentin sialophosphoprotein 0.017573
GOLM1 golgi membrane protein 1 0.0173943
LMNA lamin A/C 0.0173432
KLF6 Kruppel-like factor 6 0.0172586
ABHD2 abhydrolase domain containing 2 0.0172367
IQGAP1 IQ motif containing GTPase activating protein 1 0.0170309
JAZF1 JAZF zinc finger 1 0.0169353
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0167361
CTBP2 C-terminal binding protein 2 0.0164777
KIF16B kinesin family member 16B 0.0164283
DIAPH1 diaphanous-related formin 1 0.0163986
CENPF centromere protein F, 350/400kDa 0.0162572
SHTN1 shootin 1 0.0159871
RDH10 retinol dehydrogenase 10 (all-trans) 0.0159332
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.015882
H1-4 H1.4 linker histone, cluster member 0.015873
MSI2 musashi RNA-binding protein 2 0.0157699
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0156652
RPL3 ribosomal protein L3 0.015648
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0155699
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0154075
AKAP13 A kinase (PRKA) anchor protein 13 0.0153619

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.151143
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150934
VGF VGF nerve growth factor inducible -0.120633
CALCA calcitonin-related polypeptide alpha -0.113551
FTL ferritin, light polypeptide -0.101948
MT2A metallothionein 2A -0.0987463
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0948153
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.094246
STC1 stanniocalcin 1 -0.0923431
PTMA prothymosin, alpha -0.0911798
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.079848
EGR1 early growth response 1 -0.0787098
NALF1 NALCN channel auxiliary factor 1 -0.074688
RPS21 ribosomal protein S21 -0.0721525
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0686689
SNAP25 synaptosomal-associated protein, 25kDa -0.0659635
RPS6 ribosomal protein S6 -0.0637244
RPS3 ribosomal protein S3 -0.0610017
RPLP1 ribosomal protein, large, P1 -0.0596002
RPS8 ribosomal protein S8 -0.0582529
RPL26 ribosomal protein L26 -0.0582489
ACTG1 actin gamma 1 -0.0568626
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.054398
S100A9 S100 calcium binding protein A9 -0.0535983
RPL8 ribosomal protein L8 -0.0491475
NDRG1 N-myc downstream regulated 1 -0.0475371
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.04744
RPL37 ribosomal protein L37 -0.0457211
RPL37A ribosomal protein L37a -0.0445201
MCL1 myeloid cell leukemia 1 -0.0441254
RORA RAR-related orphan receptor A -0.0439197
IFI6 interferon, alpha-inducible protein 6 -0.0435679
ATP5F1E ATP synthase F1 subunit epsilon -0.0430926
RPS19 ribosomal protein S19 -0.0430168
ISG15 ISG15 ubiquitin-like modifier -0.0413619
ZNF292 zinc finger protein 292 -0.0401028
PTCHD4 patched domain containing 4 -0.040052
RPS16 ribosomal protein S16 -0.0396719
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0386964
LOC112694756 uncharaterized LOC112694756 -0.0382804
RPL19 ribosomal protein L19 -0.0381793
SNTG1 syntrophin, gamma 1 -0.0380879
RPL23 ribosomal protein L23 -0.0375945
TENT5A terminal nucleotidyltransferase 5A -0.0372249
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0368962
RPL38 ribosomal protein L38 -0.0365391
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0361632
RPL36 ribosomal protein L36 -0.0358185
POTEF POTE ankyrin domain family, member F -0.0356615
RPS27 ribosomal protein S27 -0.0356606
PFN1 profilin 1 -0.035552
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0350464
RPS23 ribosomal protein S23 -0.0349432
RPL32 ribosomal protein L32 -0.0342195
RPS29 ribosomal protein S29 -0.0336328
RPL31 ribosomal protein L31 -0.0326297
PEG10 paternally expressed 10 -0.0325914
RPL30 ribosomal protein L30 -0.032393
RPS25 ribosomal protein S25 -0.031997
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0318308
RPL11 ribosomal protein L11 -0.0318207
GNAS GNAS complex locus -0.0316745
ATP5F1B ATP synthase F1 subunit beta -0.0314553
RPS12 ribosomal protein S12 -0.0314519
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0311987
IRS2 insulin receptor substrate 2 -0.0308169
RPLP2 ribosomal protein, large, P2 -0.0306154
RPS27A ribosomal protein S27a -0.0305815
RPL35A ribosomal protein L35a -0.0305093
TMSB10 thymosin beta 10 -0.030425
TOX thymocyte selection-associated high mobility group box -0.0300763
RPL5 ribosomal protein L5 -0.0299556
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0299331
RPL12 ribosomal protein L12 -0.0299162
NIPBL Nipped-B homolog (Drosophila) -0.0293254
RPL35 ribosomal protein L35 -0.0288752
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0287126
TNRC6B trinucleotide repeat containing 6B -0.0280708
ESRRG estrogen-related receptor gamma -0.0272724
RPS14 ribosomal protein S14 -0.0268076
FAAH2 fatty acid amide hydrolase 2 -0.0266376
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0263914
TUBB4B tubulin, beta 4B class IVb -0.0261887
RPL34 ribosomal protein L34 -0.0259336
RPL7 ribosomal protein L7 -0.0259155
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0258798
RPS5 ribosomal protein S5 -0.0258114
DOCK5 dedicator of cytokinesis 5 -0.0256084
RPL28 ribosomal protein L28 -0.0255814
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0255403
COX6C cytochrome c oxidase subunit VIc -0.0254874
RPLP0 ribosomal protein, large, P0 -0.0254261
MCTP1 multiple C2 domains, transmembrane 1 -0.0253396
RGS7 regulator of G-protein signaling 7 -0.0250408
DEK DEK proto-oncogene -0.0249527
LSAMP limbic system-associated membrane protein -0.0249153
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0249112
B2M beta-2-microglobulin -0.0248975
SINHCAF SIN3-HDAC complex associated factor -0.0248216
EIF4A1 eukaryotic translation initiation factor 4A1 -0.024802