Pleural mesothelioma Gene Set

Dataset WikiPathways Pathways 2024
Category structural or functional annotations
Type pathway
Description A Malignant mesothelioma originating from cells of the pleura (the thin layer of mesothelium lining the lungs). Pleural mesothelioma is the most common form of mesothelioma. (Human Phenotype Ontology, HP_0100002)
External Link https://www.wikipathways.org/pathways/WP5087.html
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Genes

437 proteins participating in the Pleural mesothelioma pathway from the WikiPathways Pathways 2024 dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGER advanced glycosylation end product-specific receptor
AJUBA ajuba LIM protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMOT angiomotin
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPT4 angiopoietin 4
APC adenomatous polyposis coli
AREG amphiregulin
ASXL1 additional sex combs like transcriptional regulator 1
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATG13 autophagy related 13
ATM ATM serine/threonine kinase
AXIN1 axin 1
BAG2 BCL2-associated athanogene 2
BAK1 BCL2-antagonist/killer 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BARD1 BRCA1 associated RING domain 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BTC betacellulin
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1B-PAK6 BUB1B-PAK6 readthrough
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCN2 cellular communication network factor 2
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CD274 CD274 molecule
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH12 cadherin 12, type 2 (N-cadherin 2)
CDH13 cadherin 13
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDH16 cadherin 16, KSP-cadherin
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDH18 cadherin 18, type 2
CDH19 cadherin 19, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH20 cadherin 20, type 2
CDH22 cadherin 22, type 2
CDH24 cadherin 24, type 2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDH7 cadherin 7, type 2
CDH8 cadherin 8, type 2
CDH9 cadherin 9, type 2 (T1-cadherin)
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CER1 cerberus 1, DAN family BMP antagonist
CHD8 chromodomain helicase DNA binding protein 8
CIT citron rho-interacting serine/threonine kinase
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CREB1 cAMP responsive element binding protein 1
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSNK1A1 casein kinase 1, alpha 1
CSNK1A1L casein kinase 1, alpha 1-like
CSNK1E casein kinase 1, epsilon
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2A3 casein kinase 2, alpha 3 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CTHRC1 collagen triple helix repeat containing 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXXC4 CXXC finger protein 4
CYCS cytochrome c, somatic
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DKK4 dickkopf WNT signaling pathway inhibitor 4
DSC3 desmocollin 3
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
E2F1 E2F transcription factor 1
EED embryonic ectoderm development
EFNA1 ephrin-A1
EFNA2 ephrin-A2
EFNA3 ephrin-A3
EFNA4 ephrin-A4
EFNA5 ephrin-A5
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELK1 ELK1, member of ETS oncogene family
EPHA2 EPH receptor A2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF11 fibroblast growth factor 11
FGF12 fibroblast growth factor 12
FGF13 fibroblast growth factor 13
FGF14 fibroblast growth factor 14
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF21 fibroblast growth factor 21
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD1 frizzled class receptor 1
FZD10 frizzled class receptor 10
FZD2 frizzled class receptor 2
FZD3 frizzled class receptor 3
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HBEGF heparin-binding EGF-like growth factor
HCFC1 host cell factor C1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMGN1 high mobility group nucleosome binding domain 1
HRAS Harvey rat sarcoma viral oncogene homolog
IDO1 indoleamine 2,3-dioxygenase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL1B interleukin 1, beta
IL34 interleukin 34
IL6 interleukin 6
INS insulin
INSR insulin receptor
ITGA1 integrin, alpha 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JUN jun proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KDR kinase insert domain receptor
KIF23 kinesin family member 23
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KMT2C lysine (K)-specific methyltransferase 2C
KREMEN1 kringle containing transmembrane protein 1
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LAMA3 laminin, alpha 3
LAMA4 laminin, alpha 4
LAMA5 laminin, alpha 5
LAMB1 laminin, beta 1
LAMB2 laminin, beta 2 (laminin S)
LAMB3 laminin, beta 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMC2 laminin, gamma 2
LAMC3 laminin, gamma 3
LATS1 large tumor suppressor kinase 1
LATS2 large tumor suppressor kinase 2
LEF1 lymphoid enhancer-binding factor 1
LGALS9 lectin, galactoside-binding, soluble, 9
LIMD1 LIM domains containing 1
LIN28B lin-28 homolog B (C. elegans)
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAX MYC associated factor X
MCL1 myeloid cell leukemia 1
MCU mitochondrial calcium uniporter
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEF2D myocyte enhancer factor 2D
MET MET proto-oncogene, receptor tyrosine kinase
MINK1 misshapen-like kinase 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MOB1A MOB kinase activator 1A
MOB1B MOB kinase activator 1B
MST1 macrophage stimulating 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NF2 neurofibromin 2 (merlin)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NLRP3 NLR family, pyrin domain containing 3
NOTUM notum pectinacetylesterase homolog (Drosophila)
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK5 p21 (RAC1) activated kinase 5
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGF placental growth factor
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PODXL podocalyxin-like
PORCN porcupine homolog (Drosophila)
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRB1 proline-rich protein BstNI subfamily 1
PRB2 proline-rich protein BstNI subfamily 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PRSS23 protease, serine, 23
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RASSF6 Ras association (RalGDS/AF-6) domain family member 6
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RB1CC1 RB1-inducible coiled-coil 1
RBBP4 retinoblastoma binding protein 4
RHEB Ras homolog enriched in brain
RING1 ring finger protein 1
RNF2 ring finger protein 2
ROR1 receptor tyrosine kinase-like orphan receptor 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RPTOR regulatory associated protein of MTOR, complex 1
RYK receptor-like tyrosine kinase
SAV1 salvador family WW domain containing protein 1
SELE selectin E
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SETD2 SET domain containing 2
SETD5 SET domain containing 5
SETDB1 SET domain, bifurcated 1
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP4 secreted frizzled-related protein 4
SFRP5 secreted frizzled-related protein 5
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOS1 son of sevenless homolog 1 (Drosophila)
SOST sclerostin
SOX17 SRY (sex determining region Y)-box 17
SP1 Sp1 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STK3 serine/threonine kinase 3
STK38L serine/threonine kinase 38 like
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2 TEA domain family member 2
TEAD3 TEA domain family member 3
TEAD4 TEA domain family member 4
TEK TEK tyrosine kinase, endothelial
TELO2 telomere maintenance 2
TERT telomerase reverse transcriptase
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TNIK TRAF2 and NCK interacting kinase
TNNT1 troponin T type 1 (skeletal, slow)
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTI1 TELO2 interacting protein 1
UHRF1 ubiquitin-like with PHD and ring finger domains 1
ULK1 unc-51 like autophagy activating kinase 1
ULK2 unc-51 like autophagy activating kinase 2
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VEGFD vascular endothelial growth factor D
VGLL4 vestigial-like family member 4
WDR5 WD repeat domain 5
WIF1 WNT inhibitory factor 1
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
WNT10B wingless-type MMTV integration site family, member 10B
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
WNT2B wingless-type MMTV integration site family, member 2B
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
WNT6 wingless-type MMTV integration site family, member 6
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WWC1 WW and C2 domain containing 1
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YY1 YY1 transcription factor