Pleurisy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. (Human Disease Ontology, DOID_10247)
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Genes

202 genes co-occuring with the disease Pleurisy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ADA adenosine deaminase 2.735
IL1B interleukin 1, beta 2.538
TNF tumor necrosis factor 2.437
KNG1 kininogen 1 2.343
IFNG interferon, gamma 2.323
CRP C-reactive protein, pentraxin-related 2.296
MPO myeloperoxidase 2.286
IL6 interleukin 6 2.27
MEFV Mediterranean fever 2.126
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.123
IL10 interleukin 10 2.122
ANXA1 annexin A1 2.023
CD4 CD4 molecule 1.99
ALB albumin 1.945
IL1A interleukin 1, alpha 1.928
IL4 interleukin 4 1.913
PTGES prostaglandin E synthase 1.904
ICAM1 intercellular adhesion molecule 1 1.884
IL2 interleukin 2 1.881
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.838
ALOX5 arachidonate 5-lipoxygenase 1.822
IL17A interleukin 17A 1.818
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.816
CCL2 chemokine (C-C motif) ligand 2 1.814
CXCL8 chemokine (C-X-C motif) ligand 8 1.807
IL5 interleukin 5 1.792
TSC22D3 TSC22 domain family, member 3 1.777
CCL11 chemokine (C-C motif) ligand 11 1.762
CD8A CD8a molecule 1.757
TGFB1 transforming growth factor, beta 1 1.746
PRTN3 proteinase 3 1.745
TLR4 toll-like receptor 4 1.731
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.676
KLKB1 kallikrein B, plasma (Fletcher factor) 1 1.667
CALB2 calbindin 2 1.661
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.64
HMOX1 heme oxygenase 1 1.636
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 1.633
TAC1 tachykinin, precursor 1 1.622
NOS2 nitric oxide synthase 2, inducible 1.62
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.602
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.596
IL13 interleukin 13 1.594
MSLN mesothelin 1.572
PTGER3 prostaglandin E receptor 3 (subtype EP3) 1.568
IL18 interleukin 18 1.565
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.555
TLR2 toll-like receptor 2 1.555
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.526
VCAM1 vascular cell adhesion molecule 1 1.514
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.513
CXCL10 chemokine (C-X-C motif) ligand 10 1.486
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.473
C3 complement component 3 1.471
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.465
ZNF740 zinc finger protein 740 1.462
CCL5 chemokine (C-C motif) ligand 5 1.459
MMP9 matrix metallopeptidase 9 1.448
NLRP3 NLR family, pyrin domain containing 3 1.447
FPR2 formyl peptide receptor 2 1.445
LTF lactotransferrin 1.445
TRIM21 tripartite motif containing 21 1.437
PTGES2 prostaglandin E synthase 2 1.429
SELL selectin L 1.421
CCL3 chemokine (C-C motif) ligand 3 1.394
KEAP1 kelch-like ECH-associated protein 1 1.391
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.389
FASLG Fas ligand (TNF superfamily, member 6) 1.383
ELANE elastase, neutrophil expressed 1.376
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.375
IFNA1 interferon, alpha 1 1.364
MCL1 myeloid cell leukemia 1 1.364
PTGES3 prostaglandin E synthase 3 (cytosolic) 1.36
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.359
ALOX5AP arachidonate 5-lipoxygenase-activating protein 1.35
CCL4 chemokine (C-C motif) ligand 4 1.344
HP haptoglobin 1.34
LTB4R leukotriene B4 receptor 1.339
LOX lysyl oxidase 1.338
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.329
PDE4A phosphodiesterase 4A, cAMP-specific 1.326
PPARG peroxisome proliferator-activated receptor gamma 1.325
MAPK3 mitogen-activated protein kinase 3 1.311
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.298
SSB Sjogren syndrome antigen B (autoantigen La) 1.296
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.289
IFNB1 interferon, beta 1, fibroblast 1.282
ACE2 angiotensin I converting enzyme 2 1.281
ACE angiotensin I converting enzyme 1.28
F2 coagulation factor II (thrombin) 1.276
TBP TATA box binding protein 1.268
BCL2 B-cell CLL/lymphoma 2 1.268
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 1.264
CKB creatine kinase, brain 1.262
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.256
CKMT1B creatine kinase, mitochondrial 1B 1.255
TLR9 toll-like receptor 9 1.251
CKM creatine kinase, muscle 1.251
PXDNL peroxidasin-like 1.249
