Plicamycin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Plicamycin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Plicamycin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.129781
VIM vimentin 0.112777
AREG amphiregulin 0.0968587
PTMA prothymosin, alpha 0.0815555
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0782987
PCBP2 poly(rC) binding protein 2 0.0767093
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0598858
RPS12 ribosomal protein S12 0.0541285
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0433313
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0411437
FTL ferritin, light polypeptide 0.0334351
FXR1 fragile X mental retardation, autosomal homolog 1 0.0304311
EIF1 eukaryotic translation initiation factor 1 0.0283548
PTMS parathymosin 0.0279561
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.026886
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.026686
KTN1 kinectin 1 (kinesin receptor) 0.0266227
RPS3 ribosomal protein S3 0.0264654
KMT2E lysine (K)-specific methyltransferase 2E 0.0263615
AKAP9 A kinase (PRKA) anchor protein 9 0.0261728
RPL37A ribosomal protein L37a 0.0259726
RPS6 ribosomal protein S6 0.0258647
CPOX coproporphyrinogen oxidase 0.025788
EEF2 eukaryotic translation elongation factor 2 0.0257347
SET SET nuclear proto-oncogene 0.0254844
HDGF hepatoma-derived growth factor 0.0239968
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0231896
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0231269
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0230827
POTEF POTE ankyrin domain family, member F 0.0230666
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0223654
S100A6 S100 calcium binding protein A6 0.0223362
RPL3 ribosomal protein L3 0.022248
ZNF292 zinc finger protein 292 0.0216077
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.021361
PFN1 profilin 1 0.0210544
RPS8 ribosomal protein S8 0.0189509
GOLGA4 golgin A4 0.0188315
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0187923
CDK19 cyclin-dependent kinase 19 0.0187023
SETD5 SET domain containing 5 0.0181331
CCNL1 cyclin L1 0.0180588
RPL23 ribosomal protein L23 0.0180475
RPL7 ribosomal protein L7 0.0179432
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.017863
CSNK1A1 casein kinase 1, alpha 1 0.0176322
YBX1 Y box binding protein 1 0.0176091
DCAF7 DDB1 and CUL4 associated factor 7 0.0172543
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0171731
GARS1 glycyl-tRNA synthetase 1 0.0169161
GPBP1 GC-rich promoter binding protein 1 0.0165619
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0165185
TPM3 tropomyosin 3 0.0163859
RPL36 ribosomal protein L36 0.0161426
SSRP1 structure specific recognition protein 1 0.0159039
LDHB lactate dehydrogenase B 0.0157645
PRRC2C proline-rich coiled-coil 2C 0.0157566
RPS18 ribosomal protein S18 0.0157115
UBE2B ubiquitin-conjugating enzyme E2B 0.0151747
PRKCI protein kinase C, iota 0.0150737
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0150069
PDIA6 protein disulfide isomerase family A, member 6 0.014873
HELZ helicase with zinc finger 0.0146174
MSN moesin 0.0145778
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0143113
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0142919
EEF1G eukaryotic translation elongation factor 1 gamma 0.0142483
PNN pinin, desmosome associated protein 0.0142015
PA2G4 proliferation-associated 2G4, 38kDa 0.0141332
RPL9 ribosomal protein L9 0.0141196
EIF5B eukaryotic translation initiation factor 5B 0.0139839
UBA6 ubiquitin-like modifier activating enzyme 6 0.0139707
NUP58 nucleoporin 58 0.013838
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0136825
RB1CC1 RB1-inducible coiled-coil 1 0.0135848
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0135648
RPL31 ribosomal protein L31 0.0134298
KDM2A lysine (K)-specific demethylase 2A 0.0133581
GIGYF2 GRB10 interacting GYF protein 2 0.0131661
SRRM1 serine/arginine repetitive matrix 1 0.0130774
CBX3 chromobox homolog 3 0.0130628
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0130572
MATR3 matrin 3 0.0130152
RPL21 ribosomal protein L21 0.0129538
GGNBP2 gametogenetin binding protein 2 0.0128627
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.012826
ARRDC3 arrestin domain containing 3 0.012819
SRRM2 serine/arginine repetitive matrix 2 0.0128075
HLA-A major histocompatibility complex, class I, A 0.0127926
CHD1 chromodomain helicase DNA binding protein 1 0.012753
B2M beta-2-microglobulin 0.0127422
RPS27 ribosomal protein S27 0.01274
UBC ubiquitin C 0.0127047
YTHDC1 YTH domain containing 1 0.0126777
NACA nascent polypeptide-associated complex alpha subunit 0.0126692
RPS27A ribosomal protein S27a 0.0126412
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.012623
VMP1 vacuole membrane protein 1 0.0126113
ADAM17 ADAM metallopeptidase domain 17 0.0126067
EDN1 endothelin 1 0.0125195

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.224124
NLGN1 neuroligin 1 -0.209252
