Plicamycin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Plicamycin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Plicamycin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0754365
TPM3 tropomyosin 3 0.0707409
PCBP2 poly(rC) binding protein 2 0.054764
RPL3 ribosomal protein L3 0.0342587
SAMD4A sterile alpha motif domain containing 4A 0.0307621
RPS18 ribosomal protein S18 0.0305057
APP amyloid beta (A4) precursor protein 0.0301545
CCNL1 cyclin L1 0.0299484
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.028105
MCL1 myeloid cell leukemia 1 0.0276791
MYH9 myosin, heavy chain 9, non-muscle 0.0264446
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0263997
RPS12 ribosomal protein S12 0.0253744
WDR43 WD repeat domain 43 0.0250613
MACF1 microtubule-actin crosslinking factor 1 0.0233676
UBASH3B ubiquitin associated and SH3 domain containing B 0.0232475
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0230807
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0230177
KTN1 kinectin 1 (kinesin receptor) 0.0226644
BIRC3 baculoviral IAP repeat containing 3 0.0225881
MSN moesin 0.022421
PTMA prothymosin, alpha 0.0216914
RNF145 ring finger protein 145 0.0214608
FMNL2 formin-like 2 0.0213023
PDLIM5 PDZ and LIM domain 5 0.02116
ADAM17 ADAM metallopeptidase domain 17 0.0210144
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0208471
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0199502
ERRFI1 ERBB receptor feedback inhibitor 1 0.0197559
ANKRD11 ankyrin repeat domain 11 0.0194159
HDGF hepatoma-derived growth factor 0.019367
ZFAND3 zinc finger, AN1-type domain 3 0.0187917
RBM25 RNA binding motif protein 25 0.0186628
MATR3 matrin 3 0.0184165
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0181135
TRIO trio Rho guanine nucleotide exchange factor 0.0179361
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0176155
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0172626
AKAP12 A kinase (PRKA) anchor protein 12 0.0166522
CSDE1 cold shock domain containing E1, RNA-binding 0.0161351
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0161082
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.016066
CDC73 cell division cycle 73 0.0156091
NUP58 nucleoporin 58 0.0155587
PUM2 pumilio RNA-binding family member 2 0.015199
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0151278
UBA6 ubiquitin-like modifier activating enzyme 6 0.0150737
PAWR PRKC, apoptosis, WT1, regulator 0.0150271
CASC3 cancer susceptibility candidate 3 0.0147663
WAC WW domain containing adaptor with coiled-coil 0.0147129
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0146231
PFKP phosphofructokinase, platelet 0.0146225
DIAPH1 diaphanous-related formin 1 0.0145392
IWS1 IWS1 homolog (S. cerevisiae) 0.0141128
DGKD diacylglycerol kinase, delta 130kDa 0.014096
MYOF myoferlin 0.0140617
COPA coatomer protein complex, subunit alpha 0.0139827
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0139616
AKAP13 A kinase (PRKA) anchor protein 13 0.0139128
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0138285
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0138098
SMAD3 SMAD family member 3 0.0137741
PNN pinin, desmosome associated protein 0.0137017
PICALM phosphatidylinositol binding clathrin assembly protein 0.0136878
RPS7 ribosomal protein S7 0.0136558
PABPN1 poly(A) binding protein, nuclear 1 0.0136384
BIRC6 baculoviral IAP repeat containing 6 0.0134912
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0133343
RB1CC1 RB1-inducible coiled-coil 1 0.0131273
CCNY cyclin Y 0.0130973
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0130376
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0130219
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0128421
KIF5B kinesin family member 5B 0.0126458
SRSF5 serine/arginine-rich splicing factor 5 0.012558
YTHDC1 YTH domain containing 1 0.0125363
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0124605
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0124493
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0123958
CFLAR CASP8 and FADD-like apoptosis regulator 0.0123747
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0122219
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0122081
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0120915
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.012046
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0119442
SFPQ splicing factor proline/glutamine-rich 0.0119154
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0118815
BCLAF1 BCL2-associated transcription factor 1 0.0117448
YY1AP1 YY1 associated protein 1 0.011643
TJP1 tight junction protein 1 0.0116365
CTNND1 catenin (cadherin-associated protein), delta 1 0.0116286
PNISR PNN-interacting serine/arginine-rich protein 0.0114974
HYOU1 hypoxia up-regulated 1 0.0114076
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0113747
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0113142
XPO1 exportin 1 0.0112622