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.249
PTX4 pentraxin 4, long 1.248
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.248
ACTB actin, beta 1.248
PXDN peroxidasin 1.247
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 1.246
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.245
FN1 fibronectin 1 1.244
GPX2 glutathione peroxidase 2 1.239
PLG plasminogen 1.232
NOX4 NADPH oxidase 4 1.228
SELE selectin E 1.226
CDK7 cyclin-dependent kinase 7 1.222
ENO2 enolase 2 (gamma, neuronal) 1.222
MVK mevalonate kinase 1.22
F3 coagulation factor III (thromboplastin, tissue factor) 1.213
MYD88 myeloid differentiation primary response 88 1.211
APP amyloid beta (A4) precursor protein 1.21
GPX5 glutathione peroxidase 5 1.205
GPX7 glutathione peroxidase 7 1.201
IL22 interleukin 22 1.201
JUN jun proto-oncogene 1.201
INS insulin 1.195
POMC proopiomelanocortin 1.195
PTGDR2 prostaglandin D2 receptor 2 1.193
CSF3 colony stimulating factor 3 (granulocyte) 1.193
GPX6 glutathione peroxidase 6 1.193
GPX8 glutathione peroxidase 8 (putative) 1.192
RPS19 ribosomal protein S19 1.189
MBL2 mannose-binding lectin (protein C) 2, soluble 1.187
SAA1 serum amyloid A1 1.186
GPX3 glutathione peroxidase 3 1.183
MRC1 mannose receptor, C type 1 1.183
CD19 CD19 molecule 1.178
CD34 CD34 molecule 1.177
STAT1 signal transducer and activator of transcription 1, 91kDa 1.177
SAA2 serum amyloid A2 1.176
CD163 CD163 molecule 1.171
CD68 CD68 molecule 1.167
LTA4H leukotriene A4 hydrolase 1.166
KRT5 keratin 5, type II 1.163
FOXP3 forkhead box P3 1.163
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.159
CYBB cytochrome b-245, beta polypeptide 1.157
XDH xanthine dehydrogenase 1.156
NFE2L2 nuclear factor, erythroid 2-like 2 1.155
ADA2 adenosine deaminase 2 1.154
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.146
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 1.14
HPGDS hematopoietic prostaglandin D synthase 1.138
CCR2 chemokine (C-C motif) receptor 2 1.135
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.133
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.129
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.127
TLR7 toll-like receptor 7 1.124
APOH apolipoprotein H (beta-2-glycoprotein I) 1.121
PPARA peroxisome proliferator-activated receptor alpha 1.12
ARG1 arginase 1 1.117
CTSG cathepsin G 1.11
WT1 Wilms tumor 1 1.11
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.101
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.097
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.096
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.091
MUC1 mucin 1, cell surface associated 1.089
NOD2 nucleotide-binding oligomerization domain containing 2 1.084
NOS1 nitric oxide synthase 1 (neuronal) 1.083
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.083
LPIN2 lipin 2 1.077
PPARD peroxisome proliferator-activated receptor delta 1.06
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.059
IL1RN interleukin 1 receptor antagonist 1.058
CHUK conserved helix-loop-helix ubiquitous kinase 1.057
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.053
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 1.048
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.048
PECAM1 platelet/endothelial cell adhesion molecule 1 1.045
NPPB natriuretic peptide B 1.042
NCF1 neutrophil cytosolic factor 1 1.039
FOS FBJ murine osteosarcoma viral oncogene homolog 1.038
NAPSA napsin A aspartic peptidase 1.037
NOS3 nitric oxide synthase 3 (endothelial cell) 1.036
ANXA5 annexin A5 1.033
SPP1 secreted phosphoprotein 1 1.031
HRH4 histamine receptor H4 1.029
PRF1 perforin 1 (pore forming protein) 1.027
IFNA2 interferon, alpha 2 1.026
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 1.022
EGFR epidermal growth factor receptor 1.018
CD40LG CD40 ligand 1.018
CXCL9 chemokine (C-X-C motif) ligand 9 1.018
CDK9 cyclin-dependent kinase 9 1.017
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.013
TP53 tumor protein p53 1.01
CD274 CD274 molecule 1.009
C5AR1 complement component 5a receptor 1 1.008
MMP3 matrix metallopeptidase 3 1.008
IL1R1 interleukin 1 receptor, type I 1.007
IRF3 interferon regulatory factor 3 1.007
CD40 CD40 molecule, TNF receptor superfamily member 5 1.006
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.003
IL33 interleukin 33 1.003
KRT19 keratin 19, type I 1.001