PDE4D phosphodiesterase 4D, cAMP-specific -0.151404
PCDH7 protocadherin 7 -0.0842549
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0749613
CELF2 CUGBP, Elav-like family member 2 -0.0657918
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0641427
MMP12 matrix metallopeptidase 12 -0.0593822
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0578989
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0538875
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0475822
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0462766
ZNF804A zinc finger protein 804A -0.0453632
AHNAK AHNAK nucleoprotein -0.0447421
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0445641
HMGA2 high mobility group AT-hook 2 -0.0438917
SLC38A2 solute carrier family 38, member 2 -0.0434696
ADGRG6 adhesion G protein-coupled receptor G6 -0.0420581
DPYD dihydropyrimidine dehydrogenase -0.0418599
DLC1 DLC1 Rho GTPase activating protein -0.0399506
RIMS2 regulating synaptic membrane exocytosis 2 -0.0388851
LMO7 LIM domain 7 -0.0372787
MTAP methylthioadenosine phosphorylase -0.0370451
YAP1 Yes-associated protein 1 -0.0360053
DST dystonin -0.0359639
BCHE butyrylcholinesterase -0.0346758
RASAL2 RAS protein activator like 2 -0.034488
PDGFC platelet derived growth factor C -0.0343942
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0338503
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0335125
ANKRD28 ankyrin repeat domain 28 -0.0329878
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0323994
EDARADD EDAR-associated death domain -0.032283
TENM3 teneurin transmembrane protein 3 -0.0317853
TAS2R14 taste receptor, type 2, member 14 -0.0307975
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0300823
FUS FUS RNA binding protein -0.0298979
ACTG1 actin gamma 1 -0.0298301
NHSL1 NHS-like 1 -0.0281002
NEBL nebulette -0.0260268
CCND1 cyclin D1 -0.0260174
CCSER1 coiled-coil serine-rich protein 1 -0.0259477
RAB7A RAB7A, member RAS oncogene family -0.0258127
ZNF217 zinc finger protein 217 -0.0254032
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0253056
NABP1 nucleic acid binding protein 1 -0.0248709
CMIP c-Maf inducing protein -0.0242313
RABGAP1L RAB GTPase activating protein 1-like -0.0223274
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0222063
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0218111
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0211995
TPT1 tumor protein, translationally-controlled 1 -0.0209364
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0207374
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0202666
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0202111
DOCK1 dedicator of cytokinesis 1 -0.0202106
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0202002
ADIPOR2 adiponectin receptor 2 -0.0201911
ZFAND3 zinc finger, AN1-type domain 3 -0.0200546
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0200366
TMEM123 transmembrane protein 123 -0.0197804
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0195661
H1-0 H1.0 linker histone -0.0194067
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0194047
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0192849
MKI67 marker of proliferation Ki-67 -0.0192736
MSRB3 methionine sulfoxide reductase B3 -0.0191467
EHBP1 EH domain binding protein 1 -0.0191384
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0189383
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.01889
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0188769
NPC1 Niemann-Pick disease, type C1 -0.0188181
USP34 ubiquitin specific peptidase 34 -0.0186762
NF1 neurofibromin 1 -0.0186753
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0184669
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0182156
DNAH14 dynein, axonemal, heavy chain 14 -0.0182128
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0180079
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0178449
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0176863
DTNA dystrobrevin, alpha -0.0176115
MYPN myopalladin -0.0173007
HDLBP high density lipoprotein binding protein -0.0171253
CEP112 centrosomal protein 112kDa -0.0171137
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0169855
GJA1 gap junction protein, alpha 1, 43kDa -0.016761
LPP LIM domain containing preferred translocation partner in lipoma -0.0167476
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0167345
COMMD10 COMM domain containing 10 -0.0165913
TUBB tubulin, beta class I -0.0162092
CLDN1 claudin 1 -0.0160986
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0159396
CSMD3 CUB and Sushi multiple domains 3 -0.0158922
THSD7A thrombospondin, type I, domain containing 7A -0.0158667
EGR1 early growth response 1 -0.0156579
CDK6 cyclin-dependent kinase 6 -0.0154573
HDAC9 histone deacetylase 9 -0.015248
ETV6 ets variant 6 -0.0152165
LARP4B La ribonucleoprotein domain family, member 4B -0.0149511
PDE4B phosphodiesterase 4B, cAMP-specific -0.0149306