Plicamycin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Plicamycin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Plicamycin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0796859
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0739261
ARHGAP26 Rho GTPase activating protein 26 0.0545047
STS steroid sulfatase (microsomal), isozyme S 0.0497127
EPSTI1 epithelial stromal interaction 1 (breast) 0.0496515
RAD51B RAD51 paralog B 0.048397
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0477572
INTS6 integrator complex subunit 6 0.0454936
SMAD3 SMAD family member 3 0.0446211
GMDS GDP-mannose 4,6-dehydratase 0.0402293
RNF213 ring finger protein 213 0.0388353
PLSCR2 phospholipid scramblase 2 0.036591
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0357719
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0278799
MX1 MX dynamin-like GTPase 1 0.02747
PADI1 peptidyl arginine deiminase, type I 0.0274632
TSHZ2 teashirt zinc finger homeobox 2 0.0267726
KIF16B kinesin family member 16B 0.0266599
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0264308
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0247085
SORBS1 sorbin and SH3 domain containing 1 0.0240113
FNDC3B fibronectin type III domain containing 3B 0.0240099
TRIO trio Rho guanine nucleotide exchange factor 0.0237797
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0229938
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0216967
DIAPH1 diaphanous-related formin 1 0.0214088
SSH2 slingshot protein phosphatase 2 0.0205004
NPSR1 neuropeptide S receptor 1 0.0204416
CATSPERB catsper channel auxiliary subunit beta 0.0203904
TNS4 tensin 4 0.0201392
MLPH melanophilin 0.0198428
SH3PXD2A SH3 and PX domains 2A 0.0196029
SAMD12 sterile alpha motif domain containing 12 0.0194715
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0194522
LPP LIM domain containing preferred translocation partner in lipoma 0.0193406
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0188662
ATP10B ATPase, class V, type 10B 0.0188285
RABGAP1L RAB GTPase activating protein 1-like 0.0180109
RIGI RNA sensor RIG-I 0.0180042
MYH9 myosin, heavy chain 9, non-muscle 0.017619
IGF1R insulin-like growth factor 1 receptor 0.0170898
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0168745
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0167804
BCL2L1 BCL2-like 1 0.0166168
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0164467
SHB Src homology 2 domain containing adaptor protein B 0.0163723
ANKRD10 ankyrin repeat domain 10 0.016098
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0158815
PTK2 protein tyrosine kinase 2 0.0157985
PRKCA protein kinase C, alpha 0.0157129
PRKCE protein kinase C, epsilon 0.0157083
TM4SF19 transmembrane 4 L six family member 19 0.0156202
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0155581
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0154357
PCED1B PC-esterase domain containing 1B 0.0153925
ARGLU1 arginine and glutamate rich 1 0.0152961
VCL vinculin 0.0152796
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.015145
DGKH diacylglycerol kinase, eta 0.0151095
CEMIP cell migration inducing protein, hyaluronan binding 0.0150825
IFNGR1 interferon gamma receptor 1 0.0150662
SPIDR scaffolding protein involved in DNA repair 0.0149701
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0149535
MAML2 mastermind-like 2 (Drosophila) 0.0148776
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0148568
BICRAL BICRA like chromatin remodeling complex associated protein 0.0148122
GSK3B glycogen synthase kinase 3 beta 0.0147859
EXOC4 exocyst complex component 4 0.0147092
DST dystonin 0.0145931
POF1B premature ovarian failure, 1B 0.0143804
MYO5B myosin VB 0.0143031
SETX senataxin 0.0142122
SPRED1 sprouty-related, EVH1 domain containing 1 0.0140497
SPATA6L spermatogenesis associated 6-like 0.0140081
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0139856
FAT1 FAT atypical cadherin 1 0.0135993
ARHGAP27 Rho GTPase activating protein 27 0.0133921
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0128858
YAP1 Yes-associated protein 1 0.0128411
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0127698
KDM6A lysine (K)-specific demethylase 6A 0.0127262
TRIM25 tripartite motif containing 25 0.0127246
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0126061
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0125085
ERBIN erbb2 interacting protein 0.0124602
GSDMB gasdermin B 0.0124142
CTNND1 catenin (cadherin-associated protein), delta 1 0.0123557
MED13L mediator complex subunit 13-like 0.0122477
ZHX2 zinc fingers and homeoboxes 2 0.0122168
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0120348
WWOX WW domain containing oxidoreductase 0.0119887
OARD1 O-acyl-ADP-ribose deacylase 1 0.0119376
SP140L SP140 nuclear body protein-like 0.0118815
UTRN utrophin 0.0118396
MYO10 myosin X 0.0118349
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0118135
