Pitavastatin (Calcium)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.08287
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0586967
CTNND1 catenin (cadherin-associated protein), delta 1 0.0582746
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0482607
FNDC3B fibronectin type III domain containing 3B 0.0481847
HSPA8 heat shock 70kDa protein 8 0.0414558
KDM6A lysine (K)-specific demethylase 6A 0.0379696
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0359387
PLEC plectin 0.0336527
AKAP12 A kinase (PRKA) anchor protein 12 0.033629
MYO5B myosin VB 0.031805
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0288582
ARRDC3 arrestin domain containing 3 0.0288579
FXR1 fragile X mental retardation, autosomal homolog 1 0.0287668
EPS8 epidermal growth factor receptor pathway substrate 8 0.0285032
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.028351
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0280912
FAR1 fatty acyl CoA reductase 1 0.0273872
DSCAM Down syndrome cell adhesion molecule 0.0263924
MYH9 myosin, heavy chain 9, non-muscle 0.025409
USP3 ubiquitin specific peptidase 3 0.0246051
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.024051
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0229772
ARHGAP32 Rho GTPase activating protein 32 0.0223444
LMO7 LIM domain 7 0.0219906
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0219879
MXD1 MAX dimerization protein 1 0.0208943
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0206812
GRB10 growth factor receptor-bound protein 10 0.0205912
TFG TRK-fused gene 0.0202794
AHR aryl hydrocarbon receptor 0.0199673
RREB1 ras responsive element binding protein 1 0.0195893
AFDN afadin, adherens junction formation factor 0.019224
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0189198
TXNRD1 thioredoxin reductase 1 0.0186085
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0174997
RAB18 RAB18, member RAS oncogene family 0.017425
PPME1 protein phosphatase methylesterase 1 0.017391
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0171745
NCKAP1 NCK-associated protein 1 0.017111
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0169639
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0165973
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.0164582
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0164
USP9X ubiquitin specific peptidase 9, X-linked 0.0162854
MEF2A myocyte enhancer factor 2A 0.0162183
TMEM39A transmembrane protein 39A 0.0161857
RPL3 ribosomal protein L3 0.015878
OSBPL9 oxysterol binding protein-like 9 0.0158776
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0155391
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0154776
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0153529
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0151913
GSK3B glycogen synthase kinase 3 beta 0.0151288
KMT2E lysine (K)-specific methyltransferase 2E 0.0151135
BCLAF1 BCL2-associated transcription factor 1 0.0149253
MACF1 microtubule-actin crosslinking factor 1 0.014867
CRY1 cryptochrome circadian clock 1 0.0147513
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0146877
SLK STE20-like kinase 0.0146337
ARHGAP12 Rho GTPase activating protein 12 0.0145937
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 0.0144083
ITPRID2 ITPR interacting domain containing 2 0.0142001
PNN pinin, desmosome associated protein 0.0140866
UBA6 ubiquitin-like modifier activating enzyme 6 0.0139973
ABI1 abl-interactor 1 0.0139709
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0139584
SLMAP sarcolemma associated protein 0.0138779
MTMR3 myotubularin related protein 3 0.0138652
TNIP1 TNFAIP3 interacting protein 1 0.0138627
SARNP SAP domain containing ribonucleoprotein 0.0136011
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.0135988
USP24 ubiquitin specific peptidase 24 0.0135311
H1-4 H1.4 linker histone, cluster member 0.0134955
EIF5 eukaryotic translation initiation factor 5 0.0133871
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0133266
SPPL3 signal peptide peptidase like 3 0.0132926
PARP12 poly (ADP-ribose) polymerase family, member 12 0.0132217
GADD45B growth arrest and DNA-damage-inducible, beta 0.0131592
ITCH itchy E3 ubiquitin protein ligase 0.0131092
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0131032
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0130343
ERRFI1 ERBB receptor feedback inhibitor 1 0.012999
ADAM17 ADAM metallopeptidase domain 17 0.0129435
AKAP13 A kinase (PRKA) anchor protein 13 0.0128867
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0128374
RPS18 ribosomal protein S18 0.0127368
PELI1 pellino E3 ubiquitin protein ligase 1 0.0127056
LMTK2 lemur tyrosine kinase 2 0.0126261
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.012542
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0125225
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0123363
TSC22D2 TSC22 domain family, member 2 0.0123007
HBS1L HBS1-like translational GTPase 0.0122195
AGFG1 ArfGAP with FG repeats 1 0.0122095
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0121987
