Pitavastatin (Calcium)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pitavastatin (Calcium) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pitavastatin (Calcium)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TOP1 topoisomerase (DNA) I 0.157602
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.157254
MARK3 MAP/microtubule affinity-regulating kinase 3 0.124643
AREG amphiregulin 0.101989
TXNRD1 thioredoxin reductase 1 0.0900831
JARID2 jumonji, AT rich interactive domain 2 0.080912
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0788036
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0722374
RAB10 RAB10, member RAS oncogene family 0.0721464
MYO5B myosin VB 0.0663845
HSPA8 heat shock 70kDa protein 8 0.0657064
NDRG1 N-myc downstream regulated 1 0.0641594
RCOR1 REST corepressor 1 0.0634614
FERMT1 fermitin family member 1 0.0600785
ESYT2 extended synaptotagmin-like protein 2 0.0572356
IER3 immediate early response 3 0.0547807
DSPP dentin sialophosphoprotein 0.0543219
SNX9 sorting nexin 9 0.0538419
ITPRID2 ITPR interacting domain containing 2 0.0491314
DDIT4 DNA-damage-inducible transcript 4 0.0465481
GCLC glutamate-cysteine ligase, catalytic subunit 0.0457603
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0455163
NUP58 nucleoporin 58 0.0435189
ANKRD10 ankyrin repeat domain 10 0.0432845
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0430411
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0389674
RNF145 ring finger protein 145 0.037643
ERRFI1 ERBB receptor feedback inhibitor 1 0.0375413
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0372287
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.037084
ELL2 elongation factor, RNA polymerase II, 2 0.0366704
TPT1 tumor protein, translationally-controlled 1 0.0350271
DSC3 desmocollin 3 0.0346681
CHD1 chromodomain helicase DNA binding protein 1 0.0329679
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0328749
DSCAM Down syndrome cell adhesion molecule 0.0323236
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0321833
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0320708
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0313685
NAMPT nicotinamide phosphoribosyltransferase 0.0307705
MYH9 myosin, heavy chain 9, non-muscle 0.03014
RPL3 ribosomal protein L3 0.0297046
S100A6 S100 calcium binding protein A6 0.0296586
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0293204
KLF6 Kruppel-like factor 6 0.0292218
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0285106
RAB6A RAB6A, member RAS oncogene family 0.0278176
RHOB ras homolog family member B 0.0272219
NGLY1 N-glycanase 1 0.0264153
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0252972
MACF1 microtubule-actin crosslinking factor 1 0.0246545
RREB1 ras responsive element binding protein 1 0.0238004
ADAM17 ADAM metallopeptidase domain 17 0.0236213
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.023496
HOMER1 homer scaffolding protein 1 0.0232313
WAC WW domain containing adaptor with coiled-coil 0.0231718
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0231326
PLEK2 pleckstrin 2 0.0230264
GRID1 glutamate receptor, ionotropic, delta 1 0.0228679
RAP1GAP2 RAP1 GTPase activating protein 2 0.0220762
EZR ezrin 0.0217663
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0215099
RTN4 reticulon 4 0.0213181
BAIAP2L1 BAI1-associated protein 2-like 1 0.0213041
HILPDA hypoxia inducible lipid droplet-associated 0.0213007
KLF5 Kruppel-like factor 5 (intestinal) 0.021226
EREG epiregulin 0.0210758
KRT19 keratin 19, type I 0.0210436
GRB10 growth factor receptor-bound protein 10 0.0209604
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0207606
CDCP1 CUB domain containing protein 1 0.0203442
KRT16 keratin 16, type I 0.020098
FAM107B family with sequence similarity 107, member B 0.019783
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.0194687
ARHGAP21 Rho GTPase activating protein 21 0.0194032
USP3 ubiquitin specific peptidase 3 0.0193529
STK4 serine/threonine kinase 4 0.0191304
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0186682
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0185617
RNASEH2A ribonuclease H2, subunit A 0.0185406
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0183539
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0182736
ARL8B ADP-ribosylation factor-like 8B 0.0181623
ZFP36L1 ZFP36 ring finger protein-like 1 0.0177933
DIAPH1 diaphanous-related formin 1 0.0176366
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0170929
ANXA5 annexin A5 0.0170881
ABHD3 abhydrolase domain containing 3 0.0170484
CD2AP CD2-associated protein 0.016948
GARS1 glycyl-tRNA synthetase 1 0.0169193
TMEM41B transmembrane protein 41B 0.0168697
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0165929
VSIG2 V-set and immunoglobulin domain containing 2 0.0164325
TJP2 tight junction protein 2 0.0159989
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0159864