PRSS22 protease, serine, 22 0.0118068
SRSF1 serine/arginine-rich splicing factor 1 0.0117692
FHIT fragile histidine triad 0.0117416
DENND1A DENN/MADD domain containing 1A 0.0116255

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.214767
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189108
B2M beta-2-microglobulin -0.167223
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.157213
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.143933
HLA-B major histocompatibility complex, class I, B -0.112979
EZR ezrin -0.0867054
LCN2 lipocalin 2 -0.0843438
EGR1 early growth response 1 -0.0754466
EIF1 eukaryotic translation initiation factor 1 -0.0721515
MBNL2 muscleblind-like splicing regulator 2 -0.0702953
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0700332
LMO7 LIM domain 7 -0.0698548
SQSTM1 sequestosome 1 -0.0698243
PTMA prothymosin, alpha -0.0680907
FTL ferritin, light polypeptide -0.0680857
LOC102724023 ES1 protein homolog, mitochondrial -0.0653492
MYO1E myosin IE -0.0652952
H1-0 H1.0 linker histone -0.0642146
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0617558
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0608883
RRBP1 ribosome binding protein 1 -0.0608611
IRF1 interferon regulatory factor 1 -0.0607639
RPL35A ribosomal protein L35a -0.0594476
PDIA3 protein disulfide isomerase family A, member 3 -0.0594128
UBC ubiquitin C -0.0582419
RPS6 ribosomal protein S6 -0.0577089
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0564934
MACC1 metastasis associated in colon cancer 1 -0.0549301
RPL34 ribosomal protein L34 -0.0517758
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0509394
MORF4L2 mortality factor 4 like 2 -0.0502113
RPLP1 ribosomal protein, large, P1 -0.0501704
AHI1 Abelson helper integration site 1 -0.0497323
GCLC glutamate-cysteine ligase, catalytic subunit -0.0494118
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0486946
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0483055
IFI6 interferon, alpha-inducible protein 6 -0.0479857
JUN jun proto-oncogene -0.0476308
SEC31A SEC31 homolog A (S. cerevisiae) -0.0475012
PERP PERP, TP53 apoptosis effector -0.0474276
CANX calnexin -0.0473349
RAB1A RAB1A, member RAS oncogene family -0.0459757
RHOBTB3 Rho-related BTB domain containing 3 -0.045774
NDRG1 N-myc downstream regulated 1 -0.0453719
RPL19 ribosomal protein L19 -0.0445833
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0440745
LOC112694756 uncharaterized LOC112694756 -0.0440235
HLA-C major histocompatibility complex, class I, C -0.042946
PKM pyruvate kinase, muscle -0.0426664
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0423641
HDLBP high density lipoprotein binding protein -0.042042
GOLGB1 golgin B1 -0.0409997
RPL23 ribosomal protein L23 -0.0409323
CALR calreticulin -0.0405799
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0398959
HLA-E major histocompatibility complex, class I, E -0.0398846
FTH1 ferritin, heavy polypeptide 1 -0.0397859
RPL12 ribosomal protein L12 -0.0393693
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.038141
TMSB10 thymosin beta 10 -0.037445
NAMPT nicotinamide phosphoribosyltransferase -0.0373385
S100A10 S100 calcium binding protein A10 -0.0372743
HLA-A major histocompatibility complex, class I, A -0.0371778
ARF1 ADP-ribosylation factor 1 -0.0363244
RPS8 ribosomal protein S8 -0.0362659
GOLGA4 golgin A4 -0.0359613
H3-3B H3.3 histone B -0.0352954
KDM3A lysine (K)-specific demethylase 3A -0.0350596
ZMYND8 zinc finger, MYND-type containing 8 -0.0349809
VDAC1 voltage-dependent anion channel 1 -0.0349727
EPCAM epithelial cell adhesion molecule -0.0346922
ACTG1 actin gamma 1 -0.0340231
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0339078
SLC38A1 solute carrier family 38, member 1 -0.0338983
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0332316
CSTB cystatin B (stefin B) -0.0330889
ANXA2 annexin A2 -0.0330503
RPS19 ribosomal protein S19 -0.0328637
RAB7A RAB7A, member RAS oncogene family -0.0327858
AGR2 anterior gradient 2 -0.0325885
PRRC2C proline-rich coiled-coil 2C -0.0323901
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0323295
DSTN destrin (actin depolymerizing factor) -0.0323289
RPS24 ribosomal protein S24 -0.0321936
ITPKC inositol-trisphosphate 3-kinase C -0.0320141
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0319685
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0318654
WDR45B WD repeat domain 45B -0.0316441
TXNIP thioredoxin interacting protein -0.0315559
CXCL8 chemokine (C-X-C motif) ligand 8 -0.031326
UGDH UDP-glucose 6-dehydrogenase -0.0312273
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0308722
IFI27 interferon, alpha-inducible protein 27 -0.0305286
ACBD3 acyl-CoA binding domain containing 3 -0.0296653
RPL11 ribosomal protein L11 -0.0295416
TSC22D1 TSC22 domain family, member 1 -0.0294644
MUC20 mucin 20, cell surface associated -0.0294281
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0287707
CALU calumenin -0.0285591