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0112404
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0112404
UBAP2L ubiquitin associated protein 2-like 0.0111827
AATF apoptosis antagonizing transcription factor 0.0111379

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.379618
FTL ferritin, light polypeptide -0.190967
TMSB10 thymosin beta 10 -0.118722
MT2A metallothionein 2A -0.100016
IGF2 insulin-like growth factor 2 -0.087011
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0809935
ACTG1 actin gamma 1 -0.0792147
FTH1 ferritin, heavy polypeptide 1 -0.073241
TFPI2 tissue factor pathway inhibitor 2 -0.0727157
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.070974
RPL19 ribosomal protein L19 -0.0556402
IER3 immediate early response 3 -0.0513655
TXNRD1 thioredoxin reductase 1 -0.0502262
VIM vimentin -0.0489521
THSD4 thrombospondin, type I, domain containing 4 -0.0479169
RPLP1 ribosomal protein, large, P1 -0.0455809
PDE4D phosphodiesterase 4D, cAMP-specific -0.0453953
RPS21 ribosomal protein S21 -0.042974
TM4SF1 transmembrane 4 L six family member 1 -0.0420782
RPL23 ribosomal protein L23 -0.0387571
CAVIN1 caveolae associated protein 1 -0.0383216
TPT1 tumor protein, translationally-controlled 1 -0.0368031
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0347924
EIF1 eukaryotic translation initiation factor 1 -0.0341001
RPL8 ribosomal protein L8 -0.0338327
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0312318
RPL35A ribosomal protein L35a -0.0294315
PFN1 profilin 1 -0.0292665
S100A10 S100 calcium binding protein A10 -0.0281542
RPS15 ribosomal protein S15 -0.0277024
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0274144
S100A9 S100 calcium binding protein A9 -0.0258122
SERF2 small EDRK-rich factor 2 -0.0250437
RPS8 ribosomal protein S8 -0.0247163
RAB1A RAB1A, member RAS oncogene family -0.0246988
RPS19 ribosomal protein S19 -0.0246033
RPL28 ribosomal protein L28 -0.0244186
MAML3 mastermind-like 3 (Drosophila) -0.0236555
RAB7A RAB7A, member RAS oncogene family -0.023641
S100A6 S100 calcium binding protein A6 -0.0233239
BICC1 BicC family RNA binding protein 1 -0.0233132
ASTN2 astrotactin 2 -0.023194
RPS5 ribosomal protein S5 -0.0226733
LOC102724023 ES1 protein homolog, mitochondrial -0.0226677
RPLP0 ribosomal protein, large, P0 -0.0225218
LDHA lactate dehydrogenase A -0.0205926
IGFBP3 insulin-like growth factor binding protein 3 -0.0204832
SLC38A2 solute carrier family 38, member 2 -0.0203997
RPL32 ribosomal protein L32 -0.020372
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0202903
RPS16 ribosomal protein S16 -0.0202426
FUS FUS RNA binding protein -0.019747
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0196439
RPL34 ribosomal protein L34 -0.0194726
SVIL supervillin -0.0193665
RPL36 ribosomal protein L36 -0.0191917
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0190748
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.018977
NEGR1 neuronal growth regulator 1 -0.0188784
HDAC9 histone deacetylase 9 -0.0188136
KYNU kynureninase -0.0183846
RPS23 ribosomal protein S23 -0.0183273
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0180301
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0178066
VDAC1 voltage-dependent anion channel 1 -0.0177113
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0176996
EGR1 early growth response 1 -0.0174785
ANXA2 annexin A2 -0.0174668
FGB fibrinogen beta chain -0.0173518
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0173413
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0172439
RPS6 ribosomal protein S6 -0.0165809
IGFBP4 insulin-like growth factor binding protein 4 -0.0165157
C15ORF48 chromosome 15 open reading frame 48 -0.0163572
RPS29 ribosomal protein S29 -0.0162826
RPL6 ribosomal protein L6 -0.0162798
RACK1 receptor for activated C kinase 1 -0.0161921
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0161889
RPS11 ribosomal protein S11 -0.015995
TPI1 triosephosphate isomerase 1 -0.0159577
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0159027
CDK12 cyclin-dependent kinase 12 -0.0158291
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0157386
CUX1 cut-like homeobox 1 -0.0157108
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0156436
PTK2 protein tyrosine kinase 2 -0.0153201
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0153103
JUN jun proto-oncogene -0.0149621
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0149514
MYL12B myosin, light chain 12B, regulatory -0.0149477
LOC112694756 uncharaterized LOC112694756 -0.0149363
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0149356
RPS25 ribosomal protein S25 -0.0148158
DOCK4 dedicator of cytokinesis 4 -0.0146502
RHOA ras homolog family member A -0.0146279
TUBB tubulin, beta class I -0.0145835
ARF1 ADP-ribosylation factor 1 -0.0144202
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0142341
IFITM3 interferon induced transmembrane protein 3 -0.0141257
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0141243