DPY19L1 dpy-19-like 1 (C. elegans) 0.0121057
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.0120363
ETNK1 ethanolamine kinase 1 0.0119901
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0119375

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.183827
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16504
PTMA prothymosin, alpha -0.119717
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.107589
MAML2 mastermind-like 2 (Drosophila) -0.101597
GOLGA4 golgin A4 -0.0877773
TMSB10 thymosin beta 10 -0.0849307
LOC102724023 ES1 protein homolog, mitochondrial -0.0787163
RPL35A ribosomal protein L35a -0.0732305
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.073191
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0707349
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0703495
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.070331
ACTG1 actin gamma 1 -0.0696519
SDK1 sidekick cell adhesion molecule 1 -0.069332
GNAS GNAS complex locus -0.0675783
RPLP1 ribosomal protein, large, P1 -0.0671969
RPS21 ribosomal protein S21 -0.0647179
MACC1 metastasis associated in colon cancer 1 -0.0643943
ANXA2 annexin A2 -0.0619199
NCEH1 neutral cholesterol ester hydrolase 1 -0.0614855
RPS6 ribosomal protein S6 -0.0610459
DLG1 discs, large homolog 1 (Drosophila) -0.0603682
TPT1 tumor protein, translationally-controlled 1 -0.0595476
EHBP1 EH domain binding protein 1 -0.058696
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.057215
NFIA nuclear factor I/A -0.0571208
RPL12 ribosomal protein L12 -0.0549011
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0545238
EPCAM epithelial cell adhesion molecule -0.0525208
EGR1 early growth response 1 -0.0514621
BCL2L1 BCL2-like 1 -0.0508066
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0476376
TTC3 tetratricopeptide repeat domain 3 -0.0474012
PCLO piccolo presynaptic cytomatrix protein -0.0473217
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0471569
ZBTB20 zinc finger and BTB domain containing 20 -0.0470481
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0469741
RPLP2 ribosomal protein, large, P2 -0.0464265
RPL28 ribosomal protein L28 -0.0463011
WWC1 WW and C2 domain containing 1 -0.0459391
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0455534
S100A10 S100 calcium binding protein A10 -0.0450814
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0442658
PKP4 plakophilin 4 -0.0439147
NKD1 naked cuticle homolog 1 (Drosophila) -0.0434792
EIF1 eukaryotic translation initiation factor 1 -0.0433236
FTH1 ferritin, heavy polypeptide 1 -0.0432183
RAB7A RAB7A, member RAS oncogene family -0.0427691
RPL31 ribosomal protein L31 -0.0422299
RPS13 ribosomal protein S13 -0.0419365
NIPBL Nipped-B homolog (Drosophila) -0.0417905
KRT18 keratin 18, type I -0.0417746
HLA-A major histocompatibility complex, class I, A -0.0417336
RPL8 ribosomal protein L8 -0.0417119
MKI67 marker of proliferation Ki-67 -0.0412965
LOC112694756 uncharaterized LOC112694756 -0.0409418
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0404078
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0403942
GSTP1 glutathione S-transferase pi 1 -0.0403316
RPS19 ribosomal protein S19 -0.0401668
ADNP activity-dependent neuroprotector homeobox -0.0400068
CCND1 cyclin D1 -0.0399346
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0393095
FBXO11 F-box protein 11 -0.0390941
B2M beta-2-microglobulin -0.038992
STAU1 staufen double-stranded RNA binding protein 1 -0.0383058
CST3 cystatin C -0.0380398
MYOF myoferlin -0.0379939
TPM4 tropomyosin 4 -0.0379836
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.037898
PATJ PATJ crumbs cell polarity complex component -0.0378345
RPL19 ribosomal protein L19 -0.037691
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0375628
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0373081
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0372257
S100A9 S100 calcium binding protein A9 -0.0370922
RPL32 ribosomal protein L32 -0.0369132
RPS3 ribosomal protein S3 -0.0366244
SLC38A1 solute carrier family 38, member 1 -0.0359838
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0359777
RPL13A ribosomal protein L13a -0.0358184
OSBPL10 oxysterol binding protein-like 10 -0.0356427
CENPF centromere protein F, 350/400kDa -0.0356159
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0348844
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0347719
RPL37A ribosomal protein L37a -0.0346765
SMYD3 SET and MYND domain containing 3 -0.0341449
IFRD1 interferon-related developmental regulator 1 -0.0340332
IFITM1 interferon induced transmembrane protein 1 -0.0339425
IER3 immediate early response 3 -0.0337992
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0337872
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0337749
RPL34 ribosomal protein L34 -0.0337376
RPL18 ribosomal protein L18 -0.0336364
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0336328
S100A6 S100 calcium binding protein A6 -0.0335258
ACTN4 actinin, alpha 4 -0.0332798
PRRC2B proline-rich coiled-coil 2B -0.0330212
RPS25 ribosomal protein S25 -0.0322567