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0157326
WDR43 WD repeat domain 43 0.0155787
LAMC2 laminin, gamma 2 0.0154691
FMNL2 formin-like 2 0.0153725
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0153695

decreased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) -0.151803
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.140017
RAD51B RAD51 paralog B -0.135199
HMGA2 high mobility group AT-hook 2 -0.122722
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.117025
OXR1 oxidation resistance 1 -0.0881806
EGFR epidermal growth factor receptor -0.0847741
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0841431
NCEH1 neutral cholesterol ester hydrolase 1 -0.0823004
CCSER1 coiled-coil serine-rich protein 1 -0.0818772
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0747132
FHIT fragile histidine triad -0.0731005
ACTG1 actin gamma 1 -0.0713941
ATXN1 ataxin 1 -0.070376
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0669997
LMO7 LIM domain 7 -0.0651046
DOCK5 dedicator of cytokinesis 5 -0.0646676
PTMA prothymosin, alpha -0.0643794
AKAP9 A kinase (PRKA) anchor protein 9 -0.0635914
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0631977
VCL vinculin -0.0627177
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0600322
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0588504
ACTN4 actinin, alpha 4 -0.0555916
EEF2 eukaryotic translation elongation factor 2 -0.054422
UBC ubiquitin C -0.05344
SMYD3 SET and MYND domain containing 3 -0.0525636
EMP1 epithelial membrane protein 1 -0.0520032
GPHN gephyrin -0.0511134
TBC1D5 TBC1 domain family, member 5 -0.0484621
CANX calnexin -0.0481524
BCL2L1 BCL2-like 1 -0.0478973
FAT1 FAT atypical cadherin 1 -0.0464976
EXOC4 exocyst complex component 4 -0.0463286
ITPKC inositol-trisphosphate 3-kinase C -0.0447393
RBM25 RNA binding motif protein 25 -0.0445603
LOC102724023 ES1 protein homolog, mitochondrial -0.0436806
MTUS1 microtubule associated tumor suppressor 1 -0.0435427
VMP1 vacuole membrane protein 1 -0.0425036
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0418431
HDAC2 histone deacetylase 2 -0.0416254
PHF14 PHD finger protein 14 -0.0416253
EHBP1 EH domain binding protein 1 -0.0412081
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0407247
PATJ PATJ crumbs cell polarity complex component -0.040634
MKI67 marker of proliferation Ki-67 -0.040436
CENPF centromere protein F, 350/400kDa -0.0401154
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0396441
TXNIP thioredoxin interacting protein -0.0396124
SMAD3 SMAD family member 3 -0.0392091
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.039061
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0386541
KITLG KIT ligand -0.0383613
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0382762
PKP4 plakophilin 4 -0.036663
TBC1D22A TBC1 domain family, member 22A -0.0366089
AHNAK AHNAK nucleoprotein -0.0356993
CUX1 cut-like homeobox 1 -0.0356217
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0352561
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0349187
MTAP methylthioadenosine phosphorylase -0.0346683
NF1 neurofibromin 1 -0.0345639
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0335675
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0334333
AXIN2 axin 2 -0.0332184
RUNX2 runt-related transcription factor 2 -0.033188
RPS27A ribosomal protein S27a -0.0329215
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0328583
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0328391
ZBTB20 zinc finger and BTB domain containing 20 -0.0327766
MED13L mediator complex subunit 13-like -0.0322485
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0322227
ANKRD17 ankyrin repeat domain 17 -0.0320363
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0320126
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0319757
PARD3B par-3 family cell polarity regulator beta -0.0317577
FRMD5 FERM domain containing 5 -0.0312067
RPS24 ribosomal protein S24 -0.0308752
BIRC6 baculoviral IAP repeat containing 6 -0.0308499
GOLGA4 golgin A4 -0.0303782
CALU calumenin -0.0302673
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0301469
PDE4B phosphodiesterase 4B, cAMP-specific -0.0300525
SERINC5 serine incorporator 5 -0.0292847
NUP50 nucleoporin 50kDa -0.0289697
ECT2 epithelial cell transforming 2 -0.0289586
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0289459
FHL2 four and a half LIM domains 2 -0.0287815
FER fer (fps/fes related) tyrosine kinase -0.0284655
CLTC clathrin, heavy chain (Hc) -0.0283837
AOPEP aminopeptidase O (putative) -0.0281524
BPTF bromodomain PHD finger transcription factor -0.0281173
MSI2 musashi RNA-binding protein 2 -0.0280284
POTEF POTE ankyrin domain family, member F -0.0279101
CD9 CD9 molecule -0.0278432
AKAP12 A kinase (PRKA) anchor protein 12 -0.0274961
TTC3 tetratricopeptide repeat domain 3 -0.0274646
PRELID2 PRELI domain containing 2 -0.027237
PTPRK protein tyrosine phosphatase, receptor type, K -0.0269212
TNS3 tensin 3 -0.0265192